Concomitant activation of pathways downstream of Grb2 and PI 3-kinase is required for MET-mediated metastasis. (Q53426359)

14 May 2018

title

Concomitant activation of pathways downstream of Grb2 and PI 3-kinase is required for MET-mediated metastasis. (English)

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14 May 2018

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14 May 2018

Paolo M. Comoglio

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14 May 2018

Bardelli A

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Basile ML

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14 May 2018

Giordano S

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14 May 2018

Wennström S

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14 May 2018

Ménard S

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14 May 2018

Ponzetto C

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14 May 2018

language of work or name

English

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publication date

1 February 1999

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14 May 2018

published in

Oncogene

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14 May 2018

volume

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14 May 2018

issue

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14 May 2018

page(s)

1139-1146

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14 May 2018

"Invasive-growth" signaling by the Met/HGF receptor: the hereditary renal carcinoma connection.

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Gab1 coupling to the HGF/Met receptor multifunctional docking site requires binding of Grb2 and correlates with the transforming potential.

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Regulation of the urokinase-type plasminogen activator gene by the oncogene Tpr-Met involves GRB2.

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Induction of epithelial tubules by growth factor HGF depends on the STAT pathway

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Identification of the Hepatocyte Growth Factor Receptor As the c- met Proto-Oncogene Product

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7 January 2021

Molecular cloning of a new transforming gene from a chemically transformed human cell line.

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7 January 2021

HGF-mediated chemotaxis and tubulogenesis require activation of the phosphatidylinositol 3-kinase

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7 January 2021

Scatter factor protects epithelial and carcinoma cells against apoptosis induced by DNA-damaging agents

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7 January 2021

Distinct phosphotyrosines on a growth factor receptor bind to specific molecules that mediate different signaling pathways

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7 January 2021

Duplication and overexpression of the mutant allele of the MET proto-oncogene in multiple hereditary papillary renal cell tumours

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7 January 2021

Efficient Cellular Transformation by the Met Oncoprotein Requires a Functional Grb2 Binding Site and Correlates with Phosphorylation of the Grb2-associated Proteins, Cbl and Gab1

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A point mutation in the MET oncogene abrogates metastasis without affecting transformation.

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A Grb2-associated docking protein in EGF- and insulin-receptor signalling

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7 January 2021

The protooncogene c-sea encodes a transmembrane protein-tyrosine kinase related to the Met/hepatocyte growth factor/scatter factor receptor

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Suppression of c-Myc-induced apoptosis by Ras signalling through PI(3)K and PKB.

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Cdc42 and Rac1 induce integrin-mediated cell motility and invasiveness through PI(3)K

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7 January 2021

Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway

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7 January 2021

Phosphoinositide 3-kinase induces scattering and tubulogenesis in epithelial cells through a novel pathway

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7 January 2021

Construction of an SH2 domain-binding site with mixed specificity

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7 January 2021

Uncoupling of Grb2 from the Met receptor in vivo reveals complex roles in muscle development

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7 January 2021

The tyrosine kinase receptors Ron and Sea control "scattering" and morphogenesis of liver progenitor cells in vitro

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7 January 2021

Association of the Multisubstrate Docking Protein Gab1 with the Hepatocyte Growth Factor Receptor Requires a Functional Grb2 Binding Site Involving Tyrosine 1356

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7 January 2021

Mechanism of met oncogene activation

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7 January 2021

A novel recognition motif for phosphatidylinositol 3-kinase binding mediates its association with the hepatocyte growth factor/scatter factor receptor

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7 January 2021

A multifunctional docking site mediates signaling and transformation by the hepatocyte growth factor/scatter factor receptor family

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7 January 2021

Specific uncoupling of GRB2 from the Met receptor. Differential effects on transformation and motility

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7 January 2021

Dimerization mediated through a leucine zipper activates the oncogenic potential of the met receptor tyrosine kinase

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7 January 2021

Hepatocyte growth factor-induced scatter of Madin-Darby canine kidney cells requires phosphatidylinositol 3-kinase.

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7 January 2021

Germline and somatic mutations in the tyrosine kinase domain of the MET proto-oncogene in papillary renal carcinomas

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7 January 2021

Activation of Phosphoinositide 3-OH Kinase by the α6β4 Integrin Promotes Carcinoma Invasion

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7 January 2021

The v-sea oncogene of avian erythroblastosis retrovirus S13: another member of the protein-tyrosine kinase gene family

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7 January 2021

The war on cancer: a review

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7 January 2021

Scatter factor is a fibroblast-derived modulator of epithelial cell mobility

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7 January 2021

Interaction between Gab1 and the c-Met receptor tyrosine kinase is responsible for epithelial morphogenesis

1 reference

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7 January 2021

The Met receptor tyrosine kinase transduces motility, proliferation, and morphogenic signals of scatter factor/hepatocyte growth factor in epithelial cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202607

7 January 2021

Trisomy 7-harbouring non-random duplication of the mutant MET allele in hereditary papillary renal carcinomas

1 reference

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7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1202607

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14 May 2018

Dimensions Publication ID

1027189119

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1 reference

14 May 2018