Why neurodegenerative diseases are progressive: uncontrolled inflammation drives disease progression. (Q36692860)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18599350%20AND%20SRC:MED&resulttype=core&format=json

10 January 2020

review article

1 reference

title

Why neurodegenerative diseases are progressive: uncontrolled inflammation drives disease progression (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18599350%20AND%20SRC:MED&resulttype=core&format=json

10 January 2020

0 references

1 reference

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18599350%20AND%20SRC:MED&resulttype=core&format=json

10 January 2020

Hui-Ming Gao

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10 January 2020

publication date

1 July 2008

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10 January 2020

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10 January 2020

volume

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10 January 2020

issue

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10 January 2020

page(s)

357-365

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Immunity to self and self-maintenance: a unified theory of brain pathologies

10 January 2020

cites work

1 reference

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Inside, outside, upside down: damage-associated molecular-pattern molecules (DAMPs) and redox

30 September 2017

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Therapeutic approaches to inflammation in neurodegenerative disease

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Systemic LPS causes chronic neuroinflammation and progressive neurodegeneration

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Valproate protects dopaminergic neurons in midbrain neuron/glia cultures by stimulating the release of neurotrophic factors from astrocytes.

30 September 2017

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The inflammatory NADPH oxidase enzyme modulates motor neuron degeneration in amyotrophic lateral sclerosis mice

30 September 2017

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NSAIDs and Alzheimer disease: epidemiological, animal model and clinical studies

30 September 2017

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Nonsteroidal antiinflammatory drug use and the risk for Parkinson's disease

30 September 2017

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To be or not to be (inflamed)--is that the question in anti-inflammatory drug therapy of neurodegenerative disorders?

30 September 2017

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Neurosphere-derived multipotent precursors promote neuroprotection by an immunomodulatory mechanism.

30 September 2017

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Neutrophil beta2 integrins: moderators of life or death decisions

30 September 2017

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ATP mediates rapid microglial response to local brain injury in vivo

30 September 2017

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Activation of microglia by aggregated beta-amyloid or lipopolysaccharide impairs MHC-II expression and renders them cytotoxic whereas IFN-gamma and IL-4 render them protective.

30 September 2017

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Interleukin-10 inhibits endotoxin-induced pro-inflammatory cytokines in microglial cell cultures

30 September 2017

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Glia and their cytokines in progression of neurodegeneration

30 September 2017

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Neural regulators of innate immune responses and inflammation.

30 September 2017

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Microglia and neuroinflammation: a pathological perspective

30 September 2017

1 reference

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A common vaccine for fighting neurodegenerative disorders: recharging immunity for homeostasis

30 September 2017

1 reference

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Glial modulation of synaptic transmission: Insights from the supraoptic nucleus of the hypothalamus.

30 September 2017

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Therapeutic immunization protects dopaminergic neurons in a mouse model of Parkinson's disease

30 September 2017

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Effects of 6-hydroxydopamine on primary cultures of substantia nigra: specific damage to dopamine neurons and the impact of glial cell line-derived neurotrophic factor

30 September 2017

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Physiological contribution of the astrocytic environment of neurons to intersynaptic crosstalk

30 September 2017

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Neuroprotective effect of dextromethorphan in the MPTP Parkinson's disease model: role of NADPH oxidase

30 September 2017

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Immunotherapeutic Approaches to Alzheimer's Disease

30 September 2017

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Neuromelanin of the substantia nigra: a neuronal black hole with protective and toxic characteristics

30 September 2017

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Novel anti-inflammatory therapy for Parkinson's disease.

30 September 2017

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Critical role for microglial NADPH oxidase in rotenone-induced degeneration of dopaminergic neurons.

30 September 2017

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Therapeutic vaccine for acute and chronic motor neuron diseases: implications for amyotrophic lateral sclerosis

30 September 2017

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In vivo gene delivery of glial cell line--derived neurotrophic factor for Parkinson's disease

30 September 2017

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Role of microglia in inflammation-mediated neurodegenerative diseases: mechanisms and strategies for therapeutic intervention.

30 September 2017

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Mice deficient in TNF receptors are protected against dopaminergic neurotoxicity: implications for Parkinson's disease

30 September 2017

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Inflammation in neurodegenerative disease--a double-edged sword

30 September 2017

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Innate immunity: the missing link in neuroprotection and neurodegeneration?

30 September 2017

1 reference

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Immune function of microglia

30 September 2017

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Regulation of the adhesion versus cytotoxic functions of the Mac-1/CR3/alphaMbeta2-integrin glycoprotein

30 September 2017

1 reference

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Naloxone protects rat dopaminergic neurons against inflammatory damage through inhibition of microglia activation and superoxide generation.

30 September 2017

1 reference

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Association of interleukin-1 gene polymorphisms with Alzheimer's disease

30 September 2017

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'Outside-in' signalling mechanisms underlying CD11b/CD18-mediated NADPH oxidase activation in human adherent blood eosinophils

30 September 2017

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Evidence of active nerve cell degeneration in the substantia nigra of humans years after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine exposure

30 September 2017

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30 September 2017

NADPH oxidase: an update

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Microglia stimulate naive T-cell differentiation without stimulating T-cell proliferation

30 September 2017

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Microglia: a sensor to threats in the nervous system?

30 September 2017

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Microglia: a sensor for pathological events in the CNS

30 September 2017

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CR3 (CD11b, CD18): a phagocyte and NK cell membrane receptor with multiple ligand specificities and functions

30 September 2017

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Adhesion-promoting receptors on human macrophages recognize Escherichia coli by binding to lipopolysaccharide

30 September 2017

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Reactive microglia are positive for HLA-DR in the substantia nigra of Parkinson's and Alzheimer's disease brains

30 September 2017

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Microglial PHOX and Mac-1 are essential to the enhanced dopaminergic neurodegeneration elicited by A30P and A53T mutant alpha-synuclein.

30 September 2017

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Integrin Mac-1 and beta-amyloid in microglial release of nitric oxide

28 June 2018

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A novel role for the beta 2 integrin CD11b/CD18 in neutrophil apoptosis: a homeostatic mechanism in inflammation

28 June 2018

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Regulation of ciliary neurotrophic factor in cultured rat hippocampal astrocytes

28 June 2018

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Brain microglia constitutively express beta-2 integrins

28 June 2018

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Microglial activation in presymptomatic Huntington's disease gene carriers

28 June 2018

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Evidence for synaptic stripping by cortical microglia

5 September 2018

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Interleukin-10 protects lipopolysaccharide-induced neurotoxicity in primary midbrain cultures by inhibiting the function of NADPH oxidase

5 September 2018

1 reference

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Progressive dopamine neuron loss following supra-nigral lipopolysaccharide (LPS) infusion into rats exposed to LPS prenatally

5 September 2018

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Bone marrow-derived microglia play a critical role in restricting senile plaque formation in Alzheimer's disease

5 September 2018

1 reference

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The role of microglia in paraquat-induced dopaminergic neurotoxicity

5 September 2018

1 reference

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Neuronal damage in autoimmune neuroinflammation mediated by the death ligand TRAIL.

5 September 2018

1 reference

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Aggregated alpha-synuclein activates microglia: a process leading to disease progression in Parkinson's disease

5 September 2018

1 reference

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Valproate pretreatment protects dopaminergic neurons from LPS-induced neurotoxicity in rat primary midbrain cultures: role of microglia.

5 September 2018

1 reference

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Beta-amyloid-stimulated microglia induce neuron death via synergistic stimulation of tumor necrosis factor alpha and NMDA receptors.

5 September 2018

1 reference

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Nanometer size diesel exhaust particles are selectively toxic to dopaminergic neurons: the role of microglia, phagocytosis, and NADPH oxidase.

5 September 2018

1 reference

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Direct impact of T cells on neurons revealed by two-photon microscopy in living brain tissue.

5 September 2018

1 reference

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Exacerbation of motor neuron disease by chronic stimulation of innate immunity in a mouse model of amyotrophic lateral sclerosis.

5 September 2018

1 reference

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Presence of reactive microglia in monkey substantia nigra years after 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine administration

5 September 2018

1 reference

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NADPH oxidase mediates lipopolysaccharide-induced neurotoxicity and proinflammatory gene expression in activated microglia.

5 September 2018

1 reference

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Critical role of microglial NADPH oxidase-derived free radicals in the in vitro MPTP model of Parkinson's disease.

5 September 2018

1 reference

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Microglia enhance beta-amyloid peptide-induced toxicity in cortical and mesencephalic neurons by producing reactive oxygen species.

5 September 2018

1 reference

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Complement receptor 3 (CD11b/CD18) mediates type I and type II phagocytosis during nonopsonic and opsonic phagocytosis, respectively

5 September 2018

1 reference

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Microglial activation-mediated delayed and progressive degeneration of rat nigral dopaminergic neurons: relevance to Parkinson's disease.

5 September 2018

1 reference

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Polymorphisms in the interleukin-1 alpha and beta genes and the risk for Parkinson's disease

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4794280

Blockade of microglial activation is neuroprotective in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson disease.

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4794280

Enhanced glial activation and expression of specific CNS inflammation-related molecules in aged versus young rats following cortical stab injury

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4794280

Inflammatory response: pathway across the blood-brain barrier.

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4794280

Inducible nitric oxide synthase stimulates dopaminergic neurodegeneration in the MPTP model of Parkinson disease

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4794280

MAC1 mediates LPS-induced production of superoxide by microglia: the role of pattern recognition receptors in dopaminergic neurotoxicity

20 October 2018

1 reference

12 December 2020

A pivotal role of matrix metalloproteinase-3 activity in dopaminergic neuronal degeneration via microglial activation

1 reference

12 December 2020

Endogenous transforming growth factor beta 1 suppresses inflammation and promotes survival in adult CNS

1 reference

12 December 2020

Microglia: Intrinsic immuneffector cell of the brain

1 reference

12 December 2020

Neuroinflammatory processes in Parkinson's disease

1 reference

12 December 2020

Identifiers

DOI

10.1016/J.IT.2008.05.002

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18599350%20AND%20SRC:MED&resulttype=core&format=json

10 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18599350%20AND%20SRC:MED&resulttype=core&format=json

10 January 2020

PubMed publication ID

18599350

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18599350%20AND%20SRC:MED&resulttype=core&format=json