Phase I safety, pharmacokinetic and pharmacodynamic studies of 2-methoxyestradiol alone or in combination with docetaxel in patients with locally recurrent or metastatic breast cancer (Q80253632)

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scientific article published on 13 September 2006

Language	Label	Description	Also known as
English	Phase I safety, pharmacokinetic and pharmacodynamic studies of 2-methoxyestradiol alone or in combination with docetaxel in patients with locally recurrent or metastatic breast cancer	scientific article published on 13 September 2006

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16969706%20AND%20SRC:MED&resulttype=core&format=json

30 December 2019

Phase I safety, pharmacokinetic and pharmacodynamic studies of 2-methoxyestradiol alone or in combination with docetaxel in patients with locally recurrent or metastatic breast cancer (English)

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16969706%20AND%20SRC:MED&resulttype=core&format=json

30 December 2019

2-methoxyestradiol

1 reference

ChEBI release 2020-05-28

metastatic breast cancer

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

pharmacokinetics

1 reference

based on heuristic

inferred from title

pharmacodynamics

1 reference

based on heuristic

inferred from title

Kathy D. Miller

7

object named as

Kathy D Miller

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16969706%20AND%20SRC:MED&resulttype=core&format=json

30 December 2019

5

object named as

George W Sledge

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16969706%20AND%20SRC:MED&resulttype=core&format=json

30 December 2019

author name string

Jehana James

1

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16969706%20AND%20SRC:MED&resulttype=core&format=json

30 December 2019

Daryl J Murry

2

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16969706%20AND%20SRC:MED&resulttype=core&format=json

30 December 2019

Anthony M Treston

3

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16969706%20AND%20SRC:MED&resulttype=core&format=json

30 December 2019

Anna Maria Storniolo

4

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16969706%20AND%20SRC:MED&resulttype=core&format=json

30 December 2019

Carolyn Sidor

6

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16969706%20AND%20SRC:MED&resulttype=core&format=json

30 December 2019

publication date

13 September 2006

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16969706%20AND%20SRC:MED&resulttype=core&format=json

30 December 2019

Investigational New Drugs

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16969706%20AND%20SRC:MED&resulttype=core&format=json

30 December 2019

25

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16969706%20AND%20SRC:MED&resulttype=core&format=json

30 December 2019

1

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16969706%20AND%20SRC:MED&resulttype=core&format=json

30 December 2019

41-48

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16969706%20AND%20SRC:MED&resulttype=core&format=json

30 December 2019

Angiogenesis induced by "normal" human breast tissue: a probable marker for precancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/16969706

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The antiangiogenic property of docetaxel is synergistic with a recombinant humanized monoclonal antibody against vascular endothelial growth factor or 2-methoxyestradiol but antagonized by endothelial growth factors

1 reference

https://pubmed.ncbi.nlm.nih.gov/16969706

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Uterine estrogen receptor binding of catecholestrogens and of estetrol (1,3,5(10)-estratriene-3,15α,16α,17β-tetrol)

1 reference

https://pubmed.ncbi.nlm.nih.gov/16969706

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Impact of Continuously Administered Catechol Estrogens on Uterine Growth and Luteinizing Hormone Secretion*

1 reference

https://pubmed.ncbi.nlm.nih.gov/16969706

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prognostic value of prostate-specific antigen for women with breast cancer: a large United States cohort study.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16969706

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

2-Methoxyestradiol, an endogenous estrogen metabolite, induces apoptosis in endothelial cells and inhibits angiogenesis: possible role for stress-activated protein kinase signaling pathway and Fas expression.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16969706

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Association of Tumor Angiogenesis With Bone Marrow Micrometastases in Breast Cancer Patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/16969706

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Suppression of type II collagen-induced arthritis by the endogenous estrogen metabolite 2-methoxyestradiol

1 reference

https://pubmed.ncbi.nlm.nih.gov/16969706

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A phase II multicenter, randomized, double-blind, safety trial assessing the pharmacokinetics, pharmacodynamics, and efficacy of oral 2-methoxyestradiol capsules in hormone-refractory prostate cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/16969706

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antiangiogenic activity of prostate-specific antigen

1 reference

https://pubmed.ncbi.nlm.nih.gov/16969706

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanism of action of 2-methoxyestradiol: new developments

1 reference

https://pubmed.ncbi.nlm.nih.gov/16969706

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

What Is the Evidence That Tumors Are Angiogenesis Dependent?

1 reference

https://pubmed.ncbi.nlm.nih.gov/16969706

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Generation of angiostatin-like fragments from plasminogen by prostate-specific antigen

1 reference

https://pubmed.ncbi.nlm.nih.gov/16969706

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Association between tumour angiogenesis and tumour cell shedding into effluent venous blood during breast cancer surgery

1 reference

https://pubmed.ncbi.nlm.nih.gov/16969706

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tumor angiogenesis: a new significant and independent prognostic indicator in early-stage breast carcinoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/16969706

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A multicenter phase II trial of ZD6474, a vascular endothelial growth factor receptor-2 and epidermal growth factor receptor tyrosine kinase inhibitor, in patients with previously treated metastatic breast cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/16969706

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tumor growth of FGF or VEGF transfected MCF-7 breast carcinoma cells correlates with density of specific microvessels independent of the transfected angiogenic factor

1 reference

https://pubmed.ncbi.nlm.nih.gov/16969706

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transfection of thrombospondin 1 complementary DNA into a human breast carcinoma cell line reduces primary tumor growth, metastatic potential, and angiogenesis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16969706

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The endogenous oestrogen metabolite 2-methoxyoestradiol inhibits angiogenesis and suppresses tumour growth

1 reference

https://pubmed.ncbi.nlm.nih.gov/16969706

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Potent antitumor activity of 2-methoxyestradiol in human pancreatic cancer cell lines.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16969706

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The prognostic value of angiogenesis by Chalkley counting in a confirmatory study design on 836 breast cancer patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/16969706

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Carcinogenicity of catechol estrogens in Syrian hamsters

1 reference

https://pubmed.ncbi.nlm.nih.gov/16969706

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An investigation of the relationship between estrogen, estrogen metabolites and blood cholesterol levels in ovariectomized rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/16969706

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of angiogenesis and breast cancer in mice by the microtubule inhibitors 2-methoxyestradiol and taxol

1 reference

https://pubmed.ncbi.nlm.nih.gov/16969706

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enhanced prediction of breast cancer prognosis by evaluating expression of p53 and prostate-specific antigen in combination.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16969706

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Angiogenesis: A Marker for Neoplastic Transformation of Mammary Papillary Hyperplasia

1 reference

https://pubmed.ncbi.nlm.nih.gov/16969706

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tumor angiogenesis and metastasis--correlation in invasive breast carcinoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/16969706

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Docetaxel administered on a weekly basis for metastatic breast cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/16969706

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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