(Q28131781)

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Biochemistry and molecular cell biology of diabetic complications

scientific article (publication date: 13 December 2001)

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Biochemistry and molecular cell biology of diabetic complications (English)

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M Brownlee

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13 December 2001

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414

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6865

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813-20

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The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. The Diabetes Control and Complications Trial Research Group

1 reference

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7 January 2021

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Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). UK Prospective Diabetes Study (UKPDS) Group

1 reference

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7 January 2021

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Effects of diabetes and level of glycemia on all-cause and cardiovascular mortality. The San Antonio Heart Study

1 reference

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7 January 2021

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Delayed catabolism of apoB-48 lipoproteins due to decreased heparan sulfate proteoglycan production in diabetic mice

1 reference

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7 January 2021

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Insulin resistance and cardiovascular disease

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7 January 2021

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Atherosclerosis

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7 January 2021

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Cardiovascular risk continuum: implications of insulin resistance and diabetes.

1 reference

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7 January 2021

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Characterization of selective resistance to insulin signaling in the vasculature of obese Zucker (fa/fa) rats

1 reference

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7 January 2021

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Acute hyperglycemia attenuates endothelium-dependent vasodilation in humans in vivo

1 reference

https://api.crossref.org/works/10.1038%2F414813A

7 January 2021

based on heuristic

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Hyperglycemia-induced mitochondrial superoxide overproduction activates the hexosamine pathway and induces plasminogen activator inhibitor-1 expression by increasing Sp1 glycosylation

1 reference

https://api.crossref.org/works/10.1038%2F414813A

7 January 2021

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Postchallenge plasma glucose and glycemic spikes are more strongly associated with atherosclerosis than fasting glucose or HbA1c level

1 reference

https://api.crossref.org/works/10.1038%2F414813A

7 January 2021

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An unlikely sugar substrate site in the 1.65 A structure of the human aldose reductase holoenzyme implicated in diabetic complications

1 reference

https://api.crossref.org/works/10.1038%2F414813A

7 January 2021

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Identification of the mechanism for the inhibition of Na+,K(+)-adenosine triphosphatase by hyperglycemia involving activation of protein kinase C and cytosolic phospholipase A2

1 reference

https://api.crossref.org/works/10.1038%2F414813A

7 January 2021

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Hyperglycemic pseudohypoxia and diabetic complications.

1 reference

https://api.crossref.org/works/10.1038%2F414813A

7 January 2021

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Diabetic endothelial dysfunction: the role of poly(ADP-ribose) polymerase activation

1 reference

https://api.crossref.org/works/10.1038%2F414813A

7 January 2021

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Contributions of polyol pathway to oxidative stress in diabetic cataract.

1 reference

https://api.crossref.org/works/10.1038%2F414813A

7 January 2021

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Nerve conduction and aldose reductase inhibition during 5 years of diabetes or galactosaemia in dogs

1 reference

https://api.crossref.org/works/10.1038%2F414813A

7 January 2021

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Effect of aldose reductase inhibition on nerve conduction and morphometry in diabetic neuropathy. Zenarestat Study Group

1 reference

https://api.crossref.org/works/10.1038%2F414813A

7 January 2021

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Immunohistochemical colocalization of glycoxidation products and lipid peroxidation products in diabetic renal glomerular lesions. Implication for glycoxidative stress in the pathogenesis of diabetic nephropathy

1 reference

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7 January 2021

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Mechanism of autoxidative glycosylation: identification of glyoxal and arabinose as intermediates in the autoxidative modification of proteins by glucose

1 reference

https://api.crossref.org/works/10.1038%2F414813A

7 January 2021

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The glyoxalase system: new developments towards functional characterization of a metabolic pathway fundamental to biological life

1 reference

https://api.crossref.org/works/10.1038%2F414813A

7 January 2021

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Overexpression of aldehyde reductase protects PC12 cells from the cytotoxicity of methylglyoxal or 3-deoxyglucosone

1 reference

https://api.crossref.org/works/10.1038%2F414813A

7 January 2021

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Retardation by Aminoguanidine of Development of Albuminuria, Mesangial Expansion, and Tissue Fluorescence in Streptozocin-Induced Diabetic Rat

1 reference

https://api.crossref.org/works/10.1038%2F414813A

7 January 2021

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Progression of nephropathy in spontaneous diabetic rats is prevented by OPB-9195, a novel inhibitor of advanced glycation

1 reference

https://api.crossref.org/works/10.1038%2F414813A

7 January 2021

based on heuristic

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Aminoguanidine treatment inhibits the development of experimental diabetic retinopathy

1 reference

https://api.crossref.org/works/10.1038%2F414813A

7 January 2021

based on heuristic

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Nonenzymatic glycosylation in vitro and in bovine endothelial cells alters basic fibroblast growth factor activity. A model for intracellular glycosylation in diabetes

1 reference

https://api.crossref.org/works/10.1038%2F414813A

7 January 2021

based on heuristic

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Overexpression of glyoxalase-I in bovine endothelial cells inhibits intracellular advanced glycation endproduct formation and prevents hyperglycemia-induced increases in macromolecular endocytosis

1 reference

https://api.crossref.org/works/10.1038%2F414813A

7 January 2021

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Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis

1 reference

https://api.crossref.org/works/10.1038%2F414813A

7 January 2021

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Glycation induces expansion of the molecular packing of collagen

1 reference

https://api.crossref.org/works/10.1038%2F414813A

7 January 2021

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Aminoguanidine treatment increases elasticity and decreases fluid filtration of large arteries from diabetic rats

1 reference

https://api.crossref.org/works/10.1038%2F414813A

7 January 2021

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Laminin alterations after in vitro nonenzymatic glycosylation

1 reference

https://api.crossref.org/works/10.1038%2F414813A

7 January 2021

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Nonenzymatic glycosylation of laminin and the laminin peptide CIKVAVS inhibits neurite outgrowth

1 reference

https://api.crossref.org/works/10.1038%2F414813A

7 January 2021

based on heuristic

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Molecular identity and cellular distribution of advanced glycation endproduct receptors: relationship of p60 to OST-48 and p90 to 80K-H membrane proteins.

1 reference

https://api.crossref.org/works/10.1038%2F414813A

7 January 2021

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Advanced glycation end products are eliminated by scavenger-receptor-mediated endocytosis in hepatic sinusoidal Kupffer and endothelial cells

1 reference

https://api.crossref.org/works/10.1038%2F414813A

7 January 2021

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Cachectin/TNF and IL-1 induced by glucose-modified proteins: role in normal tissue remodeling

1 reference

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7 January 2021

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Receptor-specific induction of insulin-like growth factor I in human monocytes by advanced glycosylation end product-modified proteins

1 reference

https://api.crossref.org/works/10.1038%2F414813A

7 January 2021

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Synthesis and secretion of macrophage colony stimulating factor by mature human monocytes and human monocytic THP-1 cells induced by human serum albumin derivatives modified with methylglyoxal and glucose-derived advanced glycation endproducts

1 reference

https://api.crossref.org/works/10.1038%2F414813A

7 January 2021

based on heuristic

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Human and rat mesangial cell receptors for glucose-modified proteins: potential role in kidney tissue remodelling and diabetic nephropathy

1 reference

https://api.crossref.org/works/10.1038%2F414813A

7 January 2021

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Receptor-specific increase in extracellular matrix production in mouse mesangial cells by advanced glycosylation end products is mediated via platelet-derived growth factor

1 reference

https://api.crossref.org/works/10.1038%2F414813A

7 January 2021

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Advanced glycation endproducts interacting with their endothelial receptor induce expression of vascular cell adhesion molecule-1 (VCAM-1) in cultured human endothelial cells and in mice. A potential mechanism for the accelerated vasculopathy of dia

1 reference

https://api.crossref.org/works/10.1038%2F414813A

7 January 2021

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Advanced glycation end products increase retinal vascular endothelial growth factor expression

1 reference

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7 January 2021

based on heuristic

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Suppression of accelerated diabetic atherosclerosis by the soluble receptor for advanced glycation endproducts

1 reference

https://api.crossref.org/works/10.1038%2F414813A

7 January 2021

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Activation of the Receptor for Advanced Glycation End Products Triggers a p21 -dependent Mitogen-activated Protein Kinase Pathway Regulated by Oxidant Stress

1 reference

https://api.crossref.org/works/10.1038%2F414813A

7 January 2021

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Advanced glycation endproducts inhibit prostacyclin production and induce plasminogen activator inhibitor-1 in human microvascular endothelial cells

1 reference

https://api.crossref.org/works/10.1038%2F414813A

7 January 2021

based on heuristic

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Ribozyme targeting of receptor for advanced glycation end products in mouse mesangial cells

1 reference

https://api.crossref.org/works/10.1038%2F414813A

7 January 2021

based on heuristic

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Protein kinase C activation and the development of diabetic complications

1 reference

https://api.crossref.org/works/10.1038%2F414813A

7 January 2021

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Characterization of the mechanism for the chronic activation of diacylglycerol-protein kinase C pathway in diabetes and hypergalactosemia

1 reference

https://api.crossref.org/works/10.1038%2F414813A

7 January 2021

based on heuristic

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Characterization of protein kinase C beta isoform activation on the gene expression of transforming growth factor-beta, extracellular matrix components, and prostanoids in the glomeruli of diabetic rats

1 reference

https://api.crossref.org/works/10.1038%2F414813A

7 January 2021

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Etomoxir-induced PPARalpha-modulated enzymes protect during acute renal failure

1 reference

https://api.crossref.org/works/10.1038%2F414813A

7 January 2021

based on heuristic

inferred from DOI database lookup

Effect of inhibition of aldose reductase on glucose flux, diacylglycerol formation, protein kinase C, and phospholipase A2 activation

1 reference

https://api.crossref.org/works/10.1038%2F414813A

7 January 2021

based on heuristic

inferred from DOI database lookup

Amelioration of vascular dysfunctions in diabetic rats by an oral PKC beta inhibitor

1 reference

https://api.crossref.org/works/10.1038%2F414813A

7 January 2021

based on heuristic

inferred from DOI database lookup

Impaired nitric oxide-dependent cyclic guanosine monophosphate generation in glomeruli from diabetic rats. Evidence for protein kinase C-mediated suppression of the cholinergic response

1 reference

https://api.crossref.org/works/10.1038%2F414813A

7 January 2021

based on heuristic

inferred from DOI database lookup

Regulation of endothelial constitutive nitric oxide synthase gene expression in endothelial cells and in vivo : a specific vascular action of insulin.

1 reference

https://api.crossref.org/works/10.1038%2F414813A

7 January 2021

based on heuristic

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High glucose alters the response of mesangial cell protein kinase C isoforms to endothelin-1.

1 reference

https://api.crossref.org/works/10.1038%2F414813A

7 January 2021

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High Glucose Concentrations Increase Endothelial Cell Permeability via Activation of Protein Kinase Cα

1 reference

https://api.crossref.org/works/10.1038%2F414813A

7 January 2021

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Glucose-Induced Protein Kinase C Activation Regulates Vascular Permeability Factor mRNA Expression and Peptide Production by Human Vascular Smooth Muscle Cells In Vitro

1 reference

https://api.crossref.org/works/10.1038%2F414813A

7 January 2021

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Role for protein kinase C in the mediation of increased fibronectin accumulation by mesangial cells grown in high-glucose medium

1 reference

https://api.crossref.org/works/10.1038%2F414813A

7 January 2021

based on heuristic

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Nitric oxide inhibition of transforming growth factor-beta and collagen synthesis in mesangial cells

1 reference

https://api.crossref.org/works/10.1038%2F414813A

7 January 2021

based on heuristic

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Regulation of the laminin C1 promoter in cultured mesangial cells

1 reference

https://api.crossref.org/works/10.1038%2F414813A

7 January 2021

based on heuristic

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Role of protein kinase C in glucose- and angiotensin II-induced plasminogen activator inhibitor expression

1 reference

https://api.crossref.org/works/10.1038%2F414813A

7 January 2021

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Activation of Nuclear Factor-κB in Cultured Endothelial Cells by Increased Glucose Concentration: Prevention by Calphostin C

1 reference

https://api.crossref.org/works/10.1038%2F414813A

7 January 2021

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Hyperglycemia-induced activation of nuclear transcription factor kappaB in vascular smooth muscle cells

1 reference

https://api.crossref.org/works/10.1038%2F414813A

7 January 2021

based on heuristic

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Amelioration of accelerated diabetic mesangial expansion by treatment with a PKC beta inhibitor in diabetic db/db mice, a rodent model for type 2 diabetes

1 reference

https://api.crossref.org/works/10.1038%2F414813A

7 January 2021

based on heuristic

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High glucose-induced transforming growth factor beta1 production is mediated by the hexosamine pathway in porcine glomerular mesangial cells

1 reference

https://api.crossref.org/works/10.1038%2F414813A

7 January 2021

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Role of the glucosamine pathway in fat-induced insulin resistance

1 reference

https://api.crossref.org/works/10.1038%2F414813A

7 January 2021

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Sp1 sites mediate activation of the plasminogen activator inhibitor-1 promoter by glucose in vascular smooth muscle cells

1 reference

https://api.crossref.org/works/10.1038%2F414813A

7 January 2021

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Glucosamine activates the plasminogen activator inhibitor 1 gene promoter through Sp1 DNA binding sites in glomerular mesangial cells

1 reference

https://api.crossref.org/works/10.1038%2F414813A

7 January 2021

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Distinct regions of Sp1 modulate DNA binding and transcriptional activation

1 reference

https://api.crossref.org/works/10.1038%2F414813A

7 January 2021

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Modulation of O-linked N-acetylglucosamine levels on nuclear and cytoplasmic proteins in vivo using the peptide O-GlcNAc-beta-N-acetylglucosaminidase inhibitor O-(2-acetamido-2-deoxy-D-glucopyranosylidene)amino-N-phenylcarbamate

1 reference

https://api.crossref.org/works/10.1038%2F414813A

7 January 2021

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Dynamic O-linked glycosylation of nuclear and cytoskeletal proteins

1 reference

https://api.crossref.org/works/10.1038%2F414813A

7 January 2021

based on heuristic

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Hyperglycemia inhibits endothelial nitric oxide synthase activity by posttranslational modification at the Akt site

1 reference

https://api.crossref.org/works/10.1038%2F414813A

7 January 2021

based on heuristic

inferred from DOI database lookup

Demonstration that polyol accumulation is responsible for diabetic cataract by the use of transgenic mice expressing the aldose reductase gene in the lens

1 reference

https://api.crossref.org/works/10.1038%2F414813A

7 January 2021

based on heuristic

inferred from DOI database lookup

Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage

1 reference

https://api.crossref.org/works/10.1038%2F414813A

7 January 2021

based on heuristic

inferred from DOI database lookup

Oxidative stress and diabetic vascular complications

1 reference

https://api.crossref.org/works/10.1038%2F414813A

7 January 2021

based on heuristic

inferred from DOI database lookup

BCL-2 expression or antioxidants prevent hyperglycemia-induced formation of intracellular advanced glycation endproducts in bovine endothelial cells

1 reference

https://api.crossref.org/works/10.1038%2F414813A

7 January 2021

based on heuristic

inferred from DOI database lookup

High protonic potential actuates a mechanism of production of reactive oxygen species in mitochondria

1 reference

https://api.crossref.org/works/10.1038%2F414813A

7 January 2021

based on heuristic

inferred from DOI database lookup

Hyperglycemia potentiates collagen-induced platelet activation through mitochondrial superoxide overproduction

1 reference

https://api.crossref.org/works/10.1038%2F414813A

7 January 2021

based on heuristic

inferred from DOI database lookup

Overexpression of Cu2+/Zn2+ superoxide dismutase protects against early diabetic glomerular injury in transgenic mice

1 reference

https://api.crossref.org/works/10.1038%2F414813A

7 January 2021

based on heuristic

inferred from DOI database lookup

Progression of incipient diabetic retinopathy during good glycemic control.

1 reference

https://api.crossref.org/works/10.1038%2F414813A

7 January 2021

based on heuristic

inferred from DOI database lookup

Retinopathy and nephropathy in patients with type 1 diabetes four years after a trial of intensive therapy

1 reference

https://api.crossref.org/works/10.1038%2F414813A

7 January 2021

based on heuristic

inferred from DOI database lookup

Familial aggregation of coronary artery calcium in families with type 2 diabetes

1 reference

https://api.crossref.org/works/10.1038%2F414813A

7 January 2021

based on heuristic

inferred from DOI database lookup

Abnormalities of retinal metabolism in diabetes and experimental galactosemia. VII. Effect of long-term administration of antioxidants on the development of retinopathy

1 reference

https://api.crossref.org/works/10.1038%2F414813A

7 January 2021

based on heuristic

inferred from DOI database lookup

Vitamin C improves endothelium-dependent vasodilation in patients with non-insulin-dependent diabetes mellitus

1 reference

https://api.crossref.org/works/10.1038%2F414813A

7 January 2021

based on heuristic

inferred from DOI database lookup

Effects of ramipril on cardiovascular and microvascular outcomes in people with diabetes mellitus: results of the HOPE study and MICRO-HOPE substudy. Heart Outcomes Prevention Evaluation Study Investigators

1 reference

https://api.crossref.org/works/10.1038%2F414813A

7 January 2021

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A nonpeptidyl mimic of superoxide dismutase with therapeutic activity in rats

1 reference

https://api.crossref.org/works/10.1038%2F414813A

7 January 2021

based on heuristic

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Effect of M40403 treatment of diabetic rats on endoneurial blood flow, motor nerve conduction velocity and vascular function of epineurial arterioles of the sciatic nerve

1 reference

https://api.crossref.org/works/10.1038%2F414813A

7 January 2021

based on heuristic

inferred from DOI database lookup

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