Flaviviridae
Flaviviridae sunt familia virorum, quibus homines et alia mammalia ut hostes naturales prosunt. Flaviviridae maximam partem extenduntur per vectores inter arthropoda, plerumque culicidas et ixodida. Familia ex febri flava appellatur, morbo a viro typico Flaviviridarum effecto. Febris flava vicissim appellatur, quia morbum regium in aegris efficere solet.[1] Sunt in familia plus quam centum species, in quattuor genera digestae. Inter morbos notissimos cum hac familia consociatos sunt hepatitis (hepacivira); syndromae haemorrhagicae, abortus, et morbus mucosus fatalis (pestivira); ac febris haemorrhagica et encephalitis (flavivira).[2][3]
Taxinomia
[recensere | fontem recensere]- Genus Flavivirus (typus generis viri febris flavae); alia sunt virus Nili Occidentalis, febris dengue, et virus Zikanum); genus comprehendit sexaginta septem agnota hominum animaliumque vira
- Genus Hepacivirus (typus generis Hepatitis C virus[4]; genus comprehendit GB virus B)
- Genus Pegivirus; comprehendit GB virus A, GB virus C, et GB virus D
- Genus Pestivirus (typus generis diarrhoea viri bovini; inter alia sunt febris suidarum classicum, "cholera porcorum"); genus comprehendit vira, quae mammalia non humana afficiunt.
Genoma
[recensere | fontem recensere]Flaviviridis sunt genomata RNA monopartita, linearia, singulis polaritatis positivae filis, a 9.6 ad 12.3 chiliobases longa. Flaviviridarum 5'-termini methylatum nucleotidorum tegimen ferunt, cum alia huius familiae vira tegimino carent et internum situm aditialem ribosomatum habent.
Structura viriontum
[recensere | fontem recensere]Particulae virales involvuntur geometriis icosahedralibus et sphaericis, circa 40–60 nanometra per diametrum.[2]
| Genus | Structura | Symmetria | Capsidum | Ordinatio genomica | Segmentatio genomica |
|---|---|---|---|---|---|
| Hepacivirus | Quasi icosahedrale | Pseudo T=3 | Involutum | Lineare | Monopartitum |
| Flavivirus | Quasi icosahedrale | Pseudo T=3 | Involutum | Lineare | Monopartitum |
| Pegivirus | Qusai icosahedrale | Pseudo T=3 | Involutum | Lineare | Monopartitum |
| Pestivirus | Quasi icosahedrale | Pseudo T=3 | Involutum | Lineare | Monopartitum |
Momentum clinicum
[recensere | fontem recensere]Inter maiores morbos a Flaviviridis effectos sunt:
Notae
[recensere | fontem recensere]- ↑ "Flaviviridae". Microbe Wiki
- ↑ 2.0 2.1 "Viral Zone". ExPASy
- ↑ ICTV. "Virus Taxonomy: 2014 Release"
- ↑ Paula et al. 2009.
Bibliographia
[recensere | fontem recensere]- Paula, T., Pablo R., Eugenia V., Pablo B., Sabino P., et José M. 2009. New drug targets for hepatitis C and other Flaviviridae viruses. Infect. Disord. Drug Targets 9(2):133–147. PMID 19275702. doi:10.2174/187152609787847749.
Nexus externi
[recensere | fontem recensere]- "Flaviviridae," www.ncbi.nlm.nih.gov (NCBI Taxonomy Browser)
- "Flaviviridae," viralzone.expasy.org (Viralzone)
- "'Flaviviridae," www.viprbrc.org (Virus Pathogen Resource, ViPR)
- "Flaviviridae Genomes," www.vbrc.org (Viral Bioinformatics Resource Center)
- De taxinomia virorum, ictvonline.org (International Committee on Taxonomy of Viruses)