Lymphotoxin/light, lymphoid microenvironments and autoimmune disease (Q35219029)

7 August 2017

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title

Lymphotoxin/light, lymphoid microenvironments and autoimmune disease (English)

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7 August 2017

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Jennifer L Gommerman

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7 August 2017

Jeffrey L Browning

series ordinal

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7 August 2017

publication date

1 August 2003

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Nature Reviews Immunology

7 August 2017

published in

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7 August 2017

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7 August 2017

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7 August 2017

page(s)

642-655

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Chance encounters and organized rendezvous.

7 August 2017

cites work

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Organogenesis of lymphoid tissues

31 March 2020

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Concerted action of the chemokine and lymphotoxin system in secondary lymphoid-organ development

31 March 2020

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BLC expression in pancreatic islets causes B cell recruitment and lymphotoxin-dependent lymphoid neogenesis.

31 March 2020

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Lymphoid neo-organogenesis: lymphotoxin's role in inflammation and development

31 March 2020

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The molecular basis of lymphoid architecture and B cell responses: implications for immunodeficiency and immunopathology.

31 March 2020

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31 March 2020

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Expression of the lymphotoxin beta receptor on follicular stromal cells in human lymphoid tissues

31 March 2020

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Visualization of lymphotoxin-beta and lymphotoxin-beta receptor expression in mouse embryos.

31 March 2020

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Abnormal development of peripheral lymphoid organs in mice deficient in lymphotoxin

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Formation of Peyer's patches

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Development and maturation of secondary lymphoid tissues.

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Targeted disruption of LIGHT causes defects in costimulatory T cell activation and reveals cooperation with lymphotoxin beta in mesenteric lymph node genesis

31 March 2020

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Light stimulates IFNgamma-mediated intercellular adhesion molecule-1 upregulation of cancer cells

31 March 2020

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Modulation of LIGHT-HVEM costimulation prolongs cardiac allograft survival

31 March 2020

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Constitutive expression of LIGHT on T cells leads to lymphocyte activation, inflammation, and tissue destruction

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Follicular stromal cells and lymphocyte homing to follicles.

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A chemokine-driven positive feedback loop organizes lymphoid follicles

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B lymphocytes induce the formation of follicular dendritic cell clusters in a lymphotoxin alpha-dependent fashion.

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The sequential role of lymphotoxin and B cells in the development of splenic follicles.

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Mature follicular dendritic cell networks depend on expression of lymphotoxin beta receptor by radioresistant stromal cells and of lymphotoxin beta and tumor necrosis factor by B cells

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The requirement of membrane lymphotoxin for the presence of dendritic cells in lymphoid tissues

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Distinct role of surface lymphotoxin expressed by B cells in the organization of secondary lymphoid tissues

31 March 2020

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Turning off follicular dendritic cells

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Manipulation of lymphoid microenvironments in nonhuman primates by an inhibitor of the lymphotoxin pathway

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Functional effects of TNF and lymphotoxin alpha1beta2 on FDC-like cells.

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Appearance and phenotype of murine follicular dendritic cells expressing VCAM-1.

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Essential role of nuclear factor (NF)-kappaB-inducing kinase and inhibitor of kappaB (IkappaB) kinase alpha in NF-kappaB activation through lymphotoxin beta receptor, but not through tumor necrosis factor receptor I

31 March 2020

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Expression of alpha(4)beta(7) integrin defines a distinct pathway of lymphoid progenitors committed to T cells, fetal intestinal lymphotoxin producer, NK, and dendritic cells.

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31 March 2020

Marginal-zone B cells

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Integrin-mediated long-term B cell retention in the splenic marginal zone.

31 March 2020

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A critical role for lymphotoxin-beta receptor in the development of diabetes in nonobese diabetic mice

31 March 2020

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Recirculating and marginal zone B cell populations can be established and maintained independently of primary and secondary follicles

31 March 2020

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Lymphotoxin but not tumor necrosis factor functions to maintain splenic architecture and humoral responsiveness in adult mice

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Splenic T zone development is B cell dependent

31 March 2020

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Chemokines and cell migration in secondary lymphoid organs

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Lymphotoxin alpha/beta and tumor necrosis factor are required for stromal cell expression of homing chemokines in B and T cell areas of the spleen

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Leukocyte migration: scent of the T zone

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Collaboration of epithelial cells with organized mucosal lymphoid tissues.

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Elimination of colonic patches with lymphotoxin beta receptor-Ig prevents Th2 cell-type colitis

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Effect of mature lymphocytes and lymphotoxin on the development of the follicle-associated epithelium and M cells in mouse Peyer's patches

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Induction of colitis in mice deficient of Peyer's patches and mesenteric lymph nodes is associated with increased disease severity and formation of colonic lymphoid patches

31 March 2020

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'M' cells in the follicle-associated epithelium of the human colon

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Identification of multiple isolated lymphoid follicles on the antimesenteric wall of the mouse small intestine

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Isolated lymphoid follicle formation is inducible and dependent upon lymphotoxin-sufficient B lymphocytes, lymphotoxin beta receptor, and TNF receptor I function

31 March 2020

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Lymphoid neogenesis in rheumatoid synovitis

31 March 2020

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Distinct roles in lymphoid organogenesis for lymphotoxins alpha and beta revealed in lymphotoxin beta-deficient mice

31 March 2020

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Signaling via LTbetaR on the lamina propria stromal cells of the gut is required for IgA production

31 March 2020

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Postgestational lymphotoxin/lymphotoxin beta receptor interactions are essential for the presence of intestinal B lymphocytes.

31 March 2020

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Intestinal IgA synthesis: regulation of front-line body defences

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The complementation of lymphotoxin deficiency with LIGHT, a newly discovered TNF family member, for the restoration of secondary lymphoid structure and function

31 March 2020

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Abnormal immune function of hemopoietic cells from alymphoplasia (aly) mice, a natural strain with mutant NF-kappa B-inducing kinase

31 March 2020

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Immunodeficiency of alymphoplasia mice (aly/aly) in vivo: structural defect of secondary lymphoid organs and functional B cell defect

31 March 2020

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Two pathways to NF-kappaB.

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Missing pieces in the NF-kappaB puzzle

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Essential role of lymph nodes in contact hypersensitivity revealed in lymphotoxin-alpha-deficient mice.

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Lymph node germinal centers form in the absence of follicular dendritic cell networks

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Germinal centers without T cells

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The lymphotoxin beta receptor controls organogenesis and affinity maturation in peripheral lymphoid tissues

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Affinity maturation without germinal centres in lymphotoxin-alpha-deficient mice.

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Germinal center initiation, variable gene region hypermutation, and mutant B cell selection without detectable immune complexes on follicular dendritic cells

31 March 2020

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Evolution of autoantibody responses via somatic hypermutation outside of germinal centers

31 March 2020

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Arthritogenic monoclonal antibodies from K/BxN mice

31 March 2020

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Type II collagen autoimmunity in animals and provocations leading to arthritis

31 March 2020

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A role for the lymphotoxin/LIGHT axis in the pathogenesis of murine collagen-induced arthritis

31 March 2020

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Induction of Th1 and Th2 CD4+ T cell responses: the alternative approaches

31 March 2020

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Both the lymphotoxin and tumor necrosis factor pathways are involved in experimental murine models of colitis

31 March 2020

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Role of lymphotoxin alpha in T-cell responses during an acute viral infection.

31 March 2020

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Lymphotoxin-alpha-deficient mice make delayed, but effective, T and B cell responses to influenza.

31 March 2020

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Lymphotoxins and cytomegalovirus cooperatively induce interferon-beta, establishing host-virus détente.

31 March 2020

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Lymphotoxin-alpha-deficient mice can clear a productive infection with murine gammaherpesvirus 68 but fail to develop splenomegaly or lymphocytosis

31 March 2020

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Lymphotoxin alpha-/- mice develop functionally impaired CD8+ T cell responses and fail to contain virus infection of the central nervous system

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Role of an intact splenic microarchitecture in early lymphocytic choriomeningitis virus production.

31 March 2020

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Lymphotoxin-beta-deficient mice show defective antiviral immunity.

31 March 2020

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Reversal of virus-induced systemic shock and respiratory failure by blockade of the lymphotoxin pathway

31 March 2020

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Cutting edge: membrane lymphotoxin regulates CD8(+) T cell-mediated intestinal allograft rejection.

31 March 2020

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Reversal of spontaneous autoimmune insulitis in nonobese diabetic mice by soluble lymphotoxin receptor

31 March 2020

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Challenging cytokine redundancy: inflammatory cell movement and clinical course of experimental autoimmune encephalomyelitis are normal in lymphotoxin-deficient, but not tumor necrosis factor-deficient, mice

31 March 2020

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A critical role for lymphotoxin in experimental allergic encephalomyelitis

31 March 2020

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Modulation of T-cell-mediated immunity in tumor and graft-versus-host disease models through the LIGHT co-stimulatory pathway

31 March 2020

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Blockade of LIGHT/LTbeta and CD40 signaling induces allospecific T cell anergy, preventing graft-versus-host disease

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Cutting edge: selective impairment of CD8+ T cell function in mice lacking the TNF superfamily member LIGHT.

31 March 2020

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Uncoupling the proinflammatory from the immunosuppressive properties of tumor necrosis factor (TNF) at the p55 TNF receptor level: implications for pathogenesis and therapy of autoimmune demyelination

31 March 2020

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Ectopic lymphoid organogenesis: a fast track for autoimmunity

31 March 2020

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BCA-1 is highly expressed in Helicobacter pylori-induced mucosa-associated lymphoid tissue and gastric lymphoma

31 March 2020

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Follicular dendritic cells as targets for intervention in transmissible spongiform encephalopathies.

31 March 2020

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Follicular dendritic cell dedifferentiation by treatment with an inhibitor of the lymphotoxin pathway dramatically reduces scrapie susceptibility

31 March 2020

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Follicular dendritic cell contributions to HIV pathogenesis

31 March 2020

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Herpes simplex virus-1 entry into cells mediated by a novel member of the TNF/NGF receptor family

31 March 2020

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Genomic amplification of a decoy receptor for Fas ligand in lung and colon cancer

31 March 2020

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A newly identified member of tumor necrosis factor receptor superfamily (TR6) suppresses LIGHT-mediated apoptosis

31 March 2020

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TL1A is a TNF-like ligand for DR3 and TR6/DcR3 and functions as a T cell costimulator

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Signal transduction by tumor necrosis factor and its relatives

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The role of apoptosis signal-regulating kinase 1 in lymphotoxin-beta receptor-mediated cell death.

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TNF ligands and receptors--a matter of life and death

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Follicular homing T helper (Th) cells and the Th1/Th2 paradigm

31 March 2020

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Differing activities of homeostatic chemokines CCL19, CCL21, and CXCL12 in lymphocyte and dendritic cell recruitment and lymphoid neogenesis.

31 March 2020

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BLC (CXCL13) is expressed by different dendritic cell subsets in vitro and in vivo.

31 March 2020

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Aberrant high expression of B lymphocyte chemokine (BLC/CXCL13) by C11b+CD11c+ dendritic cells in murine lupus and preferential chemotaxis of B1 cells towards BLC

31 March 2020

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CXCL13 is required for B1 cell homing, natural antibody production, and body cavity immunity

31 March 2020

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Cords, channels, corridors and conduits: critical architectural elements facilitating cell interactions in the lymph node cortex

31 March 2020

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Structural aspects of the lymphocyte traffic in rat submandibular lymph node

31 March 2020

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Ectopic LTαβ Directs Lymphoid Organ Neogenesis with Concomitant Expression of Peripheral Node Addressin and a HEV-restricted Sulfotransferase

31 March 2020

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The influence of afferent lymphatic vessel interruption on vascular addressin expression

31 March 2020

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Lymph-borne chemokines and other low molecular weight molecules reach high endothelial venules via specialized conduits while a functional barrier limits access to the lymphocyte microenvironments in lymph node cortex

31 March 2020

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Cutting edge: ectopic expression of the chemokine TCA4/SLC is sufficient to trigger lymphoid neogenesis.

31 March 2020

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Ectopic expression of the murine chemokines CCL21a and CCL21b induces the formation of lymph node-like structures in pancreas, but not skin, of transgenic mice

31 March 2020

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Human follicular dendritic cells: function, origin and development

31 March 2020

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Secretion imbalance between tumour necrosis factor and its inhibitor in inflammatory bowel disease

31 March 2020

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Tumor necrosis factor-beta and hypercalcemia

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Secreted lymphotoxin-alpha is essential for the control of an intracellular bacterial infection.

31 March 2020

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Redundancy in tumor necrosis factor (TNF) and lymphotoxin (LT) signaling in vivo: mice with inactivation of the entire TNF/LT locus versus single-knockout mice

31 March 2020

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TWEAK, a new secreted ligand in the tumor necrosis factor family that weakly induces apoptosis

31 March 2020

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LIGHT, a new member of the TNF superfamily, and lymphotoxin alpha are ligands for herpesvirus entry mediator

31 March 2020

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Cutting edge: organogenesis of nasal-associated lymphoid tissue (NALT) occurs independently of lymphotoxin-alpha (LT alpha) and retinoic acid receptor-related orphan receptor-gamma, but the organization of NALT is LT alpha dependent

31 March 2020

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Initiation of NALT organogenesis is independent of the IL-7R, LTbetaR, and NIK signaling pathways but requires the Id2 gene and CD3(-)CD4(+)CD45(+) cells

31 March 2020

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Murine natural killer cell progenitors and their requirements for development

31 March 2020

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B cells control the migration of a subset of dendritic cells into B cell follicles via CXC chemokine ligand 13 in a lymphotoxin-dependent fashion

31 March 2020

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Chronic inflammation caused by lymphotoxin is lymphoid neogenesis

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LIGHT (a cellular ligand for herpes virus entry mediator and lymphotoxin receptor)-mediated thymocyte deletion is dependent on the interaction between TCR and MHC/self-peptide

31 March 2020

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The perifollicular and marginal zones of the human splenic white pulp : do fibroblasts guide lymphocyte immigration?

31 March 2020

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Regulation of lymphotoxin-beta by tumor necrosis factor, phorbol myristate acetate, and ionomycin in Jurkat T cells

31 March 2020

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Different cytokines induce surface lymphotoxin-alphabeta on IL-7 receptor-alpha cells that differentially engender lymph nodes and Peyer's patches

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Expression of lymphotoxin-beta (LT-beta) in chronic inflammatory conditions

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LIGHT, a TNF-like molecule, costimulates T cell proliferation and is required for dendritic cell-mediated allogeneic T cell response

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TNF-alpha receptor 1 (p55) on islets is necessary for the expression of LIGHT on diabetogenic T cells.

31 March 2020

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LIGHT, a novel ligand for lymphotoxin beta receptor and TR2/HVEM induces apoptosis and suppresses in vivo tumor formation via gene transfer

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Signaling through the lymphotoxin beta receptor induces the death of some adenocarcinoma tumor lines

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The TNF superfamily members LIGHT and CD154 (CD40 ligand) costimulate induction of dendritic cell maturation and elicit specific CTL activity

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Tumor necrosis factor receptor superfamily 14 is involved in atherogenesis by inducing proinflammatory cytokines and matrix metalloproteinases

31 March 2020

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LIGHT, a member of the tumor necrosis factor ligand superfamily, prevents tumor necrosis factor-alpha-mediated human primary hepatocyte apoptosis, but not Fas-mediated apoptosis

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Overexpression of M68/DcR3 in human gastrointestinal tract tumors independent of gene amplification and its location in a four-gene cluster

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Lymphotoxin-alpha deficiency completely protects C57BL/6 mice from developing clinical experimental autoimmune myasthenia gravis

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Tumor necrosis factor alpha and lymphotoxin alpha are not required for induction of acute experimental autoimmune encephalomyelitis.

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Identifiers

DOI

10.1038/NRI1151

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7 August 2017

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