CYP2C9

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Cytochroma P450 CYP2C9 (-atis, n.) (Numerus EC: 1.14.13.48) est haemoproteinum et pars gregis cytochromatum P450.

Natura structuraque biochemica

Cytochroma P450 CYP2C9 est et polypeptidum et haemoproteinum, quod ex 490 acidis aminicis (massa 55.628 Da) constitutum est. Intra cellulam enzymum hoc in ancoris membranae stat^[1].

Genetica

Nomen geni cytochromatis est CYP2C9 locus cuius geneticus in chromosomate 10 humano locatus est (10q23.33).

Pharmaca ad CYP2C9 relata

Substrati	Inhibitores^[4]	Inductores^[5]
Pharmaca relata ad CYP2C9^[2]^[3].
AINS (antinflammatoria nonsteroidalia) Celecoxibum Etoricoxibum Diclofenac Ibuprofenum^[6] Naproxenum Antidepressiva Amitriptylinum Fluoxetinum Inhibitor receptorii angiotensini II Candesartanum Irbesartanum Losartanum Sulphonylureae primae generationis Tolbutamidum secundae generationis Glipizidum Glibenclamidum Glimepiridum Glyburidum Tamoxifenum Fluvastatinum Ketaminum Torasemidum Cannabis	Fluconazolum (forte) Acidum valproicum (forte) Amiodaronum Antidepressiva Sertralinum Statini Fluvastatinum Lovastatinum	Rifampicinum (forte) Secobarbitalum (forte) Phenobarbitalum

Notae

↑ Cojocaru V, Balali-Mood K, Sansom MS, Wade RC (2011). "Structure and dynamics of the membrane-bound cytochrome P450 2C9". PLoS Comput Biol 7 (8): e1002152
↑ Cozza KL, Armstrong SC (2001). The Cytochrome P450 System. Drug Interaction Principles for Medical Practice. Washington, DC: American Psychiatric Publishing
↑ Preskorn SH (1996). Clinical Pharmacology of Selective Serotonin Reuptake Inhibitors. 1st ed.: Professional Communications, Inc.
↑ Inhibitor cum subtratorum effectibus fortioribus
↑ Inductor cum subtratorum effectibus minoribus
↑ Berka K, Hendrychová T, Anzenbacher P, Otyepka M (2011). "Membrane position of ibuprofen agrees with suggested access path entrance to cytochrome P450 2C9 active site". J Phys Chem A 115 (41): 11248-55

Nexus externi

Descriptio genetica CYP2C9: https://ghr.nlm.nih.gov/gene/CYP2C9#

[1] Cojocaru V, Balali-Mood K, Sansom MS, Wade RC (2011). "Structure and dynamics of the membrane-bound cytochrome P450 2C9". PLoS Comput Biol 7 (8): e1002152

[2] Cozza KL, Armstrong SC (2001). The Cytochrome P450 System. Drug Interaction Principles for Medical Practice. Washington, DC: American Psychiatric Publishing

[3] Preskorn SH (1996). Clinical Pharmacology of Selective Serotonin Reuptake Inhibitors. 1st ed.: Professional Communications, Inc.

[4] Inhibitor cum subtratorum effectibus fortioribus

[5] Inductor cum subtratorum effectibus minoribus

[6] Berka K, Hendrychová T, Anzenbacher P, Otyepka M (2011). "Membrane position of ibuprofen agrees with suggested access path entrance to cytochrome P450 2C9 active site". J Phys Chem A 115 (41): 11248-55

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