DHX16

DHX16
Identifiers
Aliases	DHX16, DBP2, DDX16, PRO2014, PRP8, PRPF2, Prp2, DEAH-box helicase 16, NMOAS
External IDs	OMIM: 603405; MGI: 1916442; HomoloGene: 2658; GeneCards: DHX16; OMA:DHX16 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	30,673,006 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	36,203,562 bp
RNA expression pattern
	Top expressed in
	sural nerve; ; granulocyte; ; left testis; ; right testis; ; right uterine tube; ; right lobe of thyroid gland; ; left lobe of thyroid gland; ; spleen; ; minor salivary glands; ; duodenum;
	Top expressed in
	neural layer of retina; ; granulocyte; ; morula; ; morula; ; thymus; ; ventricular zone; ; epiblast; ; blastocyst; ; medullary collecting duct; ; hair follicle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	RNA helicase activity; nucleotide binding; protein binding; ATP binding; helicase activity; hydrolase activity; nucleic acid binding; ATPase activity; RNA binding; 3'-5' RNA helicase activity;
Cellular component	spliceosomal complex; nucleus; cytoplasm; nucleoplasm; U2-type precatalytic spliceosome;
Biological process	mRNA processing; RNA splicing; mRNA splicing, via spliceosome; metabolism;
	Sources:Amigo / QuickGO
Orthologs
	8449
	69192
ENSG00000233561; ENSG00000206486; ENSG00000233418; ENSG00000231377; ENSG00000227222;
	ENSG00000204560; ENSG00000233049; ENSG00000226171
	ENSMUSG00000024422
	O60231; Q5SQH5
	n/a
	NM_001164239; NM_003587; NM_001363515
	NM_026987
	NP_001157711; NP_003578; NP_001350444
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 is an enzyme that in humans is encoded by the DHX16 gene.^[5]^[6]

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is a functional homolog of fission yeast Prp8 protein involved in cell cycle progression. This gene is mapped to the MHC region on chromosome 6p21.3, a region where many malignant, genetic and autoimmune disease genes are linked.^[6]

References

^ ^a ^b ^c ENSG00000206486, ENSG00000233418, ENSG00000231377, ENSG00000227222, ENSG00000204560, ENSG00000233049, ENSG00000226171 GRCh38: Ensembl release 89: ENSG00000233561, ENSG00000206486, ENSG00000233418, ENSG00000231377, ENSG00000227222, ENSG00000204560, ENSG00000233049, ENSG00000226171 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000024422 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Imamura O, Saiki K, Tani T, Ohshima Y, Sugawara M, Furuichi Y (Jun 1998). "Cloning and characterization of a human DEAH-box RNA helicase, a functional homolog of fission yeast Cdc28/Prp8". Nucleic Acids Res. 26 (9): 2063–8. doi:10.1093/nar/26.9.2063. PMC 147520. PMID 9547260.
^ ^a ^b "Entrez Gene: DHX16 DEAH (Asp-Glu-Ala-His) box polypeptide 16".

Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Nakayama M, Kikuno R, Ohara O (2003). "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs". Genome Res. 12 (11): 1773–84. doi:10.1101/gr.406902. PMC 187542. PMID 12421765.
Nagase T, Ishikawa K, Miyajima N, et al. (1998). "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (1): 31–9. CiteSeerX 10.1.1.610.1181. doi:10.1093/dnares/5.1.31. PMID 9628581.

This article on a gene on human chromosome 6 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] ENSG00000206486, ENSG00000233418, ENSG00000231377, ENSG00000227222, ENSG00000204560, ENSG00000233049, ENSG00000226171 GRCh38: Ensembl release 89: ENSG00000233561, ENSG00000206486, ENSG00000233418, ENSG00000231377, ENSG00000227222, ENSG00000204560, ENSG00000233049, ENSG00000226171 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000024422 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9547260-5] Imamura O, Saiki K, Tani T, Ohshima Y, Sugawara M, Furuichi Y (Jun 1998). "Cloning and characterization of a human DEAH-box RNA helicase, a functional homolog of fission yeast Cdc28/Prp8". Nucleic Acids Res. 26 (9): 2063–8. doi:10.1093/nar/26.9.2063. PMC 147520. PMID 9547260.

[entrez-6] "Entrez Gene: DHX16 DEAH (Asp-Glu-Ala-His) box polypeptide 16".

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References

Further reading