Crystal structure of the human O(6)-alkylguanine-DNA alkyltransferase (Q27620779)

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English	Crystal structure of the human O(6)-alkylguanine-DNA alkyltransferase	scientific article

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instance of

scholarly article

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title

Crystal structure of the human O(6)-alkylguanine-DNA alkyltransferase (English)

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main subject

crystal structure

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author

Peter C E Moody

object named as

P C Moody

series ordinal

3

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author name string

J E Wibley

series ordinal

1

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A E Pegg

series ordinal

2

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language of work or name

English

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publication date

15 January 2000

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published in

Nucleic Acids Research

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volume

28

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issue

2

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page(s)

393-401

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cites work

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Crystal structure of a suicidal DNA repair protein: the Ada O6-methylguanine-DNA methyltransferase from E. coli

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20 March 2017

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20 March 2017

Dictionary of protein secondary structure: pattern recognition of hydrogen-bonded and geometrical features

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20 March 2017

Solvent content of protein crystals

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20 March 2017

Crystal structure of a CAP-DNA complex: the DNA is bent by 90 degrees

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20 March 2017

A new model for how O6-methylguanine-DNA methyltransferase binds DNA

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20 March 2017

Reaction and binding of oligodeoxynucleotides containing analogues of O6-methylguanine with wild-type and mutant human O6-alkylguanine-DNA alkyltransferase

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29 September 2017

Inactivation of O6-alkylguanine-DNA alkyltransferase. 1. Novel O6-(hetarylmethyl)guanines having basic rings in the side chain

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29 September 2017

O6-(Alkyl/aralkyl)guanosine and 2‘-Deoxyguanosine Derivatives: Synthesis and Ability To Enhance Chloroethylnitrosourea Antitumor Action

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PubMed Central

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29 September 2017

Specific recognition of O6-methylguanine in DNA by active site mutants of human O6-methylguanine-DNA methyltransferase

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29 September 2017

DNA repair: enzymatic mechanisms and relevance to drug response

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29 September 2017

Synthesis of oligodeoxynucleotides containing analogs of O6-methylguanine and reaction with O6-alkylguanine-DNA alkyltransferase

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PubMed Central

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29 September 2017

Structure, Function, and Inhibition of O6-Alkylguanine-DNA Alkyltransferase

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29 September 2017

Mechanisms of carcinogenesis induced by alkylating agents

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29 September 2017

Characterisation and nucleotide sequence of ogt, the O6-alkylguanine-DNA-alkyltransferase gene of E. coli

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PubMed Central

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29 September 2017

The potential role of glycine-160 of human O6-alkylguanine-DNA alkyltransferase in reaction with O6-benzylguanine as determined by site-directed mutagenesis and molecular modelling comparisons

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PubMed Central

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2 June 2018

Resistance of the human O6-alkylguanine-DNA alkyltransferase containing arginine at codon 160 to inactivation by O6-benzylguanine.

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PubMed Central

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2 June 2018

Retrospective study of the correlation between the DNA repair protein alkyltransferase and survival of brain tumor patients treated with carmustine

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PubMed Central

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2 June 2018

Mutations in the Ada O6-alkylguanine-DNA alkyltransferase conferring sensitivity to inactivation by O6-benzylguanine and 2,4-diamino-6-benzyloxy-5-nitrosopyrimidine

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PubMed Central

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2 June 2018

Crystallization of O6-methylguanine-DNA methyltransferase from Escherichia coli

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PubMed Central

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2 June 2018

Comparison of the inactivation of mammalian and bacterial O6-alkylguanine-DNA alkyltransferases by O6-benzylguanine and O6-methylguanine

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PubMed Central

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2 June 2018

C-terminally truncated human O6-alkylguanine-DNA alkyltransferase retains activity

1 reference

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PubMed Central

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2 June 2018

Structural features of substituted purine derivatives compatible with depletion of human O6-alkylguanine-DNA alkyltransferase

1 reference

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PubMed Central

reference URL

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2 June 2018

Alteration of the conserved residue tyrosine-158 to histidine renders human O6-alkylguanine-DNA alkyltransferase insensitive to the inhibitor O6-benzylguanine.

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=102527

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27 November 2018

O6-benzylguanine and its role in chemotherapy.

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PubMed Central

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27 November 2018

Creation of human alkyltransferases resistant to O6-benzylguanine.

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PubMed Central

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27 November 2018

The role of the carboxyl-terminal tail in human O6-methylguanine DNA methyltransferase substrate specificity and temperature sensitivity.

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PubMed Central

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=102527

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27 November 2018

Enhancement by O6-benzyl-N-acetylguanosine derivatives of chloroethylnitrosourea antitumor action in chloroethylnitrosourea-resistant human malignant melanocytes.

1 reference

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PubMed Central

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27 November 2018

O6-alkylguanine-DNA alkyltransferase activity of human malignant glioma and its clinical implications

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PubMed Central

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27 November 2018

8-Substituted O6-benzylguanine, substituted 6(4)-(benzyloxy)pyrimidine, and related derivatives as inactivators of human O6-alkylguanine-DNA alkyltransferase.

1 reference

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PubMed Central

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27 November 2018

A homology model of the three-dimensional structure of human O6-alkylguanine-DNA alkyltransferase based on the crystal structure of the C-terminal domain of the Ada protein from Escherichia coli

1 reference

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PubMed Central

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=102527

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27 November 2018

High-level biosynthetic substitution of methionine in proteins by its analogs 2-aminohexanoic acid, selenomethionine, telluromethionine and ethionine in Escherichia coli.

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PubMed Central

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27 November 2018

Differential inactivation of O6-methylguanine-DNA methyltransferase activity by O6-arylmethylguanines.

1 reference

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PubMed Central

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27 November 2018

Functionality maps of binding sites: a multiple copy simultaneous search method

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PubMed Central

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27 November 2018

Processing of X-ray diffraction data collected in oscillation mode

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/10606635

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alteration of arginine-128 to alanine abolishes the ability of human O6-alkylguanine-DNA alkyltransferase to repair methylated DNA but has no effect on its reaction with O6-benzylguanine

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/10606635

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Probing the active site and mechanism of action of O6-methylguanine-DNA methyltransferase with substrate analogues (O6-substituted guanines)

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/10606635

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutations in human O6-alkylguanine-DNA alkyltransferase imparting resistance to O6-benzylguanine

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/10606635

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Substituted O6-benzylguanine derivatives and their inactivation of human O6-alkylguanine-DNA alkyltransferase

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/10606635

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

DNA binding mechanism of O6-alkylguanine-DNA alkyltransferase: stoichiometry and effects of DNA base composition and secondary structure on complex stability

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/10606635

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Repair of O6-benzylguanine by the Escherichia coli Ada and Ogt and the human O6-alkylguanine-DNA alkyltransferases

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/10606635

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

DOI

10.1093/NAR/28.2.393

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Fatcat ID

release_canjxswihfcxpj2hnwvwhkcogy

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stated in

Fatcat

reference URL

https://api.fatcat.wiki/v0/release/canjxswihfcxpj2hnwvwhkcogy

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24 November 2022

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mapped directly with Wikidata item

PMC publication ID

102527

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PubMed publication ID

10606635

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ResearchGate publication ID

242825294

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