Huntington's disease: the challenge for cell biologists (Q34106564)

31 July 2017

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title

Huntington's disease: the challenge for cell biologists (English)

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31 July 2017

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A J Tobin

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31 July 2017

E R Signer

series ordinal

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31 July 2017

publication date

1 December 2000

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31 July 2017

published in

Trends in Cell Biology

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31 July 2017

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31 July 2017

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31 July 2017

page(s)

531-536

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Trinucleotide repeats in neurogenetic disorders

31 July 2017

cites work

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A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

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Differential expression of normal and mutant Huntington's disease gene alleles

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Caspases and neurodegeneration: on the cutting edge of new therapeutic approaches.

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Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation

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A cellular model that recapitulates major pathogenic steps of Huntington's disease

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Self-assembly of polyglutamine-containing huntingtin fragments into amyloid-like fibrils: implications for Huntington's disease pathology

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Transglutaminase aggregates huntingtin into nonamyloidogenic polymers, and its enzymatic activity increases in Huntington's disease brain nuclei

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Localization of rabbit huntingtin using a new panel of monoclonal antibodies

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Mutant huntingtin forms in vivo complexes with distinct context-dependent conformations of the polyglutamine segment

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Genetic neurodegenerative diseases: the human illness and transgenic models

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Recent insights into the molecular pathogenesis of Huntington disease

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Huntingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions.

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Aggresomes: a cellular response to misfolded proteins

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Long glutamine tracts cause nuclear localization of a novel form of huntingtin in medium spiny striatal neurons in HdhQ92 and HdhQ111 knock-in mice

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The Huntington's disease protein interacts with p53 and CREB-binding protein and represses transcription

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Decreased expression of striatal signaling genes in a mouse model of Huntington's disease

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Expression of polyglutamine-expanded Huntingtin activates the SEK1-JNK pathway and induces apoptosis in a hippocampal neuronal cell line

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Nonapoptotic neurodegeneration in a transgenic mouse model of Huntington's disease

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7 January 2021

Mitochondria in neurodegeneration: bioenergetic function in cell life and death

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Decrease in striatal enkephalin mRNA in mouse models of Huntington's disease

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Energetics in the pathogenesis of neurodegenerative diseases

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10.1016/S0962-8924(00)01853-5

Identifiers

DOI

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31 July 2017

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