Premature pubarche, ovarian hyperandrogenism, hyperinsulinism and the polycystic ovary syndrome: from a complex constellation to a simple sequence of prenatal onset (Q77694072)

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scientific article published on 01 October 1998

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English	Premature pubarche, ovarian hyperandrogenism, hyperinsulinism and the polycystic ovary syndrome: from a complex constellation to a simple sequence of prenatal onset	scientific article published on 01 October 1998

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scholarly article

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9856410%20AND%20SRC:MED&resulttype=core&format=json

7 December 2019

1 reference

Europe PubMed Central

Premature pubarche, ovarian hyperandrogenism, hyperinsulinism and the polycystic ovary syndrome: from a complex constellation to a simple sequence of prenatal onset (English)

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9856410%20AND%20SRC:MED&resulttype=core&format=json

7 December 2019

polycystic ovary syndrome

1 reference

based on heuristic

inferred from title

hyperandrogenism

1 reference

based on heuristic

inferred from title

polycystic ovary

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based on heuristic

inferred from title

author name string

L Ibáñez

1

1 reference

Europe PubMed Central

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7 December 2019

F de Zegher

2

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Europe PubMed Central

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7 December 2019

N Potau

3

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Europe PubMed Central

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7 December 2019

publication date

1 October 1998

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7 December 2019

Journal of Endocrinological Investigation

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Europe PubMed Central

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7 December 2019

21

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Europe PubMed Central

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7 December 2019

9

1 reference

Europe PubMed Central

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7 December 2019

558-566

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9856410%20AND%20SRC:MED&resulttype=core&format=json

7 December 2019

Insulin resistance of puberty: a defect restricted to peripheral glucose metabolism.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9856410

12 December 2020

based on heuristic

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Disparate effects of weight reduction by diet on serum dehydroepiandrosterone-sulfate levels in obese men and women

1 reference

https://pubmed.ncbi.nlm.nih.gov/9856410

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular biology of steroid hormone synthesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/9856410

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Precocious pubarche, hyperinsulinism, and ovarian hyperandrogenism in girls: relation to reduced fetal growth.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9856410

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Defects in beta-cell function in functional ovarian hyperandrogenism

1 reference

https://pubmed.ncbi.nlm.nih.gov/9856410

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fetal nutrition and cardiovascular disease in adult life

1 reference

https://pubmed.ncbi.nlm.nih.gov/9856410

12 December 2020

based on heuristic

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Polycystic ovary syndrome

1 reference

https://pubmed.ncbi.nlm.nih.gov/9856410

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Adrenal androgen hyperresponsiveness to adrenocorticotropin in women with acne and/or hirsutism: adrenal enzyme defects and exaggerated adrenarche

1 reference

https://pubmed.ncbi.nlm.nih.gov/9856410

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence for the adrenal source of androgens in precocious adrenarche

1 reference

https://pubmed.ncbi.nlm.nih.gov/9856410

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ovarian 17-hydroxyprogesterone hyperresponsiveness to gonadotropin-releasing hormone (GnRH) agonist challenge in women with polycystic ovary syndrome is not mediated by luteinizing hormone hypersecretion: evidence from GnRH agonist and human chorion

1 reference

https://pubmed.ncbi.nlm.nih.gov/9856410

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cholesterol screening and family history of vascular disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/9856410

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Polycystic Ovary Syndrome as a Form of FunctionalOvarian Hyperandrogenism Due to Dysregulation ofAndrogen Secretion*

1 reference

https://pubmed.ncbi.nlm.nih.gov/9856410

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The regulation of 17,20 lyase activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/9856410

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin regulates the serum levels of low molecular weight insulin-like growth factor-binding protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/9856410

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin sensitivity, lipids, and body composition in childhood: is "syndrome X" present?

1 reference

https://pubmed.ncbi.nlm.nih.gov/9856410

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin resistance and the polycystic ovary syndrome: mechanism and implications for pathogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/9856410

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Usefulness of an ACTH Test in the Diagnosis of Nonclassical 21-Hydroxylase Deficiency among Children Presenting with Premature Pubarche

1 reference

https://pubmed.ncbi.nlm.nih.gov/9856410

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metabolic features of polycystic ovary syndrome are found in adolescent girls with hyperandrogenism.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9856410

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin resistance in short children with intrauterine growth retardation

1 reference

https://pubmed.ncbi.nlm.nih.gov/9856410

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Current concepts of polycystic ovary syndrome

1 reference

https://pubmed.ncbi.nlm.nih.gov/9856410

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ovarian steroidogenic responses to gonadotropin-releasing hormone agonist testing with nafarelin in hirsute women with adrenal responses to adrenocorticotropin suggestive of 3 beta-hydroxy-delta 5-steroid dehydrogenase deficiency

1 reference

https://pubmed.ncbi.nlm.nih.gov/9856410

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Normal and almost normal precocious variations in pubertal development premature pubarche and premature thelarche revisited

1 reference

https://pubmed.ncbi.nlm.nih.gov/9856410

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pubertal Changes in Insulin Secretion and Peripheral Insulin Sensitivity

1 reference

https://pubmed.ncbi.nlm.nih.gov/9856410

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Primary polycystic ovary syndrome in a premenarchal girl. A case report

1 reference

https://pubmed.ncbi.nlm.nih.gov/9856410

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pituitary-ovarian responses to nafarelin testing in the polycystic ovary syndrome

1 reference

https://pubmed.ncbi.nlm.nih.gov/9856410

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dyslipidaemia is associated with insulin resistance in women with polycystic ovaries

1 reference

https://pubmed.ncbi.nlm.nih.gov/9856410

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Premature pubarche: etiological heterogeneity

1 reference

https://pubmed.ncbi.nlm.nih.gov/9856410

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin resistance, premature adrenarche, and a risk of the Polycystic Ovary Syndrome (PCOS)

1 reference

https://pubmed.ncbi.nlm.nih.gov/9856410

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Postpubertal outcome in girls diagnosed of premature pubarche during childhood: increased frequency of functional ovarian hyperandrogenism

1 reference

https://pubmed.ncbi.nlm.nih.gov/9856410

12 December 2020

based on heuristic

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Puberty and polycystic ovarian syndrome: the insulin/insulin-like growth factor I hypothesis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9856410

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hyperinsulinemia in postpubertal girls with a history of premature pubarche and functional ovarian hyperandrogenism

1 reference

https://pubmed.ncbi.nlm.nih.gov/9856410

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin-like growth factors augment steroid production and expression of steroidogenic enzymes in human fetal adrenal cortical cells: implications for adrenal androgen regulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/9856410

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hyperinsulinaemia, dyslipaemia and cardiovascular risk in girls with a history of premature pubarche.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9856410

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Acne, hirsutism, and alopecia in adolescent girls. Clinical expressions of androgen excess

1 reference

https://pubmed.ncbi.nlm.nih.gov/9856410

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Low Birth Weight and Subsequent Male Subfertility

1 reference

https://pubmed.ncbi.nlm.nih.gov/9856410

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Normative data for insulin-like growth factors (IGFs), IGF-binding proteins, and growth hormone-binding protein in a healthy Spanish pediatric population: age- and sex-related changes

1 reference

https://pubmed.ncbi.nlm.nih.gov/9856410

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Isolated precocious pubarche: an approach

1 reference

https://pubmed.ncbi.nlm.nih.gov/9856410

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin-like growth factor I and insulin potentiate luteinizing hormone-induced androgen synthesis by rat ovarian thecal-interstitial cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/9856410

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of adrenal hyperandrogenism, insulin resistance, and obesity in the pathogenesis of polycystic ovarian syndrome.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9856410

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The central role of obesity (hyperinsulinemia) in the pathogenesis of the polycystic ovary syndrome

1 reference

https://pubmed.ncbi.nlm.nih.gov/9856410

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Presence of immunoreactive corticotropin-releasing hormone in normal and polycystic human ovaries

1 reference

https://pubmed.ncbi.nlm.nih.gov/9856410

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin stimulates androgen accumulation in incubations of ovarian stroma obtained from women with hyperandrogenism

1 reference

https://pubmed.ncbi.nlm.nih.gov/9856410

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The regulation of human P450c17 activity: relationship to premature adrenarche, insulin resistance and the polycystic ovary syndrome

1 reference

https://pubmed.ncbi.nlm.nih.gov/9856410

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Source localization of androgen excess in adolescent girls.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9856410

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ovaries in sexual precocity

1 reference

https://pubmed.ncbi.nlm.nih.gov/9856410

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

BENIGN PREMATURE ADRENARCHE: CLINICAL FEATURES AND SERUM STEROID LEVELS

1 reference

https://pubmed.ncbi.nlm.nih.gov/9856410

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin and insulin-like growth factor I stimulate the proliferation of human ovarian theca-interstitial cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/9856410

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence for insulin resistance in nonobese patients with polycystic ovarian disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/9856410

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Natural history of premature pubarche: an auxological study

1 reference

https://pubmed.ncbi.nlm.nih.gov/9856410

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

RELATIONSHIP BETWEEN THE PUBERTAL FALL INSEX HORMONE BINDING GLOBULIN AND INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN-I. A SYNCHRONIZED APPROACH TO PUBERTAL DEVELOPMENT?

1 reference

https://pubmed.ncbi.nlm.nih.gov/9856410

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased insulin secretion in puberty: a compensatory response to reductions in insulin sensitivity

1 reference

https://pubmed.ncbi.nlm.nih.gov/9856410

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lipid and apolipoprotein abnormalities in hirsute women. I. The association with insulin resistance

1 reference

https://pubmed.ncbi.nlm.nih.gov/9856410

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genetic defects of steroidogenesis in premature pubarche

1 reference

https://pubmed.ncbi.nlm.nih.gov/9856410

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A dopamine D3 receptor genotype is associated with hyperandrogenic chronic anovulation and resistant to ovulation induction with clomiphene citrate in female Hispanics

1 reference

https://pubmed.ncbi.nlm.nih.gov/9856410

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hyperinsulinemia and Decreased Insulin-Like Growth Factor-Binding Protein-1 Are Common Features in Prepubertal and Pubertal Girls with a History of Premature Pubarche1

1 reference

https://pubmed.ncbi.nlm.nih.gov/9856410

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interplay between insulin signalling and protein kinase C.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9856410

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Adrenarche as a cause of benign pseudopuberty in boys

1 reference

https://pubmed.ncbi.nlm.nih.gov/9856410

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Studies of 3 beta-hydroxysteroid dehydrogenase genes in infants and children manifesting premature pubarche and increased adrenocorticotropin-stimulated delta 5-steroid levels

1 reference

https://pubmed.ncbi.nlm.nih.gov/9856410

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pathophysiology, genetics, and treatment of hyperandrogenism

1 reference

https://pubmed.ncbi.nlm.nih.gov/9856410

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin, somatotropic, and luteinizing hormone axes in lean and obese women with polycystic ovary syndrome: common and distinct features

1 reference

https://pubmed.ncbi.nlm.nih.gov/9856410

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence of a distinct derangement of opioid tone in hyperinsulinemic patients with polycystic ovarian syndrome: relationship with insulin and luteinizing hormone secretion

1 reference

https://pubmed.ncbi.nlm.nih.gov/9856410

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence for a primary abnormality of thecal cell steroidogenesis in the polycystic ovary syndrome

1 reference

https://pubmed.ncbi.nlm.nih.gov/9856410

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genotyping Steroid 21-Hydroxylase Deficiency: Hormonal Reference Data*

1 reference

https://pubmed.ncbi.nlm.nih.gov/9856410

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Growth hormone, insulin-like growth factor-I axis, and insulin secretion in hyperandrogenic adolescents

1 reference

https://pubmed.ncbi.nlm.nih.gov/9856410

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Plasma 17-ketosteroids and 17-beta hydroxysteroids in girls with premature development of sexual hair.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9856410

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CYP11B1 Mutations Causing Non-Classic Adrenal Hyperplasia due to 11 -Hydroxylase Deficiency

1 reference

https://pubmed.ncbi.nlm.nih.gov/9856410

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin-like growth factors enhance steroidogenic enzyme and corticotropin receptor messenger ribonucleic acid levels and corticotropin steroidogenic responsiveness in cultured human adrenocortical cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9856410

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin infusion amplifies 17 alpha-hydroxycorticosteroid intermediates response to adrenocorticotropin in hyperandrogenic women: apparent relative impairment of 17,20-lyase activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/9856410

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sex hormone-binding globulin: a marker for hyperinsulinemia and/or insulin resistance?

1 reference

https://pubmed.ncbi.nlm.nih.gov/9856410

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Detection of Functional Ovarian Hyperandrogenism in Women with Androgen Excess

1 reference

https://pubmed.ncbi.nlm.nih.gov/9856410

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Is polycystic ovary syndrome a neuroendocrine or an ovarian disorder?

1 reference

https://pubmed.ncbi.nlm.nih.gov/9856410

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Type 2 (non-insulin-dependent) diabetes mellitus, hypertension and hyperlipidaemia (syndrome X): relation to reduced fetal growth

1 reference

https://pubmed.ncbi.nlm.nih.gov/9856410

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Profound peripheral insulin resistance, independent of obesity, in polycystic ovary syndrome

1 reference

https://pubmed.ncbi.nlm.nih.gov/9856410

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Decreases in ovarian cytochrome P450c17 alpha activity and serum free testosterone after reduction of insulin secretion in polycystic ovary syndrome

1 reference

https://pubmed.ncbi.nlm.nih.gov/9856410

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Adrenarche and fetal growth

1 reference

https://pubmed.ncbi.nlm.nih.gov/9856410

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Serine phosphorylation of human P450c17 increases 17,20-lyase activity: implications for adrenarche and the polycystic ovary syndrome

1 reference

https://pubmed.ncbi.nlm.nih.gov/9856410

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The physiology and pathophysiology of intrauterine growth retardation

1 reference

https://pubmed.ncbi.nlm.nih.gov/9856410

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Girls diagnosed with premature pubarche show an exaggerated ovarian androgen synthesis from the early stages of puberty: evidence from gonadotropin-releasing hormone agonist testing

1 reference

https://pubmed.ncbi.nlm.nih.gov/9856410

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence that idiopathic functional adrenal hyperandrogenism is caused by dysregulation of adrenal steroidogenesis and that hyperinsulinemia may be involved

1 reference

https://pubmed.ncbi.nlm.nih.gov/9856410

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Corticotropin-Releasing Factor Inhibits Luteinizing Hormone-Stimulated P450c17 Gene Expression and Androgen Production by Isolated Thecal Cells of Human Ovarian Follicles1

1 reference

https://pubmed.ncbi.nlm.nih.gov/9856410

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lean Women with Polycystic Ovary Syndrome Respond to Insulin Reduction with Decreases in Ovarian P450c17α Activity and Serum Androgens1

1 reference

https://pubmed.ncbi.nlm.nih.gov/9856410

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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