Identification of potential therapeutic drugs for huntington's disease using Caenorhabditis elegans (Q21144448)

18 August 2022

Hemant Varma

Hemant

Varma

1 reference

18 August 2022

Nicola Walker

Nicola

Walker

1 reference

18 August 2022

Emily A Bates

Emily A

Bates

1 reference

18 August 2022

Brent R Stockwell

Brent R

Stockwell

1 reference

18 August 2022

Anne C Hart

Anne C

Hart

1 reference

Creative Commons Attribution 4.0 International

18 August 2022

language of work or name

English

0 references

publication date

2007

0 references

0 references

0 references

0 references

e504

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start time

6 June 2007

1 reference

April 2022 Public Data File from Crossref

copyrighted

0 references

cites work

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A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

19 March 2017

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The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans

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daf-16: An HNF-3/forkhead family member that can function to double the life-span of Caenorhabditis elegans

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Regulation of Aging and Age-Related Disease by DAF-16 and Heat-Shock Factor

19 March 2017

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The threshold for polyglutamine-expansion protein aggregation and cellular toxicity is dynamic and influenced by aging in Caenorhabditis elegans

7 April 2017

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Histone deacetylase inhibitors arrest polyglutamine-dependent neurodegeneration in Drosophila

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7 April 2017

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DAF-16/FOXO regulates transcription of cki-1/Cip/Kip and repression of lin-4 during C. elegans L1 arrest.

12 September 2017

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SIRT1, neuronal cell survival and the insulin/IGF-1 aging paradox

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Compounds blocking mutant huntingtin toxicity identified using a Huntington's disease neuronal cell model

12 September 2017

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Multicomponent therapeutics for networked systems

12 September 2017

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Chemotherapy for the brain: the antitumor antibiotic mithramycin prolongs survival in a mouse model of Huntington's disease

12 September 2017

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Genome-wide RNA interference screen identifies previously undescribed regulators of polyglutamine aggregation

12 September 2017

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Regulation of longevity in Caenorhabditis elegans by heat shock factor and molecular chaperones

12 September 2017

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A cell-based assay for aggregation inhibitors as therapeutics of polyglutamine-repeat disease and validation in Drosophila

12 September 2017

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Suberoylanilide hydroxamic acid, a histone deacetylase inhibitor, ameliorates motor deficits in a mouse model of Huntington's disease

12 September 2017

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Glutamine/proline-rich PQE-1 proteins protect Caenorhabditis elegans neurons from huntingtin polyglutamine neurotoxicity

12 September 2017

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Genetic analysis of tissue aging in Caenorhabditis elegans: a role for heat-shock factor and bacterial proliferation.

12 September 2017

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Histone deacetylase inhibitors reduce polyglutamine toxicity

12 September 2017

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Caenorhabditis elegans: how good a model for veterinary parasites?

12 September 2017

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Altered transcription in yeast expressing expanded polyglutamine

12 September 2017

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Molecular targets of lithium action

12 September 2017

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Muscular dystrophy: the worm turns to genetic disease

12 September 2017

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Regulation of expanded polyglutamine protein aggregation and nuclear localization by the glucocorticoid receptor

12 September 2017

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Polyglutamine-mediated dysfunction and apoptotic death of a Caenorhabditis elegans sensory neuron

12 September 2017

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Selective inhibitors of death in mutant huntingtin cells

12 September 2017

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Huntington's disease: CAG genetics expands neurobiology

27 September 2017

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27 September 2017

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Genetic suppression of phenotypes arising from mutations in dystrophin-related genes in Caenorhabditis elegans.

27 September 2017

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Oxidative stress and ageing in Caenorhabditis elegans

30 May 2018

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Expression of beta-galactosidase under the control of the human c-myc promoter in transgenic mice is inhibited by mithramycin

30 May 2018

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30 May 2018

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30 May 2018

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Differential contributions of Caenorhabditis elegans histone deacetylases to huntingtin polyglutamine toxicity.

21 January 2018

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C. elegans DAF-18/PTEN mediates nutrient-dependent arrest of cell cycle and growth in the germline.

21 January 2018

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A screen for drugs that protect against the cytotoxicity of polyglutamine-expanded androgen receptor.

21 January 2018

1 reference

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Glycogen synthase kinase-3beta inhibitors prevent cellular polyglutamine toxicity caused by the Huntington's disease mutation

21 January 2018

1 reference

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Lithium rescues toxicity of aggregate-prone proteins in Drosophila by perturbing Wnt pathway.

21 January 2018

1 reference

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Rapid aggregate formation of the huntingtin N-terminal fragment carrying an expanded polyglutamine tract

21 January 2018

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Pivotal role of oligomerization in expanded polyglutamine neurodegenerative disorders.

21 January 2018

1 reference

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Cystamine treatment is neuroprotective in the YAC128 mouse model of Huntington disease.

21 January 2018

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Prolonged survival and decreased abnormal movements in transgenic model of Huntington disease, with administration of the transglutaminase inhibitor cystamine

21 January 2018

1 reference

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Suppression of aggregate formation and apoptosis by transglutaminase inhibitors in cells expressing truncated DRPLA protein with an expanded polyglutamine stretch.

21 January 2018

1 reference

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Therapeutic effects of cystamine in a murine model of Huntington's disease.

21 January 2018

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10.1371/JOURNAL.PONE.0000504

29 November 2018

Identifiers

DOI

1 reference

ADS bibcode

2007PLoSO...2..504V

0 references

1 reference

1 reference

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