The DNA-dependent protein kinase catalytic subunit is phosphorylated in vivo on threonine 3950, a highly conserved amino acid in the protein kinase domain (Q40198361)

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scientific article published on 11 December 2006

Language	Label	Description	Also known as
English	The DNA-dependent protein kinase catalytic subunit is phosphorylated in vivo on threonine 3950, a highly conserved amino acid in the protein kinase domain	scientific article published on 11 December 2006

Statements

scholarly article

1 reference

Europe PubMed Central

PMC publication ID

18 September 2017

The DNA-dependent protein kinase catalytic subunit is phosphorylated in vivo on threonine 3950, a highly conserved amino acid in the protein kinase domain (English)

1 reference

Europe PubMed Central

PMC publication ID

18 September 2017

phosphorylation

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author name string

Pauline Douglas

1

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Europe PubMed Central

PMC publication ID

18 September 2017

Xiaoping Cui

2

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Europe PubMed Central

PMC publication ID

18 September 2017

Wesley D Block

3

1 reference

Europe PubMed Central

PMC publication ID

18 September 2017

Yaping Yu

4

1 reference

Europe PubMed Central

PMC publication ID

18 September 2017

Shikha Gupta

5

1 reference

Europe PubMed Central

PMC publication ID

18 September 2017

Qi Ding

6

1 reference

Europe PubMed Central

PMC publication ID

18 September 2017

Ruiqiong Ye

7

1 reference

Europe PubMed Central

PMC publication ID

18 September 2017

Nick Morrice

8

1 reference

Europe PubMed Central

PMC publication ID

18 September 2017

Susan P Lees-Miller

9

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18 September 2017

Katheryn Meek

10

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18 September 2017

language of work or name

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publication date

11 December 2006

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18 September 2017

Molecular and Cellular Biology

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18 September 2017

27

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18 September 2017

5

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18 September 2017

1581-1591

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Europe PubMed Central

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18 September 2017

ATR-dependent phosphorylation of DNA-dependent protein kinase catalytic subunit in response to UV-induced replication stress

1 reference

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22 September 2017

Preclinical evaluation of a potent novel DNA-dependent protein kinase inhibitor NU7441.

1 reference

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22 September 2017

The leucine rich region of DNA-PKcs contributes to its innate DNA affinity.

1 reference

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22 September 2017

The DNA-dependent protein kinase catalytic subunit phosphorylation sites in human Artemis

1 reference

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22 September 2017

DNA-PK-dependent phosphorylation of Ku70/80 is not required for non-homologous end joining.

1 reference

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22 September 2017

Cell cycle dependence of DNA-dependent protein kinase phosphorylation in response to DNA double strand breaks.

1 reference

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22 September 2017

DNA-dependent protein kinase and XRCC4-DNA ligase IV mobilization in the cell in response to DNA double strand breaks.

1 reference

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22 September 2017

Regulation of protein kinases; controlling activity through activation segment conformation

1 reference

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22 September 2017

Autophosphorylation-dependent remodeling of the DNA-dependent protein kinase catalytic subunit regulates ligation of DNA ends

1 reference

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22 September 2017

Large-scale characterization of HeLa cell nuclear phosphoproteins

1 reference

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22 September 2017

The DNA-dependent protein kinase: the director at the end.

1 reference

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22 September 2017

Biochemical characterization of the ataxia-telangiectasia mutated (ATM) protein from human cells

1 reference

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22 September 2017

Repair of DNA double strand breaks by non-homologous end joining

1 reference

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22 September 2017

Visualization of DNA-induced conformational changes in the DNA repair kinase DNA-PKcs

1 reference

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22 September 2017

Autophosphorylation of the catalytic subunit of the DNA-dependent protein kinase is required for efficient end processing during DNA double-strand break repair

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1820444

22 September 2017

Threonines 2638/2647 in DNA-PK are essential for cellular resistance to ionizing radiation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1820444

22 September 2017

Identification and characterization of the autophosphorylation sites of phosphoinositide 3-kinase isoforms beta and gamma

1 reference

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22 September 2017

The protein kinase complement of the human genome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1820444

22 September 2017

A single amino acid substitution in DNA-PKcs explains the novel phenotype of the CHO mutant, XR-C2.

1 reference

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22 September 2017

Autophosphorylation of the DNA-dependent protein kinase catalytic subunit is required for rejoining of DNA double-strand breaks

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1820444

22 September 2017

Identification of in vitro and in vivo phosphorylation sites in the catalytic subunit of the DNA-dependent protein kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1820444

22 September 2017

Both V(D)J recombination and radioresistance require DNA-PK kinase activity, though minimal levels suffice for V(D)J recombination

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1820444

22 September 2017

Utilization of oriented peptide libraries to identify substrate motifs selected by ATM.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1820444

22 September 2017

Mammalian X-ray-sensitive mutants which are defective in non-homologous (illegitimate) DNA double-strand break repair

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1820444

22 September 2017

Requirement for the kinase activity of human DNA-dependent protein kinase catalytic subunit in DNA strand break rejoining

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1820444

22 September 2017

Autophosphorylation of p110δ phosphoinositide 3-kinase: a new paradigm for the regulation of lipid kinases in vitro and in vivo

1 reference

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22 September 2017

XR-C1, a new CHO cell mutant which is defective in DNA-PKcs, is impaired in both V(D)J coding and signal joint formation

1 reference

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22 September 2017

Human DNA-activated protein kinase phosphorylates serines 15 and 37 in the amino-terminal transactivation domain of human p53.

1 reference

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22 September 2017

Autophosphorylation of DNA-dependent protein kinase regulates DNA end processing and may also alter double-strand break repair pathway choice

1 reference

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SCID in Jack Russell terriers: a new animal model of DNA-PKcs deficiency

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25 September 2017

Protein phosphatases regulate DNA-dependent protein kinase activity

1 reference

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25 September 2017

Analyses of TCRB rearrangements substantiate a profound deficit in recombination signal sequence joining in SCID foals: implications for the role of DNA-dependent protein kinase in V(D)J recombination

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PI 3-kinase is a dual specificity enzyme: autoregulation by an intrinsic protein-serine kinase activity.

1 reference

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25 September 2017

Three-dimensional structure and regulation of the DNA-dependent protein kinase catalytic subunit (DNA-PKcs).

1 reference

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20 August 2018

Non-homologous end joining requires that the DNA-PK complex undergo an autophosphorylation-dependent rearrangement at DNA ends.

1 reference

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20 August 2018

The DNA-dependent protein kinase interacts with DNA to form a protein-DNA complex that is disrupted by phosphorylation

1 reference

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20 August 2018

Structural insights into phosphoinositide 3-kinase catalysis and signalling

1 reference

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4 November 2018

Multiple Reaction Monitoring to Identify Sites of Protein Phosphorylation with High Sensitivity

1 reference

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2 December 2018

The DNA-dependent protein kinase is inactivated by autophosphorylation of the catalytic subunit

1 reference

https://pubmed.ncbi.nlm.nih.gov/17158925

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Putative homologues of the DNA-dependent protein kinase catalytic subunit (DNA-PKcs) and other components of the non-homologous end joining machinery in Dictyostelium discoideum

1 reference

https://pubmed.ncbi.nlm.nih.gov/17158925

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Automated identification and quantification of protein phosphorylation sites by LC/MS on a hybrid triple quadrupole linear ion trap mass spectrometer

1 reference

https://pubmed.ncbi.nlm.nih.gov/17158925

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Three-Dimensional Structure of the Human DNA-PKcs/Ku70/Ku80 Complex Assembled on DNA and Its Implications for DNA DSB Repair

1 reference

https://pubmed.ncbi.nlm.nih.gov/17158925

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1128/MCB.01962-06

1 reference

Europe PubMed Central

PMC publication ID

18 September 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

18 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

18 September 2017

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