The amyloid precursor protein (APP) triplicated gene impairs neuronal precursor differentiation and neurite development through two different domains in the Ts65Dn mouse model for Down syndrome (Q37175063)

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scientific article published on 05 June 2013

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English	The amyloid precursor protein (APP) triplicated gene impairs neuronal precursor differentiation and neurite development through two different domains in the Ts65Dn mouse model for Down syndrome	scientific article published on 05 June 2013

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2 March 2020

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Continued use of retracted papers: Temporal trends in citations and (lack of) awareness of retractions shown in citation contexts in biomedicine

The amyloid precursor protein (APP) triplicated gene impairs neuronal precursor differentiation and neurite development through two different domains in the Ts65Dn mouse model for Down syndrome (English)

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Stefania Trazzi

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Elisabetta Ciani

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Claudia Fuchs

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Giovanni Perini

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Renata Bartesaghi

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5 June 2013

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2 March 2020

Journal of Biological Chemistry

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29

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2 March 2020

20817-20829

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2 March 2020

OLIG2 over-expression impairs proliferation of human Down syndrome neural progenitors

1 reference

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Secreted amyloid precursor proteins promote proliferation and glial differentiation of adult hippocampal neural progenitor cells

1 reference

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The roles of amyloid precursor protein (APP) in neurogenesis: Implications to pathogenesis and therapy of Alzheimer disease

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6 September 2017

S100B and APP Promote a Gliocentric Shift and Impaired Neurogenesis in Down Syndrome Neural Progenitors

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Ascl1/Mash1 is a novel target of Gli2 during Gli2-induced neurogenesis in P19 EC cells

1 reference

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AICD Overexpression in Neuro 2A Cells Regulates Expression of PTCH1 and TRPC5

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Gene network disruptions and neurogenesis defects in the adult Ts1Cje mouse model of Down syndrome

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6 September 2017

Meiotic behavior of aneuploid chromatin in mouse models of Down syndrome.

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6 September 2017

The genetic architecture of Down syndrome phenotypes revealed by high-resolution analysis of human segmental trisomies

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Region-specific differentiation potential of adult rat spinal cord neural stem/precursors and their plasticity in response to in vitro manipulation

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6 September 2017

The amyloid precursor protein intracellular domain (AICD) as modulator of gene expression, apoptosis, and cytoskeletal dynamics-relevance for Alzheimer's disease

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6 September 2017

Mental retardation and associated neurological dysfunctions in Down syndrome: a consequence of dysregulation in critical chromosome 21 genes and associated molecular pathways

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6 September 2017

Defective cerebellar response to mitogenic Hedgehog signaling in Down [corrected] syndrome mice

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6 September 2017

Cooperative requirement of the Gli proteins in neurogenesis

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6 September 2017

On dendrites in Down syndrome and DS murine models: a spiny way to learn.

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6 September 2017

Hes binding to STAT3 mediates crosstalk between Notch and JAK-STAT signalling

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6 September 2017

Protein measurement with the Folin phenol reagent

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6 September 2017

All mouse ventral spinal cord patterning by hedgehog is Gli dependent and involves an activator function of Gli3

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6 September 2017

Down's syndrome

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6 September 2017

Small molecule modulation of Smoothened activity

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6 September 2017

A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60

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6 September 2017

Crystal structure of the N-terminal, growth factor-like domain of Alzheimer amyloid precursor protein

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6 September 2017

Combinatorial Gli gene function in floor plate and neuronal inductions by Sonic hedgehog

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6 September 2017

The growth of non-pyramidal neurons in the primary motor cortex of man: a Golgi study

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6 September 2017

Stat3: a STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6

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6 September 2017

The beta-amyloid protein precursor of Alzheimer disease has soluble derivatives found in human brain and cerebrospinal fluid

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6 September 2017

Synaptic Dysgenesis

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6 September 2017

Involvement of notch signaling pathway in amyloid precursor protein induced glial differentiation.

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14 September 2017

Amyloid-β precursor protein induces glial differentiation of neural progenitor cells by activation of the IL-6/gp130 signaling pathway

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14 September 2017

Transient Notch activation initiates an irreversible switch from neurogenesis to gliogenesis by neural crest stem cells

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28 September 2017

Mash1 and neurogenin1 expression patterns define complementary domains of neuroepithelium in the developing CNS and are correlated with regions expressing notch ligands

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28 September 2017

Segmental trisomy as a mouse model for Down syndrome

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28 September 2017

Hippocampal hypocellularity in the Ts65Dn mouse originates early in development

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Role of founder cell deficit and delayed neuronogenesis in microencephaly of the trisomy 16 mouse.

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Cellular actions of beta-amyloid precursor protein and its soluble and fibrillogenic derivatives

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27 June 2018

A mouse model for Down syndrome exhibits learning and behaviour deficits.

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27 June 2018

Abnormal neuronal development in the visual cortex of the human fetus and infant with down's syndrome. A quantitative and qualitative Golgi study

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27 June 2018

Brain growth in Down syndrome subjects 15 to 22 weeks of gestational age and birth to 60 months

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27 June 2018

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27 June 2018

APP-dependent up-regulation of Ptch1 underlies proliferation impairment of neural precursors in Down syndrome.

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3 September 2018

Widespread proliferation impairment and hypocellularity in the cerebellum of fetuses with down syndrome.

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3 September 2018

Cell cycle elongation impairs proliferation of cerebellar granule cell precursors in the Ts65Dn mouse, an animal model for Down syndrome

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3 September 2018

Neurogenesis impairment and increased cell death reduce total neuron number in the hippocampal region of fetuses with Down syndrome.

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Defects in embryonic neurogenesis and initial synapse formation in the forebrain of the Ts65Dn mouse model of Down syndrome

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3 September 2018

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3 September 2018

Cell cycle alteration and decreased cell proliferation in the hippocampal dentate gyrus and in the neocortical germinal matrix of fetuses with Down syndrome and in Ts65Dn mice

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3 September 2018

Amyloid precursor protein regulates differentiation of human neural stem cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3774353

3 September 2018

Activation of the Notch pathway in Down syndrome: cross-talk of Notch and APP.

1 reference

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3 September 2018

Synaptic structural abnormalities in the Ts65Dn mouse model of Down Syndrome.

1 reference

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3 September 2018

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1 reference

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3 September 2018

Down syndrome mouse models Ts65Dn, Ts1Cje, and Ms1Cje/Ts65Dn exhibit variable severity of cerebellar phenotypes.

1 reference

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3 September 2018

Quantitative PCR genotyping assay for the Ts65Dn mouse model of Down syndrome

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3 September 2018

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3 September 2018

Regulation of Gliogenesis in the Central Nervous System by the JAK-STAT Signaling Pathway

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3 September 2018

Down's syndrome: Is there a decreased population of neurons?

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3 September 2018

Dendrites, dementia and the Down syndrome.

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3 September 2018

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1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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1 reference

https://pubmed.ncbi.nlm.nih.gov/23740250

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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10.1074/JBC.M113.451088

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2 March 2020

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Europe PubMed Central

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2 March 2020

PubMed publication ID

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Europe PubMed Central

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2 March 2020

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