(Q28141707)

GOA release 2020-03-11

Presenilin 1

1 reference

GOA release 2020-03-11

R Kopan

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A Goate

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B De Strooper

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W Annaert

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P Cupers

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P Saftig

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K Craessaerts

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J S Mumm

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E H Schroeter

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V Schrijvers

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M S Wolfe

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W J Ray

Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene

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language of work or name

English

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publication date

8 April 1999

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published in

Nature

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volume

398

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issue

6727

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page(s)

518-22

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cites work

1 reference

7 January 2021

Presenilin 1 is required for Notch1 and DII1 expression in the paraxial mesoderm

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7 January 2021

Skeletal and CNS defects in Presenilin-1-deficient mice

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7 January 2021

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

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7 January 2021

The Notch1 receptor is cleaved constitutively by a furin-like convertase

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7 January 2021

Intracellular Cleavage of Notch Leads to a Heterodimeric Receptor on the Plasma Membrane

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7 January 2021

Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain

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7 January 2021

Nuclear access and action of notch in vivo

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7 January 2021

Indirect evidence for Delta-dependent intracellular processing of notch in Drosophila embryos

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7 January 2021

Exploring the etiology of Alzheimer disease using molecular genetics

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7 January 2021

Signal transduction by activated mNotch: importance of proteolytic processing and its regulation by the extracellular domain.

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7 January 2021

Beta-amyloid precursor protein. Location of transmembrane domain and specificity of gamma-secretase cleavage

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7 January 2021

The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor

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7 January 2021

Amyloid precursor protein processing in sterol regulatory element-binding protein site 2 protease-deficient Chinese hamster ovary cells.

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7 January 2021

A substrate-based difluoro ketone selectively inhibits Alzheimer's gamma-secretase activity.

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7 January 2021

Evidence that the 42- and 40-amino acid forms of amyloid beta protein are generated from the beta-amyloid precursor protein by different protease activities

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7 January 2021

The carboxyl termini of beta-amyloid peptides 1-40 and 1-42 are generated by distinct gamma-secretase activities

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7 January 2021

Specific increase in amyloid beta-protein 42 secretion ratio by calpain inhibition

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7 January 2021

Evidence for a physical interaction between presenilin and Notch

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7 January 2021

Formation of stable complexes between two Alzheimer's disease gene products: presenilin-2 and beta-amyloid precursor protein

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7 January 2021

Interaction between amyloid precursor protein and presenilins in mammalian cells: Implications for the pathogenesis of Alzheimer disease

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7 January 2021

Downregulation of PS1 expression in neurons decreases beta-amyloid production: a biochemical link between the two major familial Alzheimer's disease genes

1 reference

7 January 2021

Complementation cloning of S2P, a gene encoding a putative metalloprotease required for intramembrane cleavage of SREBPs

1 reference

7 January 2021

The alpha beta versus gamma delta T-cell lineage choice

1 reference

7 January 2021

Roles for proteolysis and trafficking in notch maturation and signal transduction

1 reference

7 January 2021