Regulation of membrane dynamics by Parkinson's disease-associated genes (Q64864833)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30027905%20AND%20SRC:MED&resulttype=core&format=json

13 April 2020

title

Regulation of membrane dynamics by Parkinson's disease-associated genes (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30027905%20AND%20SRC:MED&resulttype=core&format=json

13 April 2020

main subject

disease-related genes

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Tsuyoshi Inoshita

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13 April 2020

Changxu Cui

series ordinal

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13 April 2020

publication date

1 July 2018

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13 April 2020

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13 April 2020

volume

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13 April 2020

issue

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13 April 2020

page(s)

715-725

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The precursor protein of non-A beta component of Alzheimer's disease amyloid is a presynaptic protein of the central nervous system

13 April 2020

cites work

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12 December 2020

Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

1 reference

12 December 2020

Novel Genes Involved in Endosomal Traffic in Yeast Revealed by Suppression of a Targeting-defective Plasma Membrane ATPase Mutant

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12 December 2020

Synaptojanin 2, a Novel Synaptojanin Isoform with a Distinct Targeting Domain and Expression Pattern

1 reference

12 December 2020

SAC1-like domains of yeast SAC1, INP52, and INP53 and of human synaptojanin encode polyphosphoinositide phosphatases

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12 December 2020

The SH3 domains of endophilin and amphiphysin bind to the proline-rich region of synaptojanin 1 at distinct sites that display an unconventional binding specificity

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12 December 2020

A phosphatidylinositol (4,5)-bisphosphate binding site within mu2-adaptin regulates clathrin-mediated endocytosis

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12 December 2020

Role of Drosophila Rab5 during endosomal trafficking at the synapse and evoked neurotransmitter release

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12 December 2020

An essential role of Rab5 in uniformity of synaptic vesicle size

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12 December 2020

alpha-Synuclein locus triplication causes Parkinson's disease

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12 December 2020

Synaptojanin is recruited by endophilin to promote synaptic vesicle uncoating

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12 December 2020

Endophilin Is Required for Synaptic Vesicle Endocytosis by Localizing Synaptojanin

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12 December 2020

Comparison of kindreds with parkinsonism and alpha-synuclein genomic multiplications

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12 December 2020

Cargo-selective endosomal sorting for retrieval to the Golgi requires retromer

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12 December 2020

Structure of an auxilin-bound clathrin coat and its implications for the mechanism of uncoating

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12 December 2020

Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease

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12 December 2020

Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology

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12 December 2020

Alpha-synuclein cooperates with CSPalpha in preventing neurodegeneration

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12 December 2020

Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity

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12 December 2020

The Parkinson disease causing LRRK2 mutation I2020T is associated with increased kinase activity

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12 December 2020

Drosophila melanogaster auxilin regulates the internalization of Delta to control activity of the Notch signaling pathway

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12 December 2020

Alpha-synuclein blocks ER-Golgi traffic and Rab1 rescues neuron loss in Parkinson's models

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12 December 2020

Hereditary parkinsonism with dementia is caused by mutations in ATP13A2, encoding a lysosomal type 5 P-type ATPase

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12 December 2020

Kinase activity of mutant LRRK2 mediates neuronal toxicity

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12 December 2020

Drosophila Vps35 function is necessary for normal endocytic trafficking and actin cytoskeleton organisation.

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12 December 2020

Polyunsaturated fatty acids influence synaptojanin localization to regulate synaptic vesicle recycling

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12 December 2020

The Parkinson's disease protein alpha-synuclein disrupts cellular Rab homeostasis

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12 December 2020

The Atg18-Atg2 complex is recruited to autophagic membranes via phosphatidylinositol 3-phosphate and exerts an essential function

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12 December 2020

Phosphorylation of 4E-BP by LRRK2 affects the maintenance of dopaminergic neurons in Drosophila

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12 December 2020

Genomewide association study for susceptibility genes contributing to familial Parkinson disease

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12 December 2020

Alpha-synuclein is part of a diverse and highly conserved interaction network that includes PARK9 and manganese toxicity

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12 December 2020

Analysis of articulation between clathrin and retromer in retrograde sorting on early endosomes.

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12 December 2020

Exogenous alpha-synuclein fibrils seed the formation of Lewy body-like intracellular inclusions in cultured cells

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12 December 2020

Genome-wide association study reveals genetic risk underlying Parkinson's disease

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12 December 2020

Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease

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12 December 2020

Coordinated actions of actin and BAR proteins upstream of dynamin at endocytic clathrin-coated pits

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12 December 2020

Mutations in the small GTPase gene RAB39B are responsible for X-linked mental retardation associated with autism, epilepsy, and macrocephaly

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12 December 2020

Endocytosis and clathrin-uncoating defects at synapses of auxilin knockout mice

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12 December 2020

Retromer-mediated direct sorting is required for proper endosomal recycling of the mammalian iron transporter DMT1

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12 December 2020

Loss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation of alpha-synuclein, and apoptotic cell death in aged mice

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12 December 2020

Alpha-synuclein promotes SNARE-complex assembly in vivo and in vitro

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12 December 2020

Structure of the PTEN-like Region of Auxilin, a Detector of Clathrin-Coated Vesicle Budding

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12 December 2020

αβγ-Synuclein triple knockout mice reveal age-dependent neuronal dysfunction

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12 December 2020

Oxidant stress evoked by pacemaking in dopaminergic neurons is attenuated by DJ-1

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12 December 2020

An endophilin-dynamin complex promotes budding of clathrin-coated vesicles during synaptic vesicle recycling

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12 December 2020

LRRK2 controls synaptic vesicle storage and mobilization within the recycling pool

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12 December 2020

Synaptojanin 1-mediated PI(4,5)P2 hydrolysis is modulated by membrane curvature and facilitates membrane fission

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12 December 2020

Auxilin is required for formation of Golgi-derived clathrin-coated vesicles during Drosophila spermatogenesis

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12 December 2020

SNX27 mediates retromer tubule entry and endosome-to-plasma membrane trafficking of signalling receptors

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12 December 2020

Gaucher disease glucocerebrosidase and α-synuclein form a bidirectional pathogenic loop in synucleinopathies

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12 December 2020

VPS35 mutations in Parkinson disease

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12 December 2020

A mutation in VPS35, encoding a subunit of the retromer complex, causes late-onset Parkinson disease

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12 December 2020

LRRK2 protein levels are determined by kinase function and are crucial for kidney and lung homeostasis in mice

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12 December 2020

Leucine-rich repeat kinase 2 regulates autophagy through a calcium-dependent pathway involving NAADP

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12 December 2020

Recruitment of endophilin to clathrin-coated pit necks is required for efficient vesicle uncoating after fission

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12 December 2020

The Arp2/3 activator WASH regulates α5β1-integrin-mediated invasive migration

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12 December 2020

Roles of the Drosophila LRRK2 homolog in Rab7-dependent lysosomal positioning

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12 December 2020

Allosteric activation of the phosphoinositide phosphatase Sac1 by anionic phospholipids

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12 December 2020

A deleterious mutation in DNAJC6 encoding the neuronal-specific clathrin-uncoating co-chaperone auxilin, is associated with juvenile parkinsonism

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12 December 2020

LRRK2 knockout mice have an intact dopaminergic system but display alterations in exploratory and motor co-ordination behaviors

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12 December 2020

LRRK2 controls an EndoA phosphorylation cycle in synaptic endocytosis

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12 December 2020

DNAJC6 is responsible for juvenile parkinsonism with phenotypic variability.

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12 December 2020

RAB7L1 interacts with LRRK2 to modify intraneuronal protein sorting and Parkinson's disease risk

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12 December 2020

Interplay of LRRK2 with chaperone-mediated autophagy

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12 December 2020

Prion-like spreading of pathological α-synuclein in brain

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12 December 2020

Atg12-Atg5 conjugate enhances E2 activity of Atg3 by rearranging its catalytic site

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12 December 2020

Leucine-rich repeat kinase 2 (LRRK2)-deficient rats exhibit renal tubule injury and perturbations in metabolic and immunological homeostasis

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12 December 2020

The Sac1 domain of SYNJ1 identified mutated in a family with early-onset progressive Parkinsonism with generalized seizures

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12 December 2020

Mutation in the SYNJ1 gene associated with autosomal recessive, early-onset Parkinsonism

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12 December 2020

Interactions of the auxilin-1 PTEN-like domain with model membranes result in nanoclustering of phosphatidyl inositol phosphates

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12 December 2020

DNAJC13 mutations in Parkinson disease

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12 December 2020

Zn²⁺ dyshomeostasis caused by loss of ATP13A2/PARK9 leads to lysosomal dysfunction and alpha-synuclein accumulation

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12 December 2020

A mechanism for retromer endosomal coat complex assembly with cargo

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12 December 2020

RME-8 coordinates the activity of the WASH complex with the function of the retromer SNX dimer to control endosomal tubulation

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12 December 2020

Retromer mediates a discrete route of local membrane delivery to dendrites

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12 December 2020

PARK20 caused by SYNJ1 homozygous Arg258Gln mutation in a new Italian family

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12 December 2020

Mutation in VPS35 associated with Parkinson's disease impairs WASH complex association and inhibits autophagy

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12 December 2020

Activity-dependent facilitation of Synaptojanin and synaptic vesicle recycling by the Minibrain kinase

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12 December 2020

Retromer binding to FAM21 and the WASH complex is perturbed by the Parkinson disease-linked VPS35(D620N) mutation

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12 December 2020

Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease

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12 December 2020

LRRK2 delays degradative receptor trafficking by impeding late endosomal budding through decreasing Rab7 activity.

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12 December 2020

α-Synuclein assembles into higher-order multimers upon membrane binding to promote SNARE complex formation

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12 December 2020

Novel ethyl methanesulfonate (EMS)-induced null alleles of the Drosophila homolog of LRRK2 reveal a crucial role in endolysosomal functions and autophagy in vivo

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12 December 2020

LIMP-2 expression is critical for β-glucocerebrosidase activity and α-synuclein clearance

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12 December 2020

Retromer-dependent neurotransmitter receptor trafficking to synapses is altered by the Parkinson's disease VPS35 mutation p.D620N.

1 reference

12 December 2020

Mutations in RAB39B cause X-linked intellectual disability and early-onset Parkinson disease with α-synuclein pathology

1 reference

12 December 2020

LRRK2 functions in synaptic vesicle endocytosis through a kinase-dependent mechanism

1 reference

12 December 2020

Endophilin marks and controls a clathrin-independent endocytic pathway.

1 reference

12 December 2020

Endophilin-A2 functions in membrane scission in clathrin-independent endocytosis.

1 reference

12 December 2020

The intellectual disability protein RAB39B selectively regulates GluA2 trafficking to determine synaptic AMPAR composition.

1 reference

12 December 2020

Sac2/INPP5F is an inositol 4-phosphatase that functions in the endocytic pathway

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12 December 2020

Spatiotemporal control of phosphatidylinositol 4-phosphate by Sac2 regulates endocytic recycling

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12 December 2020

A lipid switch unlocks Parkinson's disease-associated ATP13A2

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12 December 2020

Rme-8 depletion perturbs Notch recycling and predisposes to pathogenic signaling

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12 December 2020

Retromer Ensures the Degradation of Autophagic Cargo by Maintaining Lysosome Function in Drosophila

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12 December 2020

VPS35 in Dopamine Neurons Is Required for Endosome-to-Golgi Retrieval of Lamp2a, a Receptor of Chaperone-Mediated Autophagy That Is Critical for α-Synuclein Degradation and Prevention of Pathogenesis of Parkinson's Disease

1 reference

12 December 2020

The Parkinson's Disease-Associated Protein Kinase LRRK2 Modulates Notch Signaling through the Endosomal Pathway.

1 reference

12 December 2020

ER-mitochondrial junctions can be bypassed by dominant mutations in the endosomal protein Vps13.

1 reference

12 December 2020

DNAJC6 Mutations Associated With Early-Onset Parkinson's Disease.

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12 December 2020

Auxilin facilitates membrane traffic in the early secretory pathway

1 reference

12 December 2020

Phosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPases

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12 December 2020

α-Synuclein-induced lysosomal dysfunction occurs through disruptions in protein trafficking in human midbrain synucleinopathy models

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12 December 2020

Loss of VPS13C Function in Autosomal-Recessive Parkinsonism Causes Mitochondrial Dysfunction and Increases PINK1/Parkin-Dependent Mitophagy

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12 December 2020

Identification of TMEM230 mutations in familial Parkinson's disease

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12 December 2020

The Parkinson's disease-associated genes ATP13A2 and SYT11 regulate autophagy via a common pathway

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12 December 2020

Yeast Vps13 promotes mitochondrial function and is localized at membrane contact sites

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12 December 2020

Parkinson Disease-linked Vps35 R524W Mutation Impairs the Endosomal Association of Retromer and Induces α-Synuclein Aggregation

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12 December 2020

LRRK2 and RAB7L1 coordinately regulate axonal morphology and lysosome integrity in diverse cellular contexts.

1 reference

12 December 2020

Identification of a novel homozygous mutation Arg459Pro in SYNJ1 gene of an Indian family with autosomal recessive juvenile Parkinsonism.

1 reference

12 December 2020

A LRRK2-Dependent EndophilinA Phosphoswitch Is Critical for Macroautophagy at Presynaptic Terminals.

1 reference

12 December 2020

The Vps13p-Cdc31p complex is directly required for TGN late endosome transport and TGN homotypic fusion.

1 reference

12 December 2020

Genome-Scale Networks Link Neurodegenerative Disease Genes to α-Synuclein through Specific Molecular Pathways

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12 December 2020

Auxilin Underlies Progressive Locomotor Deficits and Dopaminergic Neuron Loss in a Drosophila Model of Parkinson's Disease.

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12 December 2020

Parkinson Sac Domain Mutation in Synaptojanin 1 Impairs Clathrin Uncoating at Synapses and Triggers Dystrophic Changes in Dopaminergic Axons

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12 December 2020

α-Synuclein promotes dilation of the exocytotic fusion pore.

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12 December 2020

The SAC1 domain in synaptojanin is required for autophagosome maturation at presynaptic terminals

1 reference

12 December 2020

ATP13A2/PARK9 regulates endo-/lysosomal cargo sorting and proteostasis through a novel PI(3, 5)P2-mediated scaffolding function.

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12 December 2020

Vps35 in cooperation with LRRK2 regulates synaptic vesicle endocytosis through the endosomal pathway in Drosophila

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12 December 2020

Dopamine oxidation mediates mitochondrial and lysosomal dysfunction in Parkinson's disease

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12 December 2020

Dopamine induces soluble α-synuclein oligomers and nigrostriatal degeneration.

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12 December 2020

Parkinson's Disease-Associated LRRK2 Hyperactive Kinase Mutant Disrupts Synaptic Vesicle Trafficking in Ventral Midbrain Neurons.

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12 December 2020

Age-Dependent Dopaminergic Neurodegeneration and Impairment of the Autophagy-Lysosomal Pathway in LRRK-Deficient Mice

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12 December 2020

10.1007/S12041-018-0959-Z

Identifiers

DOI

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13 April 2020

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