Diclofenac acyl glucuronide, a major biliary metabolite, is directly involved in small intestinal injury in rats (Q77620722)

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7 December 2019

title

Diclofenac acyl glucuronide, a major biliary metabolite, is directly involved in small intestinal injury in rats (English)

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diclofenac beta-D-glucosiduronic acid

7 December 2019

main subject

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ChEBI release 2020-05-28

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S Seitz

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7 December 2019

U A Boelsterli

series ordinal

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7 December 2019

language of work or name

English

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publication date

1 December 1998

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7 December 2019

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7 December 2019

volume

115

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7 December 2019

issue

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7 December 2019

page(s)

1476-1482

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Nonsteroidal antiinflammatory drugs and the gastrointestinal tract. The double-edged sword

7 December 2019

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Nonsteroidal anti-inflammatory drug enteropathy in rats: role of permeability, bacteria, and enterohepatic circulation

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Selective protein adduct formation of diclofenac glucuronide is critically dependent on the rat canalicular conjugate export pump (Mrp2)

7 January 2021

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Acyl glucuronides revisited: is the glucuronidation process a toxification as well as a detoxification mechanism?

7 January 2021

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Evidence for covalent binding of acyl glucuronides to serum albumin via an imine mechanism as revealed by tandem mass spectrometry

7 January 2021

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Chemical and immunochemical comparison of protein adduct formation of four carboxylate drugs in rat liver and plasma

7 January 2021

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Immunochemical detection of liver protein adducts of the nonsteroidal antiinflammatory drug diclofenac

7 January 2021

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Immunochemical identification of mouse hepatic protein adducts derived from the nonsteroidal anti-inflammatory drugs diclofenac, sulindac, and ibuprofen

7 January 2021

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Studies on the reactivity of acyl glucuronides--IV. Covalent binding of diflunisal to tissues of the rat

7 January 2021

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Immunochemical detection and identification of protein adducts of diclofenac in the small intestine of rats: possible role in allergic reactions

7 January 2021

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Congenital jaundice in rats with a mutation in a multidrug resistance-associated protein gene

7 January 2021

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Drug metabolizing enzyme induction by benzoquinolines, acridine, and quinacrine; tricyclic aromatic molecules containing a single heterocyclic nitrogen

7 January 2021

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Selective induction of phase II drug metabolizing enzyme activities by quinolines and isoquinolines

7 January 2021

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A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

7 January 2021

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Biotransformation of diclofenac sodium (Voltaren) in animals and in man. I. Isolation and identification of principal metabolites

7 January 2021

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Intestinal UDP-glucuronosyltransferase activities in rat and rabbit

7 January 2021

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Role of the entero-hepatic cycle of indomethacin on its metabolism, distribution in tissues and its excretion by rats, dogs and monkeys

7 January 2021

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Enterohepatic circulation of indomethacin and its role in intestinal irritation

7 January 2021

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Mechanisms of acute and chronic intestinal inflammation induced by indomethacin

7 January 2021

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Ulcerative enterocolitis in dogs induced by drugs

7 January 2021

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Nitric oxide-releasing non-steroidal anti-inflammatory drugs: a novel approach for reducing gastrointestinal toxicity

7 January 2021

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A diclofenac derivative without ulcerogenic properties

7 January 2021

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Resistance of germfree rats to indomethacin-induced intestinal lesions

7 January 2021

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Review: The Biochemical Basis of Non-Steroidal Anti-Inflammatory Drug-Induced Damage to the Gastrointestinal Tract: A Review and a Hypothesis

7 January 2021

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NSAIDs, gastrointestinal injury, and cytoprotection

7 January 2021

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Diclofenac covalent protein binding is dependent on acyl glucuronide formation and is inversely related to P450-mediated acute cell injury in cultured rat hepatocytes

7 January 2021

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Metabolic activation and immunochemical localization of liver protein adducts of the nonsteroidal anti-inflammatory drug diclofenac

7 January 2021

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Properties of acyl glucuronides: implications for studies of the pharmacokinetics and metabolism of acidic drugs

7 January 2021

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Studies on the reactivity of acyl glucuronides--II. Interaction of diflunisal acyl glucuronide and its isomers with human serum albumin in vitro

7 January 2021

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Idiosyncratic liver toxicity of nonsteroidal antiinflammatory drugs: molecular mechanisms and pathology

7 January 2021

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Covalent modification of rat liver dipeptidyl peptidase IV (CD26) by the nonsteroidal anti-inflammatory drug diclofenac

7 January 2021

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Cytochrome P4502C11 is a target of diclofenac covalent binding in rats

7 January 2021

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Pharmacokinetics and bioavailability of diclofenac in the rat

7 January 2021

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7 January 2021

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7 January 2021

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10.1016/S0016-5085(98)70026-5

7 January 2021

Identifiers

DOI

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7 December 2019

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