Koštani morfogenetički protein 7

BMP7
Available structures
PDB	Pretraga ortologa: PDBe RCSB
List of PDB id codes
	1BMP, 1LX5, 1LXI, 1M4U
Identifikatori
Alijasi	BMP7
Spoljašnji ID	OMIM: 112267 MGI: 103302 HomoloGene: 20410 GeneCards: BMP7
Genska lokacija (miš)
Hr.	Chromosome 2 (mouse)
Kraj	172,782,114 bp
Genska ontologija
Molecular function	• везивање хепарина; • активност цитокина; • transforming growth factor beta receptor binding; • активност фактора раста; • BMP receptor binding; • GO:0001948, GO:0016582 везивање за протеине плазме;
Cellular component	• ванћелијска област; • GO:0005578 Екстрацелуларни матрикс; • ванћелијски простор; • везикула; • collagen-containing extracellular matrix;
Biological process	• eye development; • pattern specification process; • skeletal system development; • ureteric bud development; • negative regulation of neuron differentiation; • embryonic pattern specification; • mesenchyme development; • anatomical structure formation involved in morphogenesis; • negative regulation of cell cycle; • mesonephros development; • odontogenesis of dentin-containing tooth; • mesenchymal cell differentiation; • negative regulation of mitotic nuclear division; • animal organ morphogenesis; • metanephric mesenchyme morphogenesis; • metanephros development; • cellular response to hypoxia; • regulation of pathway-restricted SMAD protein phosphorylation; • regulation of removal of superoxide radicals; • steroid hormone mediated signaling pathway; • negative regulation of Notch signaling pathway; • negative regulation of cell population proliferation; • branching involved in salivary gland morphogenesis; • regulation of apoptotic process; • SMAD protein signal transduction; • ossification; • развој бубрега; • negative regulation of cell death; • tube morphogenesis; • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated; • negative regulation of prostatic bud formation; • cartilage development; • embryonic limb morphogenesis; • negative regulation of MAP kinase activity; • embryonic camera-type eye morphogenesis; • positive regulation of neuron differentiation; • positive regulation of cell differentiation; • negative regulation of phosphorylation; • regulation of branching involved in prostate gland morphogenesis; • диференцијација; • neuron projection morphogenesis; • nephrogenic mesenchyme morphogenesis; • positive regulation of heterotypic cell-cell adhesion; • epithelial cell differentiation; • response to vitamin D; • positive regulation of hyaluranon cable assembly; • positive regulation of bone mineralization; • dendrite development; • negative regulation of neurogenesis; • regulation of phosphorylation; • BMP signaling pathway; • positive regulation of osteoblast differentiation; • epithelial to mesenchymal transition; • GO:0045996 negative regulation of transcription, DNA-templated; • negative regulation of NF-kappaB transcription factor activity; • branching morphogenesis of an epithelial tube; • negative regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis; • negative regulation of glomerular mesangial cell proliferation; • response to estradiol; • monocyte aggregation; • metanephric mesenchymal cell proliferation involved in metanephros development; • positive regulation of cell death; • cell development; • negative regulation of striated muscle cell apoptotic process; • positive regulation of pathway-restricted SMAD protein phosphorylation; • mesoderm formation; • response to peptide hormone; • cellular response to BMP stimulus; • positive regulation of dendrite development; • salivary gland morphogenesis; • axon guidance; • multicellular organism development; • positive regulation of peptidyl-threonine phosphorylation; • positive regulation of apoptotic process; • protein localization to nucleus; • embryonic skeletal joint morphogenesis; • camera-type eye morphogenesis; • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II; • endocardial cushion formation; • pericardium morphogenesis; • neural fold elevation formation; • hindbrain development; • cardiac muscle tissue development; • pharyngeal system development; • cardiac septum morphogenesis; • chorio-allantoic fusion; • heart trabecula morphogenesis; • allantois development; • positive regulation of epithelial to mesenchymal transition; • positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis; • regulation of signaling receptor activity; • GO:1901313 positive regulation of gene expression; • negative regulation of NIK/NF-kappaB signaling; • regulation of MAPK cascade;
	Sources:Amigo / QuickGO
Ortolozi
	655
	12162
	ENSG00000101144
	ENSMUSG00000008999
	P18075
	P23359
	NM_001719
	NM_007557
	NP_001710; NP_001710.1
	NP_031583
	Wikidata
View/Edit Human	View/Edit Mouse

Koštani morfogenetički protein 7 ili BMP7 (takođe poznat kao osteogenski protein-1 ili OP-1) je protein koji je kod ljudi kodiran BMP7 genom.^[4]

Funkcija

Protein kodiran ovim genom je član TGF-β superfamilije. Poput drugih članova familije koštano morfogenetičkih proteina, on ima značajnu ulogu u transformaciji mesenhimalnih ćelija u kost i hrskavicu. Njega inhibira nogin i slični protein, hordin. Smatra se da BMP7 doprinosi koštanoh homeostazi. On je izražen u mozgu, bubrezima i bešiki.^[5]

BMP7 indukuje fosforilaciju SMAD1 i SMAD5, koji zatim indukuju transkripciju brojnih osteogenih gena.^[6] Pokazano je da je BMP7 tretman dovoljan da se indukuju svi genetički markeri osteoblastne diferencijacije u mnoštvu ćelijskih tipova.^[5]

Reference

^ ^а ^б ^в GRCm38: Ensembl release 89: ENSMUSG00000008999 - Ensembl, May 2017
^ „Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ „Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Hahn GV, Cohen RB, Wozney JM, Levitz CL, Shore EM, Zasloff MA, Kaplan FS (1992). „A bone morphogenetic protein subfamily: chromosomal localization of human genes for BMP5, BMP6, and BMP7”. Genomics. 14 (3): 759—62. PMID 1427904. doi:10.1016/S0888-7543(05)80181-8.
^ ^а ^б Chen D, Zhao M, Mundy GR (2004). „Bone morphogenetic proteins”. Growth Factors. 22 (4): 233—41. PMID 15621726. doi:10.1080/08977190412331279890.
^ Itoh F, Asao H, Sugamura K, Heldin CH, ten Dijke P, Itoh S (2001). „Promoting bone morphogenetic protein signaling through negative regulation of inhibitory Smads”. EMBO J. 20 (15): 4132—42. PMC 149146 . PMID 11483516. doi:10.1093/emboj/20.15.4132.