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English
Lck activity controls CD4/CD8 T cell lineage commitment.
scientific article published on March 2000
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instance of
scholarly article
1 reference
stated in
Europe PubMed Central
PubMed publication ID
10755618
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10755618%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 November 2019
title
Lck activity controls CD4/CD8 T cell lineage commitment
(English)
1 reference
stated in
Europe PubMed Central
PubMed publication ID
10755618
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10755618%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 November 2019
main subject
cell fate commitment
1 reference
based on heuristic
inferred from title
author
Ellen V. Rothenberg
series ordinal
3
1 reference
stated in
Europe PubMed Central
PubMed publication ID
10755618
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10755618%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 November 2019
Jose Alberola-Ila
series ordinal
4
1 reference
stated in
Europe PubMed Central
PubMed publication ID
10755618
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10755618%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 November 2019
author name string
G Hernández-Hoyos
series ordinal
1
1 reference
stated in
Europe PubMed Central
PubMed publication ID
10755618
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10755618%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 November 2019
S J Sohn
series ordinal
2
1 reference
stated in
Europe PubMed Central
PubMed publication ID
10755618
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10755618%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 November 2019
language of work or name
English
0 references
publication date
1 March 2000
1 reference
stated in
Europe PubMed Central
PubMed publication ID
10755618
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10755618%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 November 2019
published in
Immunity
1 reference
stated in
Europe PubMed Central
PubMed publication ID
10755618
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10755618%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 November 2019
volume
12
1 reference
stated in
Europe PubMed Central
PubMed publication ID
10755618
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10755618%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 November 2019
issue
3
1 reference
stated in
Europe PubMed Central
PubMed publication ID
10755618
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10755618%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 November 2019
page(s)
313-322
1 reference
stated in
Europe PubMed Central
PubMed publication ID
10755618
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10755618%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 November 2019
cites work
Delayed thymocyte development induced by augmented expression of p56lck
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980184-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Positive and negative selection invoke distinct signaling pathways.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980184-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
CD3 ligation on immature thymocytes generates antagonist-like signals appropriate for CD8 lineage commitment, independently of T cell receptor specificity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980184-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Signals through CD8 or CD4 can induce commitment to the CD4 lineage in the thymus
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980184-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Exclusion and inclusion of α and β T cell receptor alleles
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980184-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Thymic selection of cytotoxic T cells independent of CD8 alpha-Lck association
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980184-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Another view of the selective model of thymocyte selection
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980184-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Functional commitment to helper T cell lineage precedes positive selection and is independent of T cell receptor MHC specificity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980184-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Evidence for a stochastic mechanism in the differentiation of mature subsets of T lymphocytes.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980184-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The lck SH3 domain is required for activation of the mitogen-activated protein kinase pathway but not the initiation of T-cell antigen receptor signaling
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980184-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Restoration of thymopoiesis in pT alpha-/- mice by anti-CD3epsilon antibody treatment or with transgenes encoding activated Lck or tailless pT alpha.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980184-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Positive selection of T cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980184-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A novel method for measuring CTL and NK cell-mediated cytotoxicity using annexin V and two-color flow cytometry
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980184-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
CD8 lineage commitment in the absence of CD8.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980184-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
T cells with two functional antigen-specific receptors
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980184-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Requirement for p56lck tyrosine kinase activation in T cell receptor-mediated thymic selection
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980184-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Expression of two alpha chains on the surface of T cells in T cell receptor transgenic mice
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980184-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
T cell receptor antagonist peptides induce positive selection
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980184-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The cytoplasmic domain of CD4 promotes the development of CD4 lineage T cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980184-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Sequential interactions of the TCR with two distinct cytoplasmic tyrosine kinases
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980184-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Activation of the protein kinase ERK5/BMK1 by receptor tyrosine kinases. Identification and characterization of a signaling pathway to the nucleus
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980184-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Selective development of CD4+ T cells in transgenic mice expressing a class II MHC-restricted antigen receptor
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980184-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Helper T-cell development in the absence of CD4-p56 Ick association
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980184-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Intermediate steps in positive selection: differentiation of CD4+8int TCRint thymocytes into CD4-8+TCRhi thymocytes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980184-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cross-linking of T-cell surface molecules CD4 and CD8 stimulates phosphorylation of the lck tyrosine protein kinase at the autophosphorylation site
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980184-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
MHC class II-specific T cells can develop in the CD8 lineage when CD4 is absent
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980184-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Profound block in thymocyte development in mice lacking p56lck
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980184-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
An activated lck transgene promotes thymocyte development in RAG-1 mutant mice.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980184-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Regulation of lymphocyte function by protein phosphorylation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980184-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Selective events in T cell development
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980184-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Thymic selection in CD8 transgenic mice supports an instructive model for commitment to a CD4 or CD8 lineage
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980184-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Constitutive CD8 expression allows inefficient maturation of CD4+ helper T cells in class II major histocompatibility complex mutant mice
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980184-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Signal for T-cell differentiation to a CD4 cell lineage is delivered by CD4 transmembrane region and/or cytoplasmic tail
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980184-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The Influence of the MAPK Pathway on T Cell Lineage Commitment
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980184-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The lck tyrosine protein kinase interacts with the cytoplasmic tail of the CD4 glycoprotein through its unique amino-terminal domain
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980184-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Recombinant human CD40 ligand stimulates B cell proliferation and immunoglobulin E secretion
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980184-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Genetic evidence for the involvement of the lck tyrosine kinase in signal transduction through the T cell antigen receptor
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980184-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Asymmetric signaling requirements for thymocyte commitment to the CD4+ versus CD8+ T cell lineages: a new perspective on thymic commitment and selection
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980184-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Positive selection of CD4+ T cells by TCR-specific antibodies requires low valency TCR cross-linking: implications for repertoire selection in the thymus.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980184-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Interaction of the unique N-terminal region of tyrosine kinase p56lck with cytoplasmic domains of CD4 and CD8 is mediated by cysteine motifs
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980184-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Development of mature CD8+ thymocytes: selection rather than instruction?
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980184-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Lck regulates the tyrosine phosphorylation of the T cell receptor subunits and ZAP-70 in murine thymocytes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980184-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Engagement of CD4 and CD8 expressed on immature thymocytes induces activation of intracellular tyrosine phosphorylation pathways
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980184-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The CD4 and CD8 T cell surface antigens are associated with the internal membrane tyrosine-protein kinase p56lck
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980184-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
CD4/CD8 lineage commitment: back to instruction?
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980184-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Precocious expression of T cell functional response genes in vivo in primitive thymocytes before T lineage commitment
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980184-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Regulation of T cell receptor expression in immature CD4+CD8+ thymocytes by p56lck tyrosine kinase: basis for differential signaling by CD4 and CD8 in immature thymocytes expressing both coreceptor molecules
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980184-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1016/S1074-7613(00)80184-3
1 reference
stated in
Europe PubMed Central
PubMed publication ID
10755618
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10755618%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 November 2019
PubMed publication ID
10755618
1 reference
stated in
Europe PubMed Central
PubMed publication ID
10755618
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10755618%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 November 2019
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