| Phenotypes in Other Animal Models |
This portal contains data related to additional species used as models in disease, physiology and phenotypes.
Please feel free to contact us with suggestions for additional data or tools that would help advance your research.
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| The Chinchilla, (Chinchilla lanigera), is used to study the physiology, development and function of the auditory system, hearing, psychoacoustics, the pathobiology of bacterial and viral infections, renal physiology, heart anatomy; also used in the development and evaluation of vaccines; model for otitis media, upper respiratory tract infections, ototoxicity. Now in PhenoMiner! | Chinchilla JBrowse | Chinchilla Genome Information Page | Otitis Media Respiratory Tract Infections |
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| The 13-lined Ground Squirrel, (Ictidomys tridecemlineatus), is used for the study of retinal function and dysfunction; the ability of the squirrel to survive through repeated cycles of long periods of hypometabolic torpor interspersed with brief periods of euthermic arousal during hibernation makes it an excellent model for studies of metabolism, hypoxia/reperfusion, and longevity. | 13-Lined Ground Squirrel JBrowse | 13-Lined Ground Squirrel Genome Information Page | Retinal Degeneration Reperfusion Injury |
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| The Domestic Dog, (Canis lupus familiaris), can spontaneously develop, and is used as a model for, cancer, heart disease, rheumatoid arthritis, autoimmune disorders, allergies, thyroid disease, cataracts, epilepsy, hip dysplasia, progressive retinal atrophy and blindness, deafness; recent and extensive breed diversification makes the dog an evolutionary model. | Dog JBrowse | Dog Genome Information Page | Rheumatoid Arthritis Generalized Epilepsy Hearing Loss |
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| The Bonobo/Pygmy Chimpanzee (Pan paniscus), can spontaneously develop hypertension, cardiomyopathy with fibrosis, congestive heart failure, aortic dissection, stroke, arrhythmogenic right ventricular cardiomyopathy (ARVC) with associated sudden death. | Bonobo JBrowse | Bonobo Genome Information Page | Congestive Heart Failure Stroke Arrythmogenic Right Ventricular Cardiomyopathy |
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| The pig, (Sus scrofa), is an important model organism for health research due to parallels with humans. Similarities between humans and pigs exist in renal function, vascular structure, and respiratory rates. Pigs are used as model organism in many areas of medical research including obesity, cardiovascular disease, endocrinology, alcoholism, diabetes, nephropathy, and organ transplantation. | Pig JBrowse | Pig Genome Information Page | Congenital Heart Disease Obesity |
More data analysis at RGD…
| OLGA, the Object List Generator & Analyzer tool, is a straightforward list builder for genes from any of RGD’s species, for rat, human and mouse QTLs, or for rat strains, using any of a variety of querying options. Find objects in RGD using genomic positions or any of RGD’s functional annotations, or enter your own list of symbols, then select how you want to use that list, e.g download the list to your own computer for analysis or loading into other tools, send the list to RGD’s GA Tool for functional analyses or, for rat, send the list to the Variant Visualizer to find strain-specific variants. | The Gene Annotator takes a list of gene symbols, RGD IDs, GenBank accession numbers, Ensembl identifiers, and/or a chromosomal region, and retrieves annotation data from RGD. The tool will retrieve annotations from any or all ontologies used at RGD for genes and their orthologs, as well as links to additional information at other databases. | Variant Visualizer is a viewing and analysis tool for rat strain-specific sequence polymorphisms and for human ClinVar variants. Select samples of interest, define one or more genomic regions and, if desired, set parameters for the type(s) of desired variants and the tool will return all of the SNVs which match the input criteria, including information on read depth, zygosity and conservation score for rat variants, or clinical significance and associated phenotypes/diseases for human variants. |
American Physiological Society
Physiology Online
National Bio Resource Project
NHLBI
American Heart Association
American Lung Association