Phosphorylation at S2053 in Murine (S2056 in Human) DNA-PKcs Is Dispensable for Lymphocyte Development and Class Switch Recombination (Q64386916)

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27 April 2020

title

Phosphorylation at S2053 in Murine (S2056 in Human) DNA-PKcs Is Dispensable for Lymphocyte Development and Class Switch Recombination (English)

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27 April 2020

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27 April 2020

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27 April 2020

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27 April 2020

Verna M Estes

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27 April 2020

Xiaobin S Wang

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27 April 2020

Zhengping Shao

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27 April 2020

Brian J Lee

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27 April 2020

Jennifer L Crowe

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27 April 2020

language of work or name

English

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publication date

17 May 2019

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27 April 2020

published in

Journal of Immunology

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27 April 2020

volume

203

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27 April 2020

issue

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27 April 2020

page(s)

178-187

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Targeted disruption of the catalytic subunit of the DNA-PK gene in mice confers severe combined immunodeficiency and radiosensitivity

27 April 2020

cites work

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A targeted DNA-PKcs-null mutation reveals DNA-PK-independent functions for KU in V(D)J recombination

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Abnormal development of Purkinje cells and lymphocytes in Atm mutant mice

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Synthetic lethality between mutation in Atm and DNA-PK(cs) during murine embryogenesis

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Genetic interactions between ATM and the nonhomologous end-joining factors in genomic stability and development

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Hairpin opening and overhang processing by an Artemis/DNA-dependent protein kinase complex in nonhomologous end joining and V(D)J recombination

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IgH class switch recombination to IgG1 in DNA-PKcs-deficient B cells

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Identification of in vitro and in vivo phosphorylation sites in the catalytic subunit of the DNA-dependent protein kinase

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Autophosphorylation of the DNA-dependent protein kinase catalytic subunit is required for rejoining of DNA double-strand breaks

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12 December 2020

The DNA-dependent protein kinase interacts with DNA to form a protein-DNA complex that is disrupted by phosphorylation

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12 December 2020

DNA-dependent protein kinase activity is not required for immunoglobulin class switching

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12 December 2020

Leaky Scid phenotype associated with defective V(D)J coding end processing in Artemis-deficient mice

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12 December 2020

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12 December 2020

Autophosphorylation of the catalytic subunit of the DNA-dependent protein kinase is required for efficient end processing during DNA double-strand break repair

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Autophosphorylation-dependent remodeling of the DNA-dependent protein kinase catalytic subunit regulates ligation of DNA ends

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Cell cycle dependence of DNA-dependent protein kinase phosphorylation in response to DNA double strand breaks.

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Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage

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Autophosphorylation of DNA-dependent protein kinase regulates DNA end processing and may also alter double-strand break repair pathway choice

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12 December 2020

Terminal DNA structure and ATP influence binding parameters of the DNA-dependent protein kinase at an early step prior to DNA synapsis

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Autophosphorylation at serine 1987 is dispensable for murine Atm activation in vivo

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12 December 2020

ATR-dependent phosphorylation of DNA-dependent protein kinase catalytic subunit in response to UV-induced replication stress

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12 December 2020

The DNA-dependent protein kinase catalytic subunit is phosphorylated in vivo on threonine 3950, a highly conserved amino acid in the protein kinase domain

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12 December 2020

Ataxia telangiectasia mutated (ATM) is essential for DNA-PKcs phosphorylations at the Thr-2609 cluster upon DNA double strand break.

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12 December 2020

trans Autophosphorylation at DNA-dependent protein kinase's two major autophosphorylation site clusters facilitates end processing but not end joining

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12 December 2020

Autophosphorylation of DNA-PKCS regulates its dynamics at DNA double-strand breaks

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12 December 2020

IgH class switching and translocations use a robust non-classical end-joining pathway

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12 December 2020

Complementary functions of ATM and H2AX in development and suppression of genomic instability

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12 December 2020

Lymphocyte-specific compensation for XLF/cernunnos end-joining functions in V(D)J recombination

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12 December 2020

53BP1 facilitates long-range DNA end-joining during V(D)J recombination

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12 December 2020

Multiple autophosphorylation sites are dispensable for murine ATM activation in vivo

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12 December 2020

Essential role for DNA-PKcs in DNA double-strand break repair and apoptosis in ATM-deficient lymphocytes

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12 December 2020

Alternative end-joining catalyzes class switch recombination in the absence of both Ku70 and DNA ligase 4.

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12 December 2020

The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway

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12 December 2020

A structural model for regulation of NHEJ by DNA-PKcs autophosphorylation

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12 December 2020

Ataxia telangiectasia-mutated protein and DNA-dependent protein kinase have complementary V(D)J recombination functions

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12 December 2020

Ataxia telangiectasia mutated (Atm) and DNA-PKcs kinases have overlapping activities during chromosomal signal joint formation

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12 December 2020

Congenital bone marrow failure in DNA-PKcs mutant mice associated with deficiencies in DNA repair

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12 December 2020

YAHA: fast and flexible long-read alignment with optimal breakpoint detection

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12 December 2020

Loss of ATM kinase activity leads to embryonic lethality in mice

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12 December 2020

Kinase-dead ATM protein causes genomic instability and early embryonic lethality in mice

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12 December 2020

Functional intersection of ATM and DNA-dependent protein kinase catalytic subunit in coding end joining during V(D)J recombination

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12 December 2020

DNA repair. PAXX, a paralog of XRCC4 and XLF, interacts with Ku to promote DNA double-strand break repair

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12 December 2020

Interactome analysis identifies a new paralogue of XRCC4 in non-homologous end joining DNA repair pathway

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12 December 2020

Differential phosphorylation of DNA-PKcs regulates the interplay between end-processing and end-ligation during nonhomologous end-joining

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12 December 2020

Orientation-specific joining of AID-initiated DNA breaks promotes antibody class switching.

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12 December 2020

Spontaneous tumor development in bone marrow-rescued DNA-PKcs(3A/3A) mice due to dysfunction of telomere leading strand deprotection

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12 December 2020

Detecting DNA double-stranded breaks in mammalian genomes by linear amplification-mediated high-throughput genome-wide translocation sequencing

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12 December 2020

PAXX and XLF DNA repair factors are functionally redundant in joining DNA breaks in a G1-arrested progenitor B-cell line

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12 December 2020

PAXX promotes KU accumulation at DNA breaks and is essential for end-joining in XLF-deficient mice

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12 December 2020

NAD+ analog reveals PARP-1 substrate-blocking mechanism and allosteric communication from catalytic center to DNA-binding domains

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12 December 2020

MRI Is a DNA Damage Response Adaptor during Classical Non-homologous End Joining

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12 December 2020

Kinase-dependent structural role of DNA-PKcs during immunoglobulin class switch recombination

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12 December 2020

Kinase-dead ATR differs from ATR loss by limiting the dynamic exchange of ATR and RPA

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12 December 2020