Boosting Antioxidant Self-defenses by Grafting Astrocytes Rejuvenates the Aged Microenvironment and Mitigates Nigrostriatal Toxicity in Parkinsonian Brain via an Nrf2-Driven Wnt/β-Catenin Prosurvival Axis (Q90745439)

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scientific article published on 12 March 2020

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English	Boosting Antioxidant Self-defenses by Grafting Astrocytes Rejuvenates the Aged Microenvironment and Mitigates Nigrostriatal Toxicity in Parkinsonian Brain via an Nrf2-Driven Wnt/β-Catenin Prosurvival Axis	scientific article published on 12 March 2020

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16 April 2020

Boosting Antioxidant Self-defenses by Grafting Astrocytes Rejuvenates the Aged Microenvironment and Mitigates Nigrostriatal Toxicity in Parkinsonian Brain via an Nrf2-Driven Wnt/β-Catenin Prosurvival Axis (English)

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16 April 2020

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Maria Francesca Serapide

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16 April 2020

Francesca L'Episcopo

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Cataldo Tirolo

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Nunzio Testa

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16 April 2020

Salvatore Caniglia

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16 April 2020

Carmela Giachino

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16 April 2020

Bianca Marchetti

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16 April 2020

Frontiers in Aging Neuroscience

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16 April 2020

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16 April 2020

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Creative Commons Attribution 4.0 International

12 March 2020

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April 2022 Public Data File from Crossref

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Preparation and characterization of type 1 astrocytes cultured from adult rat cortex, cerebellum, and striatum

1 reference

https://pubmed.ncbi.nlm.nih.gov/32226376

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The neurotrophic effects of fibroblast growth factors on dopaminergic neurons in vitro are mediated by mesencephalic glia

1 reference

https://pubmed.ncbi.nlm.nih.gov/32226376

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An assessment of the validity of densitometric measures of striatal tyrosine hydroxylase-positive fibers: relationship to apomorphine-induced rotations in 6-hydroxydopamine lesioned rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/32226376

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Growth and cultivation of dissociated neurons and glial cells from embryonic chick, rat and human brain in flask cultures

1 reference

https://pubmed.ncbi.nlm.nih.gov/32226376

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mesencephalic type 1 astrocytes rescue dopaminergic neurons from death induced by serum deprivation

1 reference

https://pubmed.ncbi.nlm.nih.gov/32226376

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Parkinson's disease and the adaptive capacity of the nigrostriatal dopamine system: possible neurochemical mechanisms

1 reference

https://pubmed.ncbi.nlm.nih.gov/32226376

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Microglia: a sensor for pathological events in the CNS

1 reference

https://pubmed.ncbi.nlm.nih.gov/32226376

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cross-talk signals in the CNS: role of neurotrophic and hormonal factors, adhesion molecules and intercellular signaling agents in luteinizing hormone-releasing hormone (LHRH)-astroglial interactive network

1 reference

https://pubmed.ncbi.nlm.nih.gov/32226376

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Compensatory mechanisms in experimental and human parkinsonism: towards a dynamic approach

1 reference

https://pubmed.ncbi.nlm.nih.gov/32226376

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction of interleukin-1 associated with compensatory dopaminergic sprouting in the denervated striatum of young mice: model of aging and neurodegenerative disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/32226376

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Basic fibroblast growth factor (bFGF) acts on both neurons and glia to mediate the neurotrophic effects of astrocytes on LHRH neurons in culture

1 reference

https://pubmed.ncbi.nlm.nih.gov/32226376

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Adaptive changes in the nigrostriatal pathway in response to increased 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurodegeneration in the mouse

1 reference

https://pubmed.ncbi.nlm.nih.gov/32226376

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Basic fibroblast growth factor priming increases the responsiveness of immortalized hypothalamic luteinizing hormone releasing hormone neurones to neurotrophic factors

1 reference

https://pubmed.ncbi.nlm.nih.gov/32226376

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Exposure to a dysfunctional glucocorticoid receptor from early embryonic life programs the resistance to experimental autoimmune encephalomyelitis via nitric oxide-induced immunosuppression

1 reference

https://pubmed.ncbi.nlm.nih.gov/32226376

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glucocorticoid receptor deficiency increases vulnerability of the nigrostriatal dopaminergic system: critical role of glial nitric oxide.

1 reference

https://pubmed.ncbi.nlm.nih.gov/32226376

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bilirubin protects astrocytes from its own toxicity by inducing up-regulation and translocation of multidrug resistance-associated protein 1 (Mrp1)

1 reference

https://pubmed.ncbi.nlm.nih.gov/32226376

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glucocorticoid receptor-nitric oxide crosstalk and vulnerability to experimental parkinsonism: pivotal role for glia-neuron interactions

1 reference

https://pubmed.ncbi.nlm.nih.gov/32226376

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

To be or not to be (inflamed)--is that the question in anti-inflammatory drug therapy of neurodegenerative disorders?

1 reference

https://pubmed.ncbi.nlm.nih.gov/32226376

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Estrogen, neuroinflammation and neuroprotection in Parkinson's disease: glia dictates resistance versus vulnerability to neurodegeneration.

1 reference

https://pubmed.ncbi.nlm.nih.gov/32226376

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hormones are key actors in gene x environment interactions programming the vulnerability to Parkinson's disease: glia as a common final pathway.

1 reference

https://pubmed.ncbi.nlm.nih.gov/32226376

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of astrocyte-expressed factors that modulate neural stem/progenitor cell differentiation

1 reference

https://pubmed.ncbi.nlm.nih.gov/32226376

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transplantation of human neural stem cells exerts neuroprotection in a rat model of Parkinson's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/32226376

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Aging-related changes in the nigrostriatal dopamine system and the response to MPTP in nonhuman primates: diminished compensatory mechanisms as a prelude to parkinsonism

1 reference

https://pubmed.ncbi.nlm.nih.gov/32226376

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cellular demise and inflammatory microglial activation during beta-amyloid toxicity are governed by Wnt1 and canonical signaling pathways

1 reference

https://pubmed.ncbi.nlm.nih.gov/32226376

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protocol for the MPTP mouse model of Parkinson's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/32226376

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Behavioral improvement in a primate Parkinson's model is associated with multiple homeostatic effects of human neural stem cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/32226376

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glial reactions in Parkinson's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/32226376

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction of neurogenesis in nonconventional neurogenic regions of the adult central nervous system by niche astrocyte-produced signals

1 reference

https://pubmed.ncbi.nlm.nih.gov/32226376

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Why neurodegenerative diseases are progressive: uncontrolled inflammation drives disease progression.

1 reference

https://pubmed.ncbi.nlm.nih.gov/32226376

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The effects of aging, injury and disease on microglial function: a case for cellular senescence

1 reference

https://pubmed.ncbi.nlm.nih.gov/32226376

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Parkin deficiency increases vulnerability to inflammation-related nigral degeneration

1 reference

https://pubmed.ncbi.nlm.nih.gov/32226376

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Astrocyte-secreted GDNF and glutathione antioxidant system protect neurons against 6OHDA cytotoxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/32226376

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nrf2-mediated neuroprotection in the MPTP mouse model of Parkinson's disease: Critical role for the astrocyte

1 reference

https://pubmed.ncbi.nlm.nih.gov/32226376

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuroinflammation in Parkinson's disease: a target for neuroprotection?

1 reference

https://pubmed.ncbi.nlm.nih.gov/32226376

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transplantation of subventricular zone neural precursors induces an endogenous precursor cell response in a rat model of Parkinson's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/32226376

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of Nrf2-mediated heme oxygenase-1 upregulation in adaptive survival response to nitrosative stress

1 reference

https://pubmed.ncbi.nlm.nih.gov/32226376

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A dual-hit animal model for age-related parkinsonism

1 reference

https://pubmed.ncbi.nlm.nih.gov/32226376

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of astroglia in neuroprotection

1 reference

https://pubmed.ncbi.nlm.nih.gov/32226376

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Astrocytes: biology and pathology

1 reference

https://pubmed.ncbi.nlm.nih.gov/32226376

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nurr1 is required for maintenance of maturing and adult midbrain dopamine neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/32226376

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Triggering endogenous neuroprotective processes through exercise in models of dopamine deficiency.

1 reference

https://pubmed.ncbi.nlm.nih.gov/32226376

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inflammation and Parkinson's disease pathogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/32226376

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glia as a turning point in the therapeutic strategy of Parkinson's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/32226376

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Microglial activation and neuroinflammation in Alzheimer's disease: a critical examination of recent history

1 reference

https://pubmed.ncbi.nlm.nih.gov/32226376

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ex vivo cultures of microglia from young and aged rodent brain reveal age-related changes in microglial function

1 reference

https://pubmed.ncbi.nlm.nih.gov/32226376

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Wnt1 neuroprotection translates into improved neurological function during oxidant stress and cerebral ischemia through AKT1 and mitochondrial apoptotic pathways

1 reference

https://pubmed.ncbi.nlm.nih.gov/32226376

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

WNT signaling in activated microglia is proinflammatory.

1 reference

https://pubmed.ncbi.nlm.nih.gov/32226376

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Estimation of nuclear population from microtome sections

1 reference

https://pubmed.ncbi.nlm.nih.gov/32226376

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reactive astrocytes and Wnt/β-catenin signaling link nigrostriatal injury to repair in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/32226376

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Combining nitric oxide release with anti-inflammatory activity preserves nigrostriatal dopaminergic innervation and prevents motor impairment in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/32226376

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cross-talk between luteinizing hormone-releasing hormone (LHRH) neurons and astroglial cells: developing glia release factors that accelerate neuronal differentiation and stimulate LHRH release from GT(1-1) neuronal cell line and LHRH neurons induce

1 reference

https://pubmed.ncbi.nlm.nih.gov/32226376

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Wnt signaling in macrophages: augmenting and inhibiting mycobacteria-induced inflammatory responses

1 reference

https://pubmed.ncbi.nlm.nih.gov/32226376

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuroinflammation and α-synuclein dysfunction potentiate each other, driving chronic progression of neurodegeneration in a mouse model of Parkinson's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/32226376

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Age-specific progression of nigrostriatal dysfunction in Parkinson's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/32226376

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Recombinant WNTs differentially activate β-catenin-dependent and -independent signalling in mouse microglia-like cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/32226376

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reduction in paracrine Wnt3 factors during aging causes impaired adult neurogenesis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/32226376

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A Wnt1 regulated Frizzled-1/β-Catenin signaling pathway as a candidate regulatory circuit controlling mesencephalic dopaminergic neuron-astrocyte crosstalk: Therapeutical relevance for neuron survival and neuroprotection

1 reference

https://pubmed.ncbi.nlm.nih.gov/32226376

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Switching the microglial harmful phenotype promotes lifelong restoration of subtantia nigra dopaminergic neurons from inflammatory neurodegeneration in aged mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/32226376

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structural remodeling of astrocytes in the injured CNS

1 reference

https://pubmed.ncbi.nlm.nih.gov/32226376

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Heterogeneity of astrocytic form and function

1 reference

https://pubmed.ncbi.nlm.nih.gov/32226376

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Wnt signaling in the vertebrate central nervous system: from axon guidance to synaptic function

1 reference

https://pubmed.ncbi.nlm.nih.gov/32226376

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Plasticity of subventricular zone neuroprogenitors in MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) mouse model of Parkinson's disease involves cross talk between inflammatory and Wnt/β-catenin signaling pathways: functional consequences for n

1 reference

https://pubmed.ncbi.nlm.nih.gov/32226376

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lewy pathology and neurodegeneration in premotor Parkinson's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/32226376

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

α-Synuclein expression and Nrf2 deficiency cooperate to aggravate protein aggregation, neuronal death and inflammation in early-stage Parkinson's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/32226376

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Astrocytes and disease: a neurodevelopmental perspective

1 reference

https://pubmed.ncbi.nlm.nih.gov/32226376

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mitochondrial dysfunction in neurodegenerative diseases

1 reference

https://pubmed.ncbi.nlm.nih.gov/32226376

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gene-environment interactions in Parkinson's disease: specific evidence in humans and mammalian models

1 reference

https://pubmed.ncbi.nlm.nih.gov/32226376

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pathogenesis of Parkinson's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/32226376

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The importance of Wnt signalling for neurodegeneration in Parkinson's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/32226376

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Wnt your brain be inflamed? Yes, it Wnt!

1 reference

https://pubmed.ncbi.nlm.nih.gov/32226376

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Aging-induced Nrf2-ARE pathway disruption in the subventricular zone drives neurogenic impairment in parkinsonian mice via PI3K-Wnt/β-catenin dysregulation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/32226376

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Loss of Dickkopf-1 restores neurogenesis in old age and counteracts cognitive decline.

1 reference

https://pubmed.ncbi.nlm.nih.gov/32226376

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Uncovering novel actors in astrocyte-neuron crosstalk in Parkinson's disease: the Wnt/β-catenin signaling cascade as the common final pathway for neuroprotection and self-repair

1 reference

https://pubmed.ncbi.nlm.nih.gov/32226376

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

WNT-3A and WNT-5A counteract lipopolysaccharide-induced pro-inflammatory changes in mouse primary microglia

1 reference

https://pubmed.ncbi.nlm.nih.gov/32226376

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Therapeutic prospects for Parkinson disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/32226376

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Wnt/β-catenin signaling in midbrain dopaminergic neuron specification and neurogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/32226376

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Wnt1-regulated genetic networks in midbrain dopaminergic neuron development

1 reference

https://pubmed.ncbi.nlm.nih.gov/32226376

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Targeting Wnt signaling at the neuroimmune interface for dopaminergic neuroprotection/repair in Parkinson's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/32226376

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Wnt signaling in midbrain dopaminergic neuron development and regenerative medicine for Parkinson's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/32226376

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulating Wnt signaling: a strategy to prevent neurodegeneration and induce regeneration

1 reference

https://pubmed.ncbi.nlm.nih.gov/32226376

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Wnt/β-catenin signaling is required to rescue midbrain dopaminergic progenitors and promote neurorepair in ageing mouse model of Parkinson's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/32226376

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Slowing of neurodegeneration in Parkinson's disease and Huntington's disease: future therapeutic perspectives

1 reference

https://pubmed.ncbi.nlm.nih.gov/32226376

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Focal transplantation of human iPSC-derived glial-rich neural progenitors improves lifespan of ALS mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/32226376

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Deficient Wnt signalling triggers striatal synaptic degeneration and impaired motor behaviour in adult mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/32226376

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inflammation is genetically implicated in Parkinson's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/32226376

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activated astrocytes enhance the dopaminergic differentiation of stem cells and promote brain repair through bFGF

1 reference

https://pubmed.ncbi.nlm.nih.gov/32226376

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Parkinson's disease as a result of aging

1 reference

https://pubmed.ncbi.nlm.nih.gov/32226376

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transplantation of stem cell-derived astrocytes for the treatment of amyotrophic lateral sclerosis and spinal cord injury

1 reference

https://pubmed.ncbi.nlm.nih.gov/32226376

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Astrocyte-derived TGF-β1 accelerates disease progression in ALS mice by interfering with the neuroprotective functions of microglia and T cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/32226376

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A WNT1-regulated developmental gene cascade prevents dopaminergic neurodegeneration in adult En1(+/-) mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/32226376

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/32226376

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ALCAR Exerts Neuroprotective and Pro-Neurogenic Effects by Inhibition of Glial Activation and Oxidative Stress via Activation of the Wnt/β-Catenin Signaling in Parkinsonian Rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/32226376

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transplantation of Human Neural Stem Cells in a Parkinsonian Model Exerts Neuroprotection via Regulation of the Host Microenvironment

1 reference

https://pubmed.ncbi.nlm.nih.gov/32226376

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Age-related neuroinflammation and changes in AKT-GSK-3β and WNT/ β-CATENIN signaling in rat hippocampus

1 reference

https://pubmed.ncbi.nlm.nih.gov/32226376

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Astrocyte scar formation aids central nervous system axon regeneration

1 reference

https://pubmed.ncbi.nlm.nih.gov/32226376

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

GSK-3β-induced Tau pathology drives hippocampal neuronal cell death in Huntington's disease: involvement of astrocyte-neuron interactions

1 reference

https://pubmed.ncbi.nlm.nih.gov/32226376

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Microglia Priming with Aging and Stress

1 reference

https://pubmed.ncbi.nlm.nih.gov/32226376

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Crosstalk between Wnt/β-Catenin and NF-κB Signaling Pathway during Inflammation

1 reference

https://pubmed.ncbi.nlm.nih.gov/32226376

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neural Stem Cell Transplantation Induces Stroke Recovery by Upregulating Glutamate Transporter GLT-1 in Astrocytes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/32226376

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ageing, neurodegeneration and brain rejuvenation

1 reference

https://pubmed.ncbi.nlm.nih.gov/32226376

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A new role for oxidative stress in aging: The accelerated aging phenotype in Sod1-/- mice is correlated to increased cellular senescence

1 reference

https://pubmed.ncbi.nlm.nih.gov/32226376

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Toll-like receptor 2 is increased in neurons in Parkinson's disease brain and may contribute to alpha-synuclein pathology.

1 reference

https://pubmed.ncbi.nlm.nih.gov/32226376

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

TREM2 Promotes Microglial Survival by Activating Wnt/β-Catenin Pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/32226376

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurotoxic reactive astrocytes are induced by activated microglia

1 reference

https://pubmed.ncbi.nlm.nih.gov/32226376

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Delayed treatment of 6-Bromoindirubin-3'-oxime stimulates neurogenesis and functional recovery after focal ischemic stroke in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/32226376

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

1 reference

https://pubmed.ncbi.nlm.nih.gov/32226376

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Parkinson disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/32226376

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction of functional dopamine neurons from human astrocytes in vitro and mouse astrocytes in a Parkinson's disease model

1 reference

https://pubmed.ncbi.nlm.nih.gov/32226376

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prolonged Dysfunction of Astrocytes and Activation of Microglia Accelerate Degeneration of Dopaminergic Neurons in the Rat Substantia Nigra and Block Compensation of Early Motor Dysfunction Induced by 6-OHDA.

1 reference

https://pubmed.ncbi.nlm.nih.gov/32226376

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Role of Astrocyte Dysfunction in Parkinson's Disease Pathogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/32226376

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Toll-Like Receptor 4 (TLR4) and Triggering Receptor Expressed on Myeloid Cells-2 (TREM-2) Activation Balance Astrocyte Polarization into a Proinflammatory Phenotype.

1 reference

https://pubmed.ncbi.nlm.nih.gov/32226376

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Progressive Motor Neuron Pathology and the Role of Astrocytes in a Human Stem Cell Model of VCP-Related ALS

1 reference

https://pubmed.ncbi.nlm.nih.gov/32226376

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Wnt/β-Catenin Signaling, Disease, and Emerging Therapeutic Modalities

1 reference

https://pubmed.ncbi.nlm.nih.gov/32226376

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The emerging role of Wnt signaling dysregulation in the understanding and modification of age-associated diseases

1 reference

https://pubmed.ncbi.nlm.nih.gov/32226376

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dopamine oxidation mediates mitochondrial and lysosomal dysfunction in Parkinson's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/32226376

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Past, present, and future of Parkinson's disease: A special essay on the 200th Anniversary of the Shaking Palsy

1 reference

https://pubmed.ncbi.nlm.nih.gov/32226376

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Compensatory mechanisms in Parkinson's disease: Circuits adaptations and role in disease modification

1 reference

https://pubmed.ncbi.nlm.nih.gov/32226376

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

NADPH oxidases in Parkinson's disease: a systematic review

1 reference

https://pubmed.ncbi.nlm.nih.gov/32226376

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cografting astrocytes improves cell therapeutic outcomes in a Parkinson's disease model

1 reference

https://pubmed.ncbi.nlm.nih.gov/32226376

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Astrocytes Attenuate Mitochondrial Dysfunctions in Human Dopaminergic Neurons Derived from iPSC.

1 reference

https://pubmed.ncbi.nlm.nih.gov/32226376

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Microglia Polarization, Gene-Environment Interactions and Wnt/β-Catenin Signaling: Emerging Roles of Glia-Neuron and Glia-Stem/Neuroprogenitor Crosstalk for Dopaminergic Neurorestoration in Aged Parkinsonian Brain.

1 reference

https://pubmed.ncbi.nlm.nih.gov/32226376

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neural Stem Cell Grafts Promote Astroglia-driven Neurorestoration in the Aged Parkinsonian Brain via Wnt/β-catenin Signalling

1 reference

https://pubmed.ncbi.nlm.nih.gov/32226376

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

New approaches for brain repair—from rescue to reprogramming

1 reference

https://pubmed.ncbi.nlm.nih.gov/32226376

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

On Cell Loss and Selective Vulnerability of Neuronal Populations in Parkinson's Disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/32226376

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Determinants of dopaminergic neuron loss in Parkinson's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/32226376

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Targeting Nrf2 to Suppress Ferroptosis and Mitochondrial Dysfunction in Neurodegeneration.

1 reference

https://pubmed.ncbi.nlm.nih.gov/32226376

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Loss of canonical Wnt signaling is involved in the pathogenesis of Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/32226376

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Wnt/β-Catenin Signaling Pathway Governs a Full Program for Dopaminergic Neuron Survival, Neurorescue and Regeneration in the MPTP Mouse Model of Parkinson's Disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/32226376

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pathogenesis-targeted therapeutic strategies in Parkinson's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/32226376

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synaptic, Mitochondrial, and Lysosomal Dysfunction in Parkinson's Disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/32226376

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Crosstalk of Intercellular Signaling Pathways in the Generation of Midbrain Dopaminergic Neurons In Vivo and from Stem Cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/32226376

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuron-glia interactions in the pathophysiology of epilepsy

1 reference

https://pubmed.ncbi.nlm.nih.gov/32226376

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Parkinson's disease age at onset genome-wide association study: Defining heritability, genetic loci, and α-synuclein mechanisms

1 reference

https://pubmed.ncbi.nlm.nih.gov/32226376

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Levodopa is the best symptomatic therapy for PD: Nothing more, nothing less

1 reference

https://pubmed.ncbi.nlm.nih.gov/32226376

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Wnt Signaling Deregulation in the Aging and Alzheimer's Brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/32226376

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Astrocyte lineage cells are essential for functional neuronal differentiation and synapse maturation in human iPSC-derived neural networks

1 reference

https://pubmed.ncbi.nlm.nih.gov/32226376

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurotrophic Factors Mediated Activation of Astrocytes Ameliorate Memory Loss by Amyloid Clearance after Transplantation of Lineage Negative Stem Cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/32226376

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Astrocytic Oxidative/Nitrosative Stress Contributes to Parkinson's Disease Pathogenesis: The Dual Role of Reactive Astrocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/32226376

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Detrimental Effects of HMGB-1 Require Microglial-Astroglial Interaction: Implications for the Status Epilepticus -Induced Neuroinflammation

1 reference

https://pubmed.ncbi.nlm.nih.gov/32226376

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Parkinson's disease, aging and adult neurogenesis: Wnt/β-catenin signalling as the key to unlock the mystery of endogenous brain repair

1 reference

https://pubmed.ncbi.nlm.nih.gov/32226376

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.3389/FNAGI.2020.00024

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32226376%20AND%20SRC:MED&resulttype=core&format=json

16 April 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32226376%20AND%20SRC:MED&resulttype=core&format=json

16 April 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32226376%20AND%20SRC:MED&resulttype=core&format=json

16 April 2020

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