(Q29616804)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19478820%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

review article

1 reference

title

Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach? (English)

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=19478820

30 April 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19478820%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

author

Dunyaporn Trachootham

series ordinal

1 reference

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29 January 2020

Jerome Alexandre

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19478820%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

Peng Huang

series ordinal

1 reference

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=19478820

29 January 2020

language of work or name

1 reference

30 April 2017

publication date

29 May 2009

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19478820%20AND%20SRC:MED&resulttype=core&format=json

Nature Reviews Drug Discovery

29 January 2020

published in

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=19478820

30 April 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19478820%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=19478820

30 April 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19478820%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=19478820

30 April 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19478820%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

page(s)

579-591

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19478820%20AND%20SRC:MED&resulttype=core&format=json

Five-year follow-up of patients receiving imatinib for chronic myeloid leukemia

29 January 2020

cites work

1 reference

Drug development of MET inhibitors: targeting oncogene addiction and expedience

31 March 2020

1 reference

Cancer drugs. Smart weapons prove tough to design

31 March 2020

1 reference

Drug discovery: playing dirty

31 March 2020

1 reference

Drug approval triggers debate on future direction for cancer treatments

31 March 2020

1 reference

Oxidative and nitrative DNA damage in animals and patients with inflammatory diseases in relation to inflammation-related carcinogenesis

31 March 2020

1 reference

Persistent oxidative stress in cancer

31 March 2020

1 reference

Molecular events associated with reactive oxygen species and cell cycle progression in mammalian cells

31 March 2020

1 reference

Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple

31 March 2020

1 reference

How important is oxidative damage? Lessons from Alzheimer's disease

31 March 2020

1 reference

Reactive oxygen species in oncogenic transformation

31 March 2020

1 reference

The signaling mechanism of ROS in tumor progression

31 March 2020

1 reference

ROS stress in cancer cells and therapeutic implications

31 March 2020

1 reference

Reactive oxygen species in cancer cells: live by the sword, die by the sword.

31 March 2020

1 reference

Tumor intracellular redox status and drug resistance--serendipity or a causal relationship?

31 March 2020

1 reference

Chemotherapy: induction of stress responses

31 March 2020

1 reference

Chemosensitization of cancer by nitric oxide

31 March 2020

1 reference

Redox regulation of cell survival

31 March 2020

1 reference

Destructive cycles: the role of genomic instability and adaptation in carcinogenesis

31 March 2020

1 reference

Adaptation of energy metabolism in breast cancer brain metastases

31 March 2020

1 reference

Oxidative stress and cancer: have we moved forward?

31 March 2020

1 reference

Free Radical Increases in Cancer: Evidence That There Is Not a Real Increase

31 March 2020

1 reference

Free radical stress in chronic lymphocytic leukemia cells and its role in cellular sensitivity to ROS-generating anticancer agents

31 March 2020

1 reference

Expression and activity of NOX5 in the circulating malignant B cells of hairy cell leukemia.

31 March 2020

1 reference

Lipid peroxidation, total antioxidant status, and total thiol levels predict overall survival in patients with oral squamous cell carcinoma

31 March 2020

1 reference

Oxidant stress and B vitamins status in patients with non-small cell lung cancer

31 March 2020

1 reference

Oxidative stress is inherent in prostate cancer cells and is required for aggressive phenotype

31 March 2020

1 reference

Mitochondrial manganese-superoxide dismutase expression in ovarian cancer: role in cell proliferation and response to oxidative stress

31 March 2020

1 reference

Determination of glutathione, glutathione reductase, glutathione peroxidase and glutathione S-transferase levels in human lung cancer tissues

31 March 2020

1 reference

Aberrant expression of selenoproteins in the progression of colorectal cancer

31 March 2020

1 reference

Mitogenic signaling mediated by oxidants in Ras-transformed fibroblasts

31 March 2020

1 reference

Cell cycle regulation by oncogenic tyrosine kinases in myeloid neoplasias: from molecular redox mechanisms to health implications

31 March 2020

1 reference

Mitochondrial mutations in cancer

31 March 2020

1 reference

Coping with stress: multiple ways to activate p53.

31 March 2020

1 reference

c-Myc can induce DNA damage, increase reactive oxygen species, and mitigate p53 function: a mechanism for oncogene-induced genetic instability

31 March 2020

1 reference

Requirement for Rac1 in a K-ras induced lung cancer in the mouse.

31 March 2020

1 reference

Repression of sestrin family genes contributes to oncogenic Ras-induced reactive oxygen species up-regulation and genetic instability

31 March 2020

1 reference

ROS-generating mitochondrial DNA mutations can regulate tumor cell metastasis

31 March 2020

1 reference

Evidence of ROS generation by mitochondria in cells with impaired electron transport chain and mitochondrial DNA damage.

31 March 2020

1 reference

Mitochondrial DNA mutations in primary leukemia cells after chemotherapy: clinical significance and therapeutic implications.

31 March 2020

1 reference

Role of mitochondrial DNA in toxic responses to oxidative stress

31 March 2020

1 reference

Role of p53 in sensing oxidative DNA damage in response to reactive oxygen species-generating agents

31 March 2020

1 reference

The role of p53 in base excision repair following genotoxic stress

31 March 2020

1 reference

Novel role of p53 in maintaining mitochondrial genetic stability through interaction with DNA Pol gamma

31 March 2020

1 reference

The antioxidant function of the p53 tumor suppressor

31 March 2020

1 reference

Electron Transfer between Cytochrome c and p66Shc Generates Reactive Oxygen Species that Trigger Mitochondrial Apoptosis

31 March 2020

1 reference

The p53-induced gene-6 (proline oxidase) mediates apoptosis through a calcineurin-dependent pathway

31 March 2020

1 reference

Probing p53 biological functions through the use of genetically engineered mouse models

31 March 2020

1 reference

p53 in health and disease

31 March 2020

1 reference

p53 and its isoforms in cancer

31 March 2020

1 reference

Inflammation and lung cancer: roles of reactive oxygen/nitrogen species

31 March 2020

1 reference

Oxidative stress, redox, and the tumor microenvironment

31 March 2020

1 reference

Sublethal oxidative stress inhibits tumor cell adhesion and enhances experimental metastasis of murine mammary carcinoma

31 March 2020

1 reference

The role of macrophage-derived TNFa in the induction of sublethal tumor cell DNA damage

31 March 2020

1 reference

Reactive oxygen species and antioxidant mechanisms in human tissues and their relation to malignancies

31 March 2020

1 reference

Redox regulation by intrinsic species and extrinsic nutrients in normal and cancer cells

31 March 2020

1 reference

Models of reactive oxygen species in cancer

31 March 2020

1 reference

Lipid peroxidation, free radical production and antioxidant status in breast cancer.

31 March 2020

1 reference

Antioxidant status and lipid peroxidation in colorectal cancer.

31 March 2020

1 reference

Antioxidant enzyme activities and the production of MDA and 8-oxo-dG in chronic lymphocytic leukemia

31 March 2020

1 reference

CuZnSOD deficiency leads to persistent and widespread oxidative damage and hepatocarcinogenesis later in life

31 March 2020

1 reference

Regulation of reactive oxygen species, DNA damage, and c-Myc function by peroxiredoxin 1

31 March 2020

1 reference

31 March 2020

The Hallmarks of Cancer

1 reference

Mechanisms of ROS modulated cell survival during carcinogenesis

31 March 2020

1 reference

Rac1b and reactive oxygen species mediate MMP-3-induced EMT and genomic instability

31 March 2020

1 reference

Reactive oxygen species in tumor metastasis

31 March 2020

1 reference

NADPH oxidase 1 plays a critical mediating role in oncogenic Ras-induced vascular endothelial growth factor expression

31 March 2020

1 reference

Reactive oxygen species and angiogenesis: NADPH oxidase as target for cancer therapy

31 March 2020

1 reference

ROS as a tumour suppressor?

31 March 2020

1 reference

Mitogenic signalling and the p16INK4a-Rb pathway cooperate to enforce irreversible cellular senescence

31 March 2020

1 reference

Reactive oxygen species: a breath of life or death?

31 March 2020

1 reference

Adaptation to oxidative stress: quinone-mediated protection of signaling in rat lung epithelial L2 cells

31 March 2020

1 reference

Mitochondrial dysfunction, persistently elevated levels of reactive oxygen species and radiation-induced genomic instability: a review.

31 March 2020

1 reference

Redox regulation and its emerging roles in stem cells and stem-like cancer cells

31 March 2020

1 reference

Activation of antioxidant pathways in ras-mediated oncogenic transformation of human surface ovarian epithelial cells revealed by functional proteomics and mass spectrometry

31 March 2020

1 reference

Selective killing of oncogenically transformed cells through a ROS-mediated mechanism by beta-phenylethyl isothiocyanate.

31 March 2020

1 reference

c-Myc phosphorylation is required for cellular response to oxidative stress

31 March 2020

1 reference

Sustained phosphorylation of Bid is a marker for resistance to Fas-induced apoptosis during chronic liver diseases.

31 March 2020

1 reference

The mitochondrial genome in human adaptive radiation and disease: on the road to therapeutics and performance enhancement

31 March 2020

1 reference

Reactive oxygen species regulate angiogenesis and tumor growth through vascular endothelial growth factor

31 March 2020

1 reference

The role of glutathione-S-transferase in anti-cancer drug resistance

31 March 2020

1 reference

Linking stress-signaling, glutathione metabolism, signaling pathways and xenobiotic transporters

31 March 2020

1 reference

Antioxidant inhibitors for cancer therapy.

31 March 2020

1 reference

A threshold concept for cancer therapy

31 March 2020

1 reference

Sensor/effector drug design with potential relevance to cancer

31 March 2020

1 reference

Complete remission after treatment of acute promyelocytic leukemia with arsenic trioxide

31 March 2020

1 reference

Resistance to paclitaxel is proportional to cellular total antioxidant capacity.

31 March 2020

1 reference

A phase 2 consortium (P2C) trial of 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP) for advanced adenocarcinoma of the pancreas

31 March 2020

1 reference

Characterization of molecular events in a series of bladder urothelial carcinoma cell lines with progressive resistance to arsenic trioxide.

31 March 2020

1 reference

Bioenergetics and the formation of mitochondrial reactive oxygen species.

31 March 2020

1 reference

Inhibition of mitochondrial respiration: a novel strategy to enhance drug-induced apoptosis in human leukemia cells by a reactive oxygen species-mediated mechanism

31 March 2020

1 reference

Adriamycin: the role of lipid peroxidation in cardiac toxicity and tumor response

31 March 2020

1 reference

NQO1-activated phenothiazinium redox cyclers for the targeted bioreductive induction of cancer cell apoptosis

31 March 2020

1 reference

Motexafin gadolinium: a novel redox active drug for cancer therapy

31 March 2020

1 reference

Endothelial nitric oxide synthase-dependent superoxide generation from adriamycin.

31 March 2020

1 reference

Transferrin receptor-dependent iron uptake is responsible for doxorubicin-mediated apoptosis in endothelial cells: role of oxidant-induced iron signaling in apoptosis

31 March 2020

1 reference

A class of iron chelators with a wide spectrum of potent antitumor activity that overcomes resistance to chemotherapeutics

31 March 2020

1 reference

Triapine (3-aminopyridine-2-carboxaldehyde- thiosemicarbazone): A potent inhibitor of ribonucleotide reductase activity with broad spectrum antitumor activity.

31 March 2020

1 reference

Evidence for cancer-associated expression of NADPH oxidase 1 (Nox1)-based oxidase system in the human stomach.

31 March 2020

1 reference

Reactive oxygen species may have antitumor activity in metastatic melanoma

31 March 2020

1 reference

Elesclomol induces cancer cell apoptosis through oxidative stress

31 March 2020

1 reference

Induction of oxidative stress and apoptosis in myeloma cells by the aziridine-containing agent imexon

31 March 2020

1 reference

Involvement of glutathione metabolism in the cytotoxicity of the phenethyl isothiocyanate and its cysteine conjugate to human leukaemia cells in vitro

31 March 2020

1 reference

The x(c)- cystine/glutamate antiporter: a potential target for therapy of cancer and other diseases

31 March 2020

1 reference

The redox state of the lung cancer microenvironment depends on the levels of thioredoxin expressed by tumor cells and affects tumor progression and response to prooxidants.

31 March 2020

1 reference

Thioredoxin and thioredoxin-binding protein-2 in cancer and metabolic syndrome

31 March 2020

1 reference

Superoxide dismutase as a target for the selective killing of cancer cells

31 March 2020

1 reference

Copper binding by tetrathiomolybdate attenuates angiogenesis and tumor cell proliferation through the inhibition of superoxide dismutase 1.

31 March 2020

1 reference

Inhibiting catalase activity sensitizes 36B10 rat glioma cells to oxidative stress.

31 March 2020

1 reference

Enhancement of chemotherapeutic response of tumor cells by a heme oxygenase inhibitor, pegylated zinc protoporphyrin.

31 March 2020

1 reference

Resistance to oxidants associated with elevated catalase activity in HL-60 leukemia cells that overexpress multidrug-resistance protein does not contribute to the resistance to daunorubicin manifested by these cells

31 March 2020

1 reference

Changes in gene expression profiles of multiple myeloma cells induced by arsenic trioxide (ATO): possible mechanisms to explain ATO resistance in vivo.

31 March 2020

1 reference

Effective elimination of fludarabine-resistant CLL cells by PEITC through a redox-mediated mechanism

31 March 2020

1 reference

Effective killing of Gleevec-resistant CML cells with T315I mutation by a natural compound PEITC through redox-mediated mechanism

31 March 2020

1 reference

Adaptive response to GSH depletion and resistance to L-buthionine-(S,R)-sulfoximine: involvement of Nrf2 activation

31 March 2020

1 reference

Mechanism of synergy of N-(4-hydroxyphenyl)retinamide and ABT-737 in acute lymphoblastic leukemia cell lines: Mcl-1 inactivation.

31 March 2020

1 reference

A multicenter phase II trial of 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP, Triapine®) and gemcitabine in advanced non-small-cell lung cancer with pharmacokinetic evaluation using peripheral blood mononuclear cells

31 March 2020

1 reference

Oxidative stress and apoptosis: a new treatment paradigm in cancer.

31 March 2020

1 reference

Cancer stem cells in solid tumours: accumulating evidence and unresolved questions

31 March 2020

1 reference

Survival of the fittest: cancer stem cells in therapeutic resistance and angiogenesis

31 March 2020

1 reference

Intrinsic resistance of tumorigenic breast cancer cells to chemotherapy

31 March 2020

1 reference

Glioma stem cells promote radioresistance by preferential activation of the DNA damage response

31 March 2020

1 reference

A low level of reactive oxygen species selects for primitive hematopoietic stem cells that may reside in the low-oxygenic niche

31 March 2020

1 reference

Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells

31 March 2020

1 reference

Association of reactive oxygen species levels and radioresistance in cancer stem cells

31 March 2020

1 reference

FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress

31 March 2020

1 reference

Regulation of reactive oxygen species and genomic stability in hematopoietic stem cells

31 March 2020

1 reference

Novel aspects of oxidative stress-associated carcinogenesis

31 March 2020

1 reference

Oxidative stress in the regulation of normal and neoplastic hematopoiesis

31 March 2020

1 reference

The response of CD24(-/low)/CD44+ breast cancer-initiating cells to radiation

31 March 2020

1 reference

The role of oxygen availability in embryonic development and stem cell function

31 March 2020

1 reference

Cancer cell killing via ROS: to increase or decrease, that is the question

31 March 2020

1 reference

Mortality in randomized trials of antioxidant supplements for primary and secondary prevention: systematic review and meta-analysis

31 March 2020

1 reference

31 March 2020

The antioxidant paradox

1 reference

Accumulation of hydrogen peroxide is an early and crucial step for paclitaxel-induced cancer cell death both in vitro and in vivo.

31 March 2020

1 reference

Antioxidants block proteasome inhibitor function in endometrial carcinoma cells.

31 March 2020

1 reference

Randomized trial of antioxidant vitamins to prevent acute adverse effects of radiation therapy in head and neck cancer patients

31 March 2020

1 reference

An NQO1- and PARP-1-mediated cell death pathway induced in non-small-cell lung cancer cells by beta-lapachone

31 March 2020

1 reference

Rapid and selective death of leukemia stem and progenitor cells induced by the compound 4-benzyl, 2-methyl, 1,2,4-thiadiazolidine, 3,5 dione (TDZD-8)

31 March 2020

1 reference

Effective treatment of advanced solid tumors by the combination of arsenic trioxide and L-buthionine-sulfoximine

31 March 2020

1 reference

Phase I trial of imexon in patients with advanced malignancy

31 March 2020

1 reference

Improvement of the therapeutic index of anticancer drugs by the superoxide dismutase mimic mangafodipir.

31 March 2020

1 reference

Superoxide dismutase 1 (SOD1) is essential for H2O2-mediated oxidation and inactivation of phosphatases in growth factor signaling

31 March 2020

1 reference

Targeting thioredoxin reductase is a basis for cancer therapy by arsenic trioxide

31 March 2020

1 reference

Redox active disulfides: the thioredoxin system as a drug target

31 March 2020

1 reference

12 December 2020

Role of superoxide dismutase in cancer: a review

1 reference

12 December 2020

Potent and specific inhibition of glutathione synthesis by buthionine sulfoximine (S-n-butyl homocysteine sulfoximine)

1 reference

12 December 2020

Production of large amounts of hydrogen peroxide by human tumor cells

1 reference

12 December 2020

Antioxidant enzyme levels in cancer

1 reference

12 December 2020

Gene expressions associated with chemosensitivity in human hepatoma cells.

1 reference

12 December 2020

The thioredoxin redox inhibitors 1-methylpropyl 2-imidazolyl disulfide and pleurotin inhibit hypoxia-induced factor 1alpha and vascular endothelial growth factor formation.

1 reference

12 December 2020

Studies on treatment of acute promyelocytic leukemia with arsenic trioxide: remission induction, follow-up, and molecular monitoring in 11 newly diagnosed and 47 relapsed acute promyelocytic leukemia patients

1 reference

12 December 2020

Protection from oxidative stress by enhanced glycolysis; a possible mechanism of cellular immortalization.

1 reference

12 December 2020

Experimental therapeutics: targeting the redox Achilles heel of cancer

1 reference

12 December 2020

Lipid peroxidation and antioxidant status in colorectal cancer

1 reference

12 December 2020

Enhanced skin carcinogenesis in transgenic mice with high expression of glutathione peroxidase or both glutathione peroxidase and superoxide dismutase.

1 reference

12 December 2020

Increased level of the p67phox subunit of NADPH oxidase by 4HPR in head and neck squamous carcinoma cells.

1 reference

12 December 2020

Feasibility and correlates of arsenic trioxide combined with ascorbic acid-mediated depletion of intracellular glutathione for the treatment of relapsed/refractory multiple myeloma

1 reference

12 December 2020

Anticarcinogenic activities of organic isothiocyanates: chemistry and mechanisms

1 reference

12 December 2020

Antioxidant potential in esophageal, stomach and colorectal cancers.

1 reference

12 December 2020

Cellular redox status regulates hypoxia inducible factor-1 activity. Role in tumour development.

1 reference

12 December 2020

Acquired tolerance of hepatocellular carcinoma cells to selenium deficiency: a selective survival mechanism?

1 reference

12 December 2020

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=19478820

Identifiers

3 references

30 April 2017

Consolidated OpenCitations Corpus – April 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19478820%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

29 January 2020

1017656268

0 references

1 reference

Consolidated OpenCitations Corpus – April 2017

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=19478820

3 references

30 April 2017

Consolidated OpenCitations Corpus – April 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19478820%20AND%20SRC:MED&resulttype=core&format=json