(Q24681014)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17942417%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

review article

3 references

8 February 2021

31 July 2022

Two faces of p53: aging and tumor suppression (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17942417%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

1 reference

20 December 2019

1 reference

24 January 2021

1 reference

8 February 2021

Dipa Bhaumik

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17942417%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

language of work or name

English

0 references

publication date

16 October 2007

10 references

3 April 2019

28 November 2019

11 December 2019

18 December 2019

19 December 2019

20 December 2019

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17942417%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

24 January 2021

8 February 2021

31 July 2022

Nucleic Acids Research

10 references

3 April 2019

28 November 2019

11 December 2019

18 December 2019

19 December 2019

20 December 2019

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17942417%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

24 January 2021

8 February 2021

31 July 2022

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17942417%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

issue

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17942417%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

page(s)

7475-7484

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17942417%20AND%20SRC:MED&resulttype=core&format=json

Creative Commons Attribution-NonCommercial

9 January 2020

9 references

3 April 2019

28 November 2019

11 December 2019

18 December 2019

19 December 2019

20 December 2019

24 January 2021

8 February 2021

31 July 2022

on focus list of Wikimedia project

ScienceSource

0 references

cites work

DNA nucleotide excision repair-dependent signaling to checkpoint activation

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p53 isoforms can regulate p53 transcriptional activity.

7 April 2017

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Regulation of cellular response to oncogenic and oxidative stress by Seladin-1

7 April 2017

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7 April 2017

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Loss of A-type lamin expression compromises nuclear envelope integrity leading to muscular dystrophy

7 April 2017

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DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts

7 April 2017

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A biomarker that identifies senescent human cells in culture and in aging skin in vivo

7 April 2017

1 reference

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Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes

7 April 2017

1 reference

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TIGAR, a p53-inducible regulator of glycolysis and apoptosis

7 April 2017

1 reference

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Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age

7 April 2017

1 reference

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Accumulation of senescent cells in mitotic tissue of aging primates

7 April 2017

1 reference

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p53 regulates mitochondrial respiration

7 April 2017

1 reference

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Genomic instability in laminopathy-based premature aging

7 April 2017

1 reference

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Cell death: critical control points

7 April 2017

1 reference

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LMNA mutations in atypical Werner's syndrome

7 April 2017

1 reference

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Recurrent de novo point mutations in lamin A cause Hutchinson–Gilford progeria syndrome

7 April 2017

1 reference

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Genetic pathways that regulate ageing in model organisms

7 April 2017

1 reference

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Deletion of Ku86 causes early onset of senescence in mice

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2190721

Premature aging in mice deficient in DNA repair and transcription

7 April 2017

1 reference

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Genomic instability in mice lacking histone H2AX

7 April 2017

1 reference

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Mitochondria, oxidants, and aging

7 April 2017

1 reference

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Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

7 April 2017

1 reference

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Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication

7 April 2017

1 reference

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Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2190721

Increasing p16INK4a expression decreases forebrain progenitors and neurogenesis during ageing

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2190721

The antioxidant function of the p53 tumor suppressor

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2190721

Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors

7 April 2017

1 reference

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A DNA damage checkpoint response in telomere-initiated senescence

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2190721

Extended longevity in mice lacking the insulin receptor in adipose tissue

7 April 2017

1 reference

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Telomere shortening and tumor formation by mouse cells lacking telomerase RNA

7 April 2017

1 reference

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p53 is required for radiation-induced apoptosis in mouse thymocytes

7 April 2017

1 reference

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p53-dependent apoptosis modulates the cytotoxicity of anticancer agents

7 April 2017

1 reference

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Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53

7 April 2017

1 reference

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Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53

7 April 2017

1 reference

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Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms

7 April 2017

1 reference

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p53 mutant mice that display early ageing-associated phenotypes

7 April 2017

1 reference

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Tumor suppressor p53 Arg72Pro polymorphism and longevity, cancer survival, and risk of cancer in the general population

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2190721

Senescent human fibroblasts increase the early growth of xenograft tumors via matrix metalloproteinase secretion

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2190721

Loss of stem cell regenerative capacity within aged niches

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2190721

The impact of altered p53 dosage on hematopoietic stem cell dynamics during aging

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2190721

The pathological response to DNA damage does not contribute to p53-mediated tumour suppression

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2190721

p53 and metabolism: Inside the TIGAR.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2190721

Increased cell-to-cell variation in gene expression in ageing mouse heart

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2190721

ATM-Chk2-p53 activation prevents tumorigenesis at an expense of organ homeostasis upon Brca1 deficiency

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2190721

The complexity of p53 stabilization and activation

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2190721

Increased p53 activity does not accelerate telomere-driven ageing

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2190721

Tumor suppression by p53 without accelerated aging: just enough of a good thing?

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2190721

Tumor suppression and normal aging in mice with constitutively high p53 activity

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2190721

Recruitment of DNA damage checkpoint proteins to damage in transcribed and nontranscribed sequences

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2190721

The role of the BRCA1 tumor suppressor in DNA double-strand break repair

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2190721

Accelerated ageing in mice deficient in Zmpste24 protease is linked to p53 signalling activation.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2190721

Dyskeratosis congenita: telomerase, telomeres and anticipation

28 September 2017

1 reference

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Cancer and aging: the importance of telomeres in genome maintenance

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2190721

Variation in the human TP53 gene affects old age survival and cancer mortality.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2190721

Genetics of longevity and aging

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2190721

Stromal-epithelial interactions in aging and cancer: senescent fibroblasts alter epithelial cell differentiation

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2190721

Human cell senescence as a DNA damage response.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2190721

The role of oxidative damage and stress in aging.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2190721

The cellular response to general and programmed DNA double strand breaks

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2190721

Functional aging and gradual senescence in zebrafish

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2190721

Initiating cellular stress responses

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2190721

p53 moves to mitochondria: a turn on the path to apoptosis.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2190721

Modulation of mammalian life span by the short isoform of p53.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2190721

Senescing human cells and ageing mice accumulate DNA lesions with unrepairable double-strand breaks

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2190721

Reversal of human cellular senescence: roles of the p53 and p16 pathways

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2190721

Cancer and ageing: rival demons?

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2190721

Decision making by p53: life, death and cancer

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2190721

Transcriptional repression mediated by the p53 tumour suppressor

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2190721

The codon 72 polymorphic variants of p53 have markedly different apoptotic potential

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2190721

Senescence, aging, and malignant transformation mediated by p53 in mice lacking the Brca1 full-length isoform

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2190721

"Super p53" mice exhibit enhanced DNA damage response, are tumor resistant and age normally

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2190721

Dying of old age: an examination of death certificates of Minnesota centenarians

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2190721

Zmpste24 deficiency in mice causes spontaneous bone fractures, muscle weakness, and a prelamin A processing defect.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2190721

Large genome rearrangements as a primary cause of aging

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2190721

Genotoxic and non-genotoxic pathways of p53 induction

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2190721

Disease model: human aging

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2190721

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2190721

Death signal-induced localization of p53 protein to mitochondria. A potential role in apoptotic signaling

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2190721

Analysis of ku80-mutant mice and cells with deficient levels of p53

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2190721

p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2190721

Primary structure polymorphism at amino acid residue 72 of human p53.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2190721

Dissection of the genetic programs of p53-mediated G1 growth arrest and apoptosis: blocking p53-induced apoptosis unmasks G1 arrest.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2190721

The DNA damage signaling pathway is a critical mediator of oncogene-induced senescence.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2190721

Total body irradiation selectively induces murine hematopoietic stem cell senescence

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2190721

Unwind and slow down: checkpoint activation by helicase and polymerase uncoupling

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2190721

Role of DNA-dependent protein kinase in neuronal survival.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2190721

Delayed ageing through damage protection by the Arf/p53 pathway

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2190721

Mdm2 is critically and continuously required to suppress lethal p53 activity in vivo.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2190721

Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2190721

Cellular senescence in aging primates.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2190721

Complicating the role of p53 in aging.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2190721

Temporal dissection of p53 function in vitro and in vivo

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2190721

The different apoptotic potential of the p53 codon 72 alleles increases with age and modulates in vivo ischaemia-induced cell death.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2190721

Dual effect of p53 on radiation sensitivity in vivo: p53 promotes hematopoietic injury, but protects from gastro-intestinal syndrome in mice.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2190721

Cell senescence in rat kidneys in vivo increases with growth and age despite lack of telomere shortening.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2190721

Defective prelamin A processing and muscular and adipocyte alterations in Zmpste24 metalloproteinase-deficient mice.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2190721

Genetic interactions between tumor suppressors Brca1 and p53 in apoptosis, cell cycle and tumorigenesis.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2190721

Hematopoietic cells from mice deficient in wild-type p53 are more resistant to induction of apoptosis by some agents

28 November 2018

1 reference

12 December 2020

Longevity, Stress Response, and Cancer in Aging Telomerase-Deficient Mice

1 reference

12 December 2020

Cancer and ageing: a nexus at several levels

1 reference

12 December 2020

Evidence for the Direct Binding of Phosphorylated p53 to Sites of DNA BreaksIn vivo

1 reference

12 December 2020

Identifiers

DOI

10.1093/NAR/GKM744

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17942417%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17942417%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

PubMed publication ID

17942417

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17942417%20AND%20SRC:MED&resulttype=core&format=json