(Q52030809)

English

Age-related impairments in TCR/CD3 activation of ZAP-70 are associated with reduced tyrosine phosphorylations of zeta-chains and p59fyn/p56lck in human T cells.

scientific article published in November 1999

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

20 April 2018

http://europepmc.org/abstract/MED/10576607

Age-related impairments in TCR/CD3 activation of ZAP-70 are associated with reduced tyrosine phosphorylations of zeta-chains and p59fyn/p56lck in human T cells. (English)

1 reference

Europe PubMed Central

PubMed publication ID

20 April 2018

http://europepmc.org/abstract/MED/10576607

author name string

Whisler RL

1

1 reference

Europe PubMed Central

PubMed publication ID

20 April 2018

http://europepmc.org/abstract/MED/10576607

Chen M

2

1 reference

Europe PubMed Central

PubMed publication ID

20 April 2018

http://europepmc.org/abstract/MED/10576607

Liu B

3

1 reference

Europe PubMed Central

PubMed publication ID

20 April 2018

http://europepmc.org/abstract/MED/10576607

Newhouse YG

4

1 reference

Europe PubMed Central

PubMed publication ID

20 April 2018

http://europepmc.org/abstract/MED/10576607

publication date

1 November 1999

1 reference

Europe PubMed Central

PubMed publication ID

20 April 2018

http://europepmc.org/abstract/MED/10576607

Mechanisms of Ageing and Development

1 reference

Europe PubMed Central

PubMed publication ID

20 April 2018

http://europepmc.org/abstract/MED/10576607

111

1 reference

Europe PubMed Central

PubMed publication ID

20 April 2018

http://europepmc.org/abstract/MED/10576607

1

1 reference

Europe PubMed Central

PubMed publication ID

20 April 2018

http://europepmc.org/abstract/MED/10576607

49-66

1 reference

Europe PubMed Central

PubMed publication ID

20 April 2018

http://europepmc.org/abstract/MED/10576607

The CD4 and CD8 antigens are coupled to a protein-tyrosine kinase (p56lck) that phosphorylates the CD3 complex

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Effect of age on mitogen induced protein tyrosine phosphorylation in human T cell and its subsets: down-regulation of tyrosine phosphorylation of ZAP-70

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The role of protein tyrosine kinases and protein tyrosine phosphatases in T cell antigen receptor signal transduction

1 reference

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Regulation of T cell receptor signaling by a src family protein-tyrosine kinase (p59fyn).

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Human severe combined immunodeficiency due to a defect in ZAP-70, a T cell tyrosine kinase

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Interactions of p59fyn and ZAP-70 with T-cell receptor activation motifs: defining the nature of a signalling motif

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Absence of ZAP-70 prevents signaling through the antigen receptor on peripheral blood T cells but not on thymocytes

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7 January 2021

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Immunological studies of aging. Decreased production of and response to T cell growth factor by lymphocytes from aged humans

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Requirement for association of p56lck with CD4 in antigen-specific signal transduction in T cells

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Proximity and orientation underlie signaling by the non-receptor tyrosine kinase ZAP70

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Age-related changes in CD4 T cells of T cell receptor transgenic mice

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Molecular alterations in the aging immune system

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Sequential interactions of the TCR with two distinct cytoplasmic tyrosine kinases

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Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

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Admission criteria for immunogerontological studies in man: the SENIEUR protocol

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Antigen-independent changes in naive CD4 T cells with aging

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Zeta phosphorylation without ZAP-70 activation induced by TCR antagonists or partial agonists

1 reference

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The efficiency of CD4 recruitment to ligand-engaged TCR controls the agonist/partial agonist properties of peptide-MHC molecule ligands

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7 January 2021

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Fyn and ZAP-70 are required for Vav phosphorylation in T cells stimulated by antigen-presenting cells

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2899%2900074-3

7 January 2021

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Immunologic response in an elderly population with a mean age of 85

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7 January 2021

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Decreased proliferation, interleukin 2 synthesis, and interleukin 2 receptor expression are accompanied by decreased mRNA expression in phytohemagglutinin-stimulated cells from elderly donors

1 reference

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7 January 2021

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Essential role for ZAP-70 in both positive and negative selection of thymocytes

1 reference

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7 January 2021

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Hematopoietic cell phosphatase (HCP) regulates p56LCK phosphorylation and ZAP-70 binding to T cell receptor zeta chain

1 reference

https://api.crossref.org/works/10.1016%2FS0047-6374%2899%2900074-3

7 January 2021

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The T-cell antigen CD5 acts as a receptor and substrate for the protein-tyrosine kinase p56lck

1 reference

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7 January 2021

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Partial T cell signaling: altered phospho-zeta and lack of zap70 recruitment in APL-induced T cell anergy

1 reference

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7 January 2021

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Nuclear factor-kappaB induction in CD45RO+ and CD45RA+ T cell subsets during aging.

1 reference

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7 January 2021

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Lck regulates the tyrosine phosphorylation of the T cell receptor subunits and ZAP-70 in murine thymocytes

1 reference

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7 January 2021

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Signal transduction through the CD4 receptor involves the activation of the internal membrane tyrosine-protein kinase p56lck

1 reference

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7 January 2021

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Age-related decreases in IL-2 production by human T cells are associated with impaired activation of nuclear transcriptional factors AP-1 and NF-AT

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Age-related reductions in the activation of mitogen-activated protein kinases p44mapk/ERK1 and p42mapk/ERK2 in human T cells stimulated via ligation of the T cell receptor complex

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Expression and catalytic activities of protein tyrosine kinases (PTKs) Fyn and Lck in peripheral blood T cells from elderly humans stimulated through the T cell receptor (TCR)/CD3 complex

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Impaired induction of c-fos/c-jun genes and of transcriptional regulatory proteins binding distinct c-fos/c-jun promoter elements in activated human T cells during aging

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Phosphorylation and coupling of zeta-chains to activated T-cell receptor (TCR)/CD3 complexes from peripheral blood T-cells of elderly humans

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"Panning" for lymphocytes: a method for cell selection

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The kinase, SH3, and SH2 domains of Lck play critical roles in T-cell activation after ZAP-70 membrane localization

1 reference

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LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation

1 reference

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Enhancement of lymphocyte responsiveness by a gain-of-function mutation of ZAP-70.

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Identifiers

10.1016/S0047-6374(99)00074-3

1 reference

Europe PubMed Central

PubMed publication ID

20 April 2018

http://europepmc.org/abstract/MED/10576607

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

20 April 2018

http://europepmc.org/abstract/MED/10576607

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