(Q34743204)

4 August 2017

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title

Nucleic-acid therapeutics: basic principles and recent applications (English)

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4 August 2017

Joanna B Opalinska

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4 August 2017

Alan M Gewirtz

series ordinal

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4 August 2017

publication date

1 July 2002

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Nature Reviews Drug Discovery

4 August 2017

published in

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4 August 2017

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4 August 2017

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4 August 2017

page(s)

503-514

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Cancer gene therapy: hard lessons and new courses

4 August 2017

cites work

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Ex-vivo gene therapy of human vascular bypass grafts with E2F decoy: the PREVENT single-centre, randomised, controlled trial

31 March 2020

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Long-term stabilization of vein graft wall architecture and prolonged resistance to experimental atherosclerosis after E2F decoy oligonucleotide gene therapy

31 March 2020

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A placebo-controlled trial of ICAM-1 antisense oligonucleotide in the treatment of Crohn's disease

31 March 2020

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Ribozymes in gene therapy of HIV-1.

31 March 2020

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Ribozyme gene therapy for hepatitis C virus infection

31 March 2020

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Antisense oligonucleotides containing modified bases inhibit in vitro translation of Leishmania amazonensis mRNAs by invading the mini-exon hairpin

31 March 2020

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Effect of ICAM-1/LFA-1 blockade on pancreatic islet allograft survival, function, and early cytokine production

31 March 2020

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Oligonucleotide therapeutics: a step forward

31 March 2020

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Structural gene identification and mapping by DNA-mRNA hybrid-arrested cell-free translation

31 March 2020

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Inhibition of Rous sarcoma viral RNA translation by a specific oligodeoxyribonucleotide

31 March 2020

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Translational control of IS10 transposition

31 March 2020

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A unique mechanism regulating gene expression: translational inhibition by a complementary RNA transcript (micRNA)

31 March 2020

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Gene targeting in the mouse

31 March 2020

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Getting down to the core of homologous recombination

31 March 2020

1 reference

Control of oncogene expression by antisense nucleic acids

31 March 2020

1 reference

Triplex forming oligonucleotides: sequence-specific tools for gene targeting

31 March 2020

1 reference

High-frequency intrachromosomal gene conversion induced by triplex-forming oligonucleotides microinjected into mouse cells

31 March 2020

1 reference

The DNA strand of chimeric RNA/DNA oligonucleotides can direct gene repair/conversion activity in mammalian and plant cell-free extracts

31 March 2020

1 reference

Structural basis for G.C recognition in the DNA minor groove

31 March 2020

1 reference

A structural basis for recognition of A.T and T.A base pairs in the minor groove of B-DNA

31 March 2020

1 reference

Structural effects of DNA sequence on T.A recognition by hydroxypyrrole/pyrrole pairs in the minor groove

31 March 2020

1 reference

Toward rules for 1:1 polyamide:DNA recognition

31 March 2020

1 reference

Erythroid cell-specific mRNA stability elements in the alpha 2-globin 3' nontranslated region

31 March 2020

1 reference

Assembly of the alpha-globin mRNA stability complex reflects binary interaction between the pyrimidine-rich 3' untranslated region determinant and poly(C) binding protein alphaCP

31 March 2020

1 reference

Oligonucleotide-mediated modulation of mammalian gene expression.

31 March 2020

1 reference

How to design an antisense oligodeoxynucleotide experiment: a consensus approach

31 March 2020

1 reference

Identification and characterization by antisense oligonucleotides of exon and intron sequences required for splicing

31 March 2020

1 reference

Morpholino antisense oligomers: design, preparation, and properties

31 March 2020

1 reference

A critical survey of the structure-function of the antisense oligo/RNA heteroduplex as substrate for RNase H.

31 March 2020

1 reference

Molecular mechanisms of antisense drugs: RNase H.

31 March 2020

1 reference

Intracellular expression and function of antisense catalytic RNAs

31 March 2020

1 reference

Ribozymes, genomics and therapeutics

31 March 2020

1 reference

A general purpose RNA-cleaving DNA enzyme

31 March 2020

1 reference

Inhibition of bcr-abl oncogene expression by novel deoxyribozymes (DNAzymes).

31 March 2020

1 reference

Progress toward the structure and therapeutic use of the hairpin ribozyme

31 March 2020

1 reference

Role of divalent metal ions in the hammerhead RNA cleavage reaction

31 March 2020

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31 March 2020

The hammerhead ribozyme

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Kinetics and thermodynamics of intermolecular catalysis by hairpin ribozymes

31 March 2020

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A kinetic and thermodynamic framework for the hammerhead ribozyme reaction

31 March 2020

1 reference

Therapeutic efficacy of an adenovirus-mediated anti-H-ras ribozyme in experimental bladder cancer

31 March 2020

1 reference

Intracellular generation of single-stranded DNA for chromosomal triplex formation and induced recombination

31 March 2020

1 reference

Nuclease-resistant synthetic ribozymes: developing a new class of therapeutics

31 March 2020

1 reference

A DNA enzyme that cleaves RNA

31 March 2020

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A new and efficient DNA enzyme for the sequence-specific cleavage of RNA.

31 March 2020

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Nucleic acid enzymes as a novel generation of anti-gene agents

31 March 2020

1 reference

A short primer on RNAi: RNA-directed RNA polymerase acts as a key catalyst

31 March 2020

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Expanding small RNA interference

31 March 2020

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RNA interference is mediated by 21- and 22-nucleotide RNAs

31 March 2020

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Role for a bidentate ribonuclease in the initiation step of RNA interference

31 March 2020

1 reference

Argonaute2, a link between genetic and biochemical analyses of RNAi

31 March 2020

1 reference

Dicer functions in RNA interference and in synthesis of small RNA involved in developmental timing in C. elegans

31 March 2020

1 reference

Specific double-stranded RNA interference in undifferentiated mouse embryonic stem cells

31 March 2020

1 reference

Stable suppression of gene expression by RNAi in mammalian cells

31 March 2020

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Evidence that processed small dsRNAs may mediate sequence-specific mRNA degradation during RNAi in Drosophila embryos.

31 March 2020

1 reference

RNAi: double-stranded RNA directs the ATP-dependent cleavage of mRNA at 21 to 23 nucleotide intervals

31 March 2020

1 reference

Functional anatomy of siRNAs for mediating efficient RNAi in Drosophila melanogaster embryo lysate

31 March 2020

1 reference

Repair of thalassemic human beta-globin mRNA in mammalian cells by antisense oligonucleotides

31 March 2020

1 reference

Restoration of hemoglobin A synthesis in erythroid cells from peripheral blood of thalassemic patients

31 March 2020

1 reference

Modification of alternative splicing of Bcl-x pre-mRNA in prostate and breast cancer cells. analysis of apoptosis and cell death.

31 March 2020

1 reference

Mixed backbone oligonucleotides: improvement in oligonucleotide-induced toxicity in vivo

31 March 2020

1 reference

Molecular mechanisms of action of antisense drugs

31 March 2020

1 reference

Is irrelevant cleavage the price of antisense efficacy?

31 March 2020

1 reference

DNA Analogues with Nonphosphodiester Backbones

31 March 2020

1 reference

A controlled, Phase 1 clinical trial to evaluate the safety and effects in HIV-1 infected humans of autologous lymphocytes transduced with a ribozyme that cleaves HIV-1 RNA.

31 March 2020

1 reference

A phase I trial of autologous CD34+ hematopoietic progenitor cells transduced with an anti-HIV ribozyme

31 March 2020

1 reference

Pharmacokinetics and tolerability of intravenous trecovirsen (GEM 91), an antisense phosphorothioate oligonucleotide, in HIV-positive subjects

31 March 2020

1 reference

Phase I trial of an antisense oligonucleotide OL(1)p53 in hematologic malignancies

31 March 2020

1 reference

Phase I evaluation of ISIS 3521, an antisense oligodeoxynucleotide to protein kinase C-alpha, in patients with advanced cancer

31 March 2020

1 reference

Phase I clinical and pharmacokinetic study of bcl-2 antisense oligonucleotide therapy in patients with non-Hodgkin's lymphoma

31 March 2020

1 reference

Bcl-2 family proteins: regulators of chemoresistance in cancer

31 March 2020

1 reference

BCL-2 antisense therapy in patients with non-Hodgkin lymphoma

31 March 2020

1 reference

Chemosensitisation of malignant melanoma by BCL2 antisense therapy

31 March 2020

1 reference

Preliminary phase I results of G3139 (bcl-2 antisense oligonucleotide) therapy in combination with docetaxel in hormone-refractory prostate cancer

31 March 2020

1 reference

Oligodeoxynucleotide-mediated inhibition of c-myb gene expression in autografted bone marrow: a pilot study

31 March 2020

1 reference

Antisense oligonucleotides as inhibitors of signal transduction: development from research tools to therapeutic agents

31 March 2020

1 reference

A Phase I trial of H-ras antisense oligonucleotide ISIS 2503 administered as a continuous intravenous infusion in patients with advanced carcinoma

31 March 2020

1 reference

Antitumor activity of a phosphorothioate antisense oligodeoxynucleotide targeted against C-raf kinase

31 March 2020

1 reference

Cationic lipid is not required for uptake and selective inhibitory activity of ICAM-1 phosphorothioate antisense oligonucleotides in keratinocytes

31 March 2020

1 reference

Enhanced metastatic ability of TNF-alpha-treated malignant melanoma cells is reduced by intercellular adhesion molecule-1 (ICAM-1, CD54) antisense oligonucleotides

31 March 2020

1 reference

Absence of efficacy of subcutaneous antisense ICAM-1 treatment of chronic active Crohn's disease

31 March 2020

1 reference

Reversal of epidermal hyperproliferation in psoriasis by insulin-like growth factor I receptor antisense oligonucleotides

31 March 2020

1 reference

Safety of intracoronary administration of c-myc antisense oligomers after percutaneous transluminal coronary angioplasty (PTCA)

31 March 2020

1 reference

Local intracoronary administration of antisense oligonucleotide against c-myc for the prevention of in-stent restenosis: results of the randomized investigation by the Thoraxcenter of antisense DNA using local delivery and IVUS after coronary stenti

31 March 2020

1 reference

CpG motifs in bacterial DNA trigger direct B-cell activation

31 March 2020

1 reference

Toll-like receptor expression reveals CpG DNA as a unique microbial stimulus for plasmacytoid dendritic cells which synergizes with CD40 ligand to induce high amounts of IL-12

31 March 2020

1 reference

CpG DNA can induce strong Th1 humoral and cell-mediated immune responses against hepatitis B surface antigen in young mice

31 March 2020

1 reference

The role of CpG dinucleotides in DNA vaccines

31 March 2020

1 reference

Bactericidal antisense effects of peptide-PNA conjugates.

31 March 2020

1 reference

Alternative splicing and neuritic mRNA translocation under long-term neuronal hypersensitivity

31 March 2020

1 reference

Results of a pilot study involving the use of an antisense oligodeoxynucleotide directed against the insulin-like growth factor type I receptor in malignant astrocytomas

31 March 2020

1 reference

Facilitating oligonucleotide delivery: helping antisense deliver on its promise

31 March 2020

1 reference

Antisense oligonucleotides: promise and reality.

31 March 2020

1 reference

RNA structure. Describing the elephant

31 March 2020

1 reference

Sequence-specific antitumor activity of a phosphorothioate oligodeoxyribonucleotide targeted to human C-raf kinase supports an antisense mechanism of action in vivo

31 March 2020

1 reference

Selecting effective antisense reagents on combinatorial oligonucleotide arrays

31 March 2020

1 reference

Selecting optimal antisense reagents

31 March 2020

1 reference

Mapping of RNA accessible sites for antisense experiments with oligonucleotide libraries

31 March 2020

1 reference

RNA accessibility prediction: a theoretical approach is consistent with experimental studies in cell extracts

31 March 2020

1 reference

Real time detection of DNA.RNA hybridization in living cells

31 March 2020

1 reference

Mechanism of oligonucleotide uptake by cells: involvement of specific receptors?

31 March 2020

1 reference

Binding, uptake, and intracellular trafficking of phosphorothioate-modified oligodeoxynucleotides.

31 March 2020

1 reference

Uptake of oligonucleotides by keratinocytes

31 March 2020

1 reference

Antisense pharmacodynamics: critical issues in the transport and delivery of antisense oligonucleotides

31 March 2020

1 reference

Novel cationic amphiphiles as delivery agents for antisense oligonucleotides

31 March 2020

1 reference

Alteration of proteolytic processing of c-Myb as a consequence of its truncation in murine myeloid leukemia

31 March 2020

1 reference

Investigations of antisense oligonucleotides targeted against bcl-2 RNAs.

31 March 2020

1 reference

Molecular and cellular characterization of baboon C-Raf as a target for antiproliferative effects of antisense oligonucleotides.

31 March 2020

1 reference

Dislodgment and accelerated degradation of Ras.

31 March 2020

1 reference

31 March 2020

Does antisense exist?

1 reference

Fomivirsen - a phosphorothioate oligonucleotide for the treatment of CMV retinitis

31 March 2020

1 reference

Human cytomegalovirus mutant with sequence-dependent resistance to the phosphorothioate oligonucleotide fomivirsen (ISIS 2922)

31 March 2020

1 reference

Phase II trial with ISIS 5132 in patients with small-cell (SCLC) and non-small cell (NSCLC) lung cancer. A European Organization for Research and Treatment of Cancer (EORTC) Early Clinical Studies Group report

31 March 2020

1 reference

Degradation of mRNA in eukaryotes

31 March 2020

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NRD837

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4 August 2017

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