Inhibition of Amyloid-Beta Production, Associated Neuroinflammation, and Histone Deacetylase 2-Mediated Epigenetic Modifications Prevent Neuropathology in Alzheimer's Disease in vitro Model (Q89494061)

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scientific article published on 01 January 2019

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English	Inhibition of Amyloid-Beta Production, Associated Neuroinflammation, and Histone Deacetylase 2-Mediated Epigenetic Modifications Prevent Neuropathology in Alzheimer's Disease in vitro Model	scientific article published on 01 January 2019

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scholarly article

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5 April 2020

Inhibition of Amyloid-Beta Production, Associated Neuroinflammation, and Histone Deacetylase 2-Mediated Epigenetic Modifications Prevent Neuropathology in Alzheimer's Disease in vitro Model (English)

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5 April 2020

Alzheimer's disease

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Venkata Subba Rao Atluri

1

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5 April 2020

Sneham Tiwari

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5 April 2020

Melisa Rodriguez

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Ajeet Kaushik

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Adriana Yndart

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Nagesh Kolishetti

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Mohan Yatham

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Madhavan Nair

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publication date

1 January 2019

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Frontiers in Aging Neuroscience

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5 April 2020

11

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342

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5 April 2020

copyright license

Creative Commons Attribution 4.0 International

15 January 2020

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC6974446/fullTextXML

based on heuristic

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Non-enzymatically glycated tau in Alzheimer's disease induces neuronal oxidant stress resulting in cytokine gene expression and release of amyloid beta-peptide.

1 reference

https://pubmed.ncbi.nlm.nih.gov/32009938

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enhancement of immunoreactivity for NF-kappa B in the hippocampal formation and cerebral cortex of Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/32009938

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transcription factor NF-kappaB is activated in primary neurons by amyloid beta peptides and in neurons surrounding early plaques from patients with Alzheimer disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/32009938

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of nuclear factor-κB by β-amyloid peptides and interferon-γ in murine microglia

1 reference

https://pubmed.ncbi.nlm.nih.gov/32009938

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Microglial activation by Alzheimer amyloid precursor protein and modulation by apolipoprotein E.

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https://pubmed.ncbi.nlm.nih.gov/32009938

12 December 2020

based on heuristic

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Nuclear translocation of NF-κB in cholinergic neurons of patients with Alzheimerʼs disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/32009938

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glial-neuronal interactions in Alzheimer's disease: the potential role of a 'cytokine cycle' in disease progression

1 reference

https://pubmed.ncbi.nlm.nih.gov/32009938

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Strong nuclear factor-kappaB-DNA binding parallels cyclooxygenase-2 gene transcription in aging and in sporadic Alzheimer's disease superior temporal lobe neocortex

1 reference

https://pubmed.ncbi.nlm.nih.gov/32009938

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Proinflammatory profile of cytokine production by human monocytes and murine microglia stimulated with beta-amyloid[25-35].

1 reference

https://pubmed.ncbi.nlm.nih.gov/32009938

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin-1 promotes expression and phosphorylation of neurofilament and tau proteins in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/32009938

12 December 2020

based on heuristic

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Inflammation and Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/32009938

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sequence-selective DNA binding drugs mithramycin A and chromomycin A3 are potent inhibitors of neuronal apoptosis induced by oxidative stress and DNA damage in cortical neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/32009938

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Use of isogenic human cancer cells for high-throughput screening and drug discovery

1 reference

https://pubmed.ncbi.nlm.nih.gov/32009938

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of histone acetylation during memory formation in the hippocampus.

1 reference

https://pubmed.ncbi.nlm.nih.gov/32009938

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chemotherapy for the brain: the antitumor antibiotic mithramycin prolongs survival in a mouse model of Huntington's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/32009938

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin-1 mediates Alzheimer and Lewy body pathologies.

1 reference

https://pubmed.ncbi.nlm.nih.gov/32009938

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sp1 is up-regulated in cellular and transgenic models of Huntington disease, and its reduction is neuroprotective

1 reference

https://pubmed.ncbi.nlm.nih.gov/32009938

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ESET/SETDB1 gene expression and histone H3 (K9) trimethylation in Huntington's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/32009938

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Recovery of learning and memory is associated with chromatin remodelling

1 reference

https://pubmed.ncbi.nlm.nih.gov/32009938

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of potential therapeutic drugs for huntington's disease using Caenorhabditis elegans

1 reference

https://pubmed.ncbi.nlm.nih.gov/32009938

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The NALP3 inflammasome is involved in the innate immune response to amyloid-beta

1 reference

https://pubmed.ncbi.nlm.nih.gov/32009938

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Therapeutic application of histone deacetylase inhibitors for central nervous system disorders

1 reference

https://pubmed.ncbi.nlm.nih.gov/32009938

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The inflammasome: a caspase-1-activation platform that regulates immune responses and disease pathogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/32009938

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The inflammasomes: guardians of the body

1 reference

https://pubmed.ncbi.nlm.nih.gov/32009938

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

HDAC2 negatively regulates memory formation and synaptic plasticity.

1 reference

https://pubmed.ncbi.nlm.nih.gov/32009938

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Histone deacetylases 1 and 2 form a developmental switch that controls excitatory synapse maturation and function

1 reference

https://pubmed.ncbi.nlm.nih.gov/32009938

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inflammation, microglia, and Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/32009938

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immune activation in brain aging and neurodegeneration: too much or too little?

1 reference

https://pubmed.ncbi.nlm.nih.gov/32009938

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Microglia and inflammation in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/32009938

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuroinflammation, oxidative stress and the pathogenesis of Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/32009938

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Heterogeneity of CNS myeloid cells and their roles in neurodegeneration

1 reference

https://pubmed.ncbi.nlm.nih.gov/32009938

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An epigenetic blockade of cognitive functions in the neurodegenerating brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/32009938

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Histone Deacetylase Inhibitors and Mithramycin A Impact a Similar Neuroprotective Pathway at a Crossroad between Cancer and Neurodegeneration.

1 reference

https://pubmed.ncbi.nlm.nih.gov/32009938

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/32009938

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Assessing β-amyloid-induced NLRP3 inflammasome activation in primary microglia

1 reference

https://pubmed.ncbi.nlm.nih.gov/32009938

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Withaferin A inhibits NF-kappaB activation by targeting cysteine 179 in IKKβ.

1 reference

https://pubmed.ncbi.nlm.nih.gov/32009938

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

c-Abl stabilizes HDAC2 levels by tyrosine phosphorylation repressing neuronal gene expression in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/32009938

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases.

1 reference

https://pubmed.ncbi.nlm.nih.gov/32009938

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuroinflammation in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/32009938

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Withaferin A Inhibits Nuclear Factor-κB-Dependent Pro-Inflammatory and Stress Response Pathways in the Astrocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/32009938

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuroinflammation in Alzheimer's disease: Current evidence and future directions

1 reference

https://pubmed.ncbi.nlm.nih.gov/32009938

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Targeting the HDAC2/HNF-4A/miR-101b/AMPK Pathway Rescues Tauopathy and Dendritic Abnormalities in Alzheimer's Disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/32009938

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

NLRP3 Inflammasome Inhibitor Ameliorates Amyloid Pathology in a Mouse Model of Alzheimer's Disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/32009938

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cutting Edge: TRAF6 Mediates TLR/IL-1R Signaling-Induced Nontranscriptional Priming of the NLRP3 Inflammasome

1 reference

https://pubmed.ncbi.nlm.nih.gov/32009938

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Targeting Neuroinflammation to Treat Alzheimer's Disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/32009938

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Withaferin A Suppresses Beta Amyloid in APP Expressing Cells: Studies for Tat and Cocaine Associated Neurological Dysfunctions

1 reference

https://pubmed.ncbi.nlm.nih.gov/32009938

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloid β directly interacts with NLRP3 to initiate inflammasome activation: identification of an intrinsic NLRP3 ligand in a cell-free system

1 reference

https://pubmed.ncbi.nlm.nih.gov/32009938

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IRF2 transcriptionally induces GSDMD expression for pyroptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/32009938

12 December 2020

based on heuristic

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Identifiers

10.3389/FNAGI.2019.00342

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32009938%20AND%20SRC:MED&resulttype=core&format=json

5 April 2020

PMC publication ID

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Europe PubMed Central

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5 April 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32009938%20AND%20SRC:MED&resulttype=core&format=json

5 April 2020

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