PKR knockout in the 5xFAD model of Alzheimer's disease reveals beneficial effects on spatial memory and brain lesions. (Q64912402)

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English	PKR knockout in the 5xFAD model of Alzheimer's disease reveals beneficial effects on spatial memory and brain lesions.	scientific article

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Europe PubMed Central

PMC publication ID

6516179

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30821420%20AND%20SRC:MED&resulttype=core&format=json

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26 April 2020

title

PKR knockout in the 5xFAD model of Alzheimer's disease reveals beneficial effects on spatial memory and brain lesions (English)

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stated in

Europe PubMed Central

PMC publication ID

6516179

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30821420%20AND%20SRC:MED&resulttype=core&format=json

retrieved

26 April 2020

main subject

spatial memory

1 reference

based on heuristic

inferred from title

Alzheimer's disease

1 reference

based on heuristic

inferred from title

author

Albert Giralt

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4

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Europe PubMed Central

PMC publication ID

6516179

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30821420%20AND%20SRC:MED&resulttype=core&format=json

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26 April 2020

Jean-Antoine Girault

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11

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PMC publication ID

6516179

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30821420%20AND%20SRC:MED&resulttype=core&format=json

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26 April 2020

Laure Rondi-Reig

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9

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PMC publication ID

6516179

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30821420%20AND%20SRC:MED&resulttype=core&format=json

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26 April 2020

author name string

Marion Tible

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1

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PMC publication ID

6516179

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26 April 2020

François Mouton Liger

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2

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6516179

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26 April 2020

Julien Schmitt

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3

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6516179

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26 April 2020

Karim Farid

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5

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6516179

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26 April 2020

Sylvie Thomasseau

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6

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6516179

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26 April 2020

Sarah Gourmaud

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7

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6516179

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26 April 2020

Claire Paquet

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8

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6516179

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26 April 2020

Eliane Meurs

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10

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6516179

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26 April 2020

Jacques Hugon

series ordinal

12

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PMC publication ID

6516179

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30821420%20AND%20SRC:MED&resulttype=core&format=json

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26 April 2020

publication date

1 March 2019

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Europe PubMed Central

PMC publication ID

6516179

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30821420%20AND%20SRC:MED&resulttype=core&format=json

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26 April 2020

published in

Aging Cell

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PMC publication ID

6516179

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30821420%20AND%20SRC:MED&resulttype=core&format=json

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26 April 2020

volume

18

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Europe PubMed Central

PMC publication ID

6516179

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30821420%20AND%20SRC:MED&resulttype=core&format=json

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26 April 2020

issue

3

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Europe PubMed Central

PMC publication ID

6516179

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26 April 2020

page(s)

e12887

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6516179

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26 April 2020

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ImageJ

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11 June 2022

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cites work

Deficient signaling in mice devoid of double-stranded RNA-dependent protein kinase

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PubMed

reference URL

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Spontaneous object recognition and object location memory in rats: the effects of lesions in the cingulate cortices, the medial prefrontal cortex, the cingulum bundle and the fornix

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PubMed

reference URL

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12 December 2020

based on heuristic

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PACT, a protein activator of the interferon-induced protein kinase, PKR.

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30821420

retrieved

12 December 2020

based on heuristic

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PKR stimulates NF-kappaB irrespective of its kinase function by interacting with the IkappaB kinase complex.

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30821420

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12 December 2020

based on heuristic

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Involvement of double-stranded RNA-dependent protein kinase and phosphorylation of eukaryotic initiation factor-2alpha in neuronal degeneration

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30821420

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphorylation of eukaryotic initiation factor-2alpha (eIF2alpha) is associated with neuronal degeneration in Alzheimer's disease

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30821420

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12 December 2020

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An integrated stress response regulates amino acid metabolism and resistance to oxidative stress

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30821420

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12 December 2020

based on heuristic

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Upstream signaling pathways leading to the activation of double-stranded RNA-dependent serine/threonine protein kinase in beta-amyloid peptide neurotoxicity

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/30821420

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12 December 2020

based on heuristic

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Beta-site APP cleaving enzyme up-regulation induced by 4-hydroxynonenal is mediated by stress-activated protein kinases pathways.

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/30821420

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12 December 2020

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Activated double-stranded RNA-dependent protein kinase and neuronal death in models of Alzheimer's disease

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/30821420

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12 December 2020

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Impaired sequential egocentric and allocentric memories in forebrain-specific-NMDA receptor knock-out mice during a new task dissociating strategies of navigation

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https://pubmed.ncbi.nlm.nih.gov/30821420

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12 December 2020

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Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer's disease mutations: potential factors in amyloid plaque formation.

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/30821420

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12 December 2020

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Involvement of double-stranded RNA-dependent protein kinase in ER stress-induced retinal neuron damage

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/30821420

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12 December 2020

based on heuristic

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LTP maintenance and its protein synthesis-dependence

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PubMed

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12 December 2020

based on heuristic

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Classification and basic pathology of Alzheimer disease

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https://pubmed.ncbi.nlm.nih.gov/30821420

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12 December 2020

based on heuristic

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eIF2alpha Phosphorylation-dependent translation in CA1 pyramidal cells impairs hippocampal memory consolidation without affecting general translation.

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/30821420

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12 December 2020

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Motor deficits, neuron loss, and reduced anxiety coinciding with axonal degeneration and intraneuronal Aβ aggregation in the 5XFAD mouse model of Alzheimer's disease

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/30821420

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12 December 2020

based on heuristic

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Modulation of tau phosphorylation by the kinase PKR: implications in Alzheimer's disease

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/30821420

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12 December 2020

based on heuristic

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Cerebral amyloid-β PET with florbetaben (18F) in patients with Alzheimer's disease and healthy controls: a multicentre phase 2 diagnostic study.

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/30821420

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of PKR causes amyloid ß-peptide accumulation via de-repression of BACE1 expression.

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30821420

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The PKR Activator PACT Is Induced by Aβ: Involvement in Alzheimer's Disease

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30821420

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Suppression of PKR promotes network excitability and enhanced cognition by interferon-γ-mediated disinhibition

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30821420

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased cerebrospinal fluid levels of double-stranded RNA-dependant protein kinase in Alzheimer's disease

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30821420

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxidative stress increases BACE1 protein levels through activation of the PKR-eIF2α pathway

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30821420

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PKR-dependent inflammatory signals

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30821420

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

dsRNA-dependent protein kinase PKR and its role in stress, signaling and HCV infection

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30821420

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cerebrospinal fluid PKR level predicts cognitive decline in Alzheimer's disease

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30821420

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The specific PKR inhibitor C16 prevents apoptosis and IL-1β production in an acute excitotoxic rat model with a neuroinflammatory component.

1 reference

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/30821420

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12 December 2020

based on heuristic

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The impact of PKR activation: from neurodegeneration to cancer.

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30821420

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PKR downregulation prevents neurodegeneration and β-amyloid production in a thiamine-deficient model

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30821420

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuroinflammation and Aβ accumulation linked to systemic inflammation are decreased by genetic PKR down-regulation

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30821420

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The unfolded protein response in neurodegenerative diseases: a neuropathological perspective

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30821420

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alzheimer's disease

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30821420

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The amyloid hypothesis of Alzheimer's disease at 25 years

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30821420

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12 December 2020

based on heuristic

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Drug repurposing to target proteostasis and prevent neurodegeneration: accelerating translational efforts

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30821420

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PKR involvement in Alzheimer's disease

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30821420

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ER stress is not elevated in the 5XFAD mouse model of Alzheimer's disease

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30821420

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

DOI

10.1111/ACEL.12887

1 reference

stated in

Europe PubMed Central

PMC publication ID

6516179

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30821420%20AND%20SRC:MED&resulttype=core&format=json

retrieved

26 April 2020

PMC publication ID

6516179

1 reference

stated in

Europe PubMed Central

PMC publication ID

6516179

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30821420%20AND%20SRC:MED&resulttype=core&format=json

retrieved

26 April 2020

PubMed publication ID

30821420

1 reference

stated in

Europe PubMed Central

PMC publication ID

6516179

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30821420%20AND%20SRC:MED&resulttype=core&format=json

retrieved

26 April 2020

 

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