Steering cell migration: lamellipodium dynamics and the regulation of directional persistence (Q38242035)

A nucleator arms race: cellular control of actin assembly

21 January 2018

1 reference

Actin dynamics at the leading edge: from simple machinery to complex networks.

21 January 2018

1 reference

Reconstitution of actin-based motility of Listeria and Shigella using pure proteins

21 January 2018

1 reference

Clasp-mediated microtubule bundling regulates persistent motility and contact repulsion in Drosophila macrophages in vivo.

21 January 2018

1 reference

Par3 controls neural crest migration by promoting microtubule catastrophe during contact inhibition of locomotion

21 January 2018

1 reference

Cell biology in neuroscience: mechanisms of cell migration in the nervous system

21 January 2018

1 reference

Random versus directionally persistent cell migration

21 January 2018

1 reference

The Arp2/3 complex is required for lamellipodia extension and directional fibroblast cell migration

21 January 2018

1 reference

Lamellipodin, an Ena/VASP ligand, is implicated in the regulation of lamellipodial dynamics

21 January 2018

1 reference

Arp2/3 is critical for lamellipodia and response to extracellular matrix cues but is dispensable for chemotaxis

21 January 2018

1 reference

Lamellipodin and the Scar/WAVE complex cooperate to promote cell migration in vivo

21 January 2018

1 reference

Nucleating actin for invasion

21 January 2018

1 reference

Signaling inputs to invadopodia and podosomes

21 January 2018

1 reference

The role and regulation of blebs in cell migration

21 January 2018

1 reference

Contractility of the cell rear drives invasion of breast tumor cells in 3D Matrigel

21 January 2018

1 reference

Glioblastoma motility occurs in the absence of actin polymer

21 January 2018

1 reference

New insights into mechanism and regulation of actin capping protein.

21 January 2018

1 reference

Formin is a processive motor that requires profilin to accelerate actin assembly and associated ATP hydrolysis

21 January 2018

1 reference

Antagonism between Ena/VASP proteins and actin filament capping regulates fibroblast motility

21 January 2018

1 reference

Ena/VASP proteins enhance actin polymerization in the presence of barbed end capping proteins

21 January 2018

1 reference

Ena/VASP proteins capture actin filament barbed ends

21 January 2018

1 reference

Molecular mechanism of Ena/VASP-mediated actin-filament elongation.

21 January 2018

1 reference

Clustering of VASP actively drives processive, WH2 domain-mediated actin filament elongation

21 January 2018

1 reference

VASP is a processive actin polymerase that requires monomeric actin for barbed end association

21 January 2018

1 reference

FMNL2 drives actin-based protrusion and migration downstream of Cdc42.

21 January 2018

1 reference

Arp2/3 complex interactions and actin network turnover in lamellipodia.

21 January 2018

1 reference

Arp2/3 complex-dependent actin networks constrain myosin II function in driving retrograde actin flow

21 January 2018

1 reference

Multi-level molecular clutches in motile cell processes

21 January 2018

1 reference

WASH, WHAMM and JMY: regulation of Arp2/3 complex and beyond

21 January 2018

1 reference

SCAR knockouts in Dictyostelium: WASP assumes SCAR's position and upstream regulators in pseudopods

21 January 2018

1 reference

Loss of Scar/WAVE complex promotes N-WASP- and FAK-dependent invasion.

21 January 2018

1 reference

Generation of branched actin networks: assembly and regulation of the N-WASP and WAVE molecular machines

21 January 2018

1 reference

Mechanism of regulation of WAVE1-induced actin nucleation by Rac1 and Nck

21 January 2018

1 reference

Purification and architecture of the ubiquitous Wave complex

21 January 2018

1 reference

Abi1 is essential for the formation and activation of a WAVE2 signalling complex

21 January 2018

1 reference

NESH (Abi-3) is present in the Abi/WAVE complex but does not promote c-Abl-mediated phosphorylation

21 January 2018

1 reference

Inclusion of Scar/WAVE3 in a similar complex to Scar/WAVE1 and 2

21 January 2018

1 reference

The Wave complex is intrinsically inactive

21 January 2018

1 reference

The WAVE regulatory complex is inhibited.

21 January 2018

1 reference

Structure and control of the actin regulatory WAVE complex

21 January 2018

1 reference

Rac function is crucial for cell migration but is not required for spreading and focal adhesion formation

21 January 2018

1 reference

p140Sra-1 (specifically Rac1-associated protein) is a novel specific target for Rac1 small GTPase.

21 January 2018

1 reference

Activation of the WAVE complex by coincident signals controls actin assembly

21 January 2018

1 reference

PtdIns(3,4,5)P3 binding is necessary for WAVE2-induced formation of lamellipodia

21 January 2018

1 reference

Hierarchical regulation of WASP/WAVE proteins

21 January 2018

1 reference

Arp2/3 complex is bound and activated by two WASP proteins

21 January 2018

1 reference

Structural and biochemical characterization of two binding sites for nucleation-promoting factor WASp-VCA on Arp2/3 complex

21 January 2018

1 reference

Abl interactor 1 (Abi-1) wave-binding and SNARE domains regulate its nucleocytoplasmic shuttling, lamellipodium localization, and wave-1 levels

21 January 2018

1 reference

IRSp53 is an essential intermediate between Rac and WAVE in the regulation of membrane ruffling

21 January 2018

1 reference

CDC42 switches IRSp53 from inhibition of actin growth to elongation by clustering of VASP

21 January 2018

1 reference

WAVE regulatory complex activation by cooperating GTPases Arf and Rac1

21 January 2018

1 reference

ARF6-mediated endocytic recycling impacts cell movement, cell division and lipid homeostasis

21 January 2018

1 reference

The small G proteins of the Arf family and their regulators

21 January 2018

1 reference

The Drosophila Arf1 homologue Arf79F is essential for lamellipodium formation.

21 January 2018

1 reference

ADP-ribosylation factor 1 controls the activation of the phosphatidylinositol 3-kinase pathway to regulate epidermal growth factor-dependent growth and migration of breast cancer cells

21 January 2018

1 reference

Filamin A regulates neuronal migration through brefeldin A-inhibited guanine exchange factor 2-dependent Arf1 activation.

21 January 2018

1 reference

Arf6 coordinates actin assembly through the WAVE complex, a mechanism usurped by Salmonella to invade host cells.

21 January 2018

1 reference

Exo70 isoform switching upon epithelial-mesenchymal transition mediates cancer cell invasion

21 January 2018

1 reference

Exo70 stimulates the Arp2/3 complex for lamellipodia formation and directional cell migration

21 January 2018

1 reference

Exo70 interacts with the Arp2/3 complex and regulates cell migration

21 January 2018

1 reference

Proteomic analysis of adaptor protein 1A coats selectively assembled on liposomes

21 January 2018

1 reference

Protein complexes containing CYFIP/Sra/PIR121 coordinate Arf1 and Rac1 signalling during clathrin-AP-1-coated carrier biogenesis at the TGN.

21 January 2018

1 reference

Clathrin is required for Scar/Wave-mediated lamellipodium formation

21 January 2018

1 reference

The involvement of Abl and PTP61F in the regulation of Abi protein localization and stability and lamella formation in Drosophila S2 cells

21 January 2018

1 reference

Abelson-interactor-1 promotes WAVE2 membrane translocation and Abelson-mediated tyrosine phosphorylation required for WAVE2 activation

21 January 2018

1 reference

c-Abl interacts with the WAVE2 signaling complex to induce membrane ruffling and cell spreading

21 January 2018

1 reference

c-Abl-mediated phosphorylation of WAVE3 is required for lamellipodia formation and cell migration

21 January 2018

1 reference

Imatinib mesylate (STI571)-induced cell edge translocation of kinase-active and kinase-defective Abelson kinase: requirements of myristoylation and src homology 3 domain

21 January 2018

1 reference

Scar/WAVE-1, a Wiskott-Aldrich syndrome protein, assembles an actin-associated multi-kinase scaffold

21 January 2018

1 reference

Src-dependent phosphorylation of Scar1 promotes its association with the Arp2/3 complex

21 January 2018

1 reference

Cdk5 phosphorylation of WAVE2 regulates oligodendrocyte precursor cell migration through nonreceptor tyrosine kinase Fyn.

21 January 2018

1 reference

A WAVE-1 and WRP signaling complex regulates spine density, synaptic plasticity, and memory

21 January 2018

1 reference

Phosphorylation of WAVE downstream of mitogen-activated protein kinase signaling

21 January 2018

1 reference

Effect of WAVE2 phosphorylation on activation of the Arp2/3 complex.

21 January 2018

1 reference

Phosphorylation of WAVE2 by MAP kinases regulates persistent cell migration and polarity

21 January 2018

1 reference

ERK-MAPK drives lamellipodia protrusion by activating the WAVE2 regulatory complex

21 January 2018

1 reference

A conserved amphipathic helix in WASP/Scar proteins is essential for activation of Arp2/3 complex

21 January 2018

1 reference

WAVE2 is regulated by multiple phosphorylation events within its VCA domain

21 January 2018

1 reference

Pseudopod growth and evolution during cell movement is controlled through SCAR/WAVE dephosphorylation

21 January 2018

1 reference

The WAVE Regulatory Complex Links Diverse Receptors to the Actin Cytoskeleton

21 January 2018

1 reference

Endophilin, Lamellipodin, and Mena cooperate to regulate F-actin-dependent EGF-receptor endocytosis.

21 January 2018

1 reference

GEF means go: turning on RHO GTPases with guanine nucleotide-exchange factors

21 January 2018

1 reference

Signaling specificity by Ras family GTPases is determined by the full spectrum of effectors they regulate

21 January 2018

1 reference

The interaction of Arp2/3 complex with actin: nucleation, high affinity pointed end capping, and formation of branching networks of filaments

21 January 2018

1 reference

A "primer"-based mechanism underlies branched actin filament network formation and motility

21 January 2018

1 reference

Cofilin produces newly polymerized actin filaments that are preferred for dendritic nucleation by the Arp2/3 complex

21 January 2018

1 reference

Actin filament severing by cofilin dismantles actin patches and produces mother filaments for new patches

21 January 2018

1 reference

p53-cofactor JMY is a multifunctional actin nucleation factor

21 January 2018

1 reference

The actin nucleation factor JMY is a negative regulator of neuritogenesis

21 January 2018

1 reference

A transcription co-factor integrates cell adhesion and motility with the p53 response.

21 January 2018

1 reference

JMY is involved in anterograde vesicle trafficking from the trans-Golgi network.

21 January 2018

1 reference

WHAMM is an Arp2/3 complex activator that binds microtubules and functions in ER to Golgi transport

21 January 2018

1 reference

Dip1 defines a class of Arp2/3 complex activators that function without preformed actin filaments

21 January 2018

1 reference

Interaction of SPIN90 with the Arp2/3 complex mediates lamellipodia and actin comet tail formation

21 January 2018

1 reference

A novel neural Wiskott-Aldrich syndrome protein (N-WASP) binding protein, WISH, induces Arp2/3 complex activation independent of Cdc42

21 January 2018

1 reference

DIP/WISH-deficient mice reveal Dia- and N-WASP-interacting protein as a regulator of cytoskeletal dynamics in embryonic fibroblasts

21 January 2018

1 reference

SPIN90 knockdown attenuates the formation and movement of endosomal vesicles in the early stages of epidermal growth factor receptor endocytosis

21 January 2018

1 reference

Interaction of SPIN90 with syndapin is implicated in clathrin-mediated endocytic pathway in fibroblasts

21 January 2018

1 reference

Characterization of dip1p reveals a switch in Arp2/3-dependent actin assembly for fission yeast endocytosis

21 January 2018

1 reference

Actin branching in the initiation and maintenance of lamellipodia

21 January 2018

1 reference

Loss of Arp2/3 induces an NF-κB-dependent, nonautonomous effect on chemotactic signaling

21 January 2018

1 reference

Mena, a relative of VASP and Drosophila Enabled, is implicated in the control of microfilament dynamics

21 January 2018

1 reference

c-Abl, Lamellipodin, and Ena/VASP proteins cooperate in dorsal ruffling of fibroblasts and axonal morphogenesis

21 January 2018

1 reference

Pivotal role of VASP in Arp2/3 complex-mediated actin nucleation, actin branch-formation, and Listeria monocytogenes motility

21 January 2018

1 reference

A Mena invasion isoform potentiates EGF-induced carcinoma cell invasion and metastasis

21 January 2018

1 reference

The Rho family GTPase Rif induces filopodia through mDia2.

21 January 2018

1 reference

The Diaphanous-related formin dDia2 is required for the formation and maintenance of filopodia.

21 January 2018

1 reference

Critical role of Ena/VASP proteins for filopodia formation in neurons and in function downstream of netrin-1.

21 January 2018

1 reference

Novel roles of formin mDia2 in lamellipodia and filopodia formation in motile cells

21 January 2018

1 reference

Filopodia formation induced by active mDia2/Drf3.

21 January 2018

1 reference

Lamellipodial versus filopodial mode of the actin nanomachinery: pivotal role of the filament barbed end

21 January 2018

1 reference

CARMIL is a potent capping protein antagonist: identification of a conserved CARMIL domain that inhibits the activity of capping protein and uncaps capped actin filaments

21 January 2018

1 reference

Mammalian CARMIL inhibits actin filament capping by capping protein

21 January 2018

1 reference

The Dictyostelium CARMIL protein links capping protein and the Arp2/3 complex to type I myosins through their SH3 domains

21 January 2018

1 reference

CARMIL leading edge localization depends on a non-canonical PH domain and dimerization

21 January 2018

1 reference

Distinct roles for CARMIL isoforms in cell migration.

21 January 2018

1 reference

How tropomyosin regulates lamellipodial actin-based motility: a combined biochemical and reconstituted motility approach

21 January 2018

1 reference

Actin network architecture can determine myosin motor activity

21 January 2018

1 reference

Myosin II contributes to cell-scale actin network treadmilling through network disassembly

21 January 2018

1 reference

Interactions of ADF/cofilin, Arp2/3 complex, capping protein and profilin in remodeling of branched actin filament networks

21 January 2018

1 reference

GMF is a cofilin homolog that binds Arp2/3 complex to stimulate filament debranching and inhibit actin nucleation

21 January 2018

1 reference

GMF severs actin-Arp2/3 complex branch junctions by a cofilin-like mechanism.

21 January 2018

1 reference

Structural basis for regulation of Arp2/3 complex by GMF

21 January 2018

1 reference

Glia maturation factor (GMF) interacts with Arp2/3 complex in a nucleotide state-dependent manner

21 January 2018

1 reference

Glia maturation factor gamma regulates the migration and adherence of human T lymphocytes

21 January 2018

1 reference

The expression of glia maturation factors and the effect of glia maturation factor-γ on angiogenic sprouting in zebrafish

21 January 2018

1 reference

High GMFG expression correlates with poor prognosis and promotes cell migration and invasion in epithelial ovarian cancer

21 January 2018

1 reference

Coronin 1B antagonizes cortactin and remodels Arp2/3-containing actin branches in lamellipodia

21 January 2018

1 reference

Mechanism of synergistic activation of Arp2/3 complex by cortactin and N-WASP

21 January 2018

1 reference

Cortactin promotes cell motility by enhancing lamellipodial persistence

21 January 2018

1 reference

Cortactin promotes migration and platelet-derived growth factor-induced actin reorganization by signaling to Rho-GTPases.

21 January 2018

1 reference

Cortactin controls cell motility and lamellipodial dynamics by regulating ECM secretion

21 January 2018

1 reference

Cortactin is an essential regulator of matrix metalloproteinase secretion and extracellular matrix degradation in invadopodia

21 January 2018

1 reference

Sequence-dependent sorting of recycling proteins by actin-stabilized endosomal microdomains.

21 January 2018

1 reference

Unraveling the enigma: progress towards understanding the coronin family of actin regulators.

21 January 2018

1 reference

Dictyostelium mutants lacking the cytoskeletal protein coronin are defective in cytokinesis and cell motility

21 January 2018

1 reference

Rapid actin monomer-insensitive depolymerization of Listeria actin comet tails by cofilin, coronin, and Aip1.

21 January 2018

1 reference

Coronin-1A stabilizes F-actin by bridging adjacent actin protomers and stapling opposite strands of the actin filament

21 January 2018

1 reference

Coronin switches roles in actin disassembly depending on the nucleotide state of actin

21 January 2018

1 reference

Direct regulation of Arp2/3 complex activity and function by the actin binding protein coronin

21 January 2018

1 reference

Mechanism of a Concentration-dependent Switch between Activation and Inhibition of Arp2/3 Complex by Coronin

21 January 2018

1 reference

Coronin 1B coordinates Arp2/3 complex and cofilin activities at the leading edge

21 January 2018

1 reference

Phosphorylation of coronin 1B by protein kinase C regulates interaction with Arp2/3 and cell motility

21 January 2018

1 reference

Role of coronin 1B in PDGF-induced migration of vascular smooth muscle cells

21 January 2018

1 reference

Inhibition of Arp2/3-mediated actin polymerization by PICK1 regulates neuronal morphology and AMPA receptor endocytosis

21 January 2018

1 reference

Gadkin negatively regulates cell spreading and motility via sequestration of the actin-nucleating ARP2/3 complex

21 January 2018

1 reference

PICK1 inhibition of the Arp2/3 complex controls dendritic spine size and synaptic plasticity

21 January 2018

1 reference

The small GTPase Arf1 modulates Arp2/3-mediated actin polymerization via PICK1 to regulate synaptic plasticity

21 January 2018

1 reference

Directional persistence of EGF-induced cell migration is associated with stabilization of lamellipodial protrusions

21 January 2018

1 reference

A local coupling model and compass parameter for eukaryotic chemotaxis.

21 January 2018

1 reference

Chemotaxis in shallow gradients is mediated independently of PtdIns 3-kinase by biased choices between random protrusions.

21 January 2018

1 reference

Interaction of human Arp2/3 complex and the Listeria monocytogenes ActA protein in actin filament nucleation

21 January 2018

1 reference

The tandem repeat domain in the Listeria monocytogenes ActA protein controls the rate of actin-based motility, the percentage of moving bacteria, and the localization of vasodilator-stimulated phosphoprotein and profilin

21 January 2018

1 reference

Fyn-binding protein (Fyb)/SLP-76-associated protein (SLAP), Ena/vasodilator-stimulated phosphoprotein (VASP) proteins and the Arp2/3 complex link T cell receptor (TCR) signaling to the actin cytoskeleton

21 January 2018

1 reference

Feedback loops shape cellular signals in space and time

21 January 2018

1 reference

Mathematical modeling of eukaryotic cell migration: insights beyond experiments

21 January 2018

1 reference

Beyond symmetry-breaking: competition and negative feedback in GTPase regulation

21 January 2018

1 reference

Design principles of biochemical oscillators

21 January 2018

1 reference

Spatial control of actin polymerization during neutrophil chemotaxis

21 January 2018

1 reference

Cdc42 localization and cell polarity depend on membrane traffic

21 January 2018

1 reference

Asymmetry of single cells and where that leads

21 January 2018

1 reference

Mitochondrial localization and the persistent migration of epithelial cancer cells

21 January 2018

1 reference

Crosstalk between small GTPases and polarity proteins in cell polarization.

21 January 2018

1 reference

Microtubules in cell migration

21 January 2018

1 reference

GEFs and GAPs: critical elements in the control of small G proteins

21 January 2018

1 reference

Coronin 1A promotes a cytoskeletal-based feedback loop that facilitates Rac1 translocation and activation.

21 January 2018

1 reference

Direct observation of the uncapping of capping protein-capped actin filaments by CARMIL homology domain 3.

21 January 2018

1 reference

The on-off relationship of Rho and Rac during integrin-mediated adhesion and cell migration

21 January 2018

1 reference

Paxillin kinase linker (PKL) regulates Vav2 signaling during cell spreading and migration

21 January 2018

1 reference

A PtdInsP(3)- and Rho GTPase-mediated positive feedback loop regulates neutrophil polarity

21 January 2018

1 reference

Neutrophils establish rapid and robust WAVE complex polarity in an actin-dependent fashion

21 January 2018

1 reference

Nox1-dependent reactive oxygen generation is regulated by Rac1

21 January 2018

1 reference

Reactive oxygen species regulate protrusion efficiency by controlling actin dynamics

21 January 2018

1 reference

Regulation of hyperoxia-induced NADPH oxidase activation in human lung endothelial cells by the actin cytoskeleton and cortactin

21 January 2018

1 reference

A Rac switch regulates random versus directionally persistent cell migration

21 January 2018

1 reference

Diffusion, capture and recycling of SCAR/WAVE and Arp2/3 complexes observed in cells by single-molecule imaging.

21 January 2018

1 reference

Exorcising the exocyst complex

21 January 2018

1 reference

SH3BP1, an exocyst-associated RhoGAP, inactivates Rac1 at the front to drive cell motility

21 January 2018

1 reference

SrGAP3 interacts with lamellipodin at the cell membrane and regulates Rac-dependent cellular protrusions

21 January 2018

1 reference

The WRP component of the WAVE-1 complex attenuates Rac-mediated signalling

21 January 2018

1 reference

Synergistic BAR-NPF interactions in actin-driven membrane remodeling

21 January 2018

1 reference

srGAP1 regulates lamellipodial dynamics and cell migratory behavior by modulating Rac1 activity

21 January 2018

1 reference

Traveling waves in actin dynamics and cell motility

21 January 2018

1 reference

A review of models of fluctuating protrusion and retraction patterns at the leading edge of motile cells

21 January 2018

1 reference

Cells navigate with a local-excitation, global-inhibition-biased excitable network.

21 January 2018

1 reference

Control of actin filament treadmilling in cell motility

21 January 2018

1 reference

Regulation of actin filament assembly by Arp2/3 complex and formins

21 January 2018

1 reference

Control of Actin Assembly by the WH2 Domains and Their Multifunctional Tandem Repeats in Spire and Cordon-Bleu

21 January 2018

1 reference

New players in actin polymerization--WH2-domain-containing actin nucleators

21 January 2018

1 reference

Actin nucleation and elongation factors: mechanisms and interplay

21 January 2018

1 reference

GEP100 links epidermal growth factor receptor signalling to Arf6 activation to induce breast cancer invasion.

21 January 2018

1 reference

The adaptor proteins p66Shc and Grb2 regulate the activation of the GTPases ARF1 and ARF6 in invasive breast cancer cells

21 January 2018

1 reference

VASP dynamics during lamellipodia protrusion

21 January 2018

1 reference

Phosphorylation of WAVE1 regulates actin polymerization and dendritic spine morphology

21 January 2018

1 reference

mDia2 regulates actin and focal adhesion dynamics and organization in the lamella for efficient epithelial cell migration

21 January 2018

1 reference

Rac regulates PtdInsP3 signaling and the chemotactic compass through a redox-mediated feedback loop

21 January 2018

1 reference

Whence directionality: guidance mechanisms in solitary and collective cell migration

21 January 2018

1 reference

In vivo evidence for short- and long-range cell communication in cranial neural crest cells

31 March 2020

1 reference

Understanding the role of the G-actin-binding domain of Ena/VASP in actin assembly

31 March 2020

1 reference

Identification of glia maturation factor beta as an independent prognostic predictor for serous ovarian cancer

31 March 2020

1 reference

Inhibitory signalling to the Arp2/3 complex steers cell migration

31 March 2020

1 reference

Increased spreading, Rac/p21-activated kinase (PAK) activity, and compromised cell motility in cells deficient in vasodilator-stimulated phosphoprotein (VASP)

31 March 2020

1 reference

Actin enhances the activation of human neutrophil NADPH oxidase in a cell-free system

31 March 2020

1 reference

Homo- and hetero-oligomerization of the c-Abl kinase and Abelson-interactor-1.

31 March 2020

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25145849

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Association of cortactin with dynamic actin in lamellipodia and on endosomal vesicles.

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25145849

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

The 46/50 kDa phosphoprotein VASP purified from human platelets is a novel protein associated with actin filaments and focal contacts

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25145849