The Major Heat Shock Proteins, Hsp70 and Hsp90, in 2-Methoxyestradiol-Mediated Osteosarcoma Cell Death Model (Q92812242)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31963524%20AND%20SRC:MED&resulttype=core&format=json

1 May 2020

title

The Major Heat Shock Proteins, Hsp70 and Hsp90, in 2-Methoxyestradiol-Mediated Osteosarcoma Cell Death Model (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31963524%20AND%20SRC:MED&resulttype=core&format=json

1 May 2020

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Magdalena Gorska-Ponikowska

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31963524%20AND%20SRC:MED&resulttype=core&format=json

1 May 2020

Alicja Kuban-Jankowska

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31963524%20AND%20SRC:MED&resulttype=core&format=json

1 May 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31963524%20AND%20SRC:MED&resulttype=core&format=json

1 May 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31963524%20AND%20SRC:MED&resulttype=core&format=json

1 May 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31963524%20AND%20SRC:MED&resulttype=core&format=json

1 May 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31963524%20AND%20SRC:MED&resulttype=core&format=json

1 May 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31963524%20AND%20SRC:MED&resulttype=core&format=json

Antonella Marino Gammazza

1 May 2020

series ordinal

object named as

Antonella Marino Gammazza

1 reference

1 May 2020

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31963524%20AND%20SRC:MED&resulttype=core&format=json

Hue H Luu

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1 May 2020

publication date

17 January 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31963524%20AND%20SRC:MED&resulttype=core&format=json

International Journal of Molecular Sciences

1 May 2020

published in

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1 May 2020

volume

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1 May 2020

issue

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Creative Commons Attribution 4.0 International

1 May 2020

start time

17 January 2020

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April 2022 Public Data File from Crossref

copyrighted

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describes a project that uses

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC7014403/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

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2-Methoxyestradiol Affects Mitochondrial Biogenesis Pathway and Succinate Dehydrogenase Complex Flavoprotein Subunit A in Osteosarcoma Cancer Cells

11 February 2021

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2-Methoxyestradiol Reverses the Pro-Carcinogenic Effect of L-Lactate in Osteosarcoma 143B Cells

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2-methoxyestradiol impacts on amino acids-mediated metabolic reprogramming in osteosarcoma cells by its interaction with NMDA receptor.

11 February 2021

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11 February 2021

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Neuronal Nitric Oxide Synthase-Mediated Genotoxicity of 2-Methoxyestradiol in Hippocampal HT22 Cell Line

11 February 2021

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DNA strand breaks induced by nuclear hijacking of neuronal NOS as an anti-cancer effect of 2-methoxyestradiol

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Neuronal nitric oxide synthase induction in the antitumorigenic and neurotoxic effects of 2-methoxyestradiol.

11 February 2021

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Nuclear recruitment of neuronal nitric-oxide synthase by α-syntrophin is crucial for the induction of mitochondrial biogenesis

11 February 2021

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The E-F hand calcium-binding protein S100A4 regulates the proliferation, survival and differentiation potential of human osteosarcoma cells

11 February 2021

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Regulation of endothelial nitric oxide synthase activity by protein-protein interaction.

11 February 2021

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11 February 2021

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Targeted inhibition of heat shock protein 90 disrupts multiple oncogenic signaling pathways, thus inducing cell cycle arrest and programmed cell death in human urinary bladder cancer cell lines

11 February 2021

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11 February 2021

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Ubiquitination of neuronal nitric-oxide synthase in the calmodulin-binding site triggers proteasomal degradation of the protein

11 February 2021

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11 February 2021

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Modulation of heme/substrate binding cleft of neuronal nitric-oxide synthase (nNOS) regulates binding of Hsp90 and Hsp70 proteins and nNOS ubiquitination

11 February 2021

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11 February 2021

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11 February 2021

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Insulin-like growth factor binding protein 5 suppresses tumor growth and metastasis of human osteosarcoma

11 February 2021

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A phase II study of 2-methoxyestradiol nanocrystal colloidal dispersion alone and in combination with sunitinib malate in patients with metastatic renal cell carcinoma progressing on sunitinib malate

11 February 2021

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A prospective phase II study of 2-methoxyestradiol administered in combination with bevacizumab in patients with metastatic carcinoid tumors

11 February 2021

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A phase II study of 2-methoxyestradiol (2ME2) NanoCrystal® dispersion (NCD) in patients with taxane-refractory, metastatic castrate-resistant prostate cancer (CRPC).

11 February 2021

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11 February 2021

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2-Methoxyestradiol--biology and mechanism of action

11 February 2021

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11 February 2021

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A phase I dose-escalation, safety and pharmacokinetic study of the 2-methoxyestradiol analog ENMD-1198 administered orally to patients with advanced cancer

11 February 2021

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Geldanamycin inhibits TGF-beta signaling through induction of Hsp70.

11 February 2021

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Dynamic cycling with Hsp90 stabilizes neuronal nitric oxide synthase through calmodulin-dependent inhibition of ubiquitination

11 February 2021

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Activity of 2 methoxyestradiol (Panzem NCD) in advanced, platinum-resistant ovarian cancer and primary peritoneal carcinomatosis: a Hoosier Oncology Group trial.

11 February 2021

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Establishment and characterization of a new highly metastatic human osteosarcoma cell line

11 February 2021

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11 February 2021

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Phase I trial of 2-methoxyestradiol NanoCrystal dispersion in advanced solid malignancies

11 February 2021

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11 February 2021

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The Hsp90 chaperone machinery regulates signaling by modulating ligand binding clefts

11 February 2021

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Concerted actions of multiple transcription elements confer differential transactivation of HSP90 isoforms in geldanamycin-treated 9L rat gliosarcoma cells

11 February 2021

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Geldanamycin enhances hepatocyte growth factor stimulation of eNOS phosphorylation in endothelial cells

11 February 2021

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Inhibitors of the heat shock response: biology and pharmacology

11 February 2021

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11 February 2021

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Targeting of multiple signalling pathways by heat shock protein 90 molecular chaperone inhibitors

11 February 2021

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Heat shock protein 60 or 70 activates nitric-oxide synthase (NOS) I- and inhibits NOS II-associated signaling and depresses the mitochondrial apoptotic cascade during brain stem death

11 February 2021

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2-Methoxyestradiol suppresses microtubule dynamics and arrests mitosis without depolymerizing microtubules

11 February 2021

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Phase I safety, pharmacokinetic and pharmacodynamic studies of 2-methoxyestradiol alone or in combination with docetaxel in patients with locally recurrent or metastatic breast cancer

11 February 2021

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Differential expression of Hsp90 isoforms in geldanamycin-treated 9L cells

11 February 2021

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Mitogenic estrogen metabolites alter the expression of 17beta-estradiol-regulated proteins including heat shock proteins in human MCF-7 breast cancer cells.

11 February 2021

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Phase I clinical trial of oral 2-methoxyestradiol, an antiangiogenic and apoptotic agent, in patients with solid tumors

11 February 2021

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A phase II multicenter, randomized, double-blind, safety trial assessing the pharmacokinetics, pharmacodynamics, and efficacy of oral 2-methoxyestradiol capsules in hormone-refractory prostate cancer

11 February 2021

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2-methoxyestradiol inhibits hypoxia-inducible factor 1alpha, tumor growth, and angiogenesis and augments paclitaxel efficacy in head and neck squamous cell carcinoma

11 February 2021

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Expressional patterns of chaperones in ten human tumor cell lines.

11 February 2021

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Hsp90 inhibitors deplete key anti-apoptotic proteins in pediatric solid tumor cells and demonstrate synergistic anticancer activity with cisplatin

11 February 2021

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The role of hsp90 in heme-dependent activation of apo-neuronal nitric-oxide synthase

11 February 2021

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Evidence of nuclear localization of neuronal nitric oxide synthase in cultured astrocytes of rats

11 February 2021

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Nuclear translocation of the Hsp70/Hsp90 organizing protein mSTI1 is regulated by cell cycle kinases.

11 February 2021

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New insights into 2-methoxyestradiol, a promising antiangiogenic and antitumor agent

11 February 2021

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Inhibition of superoxide generation from neuronal nitric oxide synthase by heat shock protein 90: implications in NOS regulation

11 February 2021

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2-Methoxyestradiol inhibits proliferation and induces apoptosis independently of estrogen receptors alpha and beta

11 February 2021

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hsp90 is required for heme binding and activation of apo-neuronal nitric-oxide synthase: geldanamycin-mediated oxidant generation is unrelated to any action of hsp90.

11 February 2021

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Determination of the enhancing action of HSP90 on neuronal nitric oxide synthase by EPR spectroscopy

11 February 2021

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The C-terminal half of Hsp90 is responsible for its cytoplasmic localization

11 February 2021

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Heat-shock protein 90 augments neuronal nitric oxide synthase activity by enhancing Ca2+/calmodulin binding

11 February 2021

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2-Methoxyestradiol: an endogenous antiangiogenic and antiproliferative drug candidate

11 February 2021

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Geldanamycin induces heat shock protein expression through activation of HSF1 in K562 erythroleukemic cells

11 February 2021

1 reference

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The stabilization mechanism of mutant-type p53 by impaired ubiquitination: the loss of wild-type p53 function and the hsp90 association

11 February 2021

1 reference

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Neuronal nitric-oxide synthase is regulated by the Hsp90-based chaperone system in vivo

11 February 2021

1 reference

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Dynamic activation of endothelial nitric oxide synthase by Hsp90.

11 February 2021

1 reference

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The mammalian metabolite, 2-methoxyestradiol, affects p53 levels and apoptosis induction in transformed cells but not in normal cells

11 February 2021

1 reference

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2,7‐Dihydrodichlorofluorescein diacetate as a fluorescent marker for peroxynitrite formation

11 February 2021

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Potent inhibition of inducible nitric oxide synthase by geldanamycin, a tyrosine kinase inhibitor, in endothelial, smooth muscle cells, and in rat aorta

11 February 2021

1 reference

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Nitric oxide synthases: gene structure and regulation.

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7014403

The endogenous oestrogen metabolite 2-methoxyoestradiol inhibits angiogenesis and suppresses tumour growth

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7014403

11 February 2021

Identifiers

DOI

10.3390/IJMS21020616

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31963524%20AND%20SRC:MED&resulttype=core&format=json

1 May 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31963524%20AND%20SRC:MED&resulttype=core&format=json

1 May 2020

PubMed publication ID

31963524

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31963524%20AND%20SRC:MED&resulttype=core&format=json