Pharmacological targeting of age-related changes in skeletal muscle tissue (Q92193402)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30844535%20AND%20SRC:MED&resulttype=core&format=json

27 April 2020

title

Pharmacological targeting of age-related changes in skeletal muscle tissue (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30844535%20AND%20SRC:MED&resulttype=core&format=json

27 April 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30844535%20AND%20SRC:MED&resulttype=core&format=json

27 April 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30844535%20AND%20SRC:MED&resulttype=core&format=json

27 April 2020

publication date

4 March 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30844535%20AND%20SRC:MED&resulttype=core&format=json

27 April 2020

published in

Pharmacological Research

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30844535%20AND%20SRC:MED&resulttype=core&format=json

27 April 2020

volume

154

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30844535%20AND%20SRC:MED&resulttype=core&format=json

27 April 2020

page(s)

104191

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30844535%20AND%20SRC:MED&resulttype=core&format=json

Sarcopenia: revised European consensus on definition and diagnosis

27 April 2020

cites work

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Improving Dietary Protein Quality Reduces the Negative Effects of Physical Inactivity on Body Composition and Muscle Function

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Omega-3 fatty acid supplementation attenuates skeletal muscle disuse atrophy during two weeks of unilateral leg immobilization in healthy young women

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Disease or not, aging is easily treatable

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Sarcopenia: Aging-Related Loss of Muscle Mass and Function

23 February 2021

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Impact of drugs with anti-inflammatory effects on skeletal muscle and inflammation: A systematic literature review

23 February 2021

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Effect of testosterone replacement on measures of mobility in older men with mobility limitation and low testosterone concentrations: secondary analyses of the Testosterone Trials

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Vitamin D receptor gene polymorphisms modify the association of serum 25-hydroxyvitamin D levels with handgrip strength in the elderly in Northern China

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Muscle Wasting Diseases: Novel Targets and Treatments

23 February 2021

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Equivalent Hypertrophy and Strength Gains in β-Hydroxy-β-Methylbutyrate- or Leucine-supplemented Men

23 February 2021

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Inflammaging: a new immune-metabolic viewpoint for age-related diseases

23 February 2021

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23 February 2021

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Perspective: Protein Requirements and Optimal Intakes in Aging: Are We Ready to Recommend More Than the Recommended Daily Allowance?

23 February 2021

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The efficacy and adverse events of testosterone replacement therapy in hypogonadal men: A systematic review and meta-analysis of randomized, placebo-controlled trials

23 February 2021

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Effect of Protein Intake on Lean Body Mass in Functionally Limited Older Men: A Randomized Clinical Trial

23 February 2021

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Diet Quality and Sarcopenia in Older Adults: A Systematic Review

23 February 2021

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Mechanistic Links Underlying the Impact of C-Reactive Protein on Muscle Mass in Elderly.

23 February 2021

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The Impact of Dietary Protein or Amino Acid Supplementation on Muscle Mass and Strength in Elderly People: Individual Participant Data and Meta-Analysis of RCT's.

23 February 2021

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PGC-1α affects aging-related changes in muscle and motor function by modulating specific exercise-mediated changes in old mice

23 February 2021

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Pharmacological targeting of exercise adaptations in skeletal muscle: Benefits and pitfalls

23 February 2021

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High doses of anti-inflammatory drugs compromise muscle strength and hypertrophic adaptations to resistance training in young adults.

23 February 2021

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Role of Inactivity in Chronic Diseases: Evolutionary Insight and Pathophysiological Mechanisms.

23 February 2021

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The effect of combined resistance exercise training and vitamin D3 supplementation on musculoskeletal health and function in older adults: a systematic review and meta-analysis.

23 February 2021

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A systematic review, meta-analysis and meta-regression of the effect of protein supplementation on resistance training-induced gains in muscle mass and strength in healthy adults.

23 February 2021

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Metformin to Augment Strength Training Effective Response in Seniors (MASTERS): study protocol for a randomized controlled trial

23 February 2021

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Therapeutic Potential of Targeting the Ghrelin Pathway

23 February 2021

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Harmonized Reference Ranges for Circulating Testosterone Levels in Men of Four Cohort Studies in the United States and Europe

23 February 2021

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Role of Nuclear Receptors in Exercise-Induced Muscle Adaptations.

23 February 2021

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Androgen-mediated regulation of skeletal muscle protein balance

23 February 2021

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23 February 2021

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23 February 2021

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23 February 2021

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No effect of anti-inflammatory medication on postprandial and postexercise muscle protein synthesis in elderly men with slightly elevated systemic inflammation

23 February 2021

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High mTORC1 signaling is maintained, while protein degradation pathways are perturbed in old murine skeletal muscles in the fasted state

23 February 2021

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Quantification of GDF11 and Myostatin in Human Aging and Cardiovascular Disease.

23 February 2021

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Skeletal muscle adaptation to immobilization and subsequent retraining in elderly men: No effect of anti-inflammatory medication.

23 February 2021

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23 February 2021

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The relationship between nutrition and frailty: Effects of protein intake, nutritional supplementation, vitamin D and exercise on muscle metabolism in the elderly. A systematic review.

23 February 2021

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Activation of mTORC1 by leucine is potentiated by branched-chain amino acids and even more so by essential amino acids following resistance exercise.

23 February 2021

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Lean body mass change over 6 years is associated with dietary leucine intake in an older Danish population

23 February 2021

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Effects of Testosterone Treatment in Older Men.

23 February 2021

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Leucine partially protects muscle mass and function during bed rest in middle-aged adults

23 February 2021

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Caloric restriction and exercise "mimetics'': Ready for prime time?

23 February 2021

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23 February 2021

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Pharmacological perspectives in sarcopenia: a potential role for renin-angiotensin system blockers?

23 February 2021

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23 February 2021

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The Effect of a 12-Week Omega-3 Supplementation on Body Composition, Muscle Strength and Physical Performance in Elderly Individuals with Decreased Muscle Mass.

23 February 2021

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23 February 2021

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23 February 2021

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GDF11 Increases with Age and Inhibits Skeletal Muscle Regeneration

23 February 2021

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Fish oil-derived n-3 PUFA therapy increases muscle mass and function in healthy older adults

23 February 2021

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Effect of age on basal muscle protein synthesis and mTORC1 signaling in a large cohort of young and older men and women

23 February 2021

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Effects of testosterone on lean mass gain in elderly men: systematic review with meta-analysis of controlled and randomized studies.

23 February 2021

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23 February 2021

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Clinical effectiveness of protein and amino acid supplementation on building muscle mass in elderly people: a meta-analysis

23 February 2021

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Vitamin D signaling in myogenesis: potential for treatment of sarcopenia

23 February 2021

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Losartan improves measures of activity, inflammation, and oxidative stress in older mice.

23 February 2021

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Protein ingestion to stimulate myofibrillar protein synthesis requires greater relative protein intakes in healthy older versus younger men.

23 February 2021

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The effects of vitamin D on skeletal muscle strength, muscle mass, and muscle power: a systematic review and meta-analysis of randomized controlled trials

23 February 2021

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Optimizing IGF-I for skeletal muscle therapeutics

23 February 2021

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Making new contacts: the mTOR network in metabolism and signalling crosstalk

23 February 2021

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An antibody blocking activin type II receptors induces strong skeletal muscle hypertrophy and protects from atrophy

23 February 2021

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Signaling pathways controlling skeletal muscle mass

23 February 2021

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Effect of growth hormone on aging connective tissue in muscle and tendon: gene expression, morphology, and function following immobilization and rehabilitation

23 February 2021

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A randomized study on the effect of vitamin D₃ supplementation on skeletal muscle morphology and vitamin D receptor concentration in older women

23 February 2021

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A phase IIA randomized, placebo-controlled clinical trial to study the efficacy and safety of the selective androgen receptor modulator (SARM), MK-0773 in female participants with sarcopenia

23 February 2021

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Indomethacin in combination with exercise leads to muscle and brain inflammation in mice

23 February 2021

1 reference

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Caloric restriction and its mimetics

23 February 2021

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Sustained activation of mTORC1 in skeletal muscle inhibits constitutive and starvation-induced autophagy and causes a severe, late-onset myopathy

23 February 2021

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The GH/IGF-1 axis in ageing and longevity

23 February 2021

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Prostaglandin and myokine involvement in the cyclooxygenase-inhibiting drug enhancement of skeletal muscle adaptations to resistance exercise in older adults

23 February 2021

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Protein supplementation augments the adaptive response of skeletal muscle to resistance-type exercise training: a meta-analysis.

23 February 2021

1 reference

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Rapamycin does not affect post-absorptive protein metabolism in human skeletal muscle

23 February 2021

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Angiotensin-converting enzyme inhibitor use by older adults is associated with greater functional responses to exercise

23 February 2021

1 reference

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Effect of vitamin D supplementation on muscle strength, gait and balance in older adults: a systematic review and meta-analysis

23 February 2021

1 reference

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Chronic low-grade inflammation and age-related sarcopenia.

23 February 2021

1 reference

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The selective androgen receptor modulator GTx-024 (enobosarm) improves lean body mass and physical function in healthy elderly men and postmenopausal women: results of a double-blind, placebo-controlled phase II trial.

23 February 2021

1 reference

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Vitamin D Status Affects Strength Gains in Older Adults Supplemented With a Combination of β‐Hydroxy‐β‐Methylbutyrate, Arginine, and Lysine

23 February 2021

1 reference

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The ACE gene and human performance: 12 years on.

23 February 2021

1 reference

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Losartan Restores Skeletal Muscle Remodeling and Protects Against Disuse Atrophy in Sarcopenia

23 February 2021

1 reference

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Omega-3 polyunsaturated fatty acids augment the muscle protein anabolic response to hyperinsulinaemia–hyperaminoacidaemia in healthy young and middle-aged men and women

23 February 2021

1 reference

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Mammalian target of rapamycin complex 1 activation is required for the stimulation of human skeletal muscle protein synthesis by essential amino acids

23 February 2021

1 reference

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Factors influencing vitamin D status

23 February 2021

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Influence of acetaminophen and ibuprofen on skeletal muscle adaptations to resistance exercise in older adults.

23 February 2021

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Dietary omega-3 fatty acid supplementation increases the rate of muscle protein synthesis in older adults: a randomized controlled trial

23 February 2021

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Ibuprofen administration during endurance training cancels running-distance-dependent adaptations of skeletal muscle in mice

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7100900

MK-0677 (ibutamoren mesylate) for the treatment of patients recovering from hip fracture: A multicenter, randomized, placebo-controlled phase IIb study

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7100900

Effect of vitamin D supplementation on muscle strength: a systematic review and meta-analysis.

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7100900

Effects of testosterone on skeletal muscle architecture in intermediate-frail and frail elderly men.

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7100900

Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7100900

ACE-inhibition and physical function: results from the Trial of Angiotensin-Converting Enzyme Inhibition and Novel Cardiovascular Risk Factors (TRAIN) study.

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7100900

Effects of testosterone on muscle strength, physical function, body composition, and quality of life in intermediate-frail and frail elderly men: a randomized, double-blind, placebo-controlled study

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7100900

Reduction of low grade inflammation restores blunting of postprandial muscle anabolism and limits sarcopenia in old rats

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7100900

Effects of myostatin deletion in aging mice

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7100900

Rapamycin administration in humans blocks the contraction-induced increase in skeletal muscle protein synthesis

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7100900

Angiotensin-converting enzyme inhibition and novel cardiovascular risk biomarkers: results from the Trial of Angiotensin Converting Enzyme Inhibition and Novel Cardiovascular Risk Factors (TRAIN) study

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7100900

Effects of an oral growth hormone secretagogue in older adults

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7100900

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7100900

Effects of an oral ghrelin mimetic on body composition and clinical outcomes in healthy older adults: a randomized trial

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7100900

The role of exercise and PGC1alpha in inflammation and chronic disease

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7100900

Hypothalamic-pituitary-testicular axis disruptions in older men are differentially linked to age and modifiable risk factors: the European Male Aging Study

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7100900

Effect of perindopril on physical function in elderly people with functional impairment: a randomized controlled trial

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7100900

Systematic review: the safety and efficacy of growth hormone in the healthy elderly

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7100900

Prolonged absence of myostatin reduces sarcopenia

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7100900

n-3 polyunsaturated fatty acids, inflammation, and inflammatory diseases

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7100900

A high proportion of leucine is required for optimal stimulation of the rate of muscle protein synthesis by essential amino acids in the elderly.

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7100900

Muscle fiber specific apoptosis and TNF-alpha signaling in sarcopenia are attenuated by life-long calorie restriction

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7100900

Muscle-specific expression of IGF-1 blocks angiotensin II-induced skeletal muscle wasting

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7100900

Intact insulin and insulin-like growth factor-I receptor signaling is required for growth hormone effects on skeletal muscle growth and function in vivo

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7100900

Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7100900

Essential amino acid and carbohydrate supplementation ameliorates muscle protein loss in humans during 28 days bedrest.

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7100900

Inflammatory mediators in the elderly

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7100900

Vitamin D receptor expression in human muscle tissue decreases with age.

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7100900

Alterations in the expression of mRNAs and proteins that code for species relevant to eIF2B activity after an acute bout of resistance exercise

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7100900

Androgens and Women at the Menopause and Beyond

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7100900

Testosterone-induced increase in muscle size in healthy young men is associated with muscle fiber hypertrophy

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7100900

Relation between use of angiotensin-converting enzyme inhibitors and muscle strength and physical function in older women: an observational study

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7100900

Age trends in the level of serum testosterone and other hormones in middle-aged men: longitudinal results from the Massachusetts male aging study

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7100900

Basal muscle amino acid kinetics and protein synthesis in healthy young and older men

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7100900

Angiotensin II induces skeletal muscle wasting through enhanced protein degradation and down-regulates autocrine insulin-like growth factor I

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7100900

Longitudinal effects of aging on serum total and free testosterone levels in healthy men. Baltimore Longitudinal Study of Aging

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7100900

Leucine stimulates translation initiation in skeletal muscle of postabsorptive rats via a rapamycin-sensitive pathway

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7100900

Ghrelin is a growth-hormone-releasing acylated peptide from stomach

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7100900

Targeted ablation of the vitamin D receptor: An animal model of vitamin D-dependent rickets type II with alopecia

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7100900

Effect of rhGH and rhIGF-I treatment on protein utilization in elderly women

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7100900

Effects of human growth hormone in men over 60 years old

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7100900

10.1016/J.PHRS.2019.02.030

23 February 2021

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30844535%20AND%20SRC:MED&resulttype=core&format=json

27 April 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30844535%20AND%20SRC:MED&resulttype=core&format=json

27 April 2020

PubMed publication ID

30844535

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30844535%20AND%20SRC:MED&resulttype=core&format=json