(Q35769445)

10 August 2017

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title

The CD4/CD8 lineage choice: new insights into epigenetic regulation during T cell development (English)

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10 August 2017

Wilfried Ellmeier

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10 August 2017

Dan R Littman

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10 August 2017

Ichiro Taniuchi

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10 August 2017

publication date

1 January 2004

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10 August 2017

published in

Advances in Immunology

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10 August 2017

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10 August 2017

page(s)

55-89

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Hierarchical interactions control CD4 gene expression during thymocyte development

10 August 2017

cites work

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7 January 2021

Negative regulation of CD4 gene expression by a HES-1-c-Myb complex

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7 January 2021

Characterization of the lymphocyte activation gene 3-encoded protein. A new ligand for human leukocyte antigen class II antigens

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7 January 2021

Functions of E2A-HEB heterodimers in T-cell development revealed by a dominant negative mutation of HEB

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983002-5

7 January 2021

Insulators and boundaries: versatile regulatory elements in the eukaryotic genome

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https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983002-5

7 January 2021

Coreceptor reversal in the thymus: signaled CD4+8+ thymocytes initially terminate CD8 transcription even when differentiating into CD8+ T cells

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983002-5

7 January 2021

Hematopoietic development: a balancing act.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983002-5

7 January 2021

Reciprocal regulation of CD4/CD8 expression by SWI/SNF-like BAF complexes

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983002-5

7 January 2021

Suppressor of cytokine signaling-1 is a critical regulator of interleukin-7-dependent CD8+ T cell differentiation.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983002-5

7 January 2021

Thymocyte lineage commitment: is it instructed or stochastic?

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983002-5

7 January 2021

Identification and characterization of a human CD4 silencer

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983002-5

7 January 2021

Asymmetric redundancy in CD4 silencer function

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983002-5

7 January 2021

The regulation of CD4 and CD8 coreceptor gene expression during T cell development

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983002-5

7 January 2021

An enhancer that directs lineage-specific expression of CD8 in positively selected thymocytes and mature T cells

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983002-5

7 January 2021

Multiple developmental stage-specific enhancers regulate CD8 expression in developing thymocytes and in thymus-independent T cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983002-5

7 January 2021

Combined deletion of CD8 locus cis-regulatory elements affects initiation but not maintenance of CD8 expression.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983002-5

7 January 2021

Locus control regions and epigenetic chromatin modifiers

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983002-5

7 January 2021

Heterochromatin protein 1 modifies mammalian PEV in a dose- and chromosomal-context-dependent manner

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983002-5

7 January 2021

Locus control region function and heterochromatin-induced position effect variegation

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983002-5

7 January 2021

Variegated expression of CD8 alpha resulting from in situ deletion of regulatory sequences.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983002-5

7 January 2021

Haematopoietic cell-fate decisions, chromatin regulation and ikaros

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983002-5

7 January 2021

Tissue-specific expression of human CD4 in transgenic mice

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983002-5

7 January 2021

Maintaining the status quo: T-cell homeostasis

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983002-5

7 January 2021

Selecting and maintaining a diverse T-cell repertoire

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983002-5

7 January 2021

Structure of the mouse gene encoding CD4 and an unusual transcript in brain

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983002-5

7 January 2021

Extrathymic T cell lymphopoiesis: ontogeny and contribution to gut intraepithelial lymphocytes in athymic and euthymic mice

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983002-5

7 January 2021

Specific expression of the human CD4 gene in mature CD4+ CD8- and immature CD4+ CD8+ T cells and in macrophages of transgenic mice

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983002-5

7 January 2021

The CD8alpha gene locus is regulated by the Ikaros family of proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983002-5

7 January 2021

Intraepithelial lymphocytes: exploring the Third Way in immunology

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983002-5

7 January 2021

Lck activity controls CD4/CD8 T cell lineage commitment.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983002-5

7 January 2021

Control of regulatory T cell development by the transcription factor Foxp3

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983002-5

7 January 2021

Hierarchical interactions of control elements determine CD8alpha gene expression in subsets of thymocytes and peripheral T cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983002-5

7 January 2021

A Region in the CD8 Gene Locus That Directs Expression to the Mature CD8 T Cell Subset in Transgenic Mice

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983002-5

7 January 2021

Deciphering the role of Notch signaling in lymphopoiesis

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983002-5

7 January 2021

Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983002-5

7 January 2021

Subsets of CD3+ (T cell receptor α/β or γ/δ) and CD3− lymphocytes isolated from normal human gut epithelium display phenotypical features different from their counterparts in peripheral blood

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983002-5

7 January 2021

Translating the Histone Code

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983002-5

7 January 2021

A role for pref-1 and HES-1 in thymocyte development.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983002-5

7 January 2021

Regulation of lineage commitment distinct from positive selection

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983002-5

7 January 2021

Progress toward a human CD4/CCR5 transgenic rat model for de novo infection by human immunodeficiency virus type 1.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983002-5

7 January 2021

Human CD8 alpha expression in NK cells but not cytotoxic T cells of transgenic mice

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983002-5

7 January 2021

The regulation and function of the CD4 coreceptor during T lymphocyte development.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983002-5

7 January 2021

Regulated expression of human CD4 rescues helper T cell development in mice lacking expression of endogenous CD4.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983002-5

7 January 2021

The notch pathway intermediate HES-1 silences CD4 gene expression

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983002-5

7 January 2021

Subclass-specific nuclear localization of a novel CD4 silencer binding factor

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983002-5

7 January 2021

Chromatin and CD4, CD8A and CD8B gene expression during thymic differentiation

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983002-5

7 January 2021

CD8alpha alpha memory effector T cells descend directly from clonally expanded CD8alpha +beta high TCRalpha beta T cells in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983002-5

7 January 2021

The unconventional lifestyle of NKT cells

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983002-5

7 January 2021

Precursors of functional MHC class I- or class II-restricted CD8alphaalpha(+) T cells are positively selected in the thymus by agonist self-peptides

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983002-5

7 January 2021

Deletion of the CD4 silencer element supports a stochastic mechanism of thymocyte lineage commitment

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983002-5

7 January 2021

Transcriptional repression by AML1 and LEF-1 is mediated by the TLE/Groucho corepressors

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983002-5

7 January 2021

Chromatin modification and epigenetic reprogramming in mammalian development

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983002-5

7 January 2021

A mechanism of repression by acute myeloid leukemia-1, the target of multiple chromosomal translocations in acute leukemia

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983002-5

7 January 2021

A transgenic mouse model to analyze CD8(+) effector T cell differentiation in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983002-5

7 January 2021

Independent modes of natural killing distinguished in mice lacking Lag3

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983002-5

7 January 2021

Role of histone H3 lysine 9 methylation in epigenetic control of heterochromatin assembly

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983002-5

7 January 2021

Binding of c-Myb to the core sequence of the CD4 promoter

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983002-5

7 January 2021

Characterization of the human CD4 gene promoter: transcription from the CD4 gene core promoter is tissue-specific and is activated by Ets proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983002-5

7 January 2021

T cell-specific protein-DNA interactions occurring at the CD4 locus: identification of possible transcriptional control elements of the murine CD4 gene

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983002-5

7 January 2021

Identification and characterization of a T-cell-specific enhancer adjacent to the murine CD4 gene

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983002-5

7 January 2021

A heterodimer of HEB and an E12-related protein interacts with the CD4 enhancer and regulates its activity in T-cell lines

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983002-5

7 January 2021

A lineage-specific transcriptional silencer regulates CD4 gene expression during T lymphocyte development

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983002-5

7 January 2021

Selection of the T cell repertoire.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983002-5

7 January 2021

New perspectives on a developmental dilemma: the kinetic signaling model and the importance of signal duration for the CD4/CD8 lineage decision

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983002-5

7 January 2021

PU.1, a shared transcriptional regulator of lymphoid and myeloid cell fates

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983002-5

7 January 2021

A transcriptional silencer controls the developmental expression of the CD4 gene.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983002-5

7 January 2021

Expression of the CD4 gene requires a Myb transcription factor

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983002-5

7 January 2021

Differential requirements for Runx proteins in CD4 repression and epigenetic silencing during T lymphocyte development.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983002-5

7 January 2021

Evidence for distinct CD4 silencer functions at different stages of thymocyte differentiation.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983002-5

7 January 2021

The bHLH gene Hes1 is essential for expansion of early T cell precursors

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983002-5

7 January 2021

LAG-3, a novel lymphocyte activation gene closely related to CD4

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983002-5

7 January 2021

Structure and function of the pre-T cell receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983002-5

7 January 2021

The thymus selects the useful, neglects the useless and destroys the harmful

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983002-5

7 January 2021

The surface phenotype of dendritic cells purified from mouse thymus and spleen: investigation of the CD8 expression by a subpopulation of dendritic cells

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983002-5

7 January 2021

Signal transduction by lymphocyte antigen receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983002-5

7 January 2021

Mechanisms of transcriptional regulation by Runt domain proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983002-5

7 January 2021

Inactivation of Notch 1 in immature thymocytes does not perturb CD4 or CD8T cell development

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983002-5

7 January 2021

Runx3 and Runx1 are required for CD8 T cell development during thymopoiesis

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983002-5

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983002-5

7 January 2021

Elf-1 binds to a critical element in a second CD4 enhancer

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983002-5

7 January 2021

CD8 expression up to the double-positive CD3(low/intermediate) stage of thymic differentiation is sufficient for development of peripheral functional cytotoxic T lymphocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983002-5

7 January 2021

B-lymphocyte development is regulated by the combined dosage of three basic helix-loop-helix genes, E2A, E2-2, and HEB.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983002-5

7 January 2021

Epigenetic silencing of CD4 in T cells committed to the cytotoxic lineage

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2804%2983002-5

7 January 2021

10.1016/S0065-2776(04)83002-5

Identifiers

DOI

1 reference

10 August 2017

1 reference