(Q40718061)

English

Presenilin 1 mutations activate gamma 42-secretase but reciprocally inhibit epsilon-secretase cleavage of amyloid precursor protein (APP) and S3-cleavage of notch

scientific article published on 15 July 2002

In more languages

default for all languages

No label defined

No description defined

Statements

scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

23 September 2017

Presenilin 1 mutations activate gamma 42-secretase but reciprocally inhibit epsilon-secretase cleavage of amyloid precursor protein (APP) and S3-cleavage of notch (English)

1 reference

Europe PubMed Central

PubMed publication ID

23 September 2017

Peter Henry St George-Hyslop

object named as

Peter St George-Hyslop

9

0 references

author name string

Fusheng Chen

1

1 reference

Europe PubMed Central

PubMed publication ID

23 September 2017

YongJun Gu

2

1 reference

Europe PubMed Central

PubMed publication ID

23 September 2017

Hiroshi Hasegawa

3

1 reference

Europe PubMed Central

PubMed publication ID

23 September 2017

Xueying Ruan

4

1 reference

Europe PubMed Central

PubMed publication ID

23 September 2017

Shigeki Arawaka

5

1 reference

Europe PubMed Central

PubMed publication ID

23 September 2017

Paul Fraser

6

1 reference

Europe PubMed Central

PubMed publication ID

23 September 2017

David Westaway

7

1 reference

Europe PubMed Central

PubMed publication ID

23 September 2017

Howard Mount

8

1 reference

Europe PubMed Central

PubMed publication ID

23 September 2017

language of work or name

0 references

publication date

15 July 2002

1 reference

Europe PubMed Central

PubMed publication ID

23 September 2017

Journal of Biological Chemistry

1 reference

Europe PubMed Central

PubMed publication ID

23 September 2017

277

1 reference

Europe PubMed Central

PubMed publication ID

23 September 2017

39

1 reference

Europe PubMed Central

PubMed publication ID

23 September 2017

36521-36526

1 reference

Europe PubMed Central

PubMed publication ID

23 September 2017

A novel epsilon-cleavage within the transmembrane domain of the Alzheimer amyloid precursor protein demonstrates homology with Notch processing

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205093200

21 January 2018

The amyloid precursor protein (APP)-cytoplasmic fragment generated by gamma-secretase is rapidly degraded but distributes partially in a nuclear fraction of neurones in culture

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205093200

21 January 2018

Presenilin-dependent gamma-secretase processing of beta-amyloid precursor protein at a site corresponding to the S3 cleavage of Notch

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205093200

21 January 2018

Characterization of a presenilin-mediated amyloid precursor protein carboxyl-terminal fragment gamma. Evidence for distinct mechanisms involved in gamma -secretase processing of the APP and Notch1 transmembrane domains

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205093200

21 January 2018

A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205093200

21 January 2018

Proteolytic release and nuclear translocation of Notch-1 are induced by presenilin-1 and impaired by pathogenic presenilin-1 mutations

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205093200

21 January 2018

Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205093200

21 January 2018

Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205093200

21 January 2018

Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205093200

21 January 2018

Assessment of normal and mutant human presenilin function in Caenorhabditis elegans

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205093200

21 January 2018

Human presenilin-1, but not familial Alzheimer's disease (FAD) mutants, facilitate Caenorhabditis elegans Notch signalling independently of proteolytic processing

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205093200

21 January 2018

A loss of function mutant of the presenilin homologue SEL-12 undergoes aberrant endoproteolysis in Caenorhabditis elegans and increases abeta 42 generation in human cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205093200

21 January 2018

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205093200

21 January 2018

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205093200

21 January 2018

Nicastrin binds to membrane-tethered Notch

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205093200

21 January 2018

Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205093200

21 January 2018

Mechanism of the cleavage specificity of Alzheimer's disease gamma-secretase identified by phenylalanine-scanning mutagenesis of the transmembrane domain of the amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205093200

21 January 2018

Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205093200

21 January 2018

Carboxyl-terminal fragments of Alzheimer beta-amyloid precursor protein accumulate in restricted and unpredicted intracellular compartments in presenilin 1-deficient cells.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205093200

21 January 2018

Improved electrophoretic separation and immunoblotting of beta-amyloid (A beta) peptides 1-40, 1-42, and 1-43.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205093200

21 January 2018

A loss of function mutation of presenilin-2 interferes with amyloid beta-peptide production and notch signaling

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205093200

21 January 2018

New protease inhibitors prevent gamma-secretase-mediated production of Abeta40/42 without affecting Notch cleavage

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205093200

21 January 2018

Separation of presenilin function in amyloid beta-peptide generation and endoproteolysis of Notch

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205093200

21 January 2018

An Alzheimer's disease-linked PS1 variant rescues the developmental abnormalities of PS1-deficient embryos.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205093200

21 January 2018

Screening for PS1 mutations in a referral-based series of AD cases: 21 novel mutations

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205093200

21 January 2018

Distinct intramembrane cleavage of the beta-amyloid precursor protein family resembling gamma-secretase-like cleavage of Notch

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205093200

21 January 2018

Mutation of the conserved N-terminal cysteine (Cys92) of human presenilin 1 causes increased A beta42 secretion in mammalian cells but impaired Notch/lin-12 signalling in C. elegans

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205093200

21 January 2018

Presenilin-1 and -2 are molecular targets for gamma-secretase inhibitors

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205093200

21 January 2018

Mutations in the transmembrane domain of APP altering gamma-secretase specificity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205093200

21 January 2018

Identifiers

10.1074/JBC.M205093200

1 reference

Europe PubMed Central

PubMed publication ID

23 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

23 September 2017

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q40718061&oldid=2210109166"