(Q34988301)

5 August 2017

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title

Calcium dyshomeostasis and intracellular signalling in Alzheimer's disease (English)

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5 August 2017

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Frank M LaFerla

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5 August 2017

language of work or name

English

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publication date

1 November 2002

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Nature Reviews Neuroscience

5 August 2017

published in

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5 August 2017

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5 August 2017

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5 August 2017

page(s)

862-872

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gamma-Secretase, Notch, Abeta and Alzheimer's disease: where do the presenilins fit in?

5 August 2017

cites work

1 reference

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

21 January 2018

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Calcium, membranes, aging, and Alzheimer's disease. Introduction and overview.

21 January 2018

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Calcium signaling in the ER: its role in neuronal plasticity and neurodegenerative disorders

21 January 2018

1 reference

Calcium responses in fibroblasts from asymptomatic members of Alzheimer's disease families

21 January 2018

1 reference

Alterations in synaptic transmission and long-term potentiation in hippocampal slices from young and aged PDAPP mice

21 January 2018

1 reference

Increased vulnerability of hippocampal neurons to excitotoxic necrosis in presenilin-1 mutant knock-in mice

21 January 2018

1 reference

Capacitative calcium entry deficits and elevated luminal calcium content in mutant presenilin-1 knockin mice

21 January 2018

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Calcium-destabilizing and neurodegenerative effects of aggregated beta-amyloid peptide are attenuated by basic FGF.

21 January 2018

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Transgenic mice with Alzheimer presenilin 1 mutations show accelerated neurodegeneration without amyloid plaque formation.

21 January 2018

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A physiologic signaling role for the gamma -secretase-derived intracellular fragment of APP.

21 January 2018

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Comparison of the effects of elevated intracellular aluminum and calcium levels on neuronal survival and tau immunoreactivity

21 January 2018

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Mice deficient for the amyloid precursor protein gene

21 January 2018

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Generation of APLP2 KO mice and early postnatal lethality in APLP2/APP double KO mice

21 January 2018

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Axonal transport of amyloid precursor protein is mediated by direct binding to the kinesin light chain subunit of kinesin-I

21 January 2018

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Kinesin-mediated axonal transport of a membrane compartment containing beta-secretase and presenilin-1 requires APP

21 January 2018

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Alzheimer amyloid protein precursor complexes with brain GTP-binding protein G(o)

21 January 2018

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Amyloid precursor protein family-induced neuronal death is mediated by impairment of the neuroprotective calcium/calmodulin protein kinase IV-dependent signaling pathway.

21 January 2018

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A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60

21 January 2018

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Secreted forms of beta-amyloid precursor protein protect hippocampal neurons against amyloid beta-peptide-induced oxidative injury

21 January 2018

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Evidence for excitoprotective and intraneuronal calcium-regulating roles for secreted forms of the beta-amyloid precursor protein

21 January 2018

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Secreted forms of beta-amyloid precursor protein modulate dendrite outgrowth and calcium responses to glutamate in cultured embryonic hippocampal neurons

21 January 2018

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The effect of a secreted form of beta-amyloid-precursor protein on intracellular Ca2+ increase in rat cultured hippocampal neurones

21 January 2018

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Memory-enhancing effects of secreted forms of the beta-amyloid precursor protein in normal and amnestic mice.

21 January 2018

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Effects of elevated intracellular calcium levels on the cytoskeleton and tau in cultured human cortical neurons

21 January 2018

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Free radicals and disruption of neuronal ion homeostasis in AD: a role for amyloid beta-peptide?

21 January 2018

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Abnormalities in Alzheimer's disease fibroblasts bearing the APP670/671 mutation.

21 January 2018

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The channel hypothesis of Alzheimer's disease: current status

21 January 2018

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Alzheimer disease amyloid beta protein forms calcium channels in bilayer membranes: blockade by tromethamine and aluminum

21 January 2018

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Giant multilevel cation channels formed by Alzheimer disease amyloid beta-protein [A beta P-(1-40)] in bilayer membranes

21 January 2018

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beta-Amyloid Ca(2+)-channel hypothesis for neuronal death in Alzheimer disease

21 January 2018

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Molecular mechanism of neurodegeneration induced by Alzheimer's beta-amyloid protein: channel formation and disruption of calcium homeostasis

21 January 2018

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Channel formation by a neurotoxic prion protein fragment

21 January 2018

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Alzheimer's beta-amyloid, human islet amylin, and prion protein fragment evoke intracellular free calcium elevations by a common mechanism in a hypothalamic GnRH neuronal cell line

21 January 2018

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A model for beta-amyloid aggregation and neurotoxicity based on free radical generation by the peptide: relevance to Alzheimer disease

21 January 2018

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Calcium ionophore increases amyloid beta peptide production by cultured cells

21 January 2018

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Calcium regulates processing of the Alzheimer amyloid protein precursor in a protein kinase C-independent manner

21 January 2018

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Alzheimer's Aβ(1–42) is generated in the endoplasmic reticulum/intermediate compartment of NT2N cells

21 January 2018

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Presenilin, Notch, and the genesis and treatment of Alzheimer's disease

21 January 2018

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Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

21 January 2018

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A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

21 January 2018

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gamma -Secretase cleavage and nuclear localization of ErbB-4 receptor tyrosine kinase

21 January 2018

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Presenilin-dependent gamma-secretase-like intramembrane cleavage of ErbB4.

21 January 2018

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A presenilin-1/gamma-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions

21 January 2018

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Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

21 January 2018

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Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1

21 January 2018

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Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

21 January 2018

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Biochemistry. Intramembrane proteases--mixing oil and water

21 January 2018

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Presenilin and gamma-secretase: structure meets function

21 January 2018

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Identification of signal peptide peptidase, a presenilin-type aspartic protease

21 January 2018

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Cholesterol-dependent gamma-secretase activity in buoyant cholesterol-rich membrane microdomains

21 January 2018

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Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing

21 January 2018

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aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation

21 January 2018

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Aph-2/Nicastrin: an essential component of gamma-secretase and regulator of Notch signaling and Presenilin localization

21 January 2018

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Presenilins are not required for A beta 42 production in the early secretory pathway

21 January 2018

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Deficiency of presenilin-1 increases calcium-dependent vulnerability of neurons to oxidative stress in vitro

21 January 2018

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Internal Ca2+ mobilization is altered in fibroblasts from patients with Alzheimer disease

21 January 2018

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Alzheimer's presenilin-1 mutation potentiates inositol 1,4,5-trisphosphate-mediated calcium signaling in Xenopus oocytes

21 January 2018

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Different calcium sources are narrowly tuned to the induction of different forms of LTP.

21 January 2018

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Synaptic transmission and hippocampal long-term potentiation in transgenic mice expressing FAD-linked presenilin 1.

21 January 2018

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Enhanced synaptic potentiation in transgenic mice expressing presenilin 1 familial Alzheimer's disease mutation is normalized with a benzodiazepine

21 January 2018

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Functional phenotype in transgenic mice expressing mutant human presenilin-1.

21 January 2018

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The presenilin 1 deltaE9 mutation gives enhanced basal phospholipase C activity and a resultant increase in intracellular calcium concentrations

21 January 2018

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Calbindin D28k blocks the proapoptotic actions of mutant presenilin 1: reduced oxidative stress and preserved mitochondrial function

21 January 2018

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Calsenilin: a calcium-binding protein that interacts with the presenilins and regulates the levels of a presenilin fragment

21 January 2018

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Calsenilin reverses presenilin-mediated enhancement of calcium signaling

21 January 2018

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Binding partners of Alzheimer's disease proteins: are they physiologically relevant?

21 January 2018

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A myristoylated calcium-binding protein that preferentially interacts with the Alzheimer's disease presenilin 2 protein

21 January 2018

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Presenilin 2 interacts with sorcin, a modulator of the ryanodine receptor

21 January 2018

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Presenilin-2 mutations modulate amplitude and kinetics of inositol 1, 4,5-trisphosphate-mediated calcium signals

21 January 2018

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Characterization of a presenilin-mediated amyloid precursor protein carboxyl-terminal fragment gamma. Evidence for distinct mechanisms involved in gamma -secretase processing of the APP and Notch1 transmembrane domains

21 January 2018

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Presenilin-1 mutations of leucine 166 equally affect the generation of the Notch and APP intracellular domains independent of their effect on Abeta 42 production

21 January 2018

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A novel epsilon-cleavage within the transmembrane domain of the Alzheimer amyloid precursor protein demonstrates homology with Notch processing

21 January 2018

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Insulin-degrading enzyme rapidly removes the beta-amyloid precursor protein intracellular domain (AICD)

21 January 2018

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The intracellular domain of the beta-amyloid precursor protein is stabilized by Fe65 and translocates to the nucleus in a notch-like manner

21 January 2018

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The regions of the Fe65 protein homologous to the phosphotyrosine interaction/phosphotyrosine binding domain of Shc bind the intracellular domain of the Alzheimer's amyloid precursor protein

21 January 2018

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The beta-amyloid precursor protein functions as a cytosolic anchoring site that prevents Fe65 nuclear translocation

21 January 2018

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Differential intrinsic enzymatic activity of Syk and Zap-70 protein-tyrosine kinases

21 January 2018

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The phosphotyrosine interaction domains of X11 and FE65 bind to distinct sites on the YENPTY motif of amyloid precursor protein

21 January 2018

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X11L2, a new member of the X11 protein family, interacts with Alzheimer's beta-amyloid precursor protein

21 January 2018

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Interaction of a neuron-specific protein containing PDZ domains with Alzheimer's amyloid precursor protein

21 January 2018

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Tyrosine phosphorylation of the beta-amyloid precursor protein cytoplasmic tail promotes interaction with Shc

21 January 2018

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Signal transduction through tyrosine-phosphorylated C-terminal fragments of amyloid precursor protein via an enhanced interaction with Shc/Grb2 adaptor proteins in reactive astrocytes of Alzheimer's disease brain.

21 January 2018

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The gamma -secretase-cleaved C-terminal fragment of amyloid precursor protein mediates signaling to the nucleus

21 January 2018

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PAT1, a microtubule-interacting protein, recognizes the basolateral sorting signal of amyloid precursor protein

21 January 2018

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The gamma-secretase-generated intracellular domain of beta-amyloid precursor protein binds Numb and inhibits Notch signaling

21 January 2018

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The gamma secretase-generated carboxyl-terminal domain of the amyloid precursor protein induces apoptosis via Tip60 in H4 cells

21 January 2018

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The "nonamyloidogenic" p3 fragment (amyloid beta17-42) is a major constituent of Down's syndrome cerebellar preamyloid

21 January 2018

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N-terminal heterogeneity of parenchymal and cerebrovascular Abeta deposits

21 January 2018

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Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

21 January 2018

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Identification of a family of calcium sensors as protein ligands of inositol trisphosphate receptor Ca(2+) release channels

21 January 2018

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The versatility and universality of calcium signalling

21 January 2018

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Elementary events of InsP3-induced Ca2+ liberation in Xenopus oocytes: hot spots, puffs and blips

21 January 2018

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Quantal puffs of intracellular Ca2+ evoked by inositol trisphosphate in Xenopus oocytes

21 January 2018

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A continuum of InsP3-mediated elementary Ca2+ signalling events in Xenopus oocytes

21 January 2018

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Subcellular mechanisms of presenilin-mediated enhancement of calcium signaling

21 January 2018

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Altered calcium homeostasis and mitochondrial dysfunction in cortical synaptic compartments of presenilin-1 mutant mice

21 January 2018

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Increased vulnerability of hippocampal neurons from presenilin-1 mutant knock-in mice to amyloid beta-peptide toxicity: central roles of superoxide production and caspase activation

21 January 2018

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Calcium stores in cultured fibroblasts and their changes with Alzheimer's disease.

21 January 2018

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Diminished mitogen-induced calcium uptake by lymphocytes from Alzheimer patients.

21 January 2018

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Calcium responses in human fibroblasts: a diagnostic molecular profile for Alzheimer's disease.

21 January 2018

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Cytosolic free calcium and cell spreading decrease in fibroblasts from aged and Alzheimer donors

21 January 2018

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Alterations in calcium content and biochemical processes in cultured skin fibroblasts from aged and Alzheimer donors

21 January 2018

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Altered response of fibroblasts from aged and Alzheimer donors to drugs that elevate cytosolic free calcium.

21 January 2018

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Changes in calcium homeostasis during aging and Alzheimer's disease

21 January 2018

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Presenilin-1 mutation alters NGF-induced neurite outgrowth, calcium homeostasis, and transcription factor (AP-1) activation in PC12 cells

21 January 2018

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Caspase cleavage of exon 9 deleted presenilin-1 is an early event in apoptosis induced by calcium ionophore A 23187 in SH-SY5Y neuroblastoma cells

21 January 2018

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Mutant presenilins disturb neuronal calcium homeostasis in the brain of transgenic mice, decreasing the threshold for excitotoxicity and facilitating long-term potentiation

21 January 2018

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beta-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity

21 January 2018

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Presenilin-mediated modulation of capacitative calcium entry

31 March 2020

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Antigenic changes similar to those seen in neurofibrillary tangles are elicited by glutamate and Ca2+ influx in cultured hippocampal neurons

31 March 2020

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Mice with combined gene knock-outs reveal essential and partially redundant functions of amyloid precursor protein family members.

31 March 2020

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Intrinsic signaling function of APP as a novel target of three V642 mutations linked to familial Alzheimer's disease.

31 March 2020

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Amyloid (beta)42 activates a G-protein-coupled chemoattractant receptor, FPR-like-1

31 March 2020

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Role of cyclic GMP in the regulation of neuronal calcium and survival by secreted forms of beta-amyloid precursor

31 March 2020

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Suppression of an amyloid beta peptide-mediated calcium channel response by a secreted beta-amyloid precursor protein

31 March 2020

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Secreted beta-amyloid precursor protein counteracts the proapoptotic action of mutant presenilin-1 by activation of NF-kappaB and stabilization of calcium homeostasis

31 March 2020

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The ability of amyloid beta-protein [A beta P (1-40)] to form Ca2+ channels provides a mechanism for neuronal death in Alzheimer's disease.

31 March 2020

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Pore formation by the cytotoxic islet amyloid peptide amylin

31 March 2020

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Amyloid beta-peptide impairs ion-motive ATPase activities: evidence for a role in loss of neuronal Ca2+ homeostasis and cell death

31 March 2020

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Estrogens attenuate and corticosterone exacerbates excitotoxicity, oxidative injury, and amyloid beta-peptide toxicity in hippocampal neurons

31 March 2020

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17Beta-estradiol attenuates oxidative impairment of synaptic Na+/K+-ATPase activity, glucose transport, and glutamate transport induced by amyloid beta-peptide and iron

31 March 2020

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Caffeine Stimulates Amyloid β‐Peptide Release from β‐Amyloid Precursor Protein‐Transfected HEK293 Cells

31 March 2020

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Ca(2+) stores and capacitative Ca(2+) entry in human neuroblastoma (SH-SY5Y) cells expressing a familial Alzheimer's disease presenilin-1 mutation

31 March 2020

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Presenilin-1 mutations increase levels of ryanodine receptors and calcium release in PC12 cells and cortical neurons

31 March 2020

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Generation of an apoptotic intracellular peptide by gamma-secretase cleavage of Alzheimer's amyloid beta protein precursor.

31 March 2020

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Distinct intramembrane cleavage of the beta-amyloid precursor protein family resembling gamma-secretase-like cleavage of Notch

31 March 2020

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APP-BP1, a novel protein that binds to the carboxyl-terminal region of the amyloid precursor protein

31 March 2020

1 reference

c-Jun N-terminal kinase (JNK)-interacting protein-1b/islet-brain-1 scaffolds Alzheimer's amyloid precursor protein with JNK

31 March 2020

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Processing of beta-amyloid precursor-like protein-1 and -2 by gamma-secretase regulates transcription

31 March 2020

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31 March 2020

Quantitating the occult

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Alzheimer's presenilin mutation sensitizes neural cells to apoptosis induced by trophic factor withdrawal and amyloid beta-peptide: involvement of calcium and oxyradicals.

31 March 2020

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Increased sensitivity to mitochondrial toxin-induced apoptosis in neural cells expressing mutant presenilin-1 is linked to perturbed calcium homeostasis and enhanced oxyradical production.

31 March 2020

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Calcium-activated neutral proteinase (calpain) system in aging and Alzheimer's disease

31 March 2020

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inferred from DOI database lookup

7 January 2021

based on heuristic

Calcium, free radicals, and excitotoxic neuronal death in primary cell culture

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NRN960

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Dimensions Publication ID

5 August 2017

1029013756

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