The Impact of APP on Alzheimer-like Pathogenesis and Gene Expression in Down Syndrome iPSC-Derived Neurons (Q88964540)

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scientific article published on 31 May 2018

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English	The Impact of APP on Alzheimer-like Pathogenesis and Gene Expression in Down Syndrome iPSC-Derived Neurons	scientific article published on 31 May 2018

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Europe PubMed Central

PMC publication ID

6066957

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29861166%20AND%20SRC:MED&resulttype=core&format=json

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29 March 2020

title

The Impact of APP on Alzheimer-like Pathogenesis and Gene Expression in Down Syndrome iPSC-Derived Neurons (English)

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Europe PubMed Central

PMC publication ID

6066957

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29861166%20AND%20SRC:MED&resulttype=core&format=json

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29 March 2020

main subject

Down syndrome

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author

Dmitry A Ovchinnikov

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1

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Europe PubMed Central

PMC publication ID

6066957

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Christine A Wells

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4

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6066957

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Ernst Wolvetang

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5

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6066957

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Othmar Korn

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2

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6066957

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Isaac Virshup

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3

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6066957

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publication date

31 May 2018

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6066957

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29 March 2020

published in

Stem Cell Reports

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6066957

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29 March 2020

volume

11

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6066957

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29 March 2020

issue

1

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6066957

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29 March 2020

page(s)

32-42

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6066957

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29 March 2020

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22 June 2022

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Morphological criteria for the recognition of Alzheimer's disease and the distribution pattern of cortical changes related to this disorder

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/29861166

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based on heuristic

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Down's syndrome: up-regulation of beta-amyloid protein precursor and tau mRNAs and their defective coordination

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PubMed

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based on heuristic

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Apoptosis and increased generation of reactive oxygen species in Down's syndrome neurons in vitro.

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/29861166

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12 December 2020

based on heuristic

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Regulation of APP processing by intra- and intercellular signals

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/29861166

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12 December 2020

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inferred from PubMed ID database lookup

A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/29861166

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12 December 2020

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Formation of neurofibrillary tangles in P301l tau transgenic mice induced by Abeta 42 fibrils

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/29861166

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

App gene dosage modulates endosomal abnormalities of Alzheimer's disease in a segmental trisomy 16 mouse model of down syndrome

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/29861166

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

BACE2, as a novel APP theta-secretase, is not responsible for the pathogenesis of Alzheimer's disease in Down syndrome

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/29861166

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based on heuristic

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APP duplication is sufficient to cause early onset Alzheimer's dementia with cerebral amyloid angiopathy

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/29861166

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modulation of gene expression and cytoskeletal dynamics by the amyloid precursor protein intracellular domain (AICD)

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/29861166

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based on heuristic

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APP locus duplication in a Finnish family with dementia and intracerebral haemorrhage

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/29861166

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Epidemiology of Down syndrome

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/29861166

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein expression of BACE1, BACE2 and APP in Down syndrome brains

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/29861166

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12 December 2020

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Secreted APP regulates the function of full-length APP in neurite outgrowth through interaction with integrin beta1.

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/29861166

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12 December 2020

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Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/29861166

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The genetic architecture of Down syndrome phenotypes revealed by high-resolution analysis of human segmental trisomies

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/29861166

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12 December 2020

based on heuristic

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Effect of apolipoprotein E on biomarkers of amyloid load and neuronal pathology in Alzheimer disease

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/29861166

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12 December 2020

based on heuristic

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Pyroglutamate-Aβ: Role in the natural history of Alzheimer's disease

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/29861166

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12 December 2020

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Possible roles of amyloid intracellular domain of amyloid precursor protein

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/29861166

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12 December 2020

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Proteostasis of tau. Tau overexpression results in its secretion via membrane vesicles.

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/29861166

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12 December 2020

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A human stem cell model of early Alzheimer's disease pathology in Down syndrome

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/29861166

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Integration-free induced pluripotent stem cells model genetic and neural developmental features of down syndrome etiology

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/29861166

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

1-42 β-amyloid peptide requires PDK1/nPKC/Rac 1 pathway to induce neuronal death.

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/29861166

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The amyloid precursor protein (APP) triplicated gene impairs neuronal precursor differentiation and neurite development through two different domains in the Ts65Dn mouse model for Down syndrome

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/29861166

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Single App knock-in mouse models of Alzheimer's disease.

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/29861166

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Recent Perspectives on APP, Secretases, Endosomal Pathways and How they Influence Alzheimer's Related Pathological Changes in Down Syndrome

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/29861166

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The intersection of amyloid beta and tau at synapses in Alzheimer's disease

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/29861166

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12 December 2020

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Isolation of contractile cardiomyocytes from human pluripotent stem-cell-derived cardiomyogenic cultures using a human NCX1-EGFP reporter

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PubMed

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12 December 2020

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limma powers differential expression analyses for RNA-sequencing and microarray studies

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/29861166

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12 December 2020

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inferred from PubMed ID database lookup

Brief report: isogenic induced pluripotent stem cell lines from an adult with mosaic down syndrome model accelerated neuronal ageing and neurodegeneration

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PubMed

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12 December 2020

based on heuristic

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N-butylidenephthalide attenuates Alzheimer's disease-like cytopathy in Down syndrome induced pluripotent stem cell-derived neurons

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PubMed

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

APP metabolism regulates tau proteostasis in human cerebral cortex neurons

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/29861166

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

APP overexpression in the absence of NPC1 exacerbates metabolism of amyloidogenic proteins of Alzheimer's disease

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PubMed

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based on heuristic

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Generation of Footprint-Free Induced Pluripotent Stem Cells from Human Fibroblasts Using Episomal Plasmid Vectors

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based on heuristic

inferred from PubMed ID database lookup

Amyloid-β Peptide Aβ3pE-42 Induces Lipid Peroxidation, Membrane Permeabilization, and Calcium Influx in Neurons

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PubMed

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

APP Receptor? To Be or Not To Be.

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PubMed

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12 December 2020

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Multiple signaling factors and drugs alleviate neuronal death induced by expression of human and zebrafish tau proteins in vivo

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PubMed

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Derivation of Trisomy 21 affected human embryonic stem cell line Genea021.

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Derivation of human embryonic stem cell line Genea022.

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PubMed

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based on heuristic

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Down Syndrome, Partial Trisomy 21, and Absence of Alzheimer's Disease: The Role of APP.

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/29861166

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Down syndrome and the complexity of genome dosage imbalance

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/29861166

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Identifiers

DOI

10.1016/J.STEMCR.2018.05.004

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stated in

Europe PubMed Central

PMC publication ID

6066957

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29861166%20AND%20SRC:MED&resulttype=core&format=json

retrieved

29 March 2020

PMC publication ID

6066957

1 reference

stated in

Europe PubMed Central

PMC publication ID

6066957

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29861166%20AND%20SRC:MED&resulttype=core&format=json

retrieved

29 March 2020

PubMed publication ID

29861166

1 reference

stated in

Europe PubMed Central

PMC publication ID

6066957

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29861166%20AND%20SRC:MED&resulttype=core&format=json

retrieved

29 March 2020

 

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