(Q40672888)

22 September 2017

title

The codon 72 polymorphic variants of p53 have markedly different apoptotic potential (English)

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22 September 2017

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Maureen Murphy

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Patrick Dumont

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22 September 2017

J I-Ju Leu

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22 September 2017

Anthony C Della Pietra

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22 September 2017

Donna L George

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22 September 2017

language of work or name

English

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publication date

3 February 2003

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22 September 2017

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22 September 2017

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22 September 2017

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22 September 2017

page(s)

357-365

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WAF1, a potential mediator of p53 tumor suppression

22 September 2017

cites work

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7 January 2021

Mice Lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control

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7 January 2021

p53-dependent apoptosis in the absence of transcriptional activation of p53-target genes

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7 January 2021

Myc-mediated apoptosis requires wild-type p53 in a manner independent of cell cycle arrest and the ability of p53 to induce p21waf1/cip1.

1 reference

7 January 2021

Regulation of p53 by hypoxia: dissociation of transcriptional repression and apoptosis from p53-dependent transactivation.

1 reference

7 January 2021

Induction of apoptosis in HeLa cells by trans-activation-deficient p53

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7 January 2021

Identification of a novel p53 functional domain that is necessary for efficient growth suppression

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7 January 2021

The polyproline region of p53 is required to activate apoptosis but not growth arrest.

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7 January 2021

A variation in the structure of the protein-coding region of the human p53 gene

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7 January 2021

Molecular basis for heterogeneity of the human p53 protein

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7 January 2021

Primary structure polymorphism at amino acid residue 72 of human p53.

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7 January 2021

p53 polymorphisms and haplotypes in different ethnic groups

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7 January 2021

Is p53 polymorphism maintained by natural selection?

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7 January 2021

Two polymorphic variants of wild-type p53 differ biochemically and biologically

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7 January 2021

Role of a p53 polymorphism in the development of human papillomavirus-associated cancer

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7 January 2021

A common polymorphism acts as an intragenic modifier of mutant p53 behaviour

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7 January 2021

Temperature-sensitive mutants of p53 homologs

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7 January 2021

Molecular genetics of small cell lung carcinoma

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7 January 2021

Death signal-induced localization of p53 protein to mitochondria. A potential role in apoptotic signaling

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7 January 2021

Hypoxia death stimulus induces translocation of p53 protein to mitochondria. Detection by immunofluorescence on whole cells

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7 January 2021

Versatility of the mitochondrial protein import machinery

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7 January 2021

The corepressor mSin3a interacts with the proline-rich domain of p53 and protects p53 from proteasome-mediated degradation

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7 January 2021

An intact HDM2 RING-finger domain is required for nuclear exclusion of p53.

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7 January 2021

The MDM2 RING-finger domain is required to promote p53 nuclear export

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7 January 2021

Proteolytic cleavage of the mdm2 oncoprotein during apoptosis

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7 January 2021

A Role for the Polyproline Domain of p53 in Its Regulation by Mdm2

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7 January 2021

Protein regulation by monoubiquitin

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7 January 2021

Nix and Nip3 form a subfamily of pro-apoptotic mitochondrial proteins

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7 January 2021

Mitochondrio-nuclear translocation of AIF in apoptosis and necrosis

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7 January 2021

Presence of a pre-apoptotic complex of pro-caspase-3, Hsp60 and Hsp10 in the mitochondrial fraction of jurkat cells

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7 January 2021

Hsp60 accelerates the maturation of pro-caspase-3 by upstream activator proteases during apoptosis

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7 January 2021

Determination of the allelic frequencies of an L-myc and a p53 polymorphism in human lung cancer.

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7 January 2021

P53 polymorphisms and haplotypes in lung cancer

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7 January 2021

p53 codon 72 polymorphism and risk of cervical cancer in UK.

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7 January 2021

Identifiers

DOI

10.1038/NG1093

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Dimensions Publication ID

22 September 2017

1003113338

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