Spotlight on fevipiprant and its potential in the treatment of asthma: evidence to date (Q60921618)

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English	Spotlight on fevipiprant and its potential in the treatment of asthma: evidence to date	article

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instance of

scholarly article

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title

Spotlight on fevipiprant and its potential in the treatment of asthma: evidence to date (English)

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main subject

asthma

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based on heuristic

inferred from title

author

Amit D. Parulekar

object named as

Amit D Parulekar

series ordinal

2

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author name string

Christina C Kao

series ordinal

1

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language of work or name

English

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publication date

2019

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published in

Journal of Asthma and Allergy

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volume

12

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page(s)

1-5

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copyright license

Creative Commons Attribution-NonCommercial 3.0 Unported

start time

1 January 2019

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stated in

April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

Mediator concentrations in bronchoalveolar lavage fluid of patients with mild asymptomatic bronchial asthma

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30662272

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12 December 2020

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inferred from PubMed ID database lookup

The effects of an oral thromboxane TP receptor antagonist BAY u 3405, on prostaglandin D2- and histamine-induced bronchoconstriction in asthma, and relationship to plasma drug concentrations

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stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30662272

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence for elevated levels of histamine, prostaglandin D2, and other bronchoconstricting prostaglandins in the airways of subjects with mild asthma

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30662272

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12 December 2020

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inferred from PubMed ID database lookup

Spectrum of prostanoid release after bronchoalveolar allergen challenge in atopic asthmatics and in control groups. An alteration in the ratio of bronchoconstrictive to bronchoprotective mediators

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30662272

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12 December 2020

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inferred from PubMed ID database lookup

Release of prostaglandin D2 into human airways during acute antigen challenge

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stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30662272

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CRTH2, an orphan receptor of T-helper-2-cells, is expressed on basophils and eosinophils and responds to mast cell-derived factor(s)

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stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30662272

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prostaglandin D2 selectively induces chemotaxis in T helper type 2 cells, eosinophils, and basophils via seven-transmembrane receptor CRTH2

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30662272

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selective modulation of chemokinesis, degranulation, and apoptosis in eosinophils through the PGD2 receptors CRTH2 and DP

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30662272

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The DP receptor, allergic inflammation and asthma.

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30662272

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacology and signaling of prostaglandin receptors: multiple roles in inflammation and immune modulation

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30662272

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Emerging roles of DP and CRTH2 in allergic inflammation

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stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30662272

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12 December 2020

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inferred from PubMed ID database lookup

IL-5 and eosinophilia.

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30662272

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of asthma phenotypes using cluster analysis in the Severe Asthma Research Program

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stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30662272

retrieved

12 December 2020

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Narrative review: the role of Th2 immune pathway modulation in the treatment of severe asthma and its phenotypes

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30662272

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CRTH2 expression on T cells in asthma

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stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30662272

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mast cell phenotype, location, and activation in severe asthma. Data from the Severe Asthma Research Program

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30662272

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifying adult asthma phenotypes using a clustering approach

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stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30662272

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A randomized, double-blind, placebo-controlled study of the CRTH2 antagonist OC000459 in moderate persistent asthma

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stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30662272

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Safety and efficacy of the prostaglandin D2 receptor antagonist AMG 853 in asthmatic patients

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stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30662272

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prostaglandin D₂ pathway upregulation: relation to asthma severity, control, and TH2 inflammation

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stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30662272

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prostaglandin D2 activates group 2 innate lymphoid cells through chemoattractant receptor-homologous molecule expressed on TH2 cells

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30662272

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Heightened response of eosinophilic asthmatic patients to the CRTH2 antagonist OC000459.

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30662272

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Setipiprant, a selective CRTH2 antagonist, reduces allergen-induced airway responses in allergic asthmatics

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30662272

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The prostaglandin D₂ receptor CRTH2 regulates accumulation of group 2 innate lymphoid cells in the inflamed lung.

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30662272

retrieved

12 December 2020

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inferred from PubMed ID database lookup

Efficacy of BI 671800, an oral CRTH2 antagonist, in poorly controlled asthma as sole controller and in the presence of inhaled corticosteroid treatment

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30662272

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12 December 2020

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inferred from PubMed ID database lookup

Evolving Concepts of Asthma

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30662272

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of T2 inflammation biomarkers in severe asthma

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stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30662272

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Emergence of Biomolecular Pathways to Define Novel Asthma Phenotypes. Type-2 Immunity and Beyond

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30662272

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacokinetics, Safety, and Tolerability of Fevipiprant (QAW039), a Novel CRTh2 Receptor Antagonist: Results From 2 Randomized, Phase 1, Placebo-Controlled Studies in Healthy Volunteers

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stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30662272

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The oral CRTh2 antagonist QAW039 (fevipiprant): A phase II study in uncontrolled allergic asthma

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stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30662272

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prostaglandin D2 receptor antagonism: a novel therapeutic option for eosinophilic asthma?

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stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30662272

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fevipiprant, a prostaglandin D2 receptor 2 antagonist, in patients with persistent eosinophilic asthma: a single-centre, randomised, double-blind, parallel-group, placebo-controlled trial.

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30662272

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Two Phase II randomized trials on the CRTh2 antagonist AZD1981 in adults with asthma

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30662272

retrieved

12 December 2020

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inferred from PubMed ID database lookup

Absorption, Distribution, Metabolism, and Excretion of the Oral Prostaglandin D2 Receptor 2 Antagonist Fevipiprant (QAW039) in Healthy Volunteers and In Vitro

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stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30662272

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fevipiprant, an oral prostaglandin DP2 receptor (CRTh2) antagonist, in allergic asthma uncontrolled on low-dose inhaled corticosteroids

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30662272

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Targeting the interleukin-4 and interleukin-13 pathways in severe asthma: current knowledge and future needs

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30662272

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

DOI

10.2147/JAA.S167973

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PMC publication ID

6324611

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PubMed publication ID

30662272

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