Death receptor-induced activation of initiator caspase 8 is antagonized by serine/threonine kinase PAK4. (Q39940614)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14560027%20AND%20SRC:MED&resulttype=core&format=json

20 December 2019

title

Death receptor-induced activation of initiator caspase 8 is antagonized by serine/threonine kinase PAK4 (English)

1 reference

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20 December 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14560027%20AND%20SRC:MED&resulttype=core&format=json

20 December 2019

Audrey Minden

1 reference

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20 December 2019

language of work or name

English

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publication date

1 November 2003

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14560027%20AND%20SRC:MED&resulttype=core&format=json

Molecular and Cellular Biology

20 December 2019

published in

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20 December 2019

volume

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20 December 2019

issue

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20 December 2019

page(s)

7838-7848

1 reference

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Emerging from the Pak: the p21-activated protein kinase family.

20 December 2019

cites work

1 reference

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CD28-dependent activation of protein kinase B/Akt blocks Fas-mediated apoptosis by preventing death-inducing signaling complex assembly.

22 September 2017

1 reference

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c-FLIP(L) is a dual function regulator for caspase-8 activation and CD95-mediated apoptosis

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=207651

The phosphoinositide 3-kinase pathway

22 September 2017

1 reference

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Cloning and characterization of PAK5, a novel member of mammalian p21-activated kinase-II subfamily that is predominantly expressed in brain

22 September 2017

1 reference

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p21-activated kinases: three more join the Pak.

22 September 2017

1 reference

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PAK5, a new brain-specific kinase, promotes neurite outgrowth in N1E-115 cells

22 September 2017

1 reference

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Protein kinase C regulates FADD recruitment and death-inducing signaling complex formation in Fas/CD95-induced apoptosis

22 September 2017

1 reference

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Activated PAK4 regulates cell adhesion and anchorage-independent growth

22 September 2017

1 reference

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The serine/threonine kinase PAK4 prevents caspase activation and protects cells from apoptosis

22 September 2017

1 reference

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Androgen receptor specifically interacts with a novel p21-activated kinase, PAK6

22 September 2017

1 reference

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MAPK/ERK signaling in activated T cells inhibits CD95/Fas-mediated apoptosis downstream of DISC assembly

22 September 2017

1 reference

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Recruitment of the IKK signalosome to the p55 TNF receptor: RIP and A20 bind to NEMO (IKKgamma) upon receptor stimulation

22 September 2017

1 reference

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Akt suppresses apoptosis by stimulating the transactivation potential of the RelA/p65 subunit of NF-kappaB.

22 September 2017

1 reference

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Biochemical pathways of caspase activation during apoptosis

22 September 2017

1 reference

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p21-activated kinase 1 phosphorylates the death agonist bad and protects cells from apoptosis

22 September 2017

1 reference

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Cellular survival: a play in three Akts

22 September 2017

1 reference

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NF-kappaB is a target of AKT in anti-apoptotic PDGF signalling

22 September 2017

1 reference

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Bid-deficient mice are resistant to Fas-induced hepatocellular apoptosis

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=207651

p21-activated protein kinase: a crucial component of morphological signaling?

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=207651

22 September 2017

1 reference

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Tumor necrosis factor receptor and Fas signaling mechanisms.

22 September 2017

1 reference

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NF-kappaB to the rescue: RELs, apoptosis and cellular transformation

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=207651

TNF recruits TRADD to the plasma membrane but not the trans-Golgi network, the principal subcellular location of TNF-R1

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=207651

The role of c-FLIP in modulation of CD95-induced apoptosis

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=207651

Caspase cleaved BID targets mitochondria and is required for cytochrome c release, while BCL-XL prevents this release but not tumor necrosis factor-R1/Fas death

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=207651

PAK4, a novel effector for Cdc42Hs, is implicated in the reorganization of the actin cytoskeleton and in the formation of filopodia

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=207651

Apoptotic pathways: the roads to ruin

22 September 2017

1 reference

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Essential requirement for caspase-8/FLICE in the initiation of the Fas-induced apoptotic cascade

22 September 2017

1 reference

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Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=207651

Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors

22 September 2017

1 reference

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22 September 2017

Caspases: enemies within

1 reference

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Death receptors: signaling and modulation

22 September 2017

1 reference

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Ras signalling and apoptosis

22 September 2017

1 reference

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Two CD95 (APO-1/Fas) signaling pathways

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=207651

Membrane targeting of p21-activated kinase 1 (PAK1) induces neurite outgrowth from PC12 cells

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=207651

An induced proximity model for caspase-8 activation.

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=207651

Human p21-activated kinase (Pak1) regulates actin organization in mammalian cells

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=207651

Activation of hPAK65 by caspase cleavage induces some of the morphological and biochemical changes of apoptosis

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=207651

Akt Phosphorylation of BAD Couples Survival Signals to the Cell-Intrinsic Death Machinery

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=207651

CASH, a Novel Caspase Homologue with Death Effector Domains

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=207651

Inhibition of death receptor signals by cellular FLIP

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=207651

FLICE is activated by association with the CD95 death-inducing signaling complex (DISC).

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=207651

Apoptosis by death factor

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=207651

The tumor necrosis factor receptor 2 signal transducers TRAF2 and c-IAP1 are components of the tumor necrosis factor receptor 1 signaling complex

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=207651

Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-kappaB activation prevents cell death

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=207651

An essential role for NF-kappaB in preventing TNF-alpha-induced cell death

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=207651

Human Ste20 homologue hPAK1 links GTPases to the JNK MAP kinase pathway

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=207651

FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death--inducing signaling complex

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=207651

Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1- and TNF receptor-induced cell death

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=207651

TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1 signaling complex

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=207651

TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=207651

Cytotoxicity-dependent APO-1 (Fas/CD95)-associated proteins form a death-inducing signaling complex (DISC) with the receptor

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=207651

A brain serine/threonine protein kinase activated by Cdc42 and Rac1

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=207651

The TNF receptor 1-associated protein TRADD signals cell death and NF-kappa B activation

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=207651

A novel serine kinase activated by rac1/CDC42Hs-dependent autophosphorylation is related to PAK65 and STE20

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=207651

Identification of a mouse p21Cdc42/Rac activated kinase

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=207651

RIP: a novel protein containing a death domain that interacts with Fas/APO-1 (CD95) in yeast and causes cell death

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=207651

FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=207651

A novel protein that interacts with the death domain of Fas/APO1 contains a sequence motif related to the death domain

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=207651

A conserved binding motif defines numerous candidate target proteins for both Cdc42 and Rac GTPases

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=207651

Social controls on cell survival and cell death

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=207651

HIV-1 Nef associated PAK and PI3-kinases stimulate Akt-independent Bad-phosphorylation to induce anti-apoptotic signals

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=207651

The Akt proto-oncogene links Ras to Pak and cell survival signals

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=207651

Cleavage and activation of p21-activated protein kinase gamma-PAK by CPP32 (caspase 3). Effects of autophosphorylation on activity

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=207651

Requirement for PAK4 in the anchorage-independent growth of human cancer cell lines

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=207651

p21-activated protein kinase gamma-PAK suppresses programmed cell death of BALB3T3 fibroblasts

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=207651

Targeted disruption of the mouse Caspase 8 gene ablates cell death induction by the TNF receptors, Fas/Apo1, and DR3 and is lethal prenatally.

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=207651

Caspases: Intracellular Signaling by Proteolysis

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=207651

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=207651

Selective up-regulation of phosphatidylinositol 3'-kinase activity in Th2 cells inhibits caspase-8 cleavage at the death-inducing complex: a mechanism for Th2 resistance from Fas-mediated apoptosis

2 December 2018

1 reference

12 December 2020

Membrane and morphological changes in apoptotic cells regulated by caspase-mediated activation of PAK2

1 reference

12 December 2020

TCR-mediated up-regulation of c-FLIPshort correlates with resistance toward CD95-mediated apoptosis by blocking death-inducing signaling complex activity

1 reference

12 December 2020

The central executioners of apoptosis: caspases or mitochondria?

1 reference

12 December 2020

TNF-alpha signals apoptosis through a bid-dependent conformational change in Bax that is inhibited by E1B 19K

1 reference

12 December 2020

Phosphatidylinositol 3'-kinase blocks CD95 aggregation and caspase-8 cleavage at the death-inducing signaling complex by modulating lateral diffusion of CD95

1 reference

12 December 2020

A matter of life and death

1 reference

12 December 2020

10.1128/MCB.23.21.7838-7848.2003

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14560027%20AND%20SRC:MED&resulttype=core&format=json

20 December 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14560027%20AND%20SRC:MED&resulttype=core&format=json

20 December 2019

PubMed publication ID

14560027

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14560027%20AND%20SRC:MED&resulttype=core&format=json