Bioinformatic analysis of next‑generation sequencing data to identify dysregulated genes in fibroblasts of idiopathic pulmonary fibrosis (Q64262272)

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English	Bioinformatic analysis of next‑generation sequencing data to identify dysregulated genes in fibroblasts of idiopathic pulmonary fibrosis	article

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21 April 2020

Bioinformatic analysis of next‑generation sequencing data to identify dysregulated genes in fibroblasts of idiopathic pulmonary fibrosis (English)

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21 April 2020

pulmonary fibrosis

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idiopathic pulmonary fibrosis

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Chau-Chyun Sheu

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21 April 2020

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21 April 2020

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Ming-Ju Tsai

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21 April 2020

Ssu-Hui Liao

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21 April 2020

Inn-Wen Chong

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21 April 2020

Po-Lin Kuo

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31 January 2019

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21 April 2020

International Journal of Molecular Medicine

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21 April 2020

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21 April 2020

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21 April 2020

1643-1656

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21 April 2020

Cloning of neurotrimin defines a new subfamily of differentially expressed neural cell adhesion molecules

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Follicular cells of the thyroid gland require Pax8 gene function

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Neurotrimin mediates bifunctional effects on neurite outgrowth via homophilic and heterophilic interactions.

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Increased prevalence of gastroesophageal reflux in patients with idiopathic pulmonary fibrosis

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Occupational and Environmental Risk Factors for Idiopathic Pulmonary Fibrosis: A Multicenter Case-Control Study

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Pax8 has a key role in thyroid cell differentiation

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The serine/threonine kinase PAK4 prevents caspase activation and protects cells from apoptosis

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12 December 2020

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Fibroblasts from idiopathic pulmonary fibrosis and normal lungs differ in growth rate, apoptosis, and tissue inhibitor of metalloproteinases expression

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12 December 2020

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Requirement for PAK4 in the anchorage-independent growth of human cancer cell lines

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Gene Expression Omnibus: NCBI gene expression and hybridization array data repository

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The human genome browser at UCSC

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Herpesvirus DNA is consistently detected in lungs of patients with idiopathic pulmonary fibrosis

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Paired-Box genes are frequently expressed in cancer and often required for cancer cell survival

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Death receptor-induced activation of initiator caspase 8 is antagonized by serine/threonine kinase PAK4.

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Deregulated expression of KRAP, a novel gene encoding actin-interacting protein, in human colon cancer cells

1 reference

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12 December 2020

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Idiopathic pulmonary fibrosis fibroblasts migrate and proliferate to CC chemokine ligand 21

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12 December 2020

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Fibrocytes in lung disease

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Analysis of KRAP expression and localization, and genes regulated by KRAP in a human colon cancer cell line

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Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists

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Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

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12 December 2020

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WNT5A is a regulator of fibroblast proliferation and resistance to apoptosis

1 reference

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12 December 2020

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Idiopathic pulmonary fibrosis: a disease with similarities and links to cancer biology

1 reference

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12 December 2020

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Mesd is a universal inhibitor of Wnt coreceptors LRP5 and LRP6 and blocks Wnt/beta-catenin signaling in cancer cells

1 reference

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12 December 2020

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p21-activated kinase 4 regulates ovarian cancer cell proliferation, migration, and invasion and contributes to poor prognosis in patients

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12 December 2020

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An official ATS/ERS/JRS/ALAT statement: idiopathic pulmonary fibrosis: evidence-based guidelines for diagnosis and management

1 reference

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12 December 2020

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Mesd is a general inhibitor of different Wnt ligands in Wnt/LRP signaling and inhibits PC-3 tumor growth in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/30720061

12 December 2020

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miRDeep2 accurately identifies known and hundreds of novel microRNA genes in seven animal clades

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https://pubmed.ncbi.nlm.nih.gov/30720061

12 December 2020

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Bayesian probit regression model for the diagnosis of pulmonary fibrosis: proof-of-principle

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https://pubmed.ncbi.nlm.nih.gov/30720061

12 December 2020

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Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and Cufflinks

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https://pubmed.ncbi.nlm.nih.gov/30720061

12 December 2020

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MiRmap: comprehensive prediction of microRNA target repression strength.

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The increasing secondary care burden of idiopathic pulmonary fibrosis: hospital admission trends in England from 1998 to 2010.

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PI3K p110γ overexpression in idiopathic pulmonary fibrosis lung tissue and fibroblast cells: in vitro effects of its inhibition

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https://pubmed.ncbi.nlm.nih.gov/30720061

12 December 2020

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Bleomycin induces molecular changes directly relevant to idiopathic pulmonary fibrosis: a model for "active" disease

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Genome-wide association study identifies multiple susceptibility loci for pulmonary fibrosis

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Association between the MUC5B promoter polymorphism and survival in patients with idiopathic pulmonary fibrosis

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The Pak4 protein kinase is required for oncogenic transformation of MDA-MB-231 breast cancer cells.

1 reference

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12 December 2020

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Pax8 has a critical role in epithelial cell survival and proliferation

1 reference

https://pubmed.ncbi.nlm.nih.gov/30720061

12 December 2020

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PAK4 kinase-mediated SCG10 phosphorylation involved in gastric cancer metastasis

1 reference

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12 December 2020

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Oncogenic PAK4 regulates Smad2/3 axis involving gastric tumorigenesis

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Analysis of the human tissue-specific expression by genome-wide integration of transcriptomics and antibody-based proteomics

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https://pubmed.ncbi.nlm.nih.gov/30720061

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Causal analysis approaches in Ingenuity Pathway Analysis

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Genetic variants associated with idiopathic pulmonary fibrosis susceptibility and mortality: a genome-wide association study

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1 reference

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HISAT: a fast spliced aligner with low memory requirements

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Global incidence and mortality of idiopathic pulmonary fibrosis: a systematic review.

1 reference

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Predicting effective microRNA target sites in mammalian mRNAs

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12 December 2020

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An in cellulo-derived structure of PAK4 in complex with its inhibitor Inka1

1 reference

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12 December 2020

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The matricellular protein CCN1 enhances TGF-β1/SMAD3-dependent profibrotic signaling in fibroblasts and contributes to fibrogenic responses to lung injury

1 reference

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Crohn's Disease Fibroblasts Overproduce the Novel Protein KIAA1199 to Create Proinflammatory Hyaluronan Fragments

1 reference

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Lung Fibroblasts, Aging, and Idiopathic Pulmonary Fibrosis.

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Differential Binding of Three Major Human ADAR Isoforms to Coding and Long Non-Coding Transcripts.

1 reference

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PAK4 regulates G6PD activity by p53 degradation involving colon cancer cell growth

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1 reference

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Emerging therapies for idiopathic pulmonary fibrosis, a progressive age-related disease

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Identification of novel genetic regulations associated with airway epithelial homeostasis using next-generation sequencing data and bioinformatics approaches.

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12 December 2020

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1 reference

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PAX8 activates a p53-p21-dependent pro-proliferative effect in high grade serous ovarian carcinoma.

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

MiR-224 promotes proliferation and migration of gastric cancer cells through targeting PAK4.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30720061

12 December 2020

based on heuristic

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1 reference

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Therapeutic approaches to control tissue repair and fibrosis: Extracellular matrix as a game changer

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1 reference

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1 reference

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1 reference

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10.3892/IJMM.2019.4086

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21 April 2020

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21 April 2020

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21 April 2020

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