The regulation of human P450c17 activity: relationship to premature adrenarche, insulin resistance and the polycystic ovary syndrome (Q46392578)

21 December 2017

title

The regulation of human P450c17 activity: relationship to premature adrenarche, insulin resistance and the polycystic ovary syndrome (English)

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21 December 2017

polycystic ovary syndrome

main subject

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Auchus RJ

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21 December 2017

Geller DH

series ordinal

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21 December 2017

Lee TC

series ordinal

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21 December 2017

Miller WL

series ordinal

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21 December 2017

publication date

1 February 1998

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21 December 2017

Trends in Endocrinology and Metabolism

published in

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21 December 2017

volume

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21 December 2017

issue

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21 December 2017

page(s)

47-50

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21 December 2017

Cytochrome b 5 Augments the 17,20-Lyase Activity of Human P450c17 without Direct Electron Transfer

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Evidence for a single gene effect causing polycystic ovaries and male pattern baldness

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Cytochrome P450c17 (steroid 17 alpha-hydroxylase/17,20 lyase): cloning of human adrenal and testis cDNAs indicates the same gene is expressed in both tissues

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Excessive insulin receptor serine phosphorylation in cultured fibroblasts and in skeletal muscle. A potential mechanism for insulin resistance in the polycystic ovary syndrome

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The genetic and functional basis of isolated 17,20-lyase deficiency

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Structural alignments of P450s and extrapolations to the unknown

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The role of cytochrome b5 in the biosynthesis of androgens by human P450c17.

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Dissociation of Hydroxylase and Lyase Activities by Site-Directed Mutagenesis of the Rat P45017α

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Steroid 17 alpha-hydroxylase and 17,20-lyase activities of P450c17: contributions of serine106 and P450 reductase

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Adrenal androgen hyperresponsiveness to adrenocorticotropin in women with acne and/or hirsutism: adrenal enzyme defects and exaggerated adrenarche

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Cytochrome b5 stimulates purified testicular microsomal cytochrome P-450 (C21 side-chain cleavage)

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Cloning and sequence of the human gene for P450c17 (steroid 17 alpha-hydroxylase/17,20 lyase): similarity with the gene for P450c21

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Homologous sequences in steroidogenic enzymes, steroid receptors and a steroid binding protein suggest a consensus steroid-binding sequence

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Crystal structure of hemoprotein domain of P450BM-3, a prototype for microsomal P450's

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Evidence for dissociation between adrenarche and gonadarche: studies in patients with idiopathic precocious puberty, gonadal dysgenesis, isolated gonadotropin deficiency, and constitutionally delayed growth and adolescence

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Regulation of steroidogenesis in NCI-H295 cells: a cellular model of the human fetal adrenal

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Molecular basis of apparent isolated 17,20-lyase deficiency: compound heterozygous mutations in the C-terminal region (Arg(496)----Cys, Gln(461)----Stop) actually cause combined 17 alpha-hydroxylase/17,20-lyase deficiency

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Steroid 17,20-desmolase deficiency: a new cause of male pseudohermaphroditism

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7 January 2021

Serine phosphorylation of human P450c17 increases 17,20-lyase activity: implications for adrenarche and the polycystic ovary syndrome

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7 January 2021

10.1016/S1043-2760(98)00016-2

Identifiers

DOI

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21 December 2017

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21 December 2017