Understanding and modulating cyclin-dependent kinase inhibitor specificity: molecular modeling and biochemical evaluation of pyrazolopyrimidinones as CDK2/cyclin A and CDK4/cyclin D1 inhibitors. (Q53663557)

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scientific article published in February 2005

Language	Label	Description	Also known as
English	Understanding and modulating cyclin-dependent kinase inhibitor specificity: molecular modeling and biochemical evaluation of pyrazolopyrimidinones as CDK2/cyclin A and CDK4/cyclin D1 inhibitors.	scientific article published in February 2005

Statements

scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

17 May 2018

http://europepmc.org/abstract/MED/16075305

Understanding and modulating cyclin-dependent kinase inhibitor specificity: molecular modeling and biochemical evaluation of pyrazolopyrimidinones as CDK2/cyclin A and CDK4/cyclin D1 inhibitors. (English)

1 reference

Europe PubMed Central

PubMed publication ID

17 May 2018

http://europepmc.org/abstract/MED/16075305

author name string

Karen A Rossi

1

1 reference

Europe PubMed Central

PubMed publication ID

17 May 2018

http://europepmc.org/abstract/MED/16075305

Jay A Markwalder

2

1 reference

Europe PubMed Central

PubMed publication ID

17 May 2018

http://europepmc.org/abstract/MED/16075305

Steven P Seitz

3

1 reference

Europe PubMed Central

PubMed publication ID

17 May 2018

http://europepmc.org/abstract/MED/16075305

Chong-Hwan Chang

4

1 reference

Europe PubMed Central

PubMed publication ID

17 May 2018

http://europepmc.org/abstract/MED/16075305

Sarah Cox

5

1 reference

Europe PubMed Central

PubMed publication ID

17 May 2018

http://europepmc.org/abstract/MED/16075305

Michael D Boisclair

6

1 reference

Europe PubMed Central

PubMed publication ID

17 May 2018

http://europepmc.org/abstract/MED/16075305

Leonardo Brizuela

7

1 reference

Europe PubMed Central

PubMed publication ID

17 May 2018

http://europepmc.org/abstract/MED/16075305

Stephen L Brenner

8

1 reference

Europe PubMed Central

PubMed publication ID

17 May 2018

http://europepmc.org/abstract/MED/16075305

Pieter F W Stouten

9

1 reference

Europe PubMed Central

PubMed publication ID

17 May 2018

http://europepmc.org/abstract/MED/16075305

publication date

1 February 2005

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Europe PubMed Central

PubMed publication ID

17 May 2018

http://europepmc.org/abstract/MED/16075305

Journal of Computer - Aided Molecular Design

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Europe PubMed Central

PubMed publication ID

17 May 2018

http://europepmc.org/abstract/MED/16075305

19

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Europe PubMed Central

PubMed publication ID

17 May 2018

http://europepmc.org/abstract/MED/16075305

2

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Europe PubMed Central

PubMed publication ID

17 May 2018

http://europepmc.org/abstract/MED/16075305

111-122

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Europe PubMed Central

PubMed publication ID

17 May 2018

http://europepmc.org/abstract/MED/16075305

Cell cycle control as a basis for cancer drug development (Review).

1 reference

https://pubmed.ncbi.nlm.nih.gov/16075305

12 December 2020

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Targets for cancer therapy in the cell cycle pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/16075305

12 December 2020

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WHAT IF: a molecular modeling and drug design program

1 reference

https://pubmed.ncbi.nlm.nih.gov/16075305

12 December 2020

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Crystallographic approach to identification of cyclin-dependent kinase 4 (CDK4)-specific inhibitors by using CDK4 mimic CDK2 protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/16075305

12 December 2020

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Understanding and controlling the cell cycle with natural products

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https://pubmed.ncbi.nlm.nih.gov/16075305

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Evaluation of comparative protein modeling by MODELLER

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https://pubmed.ncbi.nlm.nih.gov/16075305

12 December 2020

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Altered expression of the cyclin D1 and retinoblastoma genes in human esophageal cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/16075305

12 December 2020

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Structure-based generation of a new class of potent Cdk4 inhibitors: new de novo design strategy and library design

1 reference

https://pubmed.ncbi.nlm.nih.gov/16075305

12 December 2020

based on heuristic

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A novel approach for the development of selective Cdk4 inhibitors: library design based on locations of Cdk4 specific amino acid residues

1 reference

https://pubmed.ncbi.nlm.nih.gov/16075305

12 December 2020

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Inhibition of cyclin-dependent kinases by purine analogues: crystal structure of human cdk2 complexed with roscovitine

1 reference

https://pubmed.ncbi.nlm.nih.gov/16075305

12 December 2020

based on heuristic

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Crystal structure of the p27Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex

1 reference

https://pubmed.ncbi.nlm.nih.gov/16075305

12 December 2020

based on heuristic

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Flavopiridol induces G1 arrest with inhibition of cyclin-dependent kinase (CDK) 2 and CDK4 in human breast carcinoma cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16075305

12 December 2020

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Four-dimensional control of the cell cycle

1 reference

https://pubmed.ncbi.nlm.nih.gov/16075305

12 December 2020

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Hepatitis B virus integration in a cyclin A gene in a hepatocellular carcinoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/16075305

12 December 2020

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Mechanism of CDK activation revealed by the structure of a cyclinA-CDK2 complex

1 reference

https://pubmed.ncbi.nlm.nih.gov/16075305

12 December 2020

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Mammalian G1 cyclins

1 reference

https://pubmed.ncbi.nlm.nih.gov/16075305

12 December 2020

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Synthesis and biological evaluation of 1-aryl-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidin-4-one inhibitors of cyclin-dependent kinases

1 reference

https://pubmed.ncbi.nlm.nih.gov/16075305

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genetic alterations of cyclins, cyclin-dependent kinases, and Cdk inhibitors in human cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/16075305

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Protein Data Bank: a computer-based archival file for macromolecular structures

1 reference

https://pubmed.ncbi.nlm.nih.gov/16075305

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The cell cycle: a review of regulation, deregulation and therapeutic targets in cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/16075305

12 December 2020

based on heuristic

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p21 is a universal inhibitor of cyclin kinases

1 reference

https://pubmed.ncbi.nlm.nih.gov/16075305

12 December 2020

based on heuristic

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G1 events and regulation of cell proliferation

1 reference

https://pubmed.ncbi.nlm.nih.gov/16075305

12 December 2020

based on heuristic

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Multiple modes of ligand recognition: crystal structures of cyclin-dependent protein kinase 2 in complex with ATP and two inhibitors, olomoucine and isopentenyladenine

1 reference

https://pubmed.ncbi.nlm.nih.gov/16075305

12 December 2020

based on heuristic

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Cell cycle control in eukaryotes: molecular mechanisms of cdc2 activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/16075305

12 December 2020

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Biochemical and mutagenic analysis of the melanoma tumor suppressor gene product/p16

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https://pubmed.ncbi.nlm.nih.gov/16075305

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A cell cycle regulator potentially involved in genesis of many tumor types

1 reference

https://pubmed.ncbi.nlm.nih.gov/16075305

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Comparative protein modelling by satisfaction of spatial restraints

1 reference

https://pubmed.ncbi.nlm.nih.gov/16075305

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S10822-005-1778-X

1 reference

Europe PubMed Central

PubMed publication ID

17 May 2018

http://europepmc.org/abstract/MED/16075305

DBLP publication ID

journals/jcamd/RossiMSCCBBBS05

1 reference

DBLP Dataset 2021-01-02

28 January 2021

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

17 May 2018

http://europepmc.org/abstract/MED/16075305

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