WHIMP links the actin nucleation machinery to Src-family kinase signaling during protrusion and motility (Q90504430)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32196488%20AND%20SRC:MED&resulttype=core&format=json

14 April 2020

title

WHIMP links the actin nucleation machinery to Src-family kinase signaling during protrusion and motility (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32196488%20AND%20SRC:MED&resulttype=core&format=json

14 April 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32196488%20AND%20SRC:MED&resulttype=core&format=json

14 April 2020

Shail Kabrawala

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32196488%20AND%20SRC:MED&resulttype=core&format=json

14 April 2020

Margaret D Zimmer

series ordinal

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14 April 2020

publication date

20 March 2020

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14 April 2020

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volume

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issue

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14 April 2020

page(s)

e1008694

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Creative Commons Attribution 4.0 International

14 April 2020

start time

20 March 2020

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April 2022 Public Data File from Crossref

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC7112243/fullTextXML

inferred from PubMed Central ID database lookup

cites work

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12 December 2020

Discovery of a novel, potent, and Src family-selective tyrosine kinase inhibitor. Study of Lck- and FynT-dependent T cell activation

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12 December 2020

N-WASP, a novel actin-depolymerizing protein, regulates the cortical cytoskeletal rearrangement in a PIP2-dependent manner downstream of tyrosine kinases

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Expression of Wiskott-Aldrich syndrome protein (WASP) gene during hematopoietic differentiation.

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Induction of filopodium formation by a WASP-related actin-depolymerizing protein N-WASP

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The interaction of Arp2/3 complex with actin: nucleation, high affinity pointed end capping, and formation of branching networks of filaments

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12 December 2020

WAVE, a novel WASP-family protein involved in actin reorganization induced by Rac

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12 December 2020

Scar1 and the related Wiskott-Aldrich syndrome protein, WASP, regulate the actin cytoskeleton through the Arp2/3 complex

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12 December 2020

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12 December 2020

The interaction between N-WASP and the Arp2/3 complex links Cdc42-dependent signals to actin assembly

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12 December 2020

Identification of two human WAVE/SCAR homologues as general actin regulatory molecules which associate with the Arp2/3 complex

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12 December 2020

Regulation of actin polymerization by Arp2/3 complex and WASp/Scar proteins

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Autoinhibition and activation mechanisms of the Wiskott-Aldrich syndrome protein

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Mechanism of N-WASP activation by CDC42 and phosphatidylinositol 4, 5-bisphosphate

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12 December 2020

Integration of multiple signals through cooperative regulation of the N-WASP-Arp2/3 complex

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12 December 2020

Interaction of WASP/Scar proteins with actin and vertebrate Arp2/3 complex

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N-WASP deficiency reveals distinct pathways for cell surface projections and microbial actin-based motility

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12 December 2020

Essential role of neural Wiskott-Aldrich syndrome protein in podosome formation and degradation of extracellular matrix in src-transformed fibroblasts

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Mechanism of regulation of WAVE1-induced actin nucleation by Rac1 and Nck

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Phosphorylation of tyrosine 291 enhances the ability of WASp to stimulate actin polymerization and filopodium formation. Wiskott-Aldrich Syndrome protein

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Sustained activation of N-WASP through phosphorylation is essential for neurite extension

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Characterization of the WAVE1 knock-out mouse: implications for CNS development.

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WAVE2 deficiency reveals distinct roles in embryogenesis and Rac-mediated actin-based motility

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A conserved amphipathic helix in WASP/Scar proteins is essential for activation of Arp2/3 complex

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12 December 2020

WAVE2 is required for directed cell migration and cardiovascular development

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12 December 2020

Differential Roles of WAVE1 and WAVE2 in Dorsal and Peripheral Ruffle Formation for Fibroblast Cell Migration

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DIP (mDia interacting protein) is a key molecule regulating Rho and Rac in a Src-dependent manner

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Sra-1 and Nap1 link Rac to actin assembly driving lamellipodia formation.

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12 December 2020

Purification and architecture of the ubiquitous Wave complex

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12 December 2020

Imaging sites of N-wasp activity in lamellipodia and invadopodia of carcinoma cells

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12 December 2020

PtdIns(3,4,5)P3 binding is necessary for WAVE2-induced formation of lamellipodia

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12 December 2020

Critical conformational changes in the Arp2/3 complex are induced by nucleotide and nucleation promoting factor.

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12 December 2020

A combined approach for the localization and tandem affinity purification of protein complexes from metazoans

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12 December 2020

Abelson-interactor-1 promotes WAVE2 membrane translocation and Abelson-mediated tyrosine phosphorylation required for WAVE2 activation

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12 December 2020

The Abl/Arg substrate ArgBP2/nArgBP2 coordinates the function of multiple regulatory mechanisms converging on the actin cytoskeleton

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12 December 2020

Molecular mechanisms of invadopodium formation: the role of the N-WASP-Arp2/3 complex pathway and cofilin

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12 December 2020

A novel function of WAVE in lamellipodia: WAVE1 is required for stabilization of lamellipodial protrusions during cell spreading

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12 December 2020

Abi1 regulates the activity of N-WASP and WAVE in distinct actin-based processes

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12 December 2020

Abl kinases regulate actin comet tail elongation via an N-WASP-dependent pathway

1 reference

12 December 2020

Protein-tyrosine kinase and GTPase signals cooperate to phosphorylate and activate Wiskott-Aldrich syndrome protein (WASP)/neuronal WASP

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12 December 2020

Src-dependent phosphorylation of Scar1 promotes its association with the Arp2/3 complex

1 reference

12 December 2020

c-Abl interacts with the WAVE2 signaling complex to induce membrane ruffling and cell spreading

1 reference

12 December 2020

N-(5-chloro-1,3-benzodioxol-4-yl)-7-[2-(4-methylpiperazin-1-yl)ethoxy]-5- (tetrahydro-2H-pyran-4-yloxy)quinazolin-4-amine, a novel, highly selective, orally available, dual-specific c-Src/Abl kinase inhibitor

1 reference

12 December 2020

IQGAP1 regulates cell motility by linking growth factor signaling to actin assembly

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12 December 2020

Differential regulation of WASP and N-WASP by Cdc42, Rac1, Nck, and PI(4,5)P2.

1 reference

12 December 2020

Dia-interacting protein modulates formin-mediated actin assembly at the cell cortex.

1 reference

12 December 2020

Human subtelomeric WASH genes encode a new subclass of the WASP family

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12 December 2020

WASP family members and formin proteins coordinate regulation of cell protrusions in carcinoma cells

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12 December 2020

WHAMM is an Arp2/3 complex activator that binds microtubules and functions in ER to Golgi transport

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12 December 2020

p53-cofactor JMY is a multifunctional actin nucleation factor

1 reference

12 December 2020

Adhesion signaling - crosstalk between integrins, Src and Rho.

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12 December 2020

Cortactin promotes migration and platelet-derived growth factor-induced actin reorganization by signaling to Rho-GTPases.

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12 December 2020

Mechanical integration of actin and adhesion dynamics in cell migration

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12 December 2020

DIP/WISH-deficient mice reveal Dia- and N-WASP-interacting protein as a regulator of cytoskeletal dynamics in embryonic fibroblasts

1 reference

12 December 2020

Activation of the WAVE complex by coincident signals controls actin assembly

1 reference

12 December 2020

A FAM21-containing WASH complex regulates retromer-dependent sorting

1 reference

12 December 2020

The Arp2/3 activator WASH controls the fission of endosomes through a large multiprotein complex

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12 December 2020

Actin, a central player in cell shape and movement

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12 December 2020

Regulation of actin polymerization and adhesion-dependent cell edge protrusion by the Abl-related gene (Arg) tyrosine kinase and N-WASp

1 reference

12 December 2020

WASH and the Arp2/3 complex regulate endosome shape and trafficking

1 reference

12 December 2020

WASP: a key immunological multitasker

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12 December 2020

A nucleator arms race: cellular control of actin assembly

1 reference

12 December 2020

WASH and WAVE actin regulators of the Wiskott-Aldrich syndrome protein (WASP) family are controlled by analogous structurally related complexes

1 reference

12 December 2020

WASP family proteins: their evolution and its physiological implications.

1 reference

12 December 2020

Nuclear role of WASp in the pathogenesis of dysregulated TH1 immunity in human Wiskott-Aldrich syndrome

1 reference

12 December 2020

Structure and control of the actin regulatory WAVE complex

1 reference

12 December 2020

Hypoxia-driven cell motility reflects the interplay between JMY and HIF-1α.

1 reference

12 December 2020

WAVE regulatory complex activation by cooperating GTPases Arf and Rac1

1 reference

12 December 2020

The actin nucleation factor JMY is a negative regulator of neuritogenesis

1 reference

12 December 2020

The Arp2/3 activator WASH regulates α5β1-integrin-mediated invasive migration

1 reference

12 December 2020

Evolution of the eukaryotic ARP2/3 activators of the WASP family: WASP, WAVE, WASH, and WHAMM, and the proposed new family members WAWH and WAML

1 reference

12 December 2020

Trafficking defects in WASH-knockout fibroblasts originate from collapsed endosomal and lysosomal networks

1 reference

12 December 2020

Regulation of integrin trafficking, cell adhesion, and cell migration by WASH and the Arp2/3 complex

1 reference

12 December 2020

Structural insights into WHAMM-mediated cytoskeletal coordination during membrane remodeling

1 reference

12 December 2020

RhoD regulates cytoskeletal dynamics via the actin nucleation-promoting factor WASp homologue associated with actin Golgi membranes and microtubules

1 reference

12 December 2020

New insights into the regulation and cellular functions of the ARP2/3 complex

1 reference

12 December 2020

Loss of Scar/WAVE complex promotes N-WASP- and FAK-dependent invasion.

1 reference

12 December 2020

Measurement and analysis of in vitro actin polymerization

1 reference

12 December 2020

Mechanism of synergistic activation of Arp2/3 complex by cortactin and N-WASP

1 reference

12 December 2020

Dip1 defines a class of Arp2/3 complex activators that function without preformed actin filaments

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12 December 2020

The WAVE Regulatory Complex Links Diverse Receptors to the Actin Cytoskeleton

1 reference

12 December 2020

Structural analysis of the transitional state of Arp2/3 complex activation by two actin-bound WCAs.

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12 December 2020

Directed migration of mesenchymal cells: where signaling and the cytoskeleton meet

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12 December 2020

JMY is involved in anterograde vesicle trafficking from the trans-Golgi network.

1 reference

12 December 2020

Steering cell migration: lamellipodium dynamics and the regulation of directional persistence

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12 December 2020

Disruption of hSWI/SNF complexes in T cells by WAS mutations distinguishes X-linked thrombocytopenia from Wiskott-Aldrich syndrome

1 reference

12 December 2020

Recessive nephrocerebellar syndrome on the Galloway-Mowat syndrome spectrum is caused by homozygous protein-truncating mutations of WDR73.

1 reference

12 December 2020

WHAMM Directs the Arp2/3 Complex to the ER for Autophagosome Biogenesis through an Actin Comet Tail Mechanism

1 reference

12 December 2020

Actin nucleation by WH2 domains at the autophagosome

1 reference

12 December 2020

Rab1 recruits WHAMM during membrane remodeling but limits actin nucleation

1 reference

12 December 2020

The WH2 Domain and Actin Nucleation: Necessary but Insufficient

1 reference

12 December 2020

Role and structural mechanism of WASP-triggered conformational changes in branched actin filament nucleation by Arp2/3 complex

1 reference

12 December 2020

WASP and SCAR are evolutionarily conserved in actin-filled pseudopod-based motility

1 reference

12 December 2020

Cellular functions of WASP family proteins at a glance

1 reference

12 December 2020

An Amish founder mutation disrupts a PI(3)P-WHAMM-Arp2/3 complex-driven autophagosomal remodeling pathway

1 reference

12 December 2020

Cortactin: Cell Functions of A Multifaceted Actin-Binding Protein

1 reference

12 December 2020

Crosstalk between WIP and Rho family GTPases.

1 reference

12 December 2020

Rho GTPase signaling complexes in cell migration and invasion

1 reference

12 December 2020

New insights into the formation and the function of lamellipodia and ruffles in mesenchymal cell migration.

1 reference

12 December 2020

Assembling actin filaments for protrusion

1 reference

12 December 2020

Distinct Interaction Sites of Rac GTPase with WAVE Regulatory Complex Have Non-redundant Functions in Vivo

1 reference

12 December 2020

LC3 and STRAP regulate actin filament assembly by JMY during autophagosome formation

1 reference

12 December 2020

Enteropathogenic E. coli relies on collaboration between the formin mDia1 and the Arp2/3 complex for actin pedestal biogenesis and maintenance

1 reference

12 December 2020

N-WASP Control of LPAR1 Trafficking Establishes Response to Self-Generated LPA Gradients to Promote Pancreatic Cancer Cell Metastasis

1 reference

12 December 2020

10.1371/JOURNAL.PGEN.1008694

Identifiers

DOI

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32196488%20AND%20SRC:MED&resulttype=core&format=json

14 April 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32196488%20AND%20SRC:MED&resulttype=core&format=json

14 April 2020

PubMed publication ID

32196488

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32196488%20AND%20SRC:MED&resulttype=core&format=json