(Q40640846)

22 September 2017

title

APP intracellular domain formation and unaltered signaling in the presence of familial Alzheimer's disease mutations (English)

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22 September 2017

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Helena Karlström

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Dorota Religa

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Bengt Winblad

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22 September 2017

Lars Lannfelt

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22 September 2017

Anna Bergman

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22 September 2017

Hanna Laudon

series ordinal

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22 September 2017

Johan Lundkvist

series ordinal

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22 September 2017

Jan Näslund

series ordinal

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22 September 2017

language of work or name

English

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publication date

1 July 2003

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Experimental Cell Research

22 September 2017

published in

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22 September 2017

volume

287

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22 September 2017

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22 September 2017

page(s)

1-9

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Alzheimer's disease: genes, proteins, and therapy

22 September 2017

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1 reference

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7 January 2021

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Regulated intramembrane proteolysis: a control mechanism conserved from bacteria to humans

7 January 2021

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A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

7 January 2021

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A presenilin-1/gamma-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions

7 January 2021

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Proteolytic release of CD44 intracellular domain and its role in the CD44 signaling pathway

7 January 2021

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Presenilin-dependent intramembrane proteolysis of CD44 leads to the liberation of its intracellular domain and the secretion of an Abeta-like peptide

7 January 2021

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gamma -Secretase cleavage and nuclear localization of ErbB-4 receptor tyrosine kinase

7 January 2021

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Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo

7 January 2021

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Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

7 January 2021

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Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing

7 January 2021

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APH-1 is a multipass membrane protein essential for the Notch signaling pathway in Caenorhabditis elegans embryos

7 January 2021

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aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation

7 January 2021

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7 January 2021

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Seeding "one-dimensional crystallization" of amyloid: a pathogenic mechanism in Alzheimer's disease and scrapie?

7 January 2021

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Visualization of A beta 42(43) and A beta 40 in senile plaques with end-specific A beta monoclonals: evidence that an initially deposited species is A beta 42(43).

7 January 2021

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Presenilin-dependent gamma-secretase processing of beta-amyloid precursor protein at a site corresponding to the S3 cleavage of Notch

7 January 2021

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A novel epsilon-cleavage within the transmembrane domain of the Alzheimer amyloid precursor protein demonstrates homology with Notch processing

7 January 2021

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Characterization of a presenilin-mediated amyloid precursor protein carboxyl-terminal fragment gamma. Evidence for distinct mechanisms involved in gamma -secretase processing of the APP and Notch1 transmembrane domains

7 January 2021

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Presenilin 1 mutations activate gamma 42-secretase but reciprocally inhibit epsilon-secretase cleavage of amyloid precursor protein (APP) and S3-cleavage of notch

7 January 2021

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A RIP tide in neuronal signal transduction

7 January 2021

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A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60

7 January 2021

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A sensitive and quantitative assay for measuring cleavage of presenilin substrates

7 January 2021

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Notch receptor cleavage depends on but is not directly executed by presenilins

7 January 2021

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Mice lacking both presenilin genes exhibit early embryonic patterning defects

7 January 2021

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Correlation between elevated levels of amyloid beta-peptide in the brain and cognitive decline

7 January 2021

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L-685,458, an aspartyl protease transition state mimic, is a potent inhibitor of amyloid beta-protein precursor gamma-secretase activity

7 January 2021

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Functional gamma-secretase inhibitors reduce beta-amyloid peptide levels in brain

7 January 2021

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Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain

7 January 2021

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Retention of the Alzheimer's amyloid precursor fragment C99 in the endoplasmic reticulum prevents formation of amyloid beta-peptide

7 January 2021

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Presenilins are not required for A beta 42 production in the early secretory pathway

7 January 2021

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Nonfibrillar diffuse amyloid deposition due to a gamma(42)-secretase site mutation points to an essential role for N-truncated A beta(42) in Alzheimer's disease

7 January 2021

1 reference

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A new pathogenic mutation in the APP gene (I716V) increases the relative proportion of A beta 42(43)

7 January 2021

1 reference

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The intracellular domain of the beta-amyloid precursor protein is stabilized by Fe65 and translocates to the nucleus in a notch-like manner

7 January 2021

1 reference

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The amyloid precursor protein (APP)-cytoplasmic fragment generated by gamma-secretase is rapidly degraded but distributes partially in a nuclear fraction of neurones in culture

7 January 2021

1 reference

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Direct visualization of the gamma secretase-generated carboxyl-terminal domain of the amyloid precursor protein: association with Fe65 and translocation to the nucleus

7 January 2021

1 reference

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A physiologic signaling role for the gamma -secretase-derived intracellular fragment of APP.

7 January 2021

1 reference

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Presenilin-1 mutations of leucine 166 equally affect the generation of the Notch and APP intracellular domains independent of their effect on Abeta 42 production

7 January 2021

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Alzheimer's disease: a dysfunction of the amyloid precursor protein(1).

7 January 2021

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Intrinsic signaling function of APP as a novel target of three V642 mutations linked to familial Alzheimer's disease.

7 January 2021

1 reference

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Presenilins mediate a dual intramembranous gamma-secretase cleavage of Notch-1.

7 January 2021

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New protease inhibitors prevent gamma-secretase-mediated production of Abeta40/42 without affecting Notch cleavage

7 January 2021

1 reference

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10.1016/S0014-4827(03)00117-4

7 January 2021

Identifiers

DOI

1 reference

22 September 2017

1 reference