PI3Kδ Inhibition as a Potential Therapeutic Target in COVID-19 (Q99711572)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32973818%20AND%20SRC:MED&resulttype=core&format=json

29 September 2020

3 references

13 July 2022

22 August 2022

22 October 2022

PI3Kδ Inhibition as a Potential Therapeutic Target in COVID-19 (English)

1 reference

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29 September 2020

1 reference

Giuseppe Palma

1 reference

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29 September 2020

Teresa Pasqua

1 reference

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29 September 2020

Giovannino Silvestri

1 reference

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29 September 2020

Carmine Rocca

1 reference

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29 September 2020

Paola Gualtieri

1 reference

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29 September 2020

Antonio Barbieri

1 reference

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29 September 2020

Anna De Bartolo

1 reference

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29 September 2020

Antonino De Lorenzo

1 reference

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29 September 2020

Tommaso Angelone

1 reference

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29 September 2020

Ennio Avolio

1 reference

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29 September 2020

Gerardo Botti

1 reference

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29 September 2020

publication date

21 August 2020

4 references

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29 September 2020

13 July 2022

22 August 2022

22 October 2022

Frontiers in Immunology

4 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32973818%20AND%20SRC:MED&resulttype=core&format=json

29 September 2020

13 July 2022

22 August 2022

22 October 2022

1 reference

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29 September 2020

page(s)

2094

1 reference

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Creative Commons Attribution 4.0 International

29 September 2020

3 references

13 July 2022

22 August 2022

The immunology of COVID-19: is immune modulation an option for treatment?

22 October 2022

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7472874

BTK/ITK dual inhibitors: Modulating immunopathology and lymphopenia for COVID-19 therapy

10 February 2021

1 reference

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JAK inhibitors in COVID-19: need for vigilance regarding increased inherent thrombotic risk

10 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7472874

Body Composition Findings by Computed Tomography in SARS-CoV-2 Patients: Increased Risk of Muscle Wasting in Obesity

10 February 2021

1 reference

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Adjunct Immunotherapies for the Management of Severely Ill COVID-19 Patients

10 February 2021

1 reference

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Paediatric multisystem inflammatory syndrome temporally associated with SARS-CoV-2 mimicking Kawasaki disease (Kawa-COVID-19): a multicentre cohort

10 February 2021

1 reference

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Eating habits and lifestyle changes during COVID-19 lockdown: an Italian survey

10 February 2021

1 reference

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Risk factors for mortality in patients with Coronavirus disease 2019 (COVID-19) infection: a systematic review and meta-analysis of observational studies

10 February 2021

1 reference

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Immunology of COVID-19: Current State of the Science

10 February 2021

1 reference

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Autoimmune and inflammatory diseases following COVID-19

10 February 2021

1 reference

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Cytokine storm in COVID-19: pathogenesis and overview of anti-inflammatory agents used in treatment

10 February 2021

1 reference

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Let's talk about sex in the context of COVID-19

10 February 2021

1 reference

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COVID-19-associated cardiovascular morbidity in older adults: a position paper from the Italian Society of Cardiovascular Researches

10 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7472874

Incidence of COVID-19 in a cohort of adult and paediatric patients with rheumatic diseases treated with targeted biologic and synthetic disease-modifying anti-rheumatic drugs

10 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7472874

An outbreak of severe Kawasaki-like disease at the Italian epicentre of the SARS-CoV-2 epidemic: an observational cohort study

10 February 2021

1 reference

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JAK Inhibition as a New Treatment Strategy for Patients with COVID-19

10 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7472874

Roles of PI3K pan-inhibitors and PI3K-δ inhibitors in allergic lung inflammation: a systematic review and meta-analysis

10 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7472874

COVID-19 illness in native and immunosuppressed states: A clinical-therapeutic staging proposal

10 February 2021

1 reference

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Diagnostic and therapeutic challenges for patients with ANCA-associated vasculitides at the time of COVID-19. Response to: 'Rituximab for granulomatosis with polyangiitis in the pandemic of COVID-19: lessons from a case with severe pneumonia' by Gui

10 February 2021

1 reference

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SARS-CoV-2: A new virus but a familiar inflammation brain pattern

10 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7472874

Baricitinib therapy in COVID-19: A pilot study on safety and clinical impact

10 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7472874

Obesity and SARS-CoV-2: a population to safeguard

10 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7472874

The BTK-inhibitor ibrutinib may protect against pulmonary injury in COVID-19 infected patients

10 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7472874

Structural and Functional Basis of SARS-CoV-2 Entry by Using Human ACE2

10 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7472874

Obesity in patients younger than 60 years is a risk factor for Covid-19 hospital admission

10 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7472874

Covid-19: four fifths of cases are asymptomatic, China figures indicate

10 February 2021

1 reference

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COVID-19, ACE2, and the cardiovascular consequences

10 February 2021

1 reference

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The use of anti-inflammatory drugs in the treatment of people with severe coronavirus disease 2019 (COVID-19): The Perspectives of clinical immunologists from China

10 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7472874

Clinical course and mortality risk of severe COVID-19

10 February 2021

1 reference

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Clinical Features of 69 Cases with Coronavirus Disease 2019 in Wuhan, China

10 February 2021

1 reference

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Induction of pro-inflammatory cytokines (IL-1 and IL-6) and lung inflammation by Coronavirus-19 (COVI-19 or SARS-CoV-2): anti-inflammatory strategies

10 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7472874

Are patients with hypertension and diabetes mellitus at increased risk for COVID-19 infection?

10 February 2021

1 reference

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The origin, transmission and clinical therapies on coronavirus disease 2019 (COVID-19) outbreak - an update on the status

10 February 2021

1 reference

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Dysregulation of immune response in patients with COVID-19 in Wuhan, China

10 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7472874

COVID-19 and the cardiovascular system

10 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7472874

Understanding SARS-CoV-2-Mediated Inflammatory Responses: From Mechanisms to Potential Therapeutic Tools

10 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7472874

Clinical Characteristics of Coronavirus Disease 2019 in China

10 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7472874

Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study

10 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7472874

Baricitinib as potential treatment for 2019-nCoV acute respiratory disease

10 February 2021

1 reference

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A new coronavirus associated with human respiratory disease in China

10 February 2021

1 reference

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A pneumonia outbreak associated with a new coronavirus of probable bat origin

10 February 2021

1 reference

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Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

10 February 2021

1 reference

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Coronavirus infections and immune responses

10 February 2021

1 reference

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A Novel Coronavirus from Patients with Pneumonia in China, 2019

10 February 2021

1 reference

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Coronaviruses: genome structure, replication, and pathogenesis

10 February 2021

1 reference

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Translation of Inhaled Drug Optimization Strategies into Clinical Pharmacokinetics and Pharmacodynamics Using GSK2292767A, a Novel Inhaled Phosphoinositide 3-Kinase δ Inhibitor

10 February 2021

1 reference

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Characterizing Pharmacokinetic-Pharmacodynamic Relationships and Efficacy of PI3Kδ Inhibitors in Respiratory Models of TH2 and TH1 Inflammation

10 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7472874

Inhalation of the prodrug PI3K inhibitor CL27c improves lung function in asthma and fibrosis

10 February 2021

1 reference

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A Multicentre, Randomized, Double-Blind, Placebo-Controlled, Crossover Study To Investigate the Efficacy, Safety, Tolerability, and Pharmacokinetics of Repeat Doses of Inhaled Nemiralisib in Adults with Persistent, Uncontrolled Asthma

10 February 2021

1 reference

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Interleukin 6 Trans-Signalling and Risk of Future Cardiovascular Events

10 February 2021

1 reference

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Role of Brain Neuroinflammatory Factors on Hypertension in the Spontaneously Hypertensive Rat.

10 February 2021

1 reference

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MERS, SARS and other coronaviruses as causes of pneumonia.

10 February 2021

1 reference

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NOSH-NBP, a Novel Nitric Oxide and Hydrogen Sulfide- Releasing Hybrid, Attenuates Ischemic Stroke-Induced Neuroinflammatory Injury by Modulating Microglia Polarization

10 February 2021

1 reference

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An investigation of the anti-inflammatory effects and a potential biomarker of PI3Kδ inhibition in COPD T cells.

10 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7472874

Randomized phase 1 study of the phosphatidylinositol 3-kinase δ inhibitor idelalisib in patients with allergic rhinitis.

10 February 2021

1 reference

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Synthetic Oligodeoxynucleotides Containing Multiple Telemeric TTAGGG Motifs Suppress Inflammasome Activity in Macrophages Subjected to Oxygen and Glucose Deprivation and Reduce Ischemic Brain Injury in Stroke-Prone Spontaneously Hypertensive Rats

10 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7472874

Optimization of Novel Indazoles as Highly Potent and Selective Inhibitors of Phosphoinositide 3-Kinase δ for the Treatment of Respiratory Disease

10 February 2021

1 reference

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PI3K signalling in inflammation

10 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7472874

Long-term outcomes of patients with persistent indolent B cell malignancies undergoing nonmyeloablative allogeneic transplantation

10 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7472874

Phosphoinositide 3-kinase δ gene mutation predisposes to respiratory infection and airway damage

10 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7472874

Targeting phosphoinositide 3-kinase δ for the treatment of respiratory diseases.

10 February 2021

1 reference

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PI3K signalling in B- and T-lymphocytes: new developments and therapeutic advances

10 February 2021

1 reference

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Management of Blood Pressure in Patients With Diabetes

10 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7472874

PI3K p110delta regulates T-cell cytokine production during primary and secondary immune responses in mice and humans

10 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7472874

Inhibition of phosphoinositide 3-kinase delta attenuates allergic airway inflammation and hyperresponsiveness in murine asthma model

10 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7472874

ACE2 receptor expression and severe acute respiratory syndrome coronavirus infection depend on differentiation of human airway epithelia

10 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7472874

Effect of angiotensin-converting enzyme inhibition and angiotensin II receptor blockers on cardiac angiotensin-converting enzyme 2.

10 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7472874

Essential role for the p110delta phosphoinositide 3-kinase in the allergic response

10 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7472874

Organ distribution of severe acute respiratory syndrome (SARS) associated coronavirus (SARS-CoV) in SARS patients: implications for pathogenesis and virus transmission pathways

10 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7472874

Plasma inflammatory cytokines and chemokines in severe acute respiratory syndrome.

10 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7472874

Mechanisms and implications of phosphoinositide 3-kinase delta in promoting neutrophil trafficking into inflamed tissue.

10 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7472874

Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus

10 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7472874

Ebastine inhibits T cell migration, production of Th2‐type cytokines and proinflammatory cytokines

10 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7472874

A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1-9

10 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=7472874

10 February 2021

Identifiers

DOI

10.3389/FIMMU.2020.02094

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32973818%20AND%20SRC:MED&resulttype=core&format=json

29 September 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32973818%20AND%20SRC:MED&resulttype=core&format=json

29 September 2020

PubMed publication ID

32973818

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32973818%20AND%20SRC:MED&resulttype=core&format=json