MGMT: its role in cancer aetiology and cancer therapeutics (Q34310201)

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English	MGMT: its role in cancer aetiology and cancer therapeutics	scientific article

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scholarly article

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Europe PubMed Central

PubMed publication ID

1 August 2017

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Europe PubMed Central

MGMT: its role in cancer aetiology and cancer therapeutics (English)

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Europe PubMed Central

PubMed publication ID

1 August 2017

author name string

Stanton L Gerson

1

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Europe PubMed Central

PubMed publication ID

1 August 2017

language of work or name

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publication date

1 April 2004

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Europe PubMed Central

PubMed publication ID

1 August 2017

Nature Reviews Cancer

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Europe PubMed Central

PubMed publication ID

1 August 2017

4

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Europe PubMed Central

PubMed publication ID

1 August 2017

4

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Europe PubMed Central

PubMed publication ID

1 August 2017

296-307

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Europe PubMed Central

PubMed publication ID

1 August 2017

Mammalian base excision repair and DNA polymerase beta

1 reference

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31 March 2020

DNA damage tolerance, mismatch repair and genome instability

1 reference

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31 March 2020

Alkylation of deoxyribonucleic acid in vivo in various organs of C57BL mice by the carcinogens N-methyl-N-nitrosourea, N-ethyl-N-nitrosourea and ethyl methanesulphonate in relation to induction of thymic lymphoma. Some applications of high-pressure

1 reference

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31 March 2020

DNA methyl-adduct dosimetry and O6-alkylguanine-DNA alkyl transferase activity determinations in rat mammary carcinogenesis by procarbazine and N-methylnitrosourea

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31 March 2020

The prevention of thymic lymphomas in transgenic mice by human O6-alkylguanine-DNA alkyltransferase

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31 March 2020

Differential expression of O6-methylguanine-DNA methyltransferase during diethylnitrosamine-induced carcinogenesis and liver regeneration in Sprague-Dawley male rats

1 reference

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31 March 2020

Transgenic expression of human MGMT protects against azoxymethane-induced aberrant crypt foci and G to A mutations in the K-ras oncogene of mouse colon

1 reference

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31 March 2020

Affinity purification and characterization of human O6-alkylguanine-DNA alkyltransferase complexed with BCNU-treated, synthetic oligonucleotide

1 reference

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31 March 2020

Human tumor cell strains defective in the repair of alkylation damage.

1 reference

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31 March 2020

Persistence of O 6-Ethylguanine in Rat-Brain DNA: Correlation with Nervous System-Specific Carcinogenesis by Ethylnitrosourea

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31 March 2020

ENU mutagenesis: analyzing gene function in mice

1 reference

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31 March 2020

Effect of sequence context on O(6)-methylguanine repair and replication in vivo

1 reference

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31 March 2020

Mice over-expressing human O6 alkylguanine-DNA alkyltransferase selectively reduce O6 methylguanine mediated carcinogenic mutations to threshold levels after N-methyl-N-nitrosourea

1 reference

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31 March 2020

Cloning of the E. coli O6-methylguanine and methylphosphotriester methyltransferase gene using a functional DNA repair assay

1 reference

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31 March 2020

Isolation and structural characterization of a cDNA clone encoding the human DNA repair protein for O6-alkylguanine

1 reference

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31 March 2020

Isolation and characterization of cDNA and genomic sequences for mouse O6-methylguanine-DNA methyltransferase

1 reference

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31 March 2020

Crystal structure of the human O(6)-alkylguanine-DNA alkyltransferase

1 reference

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31 March 2020

The DNA repair protein, O(6)-methylguanine-DNA methyltransferase is a proteolytic target for the E6 human papillomavirus oncoprotein.

1 reference

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31 March 2020

Cytoplasmic sequestration of an O6-methylguanine-DNA methyltransferase enhancer binding protein in DNA repair-deficient human cells

1 reference

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31 March 2020

The nuclear targeting and nuclear retention properties of a human DNA repair protein O6-methylguanine-DNA methyltransferase are both required for its nuclear localization: the possible implications

1 reference

https://api.crossref.org/works/10.1038%2FNRC1319

31 March 2020

O6-methylguanine-DNA methyltransferase protects against nitrosamine-induced hepatocarcinogenesis

1 reference

https://api.crossref.org/works/10.1038%2FNRC1319

31 March 2020

Reduced lung tumorigenesis in human methylguanine DNA--methyltransferase transgenic mice achieved by expression of transgene within the target cell.

1 reference

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31 March 2020

Spontaneous hepatocellular carcinoma is reduced in transgenic mice overexpressing human O6- methylguanine-DNA methyltransferase

1 reference

https://api.crossref.org/works/10.1038%2FNRC1319

31 March 2020

Transgenic expression of human MGMT blocks the hypersensitivity of PMS2-deficient mice to low dose MNU thymic lymphomagenesis

1 reference

https://api.crossref.org/works/10.1038%2FNRC1319

31 March 2020

Potentiation of lymphomagenesis by methylnitrosourea in mice transgenic for LMO1 is blocked by O6-alkylguanine DNA-alkyltransferase

1 reference

https://api.crossref.org/works/10.1038%2FNRC1319

31 March 2020

Overexpression of human O6-alkylguanine DNA alkyltransferase (AGT) prevents MNU induced lymphomas in heterozygous p53 deficient mice

1 reference

https://api.crossref.org/works/10.1038%2FNRC1319

31 March 2020

Increased susceptibility to chemotherapeutic alkylating agents of mice deficient in DNA repair methyltransferase

1 reference

https://api.crossref.org/works/10.1038%2FNRC1319

31 March 2020

DNA repair methyltransferase (Mgmt) knockout mice are sensitive to the lethal effects of chemotherapeutic alkylating agents

1 reference

https://api.crossref.org/works/10.1038%2FNRC1319

31 March 2020

Separation of killing and tumorigenic effects of an alkylating agent in mice defective in two of the DNA repair genes

1 reference

https://api.crossref.org/works/10.1038%2FNRC1319

31 March 2020

Comparison of O6-alkylguanine-DNA alkyltransferase activity based on cellular DNA content in human, rat and mouse tissues

1 reference

https://api.crossref.org/works/10.1038%2FNRC1319

31 March 2020

Determinants of O(6)-alkylguanine-DNA alkyltransferase activity in normal and tumour tissue from human colon and rectum

1 reference

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31 March 2020

Intracellular Localization and intercellular heterogeneity of the human DNA repair protein O(6)-methylguanine-DNA methyltransferase

1 reference

https://api.crossref.org/works/10.1038%2FNRC1319

31 March 2020

Lack of the DNA repair protein O6-methylguanine-DNA methyltransferase in histologically normal brain adjacent to primary human brain tumors

1 reference

https://api.crossref.org/works/10.1038%2FNRC1319

31 March 2020

Modulation of nitrosourea resistance in human colon cancer by O6-methylguanine

1 reference

https://api.crossref.org/works/10.1038%2FNRC1319

31 March 2020

O6-alkylguanine-DNA alkyltransferase and sensitivity to procarbazine in human brain-tumor xenografts

1 reference

https://api.crossref.org/works/10.1038%2FNRC1319

31 March 2020

O6-Alkylguanine-DNA alkyltransferase activity correlates with the therapeutic response of human rhabdomyosarcoma xenografts to 1-(2-chloroethyl)-3-(trans-4-methylcyclohexyl)-1-nitrosourea

1 reference

https://api.crossref.org/works/10.1038%2FNRC1319

31 March 2020

Chromosomal instability, reproductive cell death and apoptosis induced by O6-methylguanine in Mex−, Mex+ and methylation-tolerant mismatch repair compromised cells: facts and models

1 reference

https://api.crossref.org/works/10.1038%2FNRC1319

31 March 2020

Induction of the alkyltransferase (MGMT) gene by DNA damaging agents and the glucocorticoid dexamethasone and comparison with the response of base excision repair genes.

1 reference

https://api.crossref.org/works/10.1038%2FNRC1319

31 March 2020

Activation of human O6-methylguanine-DNA methyltransferase gene by glucocorticoid hormone

1 reference

https://api.crossref.org/works/10.1038%2FNRC1319

31 March 2020

Cell type-specific induction of O6-alkylguanine-DNA alkyltransferase mRNA expression in rat liver during regeneration, inflammation and preneoplasia

1 reference

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31 March 2020

Methylation of Discrete Regions of the O6-Methylguanine DNA Methyltransferase (MGMT) CpG Island Is Associated with Heterochromatinization of the MGMT Transcription Start Site and Silencing of the Gene

1 reference

https://api.crossref.org/works/10.1038%2FNRC1319

31 March 2020

Epstein-barr virus-positive gastric carcinoma demonstrates frequent aberrant methylation of multiple genes and constitutes CpG island methylator phenotype-positive gastric carcinoma

1 reference

https://api.crossref.org/works/10.1038%2FNRC1319

31 March 2020

Aberrant Silencing of the CpG Island-Containing Human O6-Methylguanine DNA Methyltransferase Gene Is Associated with the Loss of Nucleosome-Like Positioning

1 reference

https://api.crossref.org/works/10.1038%2FNRC1319

31 March 2020

Regulation of the human O(6)-methylguanine-DNA methyltransferase gene by transcriptional coactivators cAMP response element-binding protein-binding protein and p300.

1 reference

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31 March 2020

Methylation of O(6)-methylguanine-DNA methyltransferase gene is associated significantly with K-ras mutation, lymph node invasion, tumor staging, and disease free survival in patients with gastric carcinoma.

1 reference

https://api.crossref.org/works/10.1038%2FNRC1319

31 March 2020

Promoter methylation of the DNA repair gene MGMT in astrocytomas is frequently associated with G:C --> A:T mutations of the TP53 tumor suppressor gene

1 reference

https://api.crossref.org/works/10.1038%2FNRC1319

31 March 2020

Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation and its relationship to aflatoxin B1-DNA adducts and p53 mutation in hepatocellular carcinoma

1 reference

https://api.crossref.org/works/10.1038%2FNRC1319

31 March 2020

Inactivation of O6-methylguanine-DNA methyltransferase in human lung adenocarcinoma relates to high-grade histology and worse prognosis among smokers.

1 reference

https://api.crossref.org/works/10.1038%2FNRC1319

31 March 2020

Inactivation of the DNA-repair gene MGMT and the clinical response of gliomas to alkylating agents

1 reference

https://api.crossref.org/works/10.1038%2FNRC1319

31 March 2020

Hypermethylation of the DNA repair gene O(6)-methylguanine DNA methyltransferase and survival of patients with diffuse large B-cell lymphoma

1 reference

https://api.crossref.org/works/10.1038%2FNRC1319

31 March 2020

Silence is golden: gene hypermethylation and survival in large-cell lymphoma

1 reference

https://api.crossref.org/works/10.1038%2FNRC1319

31 March 2020

Correlation of tumor O6 methylguanine-DNA methyltransferase levels with survival of malignant astrocytoma patients treated with bis-chloroethylnitrosourea: a Southwest Oncology Group study

1 reference

https://api.crossref.org/works/10.1038%2FNRC1319

31 March 2020

Contribution of O6‐methylguanine‐DNA methyltransferase to monofunctional alkylating‐agent resistance in human brain tumor—derived cell lines

1 reference

https://api.crossref.org/works/10.1038%2FNRC1319

31 March 2020

Acquired resistance to O6-benzylguanine plus chloroethylnitrosoureas in human breast cancer.

1 reference

https://api.crossref.org/works/10.1038%2FNRC1319

31 March 2020

Modulation of O6-alkylguanine alkyltransferase-directed DNA repair in metastatic colon cancers

1 reference

https://api.crossref.org/works/10.1038%2FNRC1319

31 March 2020

Depletion of mammalian O6-alkylguanine-DNA alkyltransferase activity by O6-benzylguanine provides a means to evaluate the role of this protein in protection against carcinogenic and therapeutic alkylating agents

1 reference

https://api.crossref.org/works/10.1038%2FNRC1319

31 March 2020

Active and alkylated human AGT structures: a novel zinc site, inhibitor and extrahelical base binding

1 reference

https://api.crossref.org/works/10.1038%2FNRC1319

31 March 2020

Synergistic efficacy of O6-benzylguanine and 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) in a human colon cancer xenograft completely resistant to BCNU alone

1 reference

https://api.crossref.org/works/10.1038%2FNRC1319

31 March 2020

Phase I trial of O6-benzylguanine for patients undergoing surgery for malignant glioma

1 reference

https://api.crossref.org/works/10.1038%2FNRC1319

31 March 2020

O6-benzylguanine in humans: metabolic, pharmacokinetic, and pharmacodynamic findings

1 reference

https://api.crossref.org/works/10.1038%2FNRC1319

31 March 2020

Phase I trial of carmustine plus O6-benzylguanine for patients with recurrent or progressive malignant glioma

1 reference

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31 March 2020

Effect of O6-(4-bromothenyl)guanine on different temozolomide schedules in a human melanoma xenograft model

1 reference

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31 March 2020

Ribozyme and free alkylated base: a dual approach for sensitizing Mex+ cells to the alkylating antineoplastic drug

1 reference

https://api.crossref.org/works/10.1038%2FNRC1319

31 March 2020

Mutations of O6-methylguanine-DNA methyltransferase gene in esophageal cancer tissues from Northern China.

1 reference

https://api.crossref.org/works/10.1038%2FNRC1319

31 March 2020

Role of codon 160 in the sensitivity of human O6-alkylguanine-DNA alkyltransferase to O6-benzylguanine.

1 reference

https://api.crossref.org/works/10.1038%2FNRC1319

31 March 2020

Novel O6-methylguanine-DNA methyltransferase SNPs: a frequency comparison of patients with familial melanoma and healthy individuals in Sweden

1 reference

https://api.crossref.org/works/10.1038%2FNRC1319

31 March 2020

Novel genetic polymorphisms in DNA repair genes: O(6)-methylguanine-DNA methyltransferase (MGMT) and N-methylpurine-DNA glycosylase (MPG) in lung cancer patients from Poland

1 reference

https://api.crossref.org/works/10.1038%2FNRC1319

31 March 2020

Specific recognition of O6-methylguanine in DNA by active site mutants of human O6-methylguanine-DNA methyltransferase

1 reference

https://api.crossref.org/works/10.1038%2FNRC1319

31 March 2020

Applied molecular evolution of O6-benzylguanine-resistant DNA alkyltransferases in human hematopoietic cells

1 reference

https://api.crossref.org/works/10.1038%2FNRC1319

31 March 2020

MGMT expression in murine bone marrow is a major determinant of animal survival after alkylating agent exposure

1 reference

https://api.crossref.org/works/10.1038%2FNRC1319

31 March 2020

High-dose carmustine, etoposide, and cisplatin and autologous bone marrow transplantation for relapsed and refractory lymphoma

1 reference

https://api.crossref.org/works/10.1038%2FNRC1319

31 March 2020

Myeloablation is not required to select and maintain expression of the drug-resistance gene, mutant MGMT, in primary and secondary recipients

1 reference

https://api.crossref.org/works/10.1038%2FNRC1319

31 March 2020

DeltaMGMT-transduced bone marrow infusion increases tolerance to O6-benzylguanine and 1,3-bis(2-chloroethyl)-1-nitrosourea and allows intensive therapy of 1,3-bis(2-chloroethyl)-1-nitrosourea-resistant human colon cancer xenografts.

1 reference

https://api.crossref.org/works/10.1038%2FNRC1319

31 March 2020

Evidence that the number of hematopoietic stem cells per animal is conserved in mammals

1 reference

https://api.crossref.org/works/10.1038%2FNRC1319

31 March 2020

Lentiviral transduction of P140K MGMT into human CD34(+) hematopoietic progenitors at low multiplicity of infection confers significant resistance to BG/BCNU and allows selection in vitro

1 reference

https://api.crossref.org/works/10.1038%2FNRC1319

31 March 2020

In vivo selection of MGMT(P140K) lentivirus–transduced human NOD/SCID repopulating cells without pretransplant irradiation conditioning

1 reference

https://api.crossref.org/works/10.1038%2FNRC1319

31 March 2020

Site-directed mutation of the Escherichia coli ada gene: effects of substitution of methyl acceptor cysteine-321 by histidine in Ada protein

1 reference

https://api.crossref.org/works/10.1038%2FNRC1319

31 March 2020

Conserved structural motifs governing the stoichiometric repair of alkylated DNA by O(6)-alkylguanine-DNA alkyltransferase

1 reference

https://api.crossref.org/works/10.1038%2FNRC1319

31 March 2020

Organization and expression of the mouse gene for DNA repair methyltransferase

1 reference

https://api.crossref.org/works/10.1038%2FNRC1319

31 March 2020

O(6)-alkylguanine-DNA alkyltransferase DNA repair in mycobacteria: pathogenic and non-pathogenic species differ

1 reference

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31 March 2020

Safety and efficacy of temozolomide in patients with recurrent anaplastic oligodendrogliomas after standard radiotherapy and chemotherapy.

1 reference

https://api.crossref.org/works/10.1038%2FNRC1319

31 March 2020

Temozolomide for recurrent high-grade glioma

1 reference

https://api.crossref.org/works/10.1038%2FNRC1319

31 March 2020

In vivo formation and repair of O6-methylguanine in human leukocyte DNA after intravenous exposure to dacarbazine.

1 reference

https://api.crossref.org/works/10.1038%2FNRC1319

31 March 2020

Long-term follow-up in managing anaplastic astrocytoma by multimodality approach with surgery followed by postoperative radiotherapy and PCV-chemotherapy: phase II trial

1 reference

https://api.crossref.org/works/10.1038%2FNRC1319

31 March 2020

A phase 3 trial of local chemotherapy with biodegradable carmustine (BCNU) wafers (Gliadel wafers) in patients with primary malignant glioma

1 reference

https://api.crossref.org/works/10.1038%2FNRC1319

31 March 2020

Genetic polymorphism of human O6-alkylguanine-DNA alkyltransferase: identification of a missense variation in the active site region

1 reference

https://api.crossref.org/works/10.1038%2FNRC1319

7 January 2021

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10.1038/NRC1319

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

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PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

1 August 2017

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