ADAMTS13

ADAMTS13
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 3GHM, 3GHN
Dynodwyr
Cyfenwau	ADAMTS13, ADAM-TS13, ADAMTS-13, C9orf8, VWFCP, vWF-CP, ADAM metallopeptidase with thrombospondin type 1 motif 13
Dynodwyr allanol	OMIM: 604134 HomoloGene: 16372 GeneCards: ADAMTS13
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • calcium ion binding • endopeptidase activity • metal ion binding • integrin binding • GO:0070122 peptidase activity • GO:0001948, GO:0016582 protein binding • metalloendopeptidase activity • hydrolase activity • metallopeptidase activity • zinc ion binding Cydrannau o'r gell • endoplasmic reticulum lumen • extracellular region • cell surface • extracellular space • GO:0005578 extracellular matrix Prosesau biolegol • hemostasis • glycoprotein metabolic process • response to interleukin-4 • response to interferon-gamma • protein processing • blood coagulation • proteolysis • platelet activation • response to tumor necrosis factor • integrin-mediated signaling pathway • cell-matrix adhesion • response to toxic substance • peptide catabolic process • response to potassium ion • cellular response to interferon-gamma • cellular response to lipopolysaccharide • response to amine • cellular response to interleukin-4 • cellular response to tumor necrosis factor Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	11093	n/a
Ensembl	ENSG00000160323 ENSG00000281244	n/a
UniProt	Q76LX8	n/a
RefSeq (mRNA)	NM_139025 NM_139026 NM_139027 NM_139028	n/a
RefSeq (protein)	NP_620594 NP_620595 NP_620596	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn ADAMTS13 yw ADAMTS13 a elwir hefyd yn ADAM metallopeptidase with thrombospondin type 1 motif 13 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 9, band 9q34.2.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn ADAMTS13.

• "A common mechanism by which type 2A von Willebrand disease mutations enhance ADAMTS13 proteolysis revealed with a von Willebrand factor A2 domain FRET construct. ". PLoS One. 2017. PMID 29186156.
• "Diagnosis of thrombotic thrombocytopenic purpura among patients with ADAMTS13 Activity 10%-20. ". Am J Hematol. 2017. PMID 28815685.
• "Expression of ADAMTS13 in Normal and Abnormal Placentae and Its Potential Role in Angiogenesis and Placenta Development. ". Arterioscler Thromb Vasc Biol. 2017. PMID 28751574.
• "Presenting ADAMTS13 antibody and antigen levels predict prognosis in immune-mediated thrombotic thrombocytopenic purpura. ". Blood. 2017. PMID 28576877.
• "Reduced ADAMTS-13 level negatively correlates with inflammation factors in plasma of acute myeloid leukemia patients.". Leuk Res. 2017. PMID 28033504.