Active and alkylated human AGT structures: a novel zinc site, inhibitor and extrahelical base binding (Q27622042)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10747039%20AND%20SRC:MED&resulttype=core&format=json

5 November 2019

title

Active and alkylated human AGT structures: a novel zinc site, inhibitor and extrahelical base binding (English)

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5 November 2019

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5 November 2019

D S Daniels

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5 November 2019

C D Mol

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5 November 2019

A S Arvai

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5 November 2019

S Kanugula

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5 November 2019

A E Pegg

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5 November 2019

language of work or name

English

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publication date

1 April 2000

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5 November 2019

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5 November 2019

volume

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5 November 2019

issue

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5 November 2019

page(s)

1719-1730

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Crystal structure of the human O(6)-alkylguanine-DNA alkyltransferase

5 November 2019

cites work

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Crystal structure of a human alkylbase-DNA repair enzyme complexed to DNA: mechanisms for nucleotide flipping and base excision

20 March 2017

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A nucleotide-flipping mechanism from the structure of human uracil-DNA glycosylase bound to DNA

29 September 2017

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Crystal structure of a suicidal DNA repair protein: the Ada O6-methylguanine-DNA methyltransferase from E. coli

20 March 2017

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Nonenzymatic methylation of DNA by the intracellular methyl group donor S-adenosyl-L-methionine is a potentially mutagenic reaction

20 March 2017

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20 March 2017

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20 March 2017

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20 March 2017

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Protein structure comparison by alignment of distance matrices

20 March 2017

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Crystal structure of a CAP-DNA complex: the DNA is bent by 90 degrees

20 March 2017

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Point mutations at multiple sites including highly conserved amino acids maintain activity, but render O6-alkylguanine-DNA alkyltransferase insensitive to O6-benzylguanine

20 March 2017

1 reference

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Role of codon 160 in the sensitivity of human O6-alkylguanine-DNA alkyltransferase to O6-benzylguanine.

29 September 2017

1 reference

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Reaction and binding of oligodeoxynucleotides containing analogues of O6-methylguanine with wild-type and mutant human O6-alkylguanine-DNA alkyltransferase

29 September 2017

1 reference

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Genetic polymorphism of human O6-alkylguanine-DNA alkyltransferase: identification of a missense variation in the active site region

29 September 2017

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Improving enzymes for cancer gene therapy

29 September 2017

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Investigation of the role of tyrosine-114 in the activity of human O6-alkylguanine-DNA alkyltranferase

29 September 2017

1 reference

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Base excision repair initiation revealed by crystal structures and binding kinetics of human uracil-DNA glycosylase with DNA.

29 September 2017

1 reference

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Isolation of human O6-alkylguanine-DNA alkyltransferase mutants highly resistant to inactivation by O6-benzylguanine

29 September 2017

1 reference

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Reaction of O6-benzylguanine-resistant mutants of human O6-alkylguanine-DNA alkyltransferase with O6-benzylguanine in oligodeoxyribonucleotides

29 September 2017

1 reference

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Specific recognition of O6-methylguanine in DNA by active site mutants of human O6-methylguanine-DNA methyltransferase

29 September 2017

1 reference

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Structural classification of HTH DNA-binding domains and protein-DNA interaction modes

29 September 2017

1 reference

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Ubiquitination-dependent proteolysis of O6-methylguanine-DNA methyltransferase in human and murine tumor cells following inactivation with O6-benzylguanine or 1,3-bis(2-chloroethyl)-1-nitrosourea

29 September 2017

1 reference

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The winged-helix DNA-binding motif: another helix-turn-helix takeoff

29 September 2017

1 reference

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Mechanism of inactivation of human O6-alkylguanine-DNA alkyltransferase by O6-benzylguanine

29 September 2017

1 reference

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Structure, Function, and Inhibition of O6-Alkylguanine-DNA Alkyltransferase

29 September 2017

1 reference

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O6-Alkylguanine-DNA alkyltransferase activity correlates with the therapeutic response of human rhabdomyosarcoma xenografts to 1-(2-chloroethyl)-3-(trans-4-methylcyclohexyl)-1-nitrosourea

29 September 2017

1 reference

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Distribution of methyl and ethyl adducts following alkylation with monofunctional alkylating agents

29 September 2017

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Depletion of mammalian O6-alkylguanine-DNA alkyltransferase activity by O6-benzylguanine provides a means to evaluate the role of this protein in protection against carcinogenic and therapeutic alkylating agents

29 September 2017

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Conserved residue lysine165 is essential for the ability of O6-alkylguanine-DNA alkyltransferase to react with O6-benzylguanine

29 September 2017

1 reference

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Effect of redox conditions on the DNA-binding efficiency of the retinoic acid receptor zinc-finger.

2 June 2018

1 reference

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Probing of conformational changes in human O6-alkylguanine-DNA alkyl transferase protein in its alkylated and DNA-bound states by limited proteolysis

2 June 2018

1 reference

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Resistance of the human O6-alkylguanine-DNA alkyltransferase containing arginine at codon 160 to inactivation by O6-benzylguanine.

2 June 2018

1 reference

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Differential inactivation of mammalian and Escherichia coli O6-alkylguanine-DNA alkyltransferases by O6-benzylguanine

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=310240

Mutations in the Ada O6-alkylguanine-DNA alkyltransferase conferring sensitivity to inactivation by O6-benzylguanine and 2,4-diamino-6-benzyloxy-5-nitrosopyrimidine

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=310240

Production of antibodies to peptide sequences present in human O6-alkylguanine-DNA alkyltransferase and their use to detect this protein in cell extracts.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=310240

Transfection and expression of human O6-methylguanine-DNA methyltransferase (MGMT) cDNA in Chinese hamster cells: the role of MGMT in protection against the genotoxic effects of alkylating agents

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=310240

Structural features of substituted purine derivatives compatible with depletion of human O6-alkylguanine-DNA alkyltransferase

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=310240

The use of 4-(2-pyridylazo)resorcinol in studies of zinc release from Escherichia coli aspartate transcarbamoylase.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=310240

Improvement of macromolecular electron-density maps by the simultaneous application of real and reciprocal space constraints.

19 June 2018

1 reference

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O6-benzylguanine: a clinical trial establishing the biochemical modulatory dose in tumor tissue for alkyltransferase-directed DNA repair.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=310240

Alteration of the conserved residue tyrosine-158 to histidine renders human O6-alkylguanine-DNA alkyltransferase insensitive to the inhibitor O6-benzylguanine.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=310240

Phase I trial of O6-benzylguanine for patients undergoing surgery for malignant glioma

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=310240

Amino acid residues affecting the activity and stability of human O6-alkylguanine-DNA alkyltransferase.

27 November 2018

1 reference

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A single amino acid change in human O6-alkylguanine-DNA alkyltransferase decreasing sensitivity to inactivation by O6-benzylguanine.

27 November 2018

1 reference

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Metabolism of O6-benzylguanine, an inactivator of O6-alkylguanine-DNA alkyltransferase.

27 November 2018

1 reference

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8-Substituted O6-benzylguanine, substituted 6(4)-(benzyloxy)pyrimidine, and related derivatives as inactivators of human O6-alkylguanine-DNA alkyltransferase.

27 November 2018

1 reference

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Differential inactivation of O6-methylguanine-DNA methyltransferase activity by O6-arylmethylguanines.

27 November 2018

1 reference

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O6-ethylguanine carcinogenic lesions in DNA: an NMR study of O6etG.C pairing in dodecanucleotide duplexes.

27 November 2018

1 reference

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Use of antibodies to human O6-alkylguanine-DNA alkyltransferase to study the content of this protein in cells treated with O6-benzylguanine or N-methyl-N'-nitro-N-nitrosoguanidine

27 November 2018

1 reference

12 December 2020

Processing of X-ray diffraction data collected in oscillation mode

1 reference

12 December 2020

O6-methylguanine methyltransferase in rat liver

1 reference

12 December 2020

Substituted O6-benzylguanine derivatives and their inactivation of human O6-alkylguanine-DNA alkyltransferase

1 reference

12 December 2020

DNA adducts and the mechanism of carcinogenesis and cytotoxicity of methylating agents of environmental and clinical significance

1 reference

12 December 2020

O6-methylguanine-DNA methyltransferase activity and sensitivity to cyclophosphamide and cisplatin in human lung tumor xenografts

1 reference

12 December 2020

Identifiers

DOI

10.1093/EMBOJ/19.7.1719

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10747039%20AND%20SRC:MED&resulttype=core&format=json

5 November 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10747039%20AND%20SRC:MED&resulttype=core&format=json

5 November 2019

PubMed publication ID

10747039

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10747039%20AND%20SRC:MED&resulttype=core&format=json