(Q34103846)

31 July 2017

1 reference

title

Mitochondrial reactive oxygen species regulate cellular signaling and dictate biological outcomes (English)

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31 July 2017

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reactive oxygen species

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0 references

Robert B Hamanaka

1 reference

31 July 2017

Navdeep S Chandel

series ordinal

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31 July 2017

publication date

27 April 2010

1 reference

Trends in Biochemical Sciences

31 July 2017

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inferred from page(s)

published in

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31 July 2017

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31 July 2017

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31 July 2017

page(s)

505-513

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SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation

31 July 2017

cites work

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5 July 2018

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The sites and topology of mitochondrial superoxide production

5 July 2018

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Elevated mitochondrial reactive oxygen species generation affects the immune response via hypoxia-inducible factor-1alpha in long-lived Mclk1+/- mouse mutants

5 July 2018

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Reactive oxygen species-generating mitochondrial DNA mutation up-regulates hypoxia-inducible factor-1alpha gene transcription via phosphatidylinositol 3-kinase-Akt/protein kinase C/histone deacetylase pathway

5 July 2018

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Reactive oxygen species prime Drosophila haematopoietic progenitors for differentiation

5 July 2018

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The cunning little vixen: Foxo and the cycle of life and death

5 July 2018

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Sirt3 blocks the cardiac hypertrophic response by augmenting Foxo3a-dependent antioxidant defense mechanisms in mice

5 July 2018

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Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?

5 July 2018

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Vitamin E, vitamin C, beta carotene, and cognitive function among women with or at risk of cardiovascular disease: The Women's Antioxidant and Cardiovascular Study

5 July 2018

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Antitumorigenesis of antioxidants in a transgenic Rac1 model of Kaposi's sarcoma

5 July 2018

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Bmi1 regulates mitochondrial function and the DNA damage response pathway

5 July 2018

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Alpha1-AMP-activated protein kinase regulates hypoxia-induced Na,K-ATPase endocytosis via direct phosphorylation of protein kinase C zeta

5 July 2018

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Tumor suppressors and cell metabolism: a recipe for cancer growth

5 July 2018

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Hypoxic activation of AMPK is dependent on mitochondrial ROS but independent of an increase in AMP/ATP ratio

5 July 2018

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Deletion of the mitochondrial superoxide dismutase sod-2 extends lifespan in Caenorhabditis elegans

5 July 2018

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Association of reactive oxygen species levels and radioresistance in cancer stem cells

5 July 2018

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Is Akt the "Warburg kinase"?-Akt-energy metabolism interactions and oncogenesis

5 July 2018

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Vitamins C and E and beta carotene supplementation and cancer risk: a randomized controlled trial

5 July 2018

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The overexpression of major antioxidant enzymes does not extend the lifespan of mice

5 July 2018

1 reference

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Akt determines replicative senescence and oxidative or oncogenic premature senescence and sensitizes cells to oxidative apoptosis

5 July 2018

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How mitochondria produce reactive oxygen species

5 July 2018

1 reference

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Thiol-based redox switches in eukaryotic proteins

5 July 2018

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Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway

5 July 2018

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Regulation of alveolar epithelial function by hypoxia

5 July 2018

1 reference

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Redox-based regulation of signal transduction: principles, pitfalls, and promises

5 July 2018

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ROS-generating mitochondrial DNA mutations can regulate tumor cell metastasis

5 July 2018

1 reference

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5 July 2018

Biology of HIF-1alpha

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Glucose restriction extends Caenorhabditis elegans life span by inducing mitochondrial respiration and increasing oxidative stress

5 July 2018

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Reduction in glutathione peroxidase 4 increases life span through increased sensitivity to apoptosis

5 July 2018

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HIF-dependent antitumorigenic effect of antioxidants in vivo

5 July 2018

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The common biology of cancer and ageing

5 July 2018

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Regulation of the protein disulfide proteome by mitochondria in mammalian cells

5 July 2018

1 reference

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Mitochondrial reactive oxygen species trigger hypoxia-inducible factor-dependent extension of the replicative life span during hypoxia

5 July 2018

1 reference

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The Qo site of the mitochondrial complex III is required for the transduction of hypoxic signaling via reactive oxygen species production

5 July 2018

1 reference

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Mortality in randomized trials of antioxidant supplements for primary and secondary prevention: systematic review and meta-analysis

5 July 2018

1 reference

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FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress

5 July 2018

1 reference

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Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases

5 July 2018

1 reference

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Mitochondrial oxidative stress, DNA damage, and heart failure

5 July 2018

1 reference

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Selective killing of oncogenically transformed cells through a ROS-mediated mechanism by beta-phenylethyl isothiocyanate.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2933303

Oxygen sensing by mitochondria at complex III: the paradox of increased reactive oxygen species during hypoxia.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2933303

The mammalian target of rapamycin (mTOR) pathway regulates mitochondrial oxygen consumption and oxidative capacity

5 July 2018

1 reference

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Oxidative stress and redox signalling in cardiac hypertrophy and heart failure.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2933303

Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2933303

Hypoxia-induced energy stress regulates mRNA translation and cell growth

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2933303

Evolutionary conservation of the clk-1-dependent mechanism of longevity: loss of mclk1 increases cellular fitness and lifespan in mice

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2933303

Mitochondrial complex III is required for hypoxia-induced ROS production and cellular oxygen sensing

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2933303

Mitochondrial dysfunction resulting from loss of cytochrome c impairs cellular oxygen sensing and hypoxic HIF-alpha activation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2933303

Reactive oxygen species promote TNFalpha-induced death and sustained JNK activation by inhibiting MAP kinase phosphatases

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2933303

Reversible oxidation of ERK-directed protein phosphatases drives oxidative toxicity in neurons

5 July 2018

1 reference

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Reversible oxidation and inactivation of the tumor suppressor PTEN in cells stimulated with peptide growth factors

5 July 2018

1 reference

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Complex III releases superoxide to both sides of the inner mitochondrial membrane

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2933303

Calcium, mitochondria and oxygen sensing in the pulmonary circulation

5 July 2018

1 reference

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Physiological and pathological responses to hypoxia

5 July 2018

1 reference

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Hypertrophy of the heart: a new therapeutic target?

5 July 2018

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Life-long reduction in MnSOD activity results in increased DNA damage and higher incidence of cancer but does not accelerate aging

5 July 2018

1 reference

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Mitochondrial formation of reactive oxygen species

5 July 2018

1 reference

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Signalling pathways of the TNF superfamily: a double-edged sword

5 July 2018

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Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes

5 July 2018

1 reference

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NF-kappaB inhibits TNF-induced accumulation of ROS that mediate prolonged MAPK activation and necrotic cell death

5 July 2018

1 reference

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Hypoxia-induced endocytosis of Na,K-ATPase in alveolar epithelial cells is mediated by mitochondrial reactive oxygen species and PKC-zeta

5 July 2018

1 reference

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Points of control in inflammation

5 July 2018

1 reference

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Voltage-dependent anion channels control the release of the superoxide anion from mitochondria to cytosol.

5 July 2018

1 reference

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Rules for making human tumor cells

5 July 2018

1 reference

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Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2933303

The phosphoinositide 3-kinase pathway

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2933303

Reversible oxidation and inactivation of protein tyrosine phosphatases in vivo

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2933303

Biochemistry and molecular cell biology of diabetic complications

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2933303

Induction of gadd45beta by NF-kappaB downregulates pro-apoptotic JNK signalling.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2933303

Reactive oxygen species are downstream products of TRAF-mediated signal transduction

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2933303

Inhibition of early apoptotic events by Akt/PKB is dependent on the first committed step of glycolysis and mitochondrial hexokinase

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2933303

Role for mitochondrial oxidants as regulators of cellular metabolism

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2933303

Redox state is a central modulator of the balance between self-renewal and differentiation in a dividing glial precursor cell

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2933303

Reactive oxygen species generated at mitochondrial complex III stabilize hypoxia-inducible factor-1alpha during hypoxia: a mechanism of O2 sensing

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2933303

Cell transformation by the superoxide-generating oxidase Mox1

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2933303

Mitochondrial reactive oxygen species trigger hypoxia-induced transcription

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2933303

Reversible inactivation of protein-tyrosine phosphatase 1B in A431 cells stimulated with epidermal growth factor

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2933303

Tumor necrosis factor alpha and interleukin-1beta regulate the murine manganese superoxide dismutase gene through a complex intronic enhancer involving C/EBP-beta and NF-kappaB.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2933303

Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-kappaB activation prevents cell death

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2933303

Neurodegeneration, myocardial injury, and perinatal death in mitochondrial superoxide dismutase-deficient mice

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2933303

Persistent oxidative stress in cancer

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2933303

Mutations in the clk-1 gene of Caenorhabditis elegans affect developmental and behavioral timing.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2933303

Dilated cardiomyopathy and neonatal lethality in mutant mice lacking manganese superoxide dismutase

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2933303

Superoxide dismutase. An enzymic function for erythrocuprein (hemocuprein)

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2933303

Induction of manganous superoxide dismutase by tumor necrosis factor: possible protective mechanism

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2933303

Manganous superoxide dismutase is essential for cellular resistance to cytotoxicity of tumor necrosis factor

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2933303

Production of large amounts of hydrogen peroxide by human tumor cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2933303

Randomized, double-blind, placebo-controlled trial on symptomatic effects of coenzyme Q(10) in Parkinson disease

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2933303

Oxygen sensing requires mitochondrial ROS but not oxidative phosphorylation

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2933303

Newborn neurons acquire high levels of reactive oxygen species and increased mitochondrial proteins upon differentiation from progenitors.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2933303

Redox regulation of forkhead proteins through a p66shc-dependent signaling pathway

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2933303

Inhibition of JNK activation through NF-kappaB target genes

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2933303

Strain-dependent high-level expression of a transgene for manganese superoxide dismutase is associated with growth retardation and decreased fertility

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2933303

Model for hypoxic pulmonary vasoconstriction involving mitochondrial oxygen sensing

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2933303

Ferritin Heavy Chain Upregulation by NF-κB Inhibits TNFα-Induced Apoptosis by Suppressing Reactive Oxygen Species

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2933303

Increases in mitochondrial reactive oxygen species trigger hypoxia-induced calcium responses in pulmonary artery smooth muscle cells

28 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20430626

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Ubisemiquinone is the electron donor for superoxide formation by complex III of heart mitochondria

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20430626

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Chemopreventive isothiocyanates induce apoptosis and caspase-3-like protease activity

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20430626

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.TIBS.2010.04.002

1 reference

31 July 2017

1 reference

31 July 2017

1 reference