(Q34340571)

1 August 2017

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title

Altered T cell signalling in ageing (English)

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1 August 2017

Pawelec G

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1 August 2017

Hirokawa K

series ordinal

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1 August 2017

Fülöp T

series ordinal

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1 August 2017

publication date

1 September 2001

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Mechanisms of Ageing and Development

1 August 2017

published in

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1 August 2017

volume

122

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1 August 2017

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1 August 2017

page(s)

1613-1637

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Long-term culture of monoclonal human T lymphocytes: models for immunosenescence?

1 August 2017

cites work

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Protein kinase Ctheta: a new essential superstar on the T-cell stage

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7 January 2021

Differential expression of CD28 and CD94/NKG2 on T cells with identical TCR beta variable regions in primary melanoma and sentinel lymph node

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7 January 2021

Induction, binding specificity and function of human ICOS

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7 January 2021

Effect of age on cytokine production in humans

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7 January 2021

Cytokine production by subsets of CD4 memory T cells differing in P-glycoprotein expression: effects of aging.

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7 January 2021

CD28 expression in T cell aging and human longevity

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7 January 2021

The T cell activation molecule H4 and the CD28-like molecule ICOS are identical

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7 January 2021

Co-stimulation in T cell responses.

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7 January 2021

Interleukin 2, interleukin 2 receptor, and interferon-gamma synthesis and mRNA expression in phorbol myristate acetate and calcium ionophore A23187-stimulated T cells from elderly humans

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7 January 2021

Proteasome inactivation upon aging and on oxidation-effect of HSP 90

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7 January 2021

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7 January 2021

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7 January 2021

Age-dependent variations in the expression of PLC isoforms upon mitogenic stimulation of peripheral blood T cells from healthy donors

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7 January 2021

Mel14+ CD4+ T cells from aged mice display functional and phenotypic characteristics of memory cells.

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7 January 2021

Changes in thymic function with age and during the treatment of HIV infection

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7 January 2021

The immunological synapse and the actin cytoskeleton: molecular hardware for T cell signaling.

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7 January 2021

Decline in CD28+ T cells in centenarians and in long-term T cell cultures: a possible cause for both in vivo and in vitro immunosenescence

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7 January 2021

Altered composition of the immunological synapse in an anergic, age-dependent memory T cell subset

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7 January 2021

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7 January 2021

Enhancement of common mucosal immunity in aged mice following their supplementation with various antioxidants

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7 January 2021

Diminished heat-shock protein synthesis following mitogen stimulation of lymphocytes from aged donors

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7 January 2021

Expansion of cytotoxic CD8+ CD28- T cells in healthy ageing people, including centenarians.

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7 January 2021

Early lymphocyte activation in elderly humans: impaired T and T-dependent B cell responses

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7 January 2021

Generation of CD28- cells from long-term-stimulated CD8+CD28+ T cells: a possible mechanism accounting for the increased number of CD8+CD28- T cells in HIV-1-infected patients

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900290-1

7 January 2021

Function and dysfunction of CD4(+) T cells in the immune response to melanoma

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900290-1

7 January 2021

Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900290-1

7 January 2021

Phytohemagglutinin induced proliferation by aged lymphocytes: reduced expression of high affinity interleukin-2 receptors and interleukin-2 secretion

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900290-1

7 January 2021

Age-dependent changes in transmembrane signalling: identification of G proteins in human lymphocytes and polymorphonuclear leukocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900290-1

7 January 2021

Cellular distribution of protein kinase C isozymes in CD3-mediated stimulation of human T lymphocytes with aging

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7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900290-1

7 January 2021

Cyclodextrin modulation of T lymphocyte signal transduction with aging

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900290-1

7 January 2021

Intercellular adhesion molecule 1 is critical for activation of CD28-deficient T cells

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900290-1

7 January 2021

Differential tyrosine phosphorylation of zeta chain dimers in mouse CD4 T lymphocytes: effect of age

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900290-1

7 January 2021

Increased Zap-70 association with CD3zeta in CD4 T cells from old mice

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900290-1

7 January 2021

Single-cell analyses reveal two defects in peptide-specific activation of naive T cells from aged mice

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900290-1

7 January 2021

CD28 and LFA-1 contribute to cyclosporin A-resistant T cell growth by stabilizing the IL-2 mRNA through distinct signaling pathways

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900290-1

7 January 2021

Recent advances in the understanding of interleukin-2 signal transduction

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900290-1

7 January 2021

Immunophenotypical changes of T lymphocytes in the elderly.

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900290-1

7 January 2021

Identification of a human OX-40 ligand, a costimulator of CD4+ T cells with homology to tumor necrosis factor

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900290-1

7 January 2021

Diminished activation of the MAP kinase pathway in CD3-stimulated T lymphocytes from old mice.

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900290-1

7 January 2021

The OX40 costimulatory receptor determines the development of CD4 memory by regulating primary clonal expansion

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900290-1

7 January 2021

The effect of immunosuppressive agents on the induction of nuclear factors that bind to sites on the interleukin 2 promoter

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900290-1

7 January 2021

Changes in the amount and level of phosphorylation of p56(lck) in PBL from aging humans.

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900290-1

7 January 2021

1 reference

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7 January 2021

Interleukin 2, but not other common gamma chain-binding cytokines, can reverse the defect in generation of CD4 effector T cells from naive T cells of aged mice

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900290-1

7 January 2021

ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900290-1

7 January 2021

Diminished Cell-Cell Binding by Lymphocytes from Healthy, Elderly Humans: Evidence for Altered Activation of LFA-1 Function With Age

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900290-1

7 January 2021

Possible involvement of proteasome inhibition in aging: implications for oxidative stress.

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900290-1

7 January 2021

TCR-mediated up-regulation of c-FLIPshort correlates with resistance toward CD95-mediated apoptosis by blocking death-inducing signaling complex activity

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900290-1

7 January 2021

Up-regulation of c-FLIPshort and reduction of activation-induced cell death in CD28-costimulated human T cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900290-1

7 January 2021

Analysis of Raf-1 activation in response to TCR activation and costimulation in murine T-lymphocytes: effect of age.

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900290-1

7 January 2021

Age-sensitive and -insensitive pathways leading to JNK activation in mouse CD4(+) T-cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900290-1

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900290-1

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900290-1

7 January 2021

TCR v(beta) usage and clonality of T cells isolated from progressing and rejected tumor sites before and after in vitro culture

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900290-1

7 January 2021

Peripheral human CD8(+)CD28(+)T lymphocytes give rise to CD28(-)progeny, but IL-4 prevents loss of CD28 expression.

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900290-1

7 January 2021

Exclusion of CD45 from the T-cell receptor signaling area in antigen-stimulated T lymphocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900290-1

7 January 2021

Impaired signal transduction in mitogen activated rat splenic lymphocytes during aging

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900290-1

7 January 2021

Antigen-independent changes in naive CD4 T cells with aging

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900290-1

7 January 2021

Interleukin-12 release by mitogen-stimulated mononuclear cells in the elderly.

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900290-1

7 January 2021

Reductions in the activation of ERK and JNK are associated with decreased IL-2 production in T cells from elderly humans stimulated by the TCR/CD3 complex and costimulatory signals

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900290-1

7 January 2021

T-cell receptor alpha locus V(D)J recombination by-products are abundant in thymocytes and mature T cells

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900290-1

7 January 2021

Recently activated T cells are costimulation-dependent in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900290-1

7 January 2021

Negative-feedback regulation of CD28 costimulation by a novel mitogen-activated protein kinase phosphatase, MKP6.

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900290-1

7 January 2021

The actions of cyclosporin A and FK506 suggest a novel step in the activation of T lymphocytes.

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900290-1

7 January 2021

Identification of a human recent thymic emigrant phenotype

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900290-1

7 January 2021

Diminished calcium influx in lectin-stimulated T cells from old mice

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900290-1

7 January 2021

Functional activation of Jak1 and Jak3 by selective association with IL-2 receptor subunits

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900290-1

7 January 2021

Age-dependent remodeling of peripheral blood CD4+ CD8+ T lymphocytes in cynomolgus monkeys

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900290-1

7 January 2021

Killer Cell Activating Receptors Function as Costimulatory Molecules on CD4+CD28null T Cells Clonally Expanded in Rheumatoid Arthritis

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900290-1

7 January 2021

NF-AT components define a family of transcription factors targeted in T-cell activation

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900290-1

7 January 2021

Expression of the human T cell antigen receptor complex in advanced age

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900290-1

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900290-1

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900290-1

7 January 2021

Activation of p21ras/MAPK signal transduction molecules decreases with age in mitogen-stimulated T cells from rats

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900290-1

7 January 2021

Interleukin 10 protects activated human T lymphocytes against growth factor withdrawal-induced cell death but only anti-fas antibody can prevent activation-induced cell death

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900290-1

7 January 2021

Human T-cell clones in long-term culture as a model of immunosenescence

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900290-1

7 January 2021

Extrathymic T cell differentiation in vitro from human CD34+ stem cells

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900290-1

7 January 2021

Longevity in vitro of human CD4+ T helper cell clones derived from young donors and elderly donors, or from progenitor cells: age-associated differences in cell surface molecule expression and cytokine secretion.

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900290-1

7 January 2021

Decreased proteasome-mediated degradation in T cells from the elderly: A role in immune senescence

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900290-1

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900290-1

7 January 2021

Peroxisome Proliferator-activated Receptor α Activation Modulates Cellular Redox Status, Represses Nuclear Factor-κB Signaling, and Reduces Inflammatory Cytokine Production in Aging

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https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900290-1

7 January 2021

Inhibition of IL-2 production by Nil-2-a in murine T cells

1 reference

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7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900290-1

7 January 2021

Mutation of Jak3 in a patient with SCID: essential role of Jak3 in lymphoid development.

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900290-1

7 January 2021

Two subsets of memory T lymphocytes with distinct homing potentials and effector functions

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900290-1

7 January 2021

The Hsp90-specific inhibitor geldanamycin selectively disrupts kinase-mediated signaling events of T-lymphocyte activation

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900290-1

7 January 2021

Enhanced surface TCR replenishment mediated by CD28 leads to greater TCR engagement during primary stimulation

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900290-1

7 January 2021

The interleukin 2 receptor alpha chain/CD25 promoter is a target for nuclear factor of activated T cells

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900290-1

7 January 2021

Loss of transcription factor AP-1 DNA binding activity during lymphocyte aging in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900290-1

7 January 2021

Protein oxidation and degradation during cellular senescence of human BJ fibroblasts: part I--effects of proliferative senescence

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900290-1

7 January 2021

Expression of c-fos, c-jun and jun B in peripheral blood lymphocytes from young and elderly adults

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900290-1

7 January 2021

Src-like adaptor protein (SLAP) is a negative regulator of T cell receptor signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900290-1

7 January 2021

Constitutive activation of NF-kappa B in an animal model of aging

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900290-1

7 January 2021

Evaluation of thymopoiesis using T cell receptor excision circles (TRECs): differential correlation between adult and pediatric TRECs and naïve phenotypes

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900290-1

7 January 2021

Morphologically and functionally intact dendritic cells can be derived from the peripheral blood of aged individuals

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900290-1

7 January 2021

In situ T cells in melanoma

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900290-1

7 January 2021

ICOS is essential for effective T-helper-cell responses

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900290-1

7 January 2021

Age-dependent alterations in the assembly of signal transduction complexes at the site of T cell/APC interaction

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900290-1

7 January 2021

Molecular mechanism of the impairment in activation signal transduction in CD4(+) T cells from old mice

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900290-1

7 January 2021

Decreased association of p56lck with CD4 may account for lowered tyrosine kinase activity in mitogen-activated human T lymphocytes during aging

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900290-1

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900290-1

7 January 2021

Evidence for lowered induction of nuclear factor kappa B in activated human T lymphocytes during aging

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900290-1

7 January 2021

Induction and regulation of NFkappaB during aging: role of protein kinases

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900290-1

7 January 2021

Influence of age on the signal transduction of T cells in mice

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900290-1

7 January 2021

Impairment of signal transduction in T cells from old mice

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900290-1

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900290-1

7 January 2021

Blocking CD40 - CD154 and CD80/CD86 - CD28 interactions during primary allogeneic stimulation results in T cell anergy and high IL-10 production

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900290-1

7 January 2021

Phospholipase D in cellular senescence

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900290-1

7 January 2021

Altered expression of various receptors on T cells in young and old mice after mitogenic stimulation: a flow cytometric analysis

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900290-1

7 January 2021

Down-regulation of CD28 via Fas (CD95): influence of CD28 on T-cell apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900290-1

7 January 2021

Functional properties of CD4+ CD28- T cells in the aging immune system

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900290-1

7 January 2021

Reduced activation of transcriptional factor AP-1 among peripheral blood T cells from elderly humans after PHA stimulation: restorative effect of phorbol diesters

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900290-1

7 January 2021

Differential expression of the alpha- and beta-isoforms of protein kinase C in peripheral blood T and B cells from young and elderly adults

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900290-1

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900290-1

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900290-1

7 January 2021

Expression and catalytic activities of protein tyrosine kinases (PTKs) Fyn and Lck in peripheral blood T cells from elderly humans stimulated through the T cell receptor (TCR)/CD3 complex

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900290-1

7 January 2021

Phosphorylation and coupling of zeta-chains to activated T-cell receptor (TCR)/CD3 complexes from peripheral blood T-cells of elderly humans

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900290-1

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900290-1

7 January 2021

Calcium signal abnormalities in murine T lymphocytes that express the multidrug transporter P-glycoprotein

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900290-1

7 January 2021

Reciprocal expression of P-glycoprotein and TAP1 accompanied by higher expression of MHC class I antigens in T cells of old mice.

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900290-1

7 January 2021

Cluster formation by protein kinase Ctheta during murine T cell activation: effect of age.

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900290-1

7 January 2021

Preliminary studies on the effect of dehydroepiandrosterone (DHEA) on both constitutive and phytohaemagglutinin (PHA)-inducible IL-6 and IL-2 mRNA expression and cytokine production in human spleen mononuclear cell suspensions in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900290-1

7 January 2021

The proteasome regulates receptor-mediated endocytosis of interleukin-2.

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2801%2900290-1

7 January 2021

10.1016/S0047-6374(01)00290-1

Identifiers

DOI

1 reference

1 August 2017

1 reference