Overexpression of heat shock protein 70 in R6/2 Huntington's disease mice has only modest effects on disease progression (Q31139684)

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English	Overexpression of heat shock protein 70 in R6/2 Huntington's disease mice has only modest effects on disease progression	scientific article

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

29 June 2017

Overexpression of heat shock protein 70 in R6/2 Huntington's disease mice has only modest effects on disease progression (English)

1 reference

Europe PubMed Central

PubMed publication ID

29 June 2017

Huntington's disease

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1 reference

based on heuristic

inferred from title

1

1 reference

Europe PubMed Central

PubMed publication ID

29 June 2017

Jesper Nylandsted

2

object named as

Jesper Nylandsted

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Europe PubMed Central

PubMed publication ID

29 June 2017

object named as

Marcel Leist

4

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6

object named as

Patrik Brundin

1 reference

Europe PubMed Central

PubMed publication ID

29 June 2017

Marja Jäättelä

object named as

Marja Jäättelä

5

1 reference

ORCID Public Data File 2021

author name string

Roger F Castilho

3

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Europe PubMed Central

PubMed publication ID

29 June 2017

language of work or name

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publication date

1 April 2003

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Europe PubMed Central

PubMed publication ID

29 June 2017

1 reference

Europe PubMed Central

PubMed publication ID

29 June 2017

970

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Europe PubMed Central

PubMed publication ID

29 June 2017

1-2

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Europe PubMed Central

PubMed publication ID

29 June 2017

47-57

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Europe PubMed Central

PubMed publication ID

29 June 2017

Impairment of the ubiquitin-proteasome system by protein aggregation

1 reference

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7 January 2021

Severe deficiencies in dopamine signaling in presymptomatic Huntington's disease mice

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7 January 2021

Bacterial and yeast chaperones reduce both aggregate formation and cell death in mammalian cell models of Huntington's disease

1 reference

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Altered brain neurotransmitter receptors in transgenic mice expressing a portion of an abnormal human huntington disease gene

1 reference

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Analysis of the role of heat shock protein (Hsp) molecular chaperones in polyglutamine disease

1 reference

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7 January 2021

Chaperone suppression of aggregation and altered subcellular proteasome localization imply protein misfolding in SCA1.

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7 January 2021

Mutation of the E6-AP ubiquitin ligase reduces nuclear inclusion frequency while accelerating polyglutamine-induced pathology in SCA1 mice.

1 reference

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7 January 2021

Over-expression of inducible HSP70 chaperone suppresses neuropathology and improves motor function in SCA1 mice

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Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation

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Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain

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Subacute systemic 3-nitropropionic acid intoxication induces a distinct motor disorder in adult C57Bl/6 mice: behavioural and histopathological characterisation

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Identification of genes that modify ataxin-1-induced neurodegeneration.

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Neuroprotective effects of creatine in a transgenic mouse model of Huntington's disease.

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Hsp104, Hsp70, and Hsp40: a novel chaperone system that rescues previously aggregated proteins

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7 January 2021

Molecular genetics: unmasking polyglutamine triggers in neurodegenerative disease

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7 January 2021

Transgenic mice expressing a Huntington's disease mutation are resistant to quinolinic acid-induced striatal excitotoxicity

1 reference

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Additive Effects of Caspase Inhibitor and Lazaroid on the Survival of Transplanted Rat and Human Embryonic Dopamine Neurons

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Polyglutamine length-dependent interaction of Hsp40 and Hsp70 family chaperones with truncated N-terminal huntingtin: their role in suppression of aggregation and cellular toxicity

1 reference

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7 January 2021

Altered proteasomal function due to the expression of polyglutamine-expanded truncated N-terminal huntingtin induces apoptosis by caspase activation through mitochondrial cytochrome c release

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A simple and sensitive antigen retrieval method for free-floating and slide-mounted tissue sections

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Protein folding in vivo: unraveling complex pathways

1 reference

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7 January 2021

Genetic suppression of polyglutamine toxicity in Drosophila

1 reference

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7 January 2021

Chaperones Hsp70 and Hsp40 suppress aggregate formation and apoptosis in cultured neuronal cells expressing truncated androgen receptor protein with expanded polyglutamine tract

1 reference

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7 January 2021

Aggregation of huntingtin in yeast varies with the length of the polyglutamine expansion and the expression of chaperone proteins

1 reference

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7 January 2021

Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice

1 reference

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7 January 2021

Progressive formation of inclusions in the striatum and hippocampus of mice transgenic for the human Huntington's disease mutation

1 reference

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7 January 2021

Hsp70 and hsp40 chaperones can inhibit self-assembly of polyglutamine proteins into amyloid-like fibrils

1 reference

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7 January 2021

Roles of molecular chaperones in the nervous system

1 reference

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7 January 2021

Transgenic mice expressing mutated full-length HD cDNA: a paradigm for locomotor changes and selective neuronal loss in Huntington's disease

1 reference

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7 January 2021

Polyglutamine aggregates alter protein folding homeostasis in Caenorhabditis elegans

1 reference

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7 January 2021

Huntingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions.

1 reference

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7 January 2021

Mutant Mice and Neuroscience: Recommendations Concerning Genetic Background

1 reference

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Nuclear inclusions in glutamine repeat disorders: are they pernicious, coincidental, or beneficial?

1 reference

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7 January 2021

Polyglutamine-expanded androgen receptors form aggregates that sequester heat shock proteins, proteasome components and SRC-1, and are suppressed by the HDJ-2 chaperone

1 reference

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7 January 2021

Identities of sequestered proteins in aggregates from cells with induced polyglutamine expression

1 reference

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A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

1 reference

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Huntington's disease: the challenge for cell biologists

1 reference

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Polyglutamine expansion as a pathological epitope in Huntington's disease and four dominant cerebellar ataxias

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Nonapoptotic neurodegeneration in a transgenic mouse model of Huntington's disease

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Delaying the onset of Huntington's in mice

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Anterior cingulate cortical transplantation in transgenic Huntington's disease mice

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Huntington disease

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Accumulation of mutant huntingtin fragments in aggresome-like inclusion bodies as a result of insufficient protein degradation

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Protein aggregation and pathogenesis of Huntington's disease: mechanisms and correlations

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Suppression of polyglutamine-mediated neurodegeneration in Drosophila by the molecular chaperone HSP70.

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Reversal of neuropathology and motor dysfunction in a conditional model of Huntington's disease

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Similarities between spinocerebellar ataxia type 7 (SCA7) cell models and human brain: proteins recruited in inclusions and activation of caspase-3.

1 reference

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7 January 2021

Chaperone suppression of cellular toxicity of huntingtin is independent of polyglutamine aggregation

1 reference

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7 January 2021

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10.1016/S0006-8993(02)04275-0

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Europe PubMed Central

PubMed publication ID

29 June 2017

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https://api.fatcat.wiki/v0/release/lt7ntyilpvhqhg3nydpzft6sq4

24 November 2022

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PubMed publication ID

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Europe PubMed Central

PubMed publication ID

29 June 2017

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